Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice |...
... whereas Th2 cells preferentially express CC chemokine receptor (CCR)3 and CCR4 (9)(10). More recently, the CCR8 is reportedly ... 1998) Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. ... 1998) The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J. Immunol. 161:547-551, pmid:9670926. ... CCR8 is not required for in vitro development of Th2 cells. Naive CD4+ T cells from CCR8+/+ (129sv) or CCR8−/− (129sv) mice ...http://jem.rupress.org/content/193/5/573
The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection | Diabetes
... cells express CCR3, CCR4, and CCR8 (2,3). Synthesis of the chemokines MIP-1α, MIP-1β, and RANTES has been shown to be ... CC chemokine receptor 5 (CCR5) is expressed preferentially by CD4+ T helper 1 (Th1) cells. We sought to determine the role of ... Through activation of the G-protein-coupled cell-surface receptor on target cells, chemokines and their receptors play a major ... CCL, CC chemokine ligand; CCR, CC chemokine receptor; CXCR, CXC chemokine receptor; ELISPOT, enzyme-linked immunosorbent spot; ...http://diabetes.diabetesjournals.org/content/51/8/2489
CCR8 (gene) - Wikipedia
This gene is located at the chemokine receptor gene cluster region. CC chemokine receptors GRCh38: Ensembl release 89: ... "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". J. Immunol. 161 (2): 547-51. PMID 9670926. ... a human monocyte and thymus receptor for the CC chemokine I-309". J. Exp. Med. 186 (1): 165-70. doi:10.1084/jem.186.1.165. PMC ... Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. CCR8 has also ...https://en.wikipedia.org/wiki/CCR8_(gene)
Frontiers | Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities | Immunology
The anti-tumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitory cell receptors. In ... The anti-tumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitory cell receptors. In ... Here, we review the anti- versus pro-tumoral activities of Vγ9Vδ2-T cells, and discuss the mechanisms underlying the ... The comprehensive understanding the dual face of Vγ9Vδ2-T cells in tumor immunology may improve the therapeutic efficacy and ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01041/full
Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight...
In these areas the majority of the chemokine receptor expressing cells were CCR5+ cells, whereas the CCR2+ cells were most ... Interestingly, microglia appears to express preferentially other members of the CC chemokine family, including CCL3 and CCL4 [ ... One possibility may be that anti-inflammatory chemokine receptors such as CCR3, CCR4, and CCR8, are induced in the CNS. This ... Double staining with phenotypic cell markers identified the chemokine receptor mRNA-expressing cells as macrophages/microglia. ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-4-14
Chemokine Levels in Subretinal Fluid Obtained during Scleral Buckling Surgery after Rhegmatogenous Retinal Detachment | IOVS |...
Some chemokines can exhibit high cell and receptor specificity. CXCL9 and CXCL10 are highly specific for T lymphocytes. 37 ... Iellem A Mariani M Lang R . Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by ... Generally, CC chemokines potently attract monocytes, T lymphocytes, eosinophils, and basophils, whereas CXC chemokines are ... cells has been suggested. For example, in vitro studies have shown that IL-1 or TNF-α stimulated RPE cells may express CCL2. 31 ...https://iovs.arvojournals.org/article.aspx?articleid=2126872
CCL18 - Wikipedia
"A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells". Nature. 387 (6634): 713-7. doi:10.1038/ ... To date, are three receptors that have been proposed for CCL18: PITPNM3, GPR30, and CCR8. PITPNM3 is a CCL18 receptor, but ... The T-regulatory cells that CCL18 attracts are not classical T-regulatory cells; these cells do not express FoxP3 as most T- ... "The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to ...https://en.wikipedia.org/wiki/CCL18
Chemokines in the Pathogenesis of Vascular Disease | Circulation Research
Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood. ... A novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997; 185: 99-109. ... Smooth muscle cells respond to a number of chemokines other than MCP-1 and possess a variety of chemokine receptors, including ... NK cells, and CD3+ T cells. CX3CR1 may be preferentially expressed on CD14lowCCR2lowCD16+ monocyte/macrophages, which are long- ...http://circres.ahajournals.org/content/95/9/858
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Human CCR3/Galpha15 Stable Cell Line-Chem-1, Human CCR2/Galpha15 Stable Cell Line-Chem-1, Human CCR1/Galpha15 Stable Cell Line- ... Human CCR7/Galpha16 Stable Cell Line-Chem-1, Monkey CCR5/Galpha15 Stable Cell Line-Chem-1, Human CCR4/Galpha15 Stable Cell Line ... 5, Human CCKBR/Galpha15 Stable Cell Line-Chem-1, Human CCKAR/Galpha15 Stable Cell Line-Chem-1, ... Chem-1, Human CMKLR1/Galpha15 Stable Cell Line-Chem-1, ... Bio-technology Products Human CCR8/Galpha15 Stable Cell Line- ...http://www.tradenote.net/trade327-sell/Bio-technology-Products-10/
005427 - B6.129P2-Ccr5|tm1Kuz|/J
... receptor 5 in these knock-out mice affects immune and a number of other physiological responses. They are useful for widespread ... Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med 208(8 ... CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing ... Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 12(2):167-77. PubMed: ...https://www.jax.org/strain/005427
Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T...
