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*  CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism
Furthermore, 5MPN suppresses glucose uptake and tumor growth in mice injected with Lewis lung carcinoma cells [49]. PFKFB4 is ... Cell culture. Human breast cancer cell lines MDA-MB-231, MCF7, SUM159 and MDA-MB-468 were cultured in high glucose DMEM ( ... Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that responds to hypoxia and prevents cell differentiation [ ... CD44 serves as a cell surface marker for cancer stem cells in many types of cancer, including breast, ovarian, lung, and ...
  http://thno.org/v08p6248.htm
*  Bordetella pertussis exhibits specific attachment, invasion, and cytotoxic capabilities toward human cancer cells. | Cancer...
Exposure of human SKmel-23 melanoma, MCF-7 breast carcinoma, or A549 lung carcinoma cells in culture to Bordetella pertussis ... Lysis was largely prevented by simultaneous treatment with 3-MA. B. pertussis targeted A549 human lung carcinomas growing s.c. ... Lewis × antigens, CD11b, and the sequence arg-gly-asp respectivelly. Invasion was also inhibited by preincubation of cancer ... Regarding safety, i.v.-injected B. pertussis showed no toxicity toward the mice after repeated injections of the highest dose ...
  http://cancerres.aacrjournals.org/content/64/7_Supplement/868.4
*  Vaccination Prevents Lung Cancer | Medgadget
... at the Symposium on Molecular Targets and Cancer Therapeutics in Prague presented his research demonstratin ... effective in preventing tumour growth in mice that were subsequently challenged with transplanted Lewis lung carcinoma, and it ... discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells ... such as hereditary breast and colon cancer and lung cancer caused by smoking or other environmental factors.. "We found that ...
  https://www.medgadget.com/2006/11/vaccination_pre.html
*  Metastatic breast cancer - Wikipedia
Such therapies, targeted to specific cell types, is hoped to be useful in the future to develop better treatments to prevent or ... of deaths due to breast cancer. Breast cancer can metastasize anywhere in body but primarily metastasizes to the bone, lungs, ... Breast Cancer Res Treat 2015. Lee, YT (July 1983). "Breast carcinoma: pattern of metastasis at autopsy". Journal of Surgical ... This has a higher response rate than solvent-based paclitaxel (15% vs 8%). Abraxane can also deliver a 49% higher dose of ...
  https://en.wikipedia.org/wiki/Metastatic_breast_cancer
*  M Herbs ~ Widdershin's Apothecary ~ Bringing Magick to Life - Botanicals in the Herb Room ~ - Greenville, SC
... not only against murine tumors but also in cases of Lewis lung carcinoma, colon adenocarcinoma 38, and C3H adenocarcinomas of ... liver cancers). Unfermented mistletoe showed a strong effect on human leukemia (Molt 4) cells. Korean mistletoe (Viscum ... the breast. The extracts are not toxic and may be administered in high doses. Twenty drops four times a day is the average dose ... Hung over a cradle it prevents the theft of a child by fairies and replaced with a changeling. Amulets and jewelry can be made ...
  http://www.angelfire.com/widderschynns/Apothecary/Herbs/M.html
*  Complementary and Alternative Medicines in Prostate Cancer: From Bench to Bedside?
... cuspidatum root prevents tumor growth and metastasis to lung and tumorinduced neovascularization in lewis lung carcinoma- ... Epigallocatechin gallate sensitizes bre ast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Res ... The PCa cell line PC3 cells, exposed to pomegranate extract (PE) at high concentrations ranging from 10 to 100 μg/mL, showed ... Modulation of cell proliferation and cell cycle regulators by vitamin E in human prostate carcinoma cell lines. J Urol. 2002; ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3380882/?lang=en-ca
*  2012 Oncomine Citations | Thermo Fisher Scientific - CN
J Cell Biochem. 2012 Nov 13. , Pubmed. *Estrogen receptor prevents p53-dependent apoptosis in breast cancer.. Bailey ST, Shin H ... Cancer Res. 2012 Mar 15;72(6):1428-37. , Pubmed. *Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory ... Mol Cell Biol. 2012 Oct;32(20):4131-40. , Pubmed. *HDAC11 is a novel drug target in carcinomas.. Deubzer HE, Schier MC, Oehme I ... Cell. 2012 Mar 2;148(5):896-907. , Pubmed. *Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1 ...
  https://www.thermofisher.com/cn/zh/home/life-science/cancer-research/cancer-genomics/cancer-genomics-data-analysis-compendia-bioscience/oncomine-cancer-genomics-data-analysis-library/oncomine-platform-citations/2012-oncomine-citations.html
*  Nutrients | Free Full-Text | Molecular Link between Vitamin D and Cancer Prevention | HTML
... indicating a potential role for vitamin D as a feasible agent to prevent cancer incidence and recurrence. With the preventive ... differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating ... Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, ... 25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell ...
  http://www.mdpi.com/2072-6643/5/10/3993/htm
*  Galatturoglicani - Metodo di Bella - Sito Ufficiale
... deoxyuridine in highly metastatic Lewis lung carcinoma cells. Neoplasma. 1990;37(5):501-10. ... cAMP effect on extracellular matrix synthesis in human breast cancer cells. Cell Prolif. 1992 Nov;25(6):633-42. ... Cancer Res. 2002 May 15;62(10):2848-55.. Perez M, Wandosell F, Colaco C, Avila J. Sulphated glycosaminoglycans prevent the ... Motoyoshi F, Kondo N, Orii T. Bisected N-acetylglucosamine residue of biantennary sugar chains and high-molecular-weight ...
  http://www.metododibella.org/it/Galatturoglicani.html
*  Barbiturate and thiobarbiturate compounds for use in cancer therapy - NUHOPE LLC
... and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may ... shown to be involved in etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cell ... breast cancer, ovarian cancer, renal medullary carcinoma, prostate cancer, gastric cancer, cervical cancer, brain cancer, ... To the extent the drug may prevent growth and/or kill existing cancer cells, it may be cytostatic and/or cytotoxic. The ...
  http://www.freepatentsonline.com/9878998.html
*  Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions |...
The interaction between circulating tumor cells and blood components, mainly platelets, plays an important role during ... Functional role of sialyl Lewis X and fibronectin-derived RGDS peptide analogue on tumor-cell arrest in lungs followed by ... Mancuso A, Sternberg CN (2006) New treatment approaches in metastatic renal cell carcinoma. Curr Opin Urol 16:337-341CrossRef ... Wong CW, Song C, Grimes MM et al (2002) Intravascular location of breast cancer cells after spontaneous metastasis to the lung ...
  https://rd.springer.com/article/10.1007/s10585-009-9299-y
*  Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-κB Activities in A549 and Lewis Lung Carcinoma Cells
Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer ... The breakdown of the ECM of the basement membrane for invasion and metastasis by cancer cells was mediated by expressing high ... Chemoprevention using non-toxic botanicals could be one of the strategies for cancer management by preventing, delaying, ... Cell culture. A549 (human lung adenocarcinoma cell line), Lewis lung carcinoma (LLC, a mouse lung cancer cell line), and MRC-5 ...
  http://www.medsci.org/v15p0280.htm
*  Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines
Tumor types with a high mutational load, such as melanoma and non-small cell lung cancer, can be infiltrated by naturally ... Langerhans cell. Le. Lewis. LN. lymph node. MGL. macrophage galactose-type lectin. moDC. monocyte-derived dendritic cell. MR. ... and carcinoma-specific Ags to the MR on human DCs led to Ag presentation and induced T cell activation [131, 152, 202-204]. In ... and CD4 and CD8 T cell responses in 20-25% [262]. Next, 3 phase I trials were performed with 41 patients with advanced breast ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5597514/
*  Methods for Tumor Targeting with Salmonella typhimurium A1-R | Springer for Research & Development
... has shown great preclinical promise as a broad-based anti-cancer therapeutic (please see Chapter 1). The present chapter ... Comparison of the selective targeting of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice. ... Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget ... Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. J Cell Biochem 112: ...
  https://rd.springer.com/protocol/10.1007/978-1-4939-3515-4_13
*  Esophageal Resection - procedure, recovery, test, blood, tube, removal, pain, complications
Cancer of the top layer of the esophageal lining is called squamous cell carcinoma; it can occur anywhere along the esophagus, ... may lead to cancer. Higher risks are also associated with smoking (45%), alcohol abuse (20%), and lung disorders (23%). ... I always had regular check ups for breast & ovarian cancer along with bowel, I was totally unaware of Esophagus Cancer! At the ... to fully expand the lungs and help prevent infection and collapse of the lungs. Walking and movement will also be encouraged to ...
  http://www.surgeryencyclopedia.com/Ce-Fi/Esophageal-Resection.html
*  An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis | Cancer Research
Significant efficacy of deoxynyboquinone at 6-fold greater potency versus β-lapachone against orthotopic Lewis lung carcinoma ( ... Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone. Cancer Res 1998;58:1876-85. ... PC-3 cells was prevented by dicoumarol (Fig. 2E), as in parental PC-3 cells. PC-3 cells treated with dicoumarol were similarly ... 7C), lung, bone marrow, spleen, or thymus; unlike humans, mice have relatively high liver NQO1 levels. Overall survival ...
  http://cancerres.aacrjournals.org/content/72/12/3038.full
*  A GM-CSF and CD40L bystander vaccine is effective in a murine breast c | BCTT
The vaccine's activity was confirmed in a second experiment using Lewis lung carcinoma (LLC) cells in C57BL/6 mice to exclude a ... interest in using cancer vaccines to treat breast cancer patients in the adjuvant setting to prevent recurrence in high risk ... vaccine is being evaluated in lung cancer and should be explored further in clinical trials of breast cancer patients at high ... There were higher levels of IL-2 and IFN-γ secreting T-cells on ELISPOT for BCG treated groups, and a trend for higher numbers ...