... human Treg cells possess a unique chemotactic response profile and preferentially express the chemokine receptors CCR4 and CCR8 ... encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8. J. Exp. Med. 189:1993-1998, pmid:10377196. ... Treg cells. Treg cells specifically express the chemokine receptors CCR4 and CCR8 and respond to the chemokines macrophage- ... Treg cells specifically express the chemokine receptors CCR4 and CCR8 and represent a major subset of circulating CD4+ T cells ...http://jem.rupress.org/content/194/6/847
Chemokines in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
... and CCR8, chemokine-receptor pairs involved in regulatory T cell trafficking.88 Thus, the CXCR3/CXCL10 axis is pivotal in ... The role of the CC chemokine ligand-5 (CCL5/RANTES) and its receptors CCR1 and CCR5 in atherosclerosis have been addressed in a ... Accordingly, human T cells, which preferentially expressed CXCL4, released only low levels of this chemokine under basal ... In mice, interstitial lymphocytes, NKT cells, monocytes, DCs, and memory subsets of CD8+ or CD4+ T cells express CXCR6, which ...http://atvb.ahajournals.org/content/28/11/1897.long
CCL22 Recruits CD4-positive CD25-positive Regulatory T Cells into Malignant Pleural Effusion | Clinical Cancer Research
CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to ... Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T ... our data also showed that regulatory T cells in peripheral blood strongly express CCR4, a chemokine receptor for CCL17 or CCL22 ... It has been shown that human regulatory T cells preferentially move to and accumulate in tumors and ascites, but rarely enter ...http://clincancerres.aacrjournals.org/content/15/7/2231
Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells | The Journal of Immunology
Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J. Pediatr. ... It is possible that IL-5+ Th2 cells differentially express other genes in addition to IL-5 (e.g., CCR8) (51) that confer ... Recurrent antigenic exposure preferentially drives the differentiation of IL-5+ Th2 cells. These results demonstrate that IL-5+ ... Although IL-4 and IL-13 share receptor components and signaling pathways, differences in the expression of these receptors as ...http://www.jimmunol.org/content/187/6/3111
Tumor cells have been shown to acquire the ability to produce growth-promoting chemokines and to express chemokine receptors. ... Deficiency of CC chemokine receptor 5 suppresses tumor development via inactivation of NF-κB and upregulation of IL-1Ra in ... it has been demonstrated that CCL1 produced by lymphatic endothelial cells in the subcapsular sinus can attract CCR8+ tumor ... whereas M2 macrophages are preferentially induced by IL4, IL13, and TGFβ. M1 macrophages exhibit tumoricidal activity and may ...http://cancerimmunolres.aacrjournals.org/content/2/12/1125
C-C chemokine receptor type 6 - Wikipedia
"Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells". J. Exp. ... The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage ... "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... chemokine receptor activity. • receptor activity. • protein binding. • C-C chemokine receptor activity. • C-C chemokine binding ...https://en.wikipedia.org/wiki/C-C_chemokine_receptor_type_6
Immunopathogenesis of psoriasis - Sabat - 2007 - Experimental Dermatology - Wiley Online Library
Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris. Clin Exp Dermatol 2004: 29: 658-663. * ... CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to ... In fact, skin-derived NK cells have been shown to express high levels of the chemokine receptors CXCR3 and CCR5, and ... in vitro culture experiments showed that CD103 was preferentially expressed on CD8+ T cells after stimulation with anti-CD3 ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00629.x/full
The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics | IRIS Università...
In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ... The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. ... suggesting an involvement of this receptor/ligand axis in the regulation of lymphocyte recruitment into the asthmatic bronchi. ... In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ...https://iris.unife.it/handle/11392/1207166