  https://www.dovepress.com/a-gm-csf-and-cd40l-bystander-vaccine-is-effective-in-a-murine-breast-c-peer-reviewed-article-BCTT
*  Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases
... cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology. ... of the sample showed high amounts of stromal CAV1 (Table 1). Also, patients with a large-cell lung cancer tumor showed a high ... key events in the progression from an in situ to an invasive breast carcinoma," Cell Cycle, vol. 12, no. 16, pp. 2684-2690, ... glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts," Cell Cycle, ...
  https://www.hindawi.com/journals/acp/2018/8651790/
*  Frontiers | Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine models | Immunology
... and are thus key targets in cancer vaccine design. Since the 2010 FDA approval of the first cancer DC-based vaccine (Sipuleucel ... and are thus key targets in cancer vaccine design. Since the 2010 FDA approval of the first cancer DC-based vaccine (Sipuleucel ... In this context, the use of experimental cancer models can help direct efforts towards an effective vaccine design. This paper ... In this context, the use of experimental cancer models can help direct efforts towards an effective vaccine design. This paper ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00243/full
*  METHODS OF IMMUNE OR HEMATOLOGICAL ENHANCEMENT, INHIBITING TUMOUR FORMATION OR GROWTH, AND TREATING OR PREVENTING CANCER,...
... or the myeloid cell count, reduce cachexia, mucositis, and anemia, stimulate the immune system and treat or prevent cancer and ... maintain or improve one or more of the white blood cell count, the red blood cell count, ... the symptoms of cancer and side-effects of cancer therapies. The methods and medicinal uses of the invention may be carried out ... the tumour cells are or the cancer is a leukemia, colon carcinoma, breast cancer, melanoma, skin or lung cancer. Tumour types ...
  http://www.sumobrain.com/patents/wipo/Methods-immune-hematological-enhancement-inhibiting/WO2008140335A2.html
*  Pharmaceuticals | Free Full-Text | Aptamers for Targeted Drug Delivery | HTML
With cell-based selection, a specific protein target is not always chosen, but selection is performed against a target cell ... Therefore, aptamers that bind cell surface receptors have been exploited for the delivery of a variety of cargoes into cells. ... All cell surface proteins cycle intracellularly to some extent, and many surface receptors are actively internalized in ... Several studies have demonstrated that aptamers that bind cell surface receptors may have functions other than just blocking ...
  http://www.mdpi.com/1424-8247/3/6/1761/htm
*  Fight Aging! Newsletter, January 13th 2014 - Fight Aging!
Lewis lung carcinoma (LLC), S37 sarcoma, and Ca755 breast carcinoma.. In mice challenged with Ca755 cells, p62 treatment had ... Most cancers abuse telomerase to keep their cells dividing to form tumors, and the SENS anti-cancer strategy of WILT would ... Heart failure spending varied widely between high-income and middle and low-income countries. High-income countries spend a ... The message is simple: Most supplements do not prevent chronic disease or death, their use is not justified, and they should be ...
  https://www.fightaging.org/archives/2014/01/fight-aging-newsletter-january-13th-2014/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Lewis lung carcinoma cells that constitutively express the firefly luciferase gene (luc1) are inoculated into one hemi-spleen ... lung carcinoma, and mouse mammary fat pad tumors); however, in this manuscript we will focus on the breast cancer model, MDA-MB ... Matrigel solidifies at body temperature to prevent leakage of cancer cells during injection. Primary tumor growth and ... This clone is a bone metastatic variant with a high rate of osteotropism and very little metastasis to lung, liver, or adrenal ...
  https://www.jove.com/visualize/abstract/22355332/itraq-identification-candidate-serum-biomarkers-associated-with
*  Melatonin in Cancer Management: Progress and Promise | Cancer Research
Many cancer types [breast, non-small cell lung, metastatic renal cell carcinoma (RCC), hepatocellular carcinoma, and brain ... including mammary carcinomas, prostate carcinomas, pituitary tumors, melanomas, Lewis lung carcinomas, colon cancer, uterine ... Preclinical Studies on Melatonin and Cancer. The effects of melatonin, using a wide range of physiologic to high pharmacologic ... This review critically evaluates progress in the ability of melatonin to prevent or reverse cancer development and progression ...
  http://cancerres.aacrjournals.org/content/66/20/9789
*  Frontiers | Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance |...
... molecule that contributes to tumor evasion and explore the possibility of targeting lactate metabolism for cancer treatment, as ... Besides tumor cells, stromal cells are another source of lactate production in the tumor microenvironment, whose role in both ... Besides tumor cells, stromal cells are another source of lactate production in the tumor microenvironment, whose role in both ... lactate-producing cells, lactate-responding cells, and how all contribute to the tumor outcome. We discuss the role of lactate ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00052/full