Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy
... R ... "Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy," ... 1The Ella Lemelbaum Institute for Melanoma, Sheba Medical Center, 52621 Tel Hashomer, Israel. 2Talpiot Medical Leadership ...https://www.hindawi.com/journals/jir/2015/902137/cta/
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study - Full Text...
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study (MelSort). The ... Adoptive Transfer of CD8+ T Cells, Sorted With HLA-peptide Multimers and Specific for Melan-A and MELOE-1 Melanoma Antigens, to ... This study evaluates the safety as well as the potential clinical efficacy of an adoptive transfer of CD8+ T cells, sorted with ... Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Nerve Tissue. Nevi and Melanomas. ...https://clinicaltrials.gov/ct2/show/NCT02424916?term=melanoma&rank=19
Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts - Full Text View -...
Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts. This study is ongoing, but ... With Ipilimumab to Enhance Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Patients With Metastatic Melanoma ... Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Nerve Tissue. Nevi and Melanomas. ... The primary endpoints of this pilot trial will be the safety and feasibility of administering ipilimumab with Adoptive Cell ...https://clinicaltrials.gov/ct2/show/NCT01701674?term=ACT+TIL&rank=2
Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma
... ... The successful adoptive transfer of antigen-specific CD4+ cells to a patient with metastatic melanoma is not only an important ... Clinical investigations of adoptive therapy in solid tumors have primarily focused on CD8+ cells. A study by Hunder et al. is ... An in vitro method was used to treat a patient with metastatic melanoma using autologous CD4+ cells against NY-ESO-1 (cancer ...https://insights.ovid.com/ncpo/200812000/01223060-200812000-00014
Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic Melanoma - Full Text View -...
Other: Adoptive Cell Transfer T-cell infusion. Drug: High Dose IL-2 Beginning approximately 12 - 16 hours after cell infusion. ... Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic Melanoma. This study is ongoing, ... Metastatic Melanoma Procedure: Surgery Drug: Administration of Lymphodepletion Other: Adoptive Cell Transfer Drug: High Dose IL ... Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic Melanoma. ...https://clinicaltrials.gov/ct2/show/NCT01005745
Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma -...
Melanoma. Regional nodal disease. Dendritic Cell Immunization. Lymphodepletion. Adoptive Cell Transfer. T Cells. Vaccine. ... Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma. ... Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma. ... Melanoma Biological: Dendritic Cell Immunization Drug: Cyclophosphamide Drug: Fludarabine Biological: T-Cells Biological: ...https://clinicaltrials.gov/ct2/show/NCT00338377
Systemic Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-Cell...
Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-Cell Transfer. ... Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-Cell Transfer ... Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-Cell Transfer ... Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-Cell Transfer ...http://cancerres.aacrjournals.org/content/early/2012/09/06/0008-5472.CAN-12-0600
Browsing Bioengineering Publications by Title
Elimination of Metastatic Melanoma Using Gold Nanoshell-Enabled Photothermal Therapy and Adoptive T Cell Transfer Bear, Adham ... In this work, articular chondrocytes (ACs) and mesenchymal stem cells (MSCs) with 1:1 and 1:3 cell ratios were co-cultured in ... Enhanced osteogenesis in co-cultures with human mesenchymal stem cells and endothelial cells on polymeric microfiber scaffolds ... Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses Noren, David P.; Chou ...https://scholarship.rice.edu/handle/1911/64877/browse?rpp=20&order=ASC&sort_by=1&etal=-1&type=title&starts_with=E
Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem...
Immune-based therapies, including the adoptive transfer of tumor-specific autologous T cells, have been used to target melanoma ... 2009) Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors ... 2002) Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma ... Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic ...http://www.pnas.org/content/108/51/E1408
Frontiers | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |...
New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses ... Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed ... New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses ... Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed ...https://www.frontiersin.org/articles/10.3389/fimmu.2012.00103/full
Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight...
We now describe the isolation and characterization of a T cell clone (9.1-2) that also transfers protective immunity against ... By means of T cell immunoblotting, we determined that 9.1-2 recognized a protein with a relative m.w. between 8,000 and 12,000 ... We have shown previously that BALB/c mice can be protected against a fatal infection with Leishmania major by adoptive transfer ... of a T cell line recognizing a protective soluble fraction (fraction 9) of promastigotes. ...https://www.semanticscholar.org/paper/Protection-against-Leishmania-major-in-BALB%2Fc-mice-Scott-Caspar/a4c6d128a748fbec8ea207e80f53b240c2ef4943
IL8 polyclonal antibody - (PAB19092) - Products - Abnova
CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy. ... IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling.. Zhou ... T cell chemotactic factor,beta-thromboglobulin-like protein,chemokine (C-X-C motif) ligand 8,emoctakin,granulocyte chemotactic ... This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. ...http://www.abnova.com/products/products_detail.asp?catalog_id=PAB19092
Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches | SpringerLink
The Epilogue of Part VII is dedicated to the enormous potential of innate lymphoid cells and unconventional T cells to be used ... Adoptive transfer of invariant NKT cells as immunotherapy for advanced melanoma: a phase I clinical trial. Clin Cancer Res. ... which stimulate robust responses from type I natural killer T cells and gammadelta T cells, respectively, or adoptive transfer ... For example, clinical adoptive transfer studies with the use of natural killer cells have already demonstrated effective anti- ...https://link.springer.com/chapter/10.1007%2F978-3-319-78655-1_29
Immunotherapy - Wikipedia
Adoptive cell transfer has been tested on lung  and other cancers, with greatest success achieved in melanoma. ... T-cell adoptive transfer. Adoptive cell transfer in vitro cultivates autologous, extracted T cells for later transfusion. ... "Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma". J. ... Clinical responses to adoptive transfer of T cells were observed in patients with metastatic melanoma resistant to multiple ...https://en.wikipedia.org/wiki/Immunomodulators
3) cancer, and the use of vaccines ( 4) or adoptive T-cell transfer ( 5) in melanoma. However, response rates using these ... T cells, natural killer (NK) cells, and APC, such as dendritic cells and B cells ( 19- 21). Bystander activation of these cells ... Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nat Rev Cancer 2003; 3: 666-75. ... In summary, sequential tumor cell apoptosis and amplification of dendritic cell function by NKT cell agonists represents an ...http://cancerres.aacrjournals.org/content/67/15/7495
Table of Contents | Clinical Cancer Research
Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy ... Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 ... The Integrin Inhibitor Cilengitide Affects Meningioma Cell Motility and Invasion. Annette Wilisch-Neumann, Nadine Kliese, ... Human Breast Cancer Cells Harboring a Gatekeeper T798M Mutation in HER2 Overexpress EGFR Ligands and Are Sensitive to Dual ...http://clincancerres.aacrjournals.org/content/19/19
Adoptive cell transfer & immune checkpoint modulators | Oncology Practice
Biomarkers for immune checkpoint inhibition therapy in melanoma. Take Quiz. Immune checkpoint inhibitors & survival outcomes. ... Monoclonal antibodies, adoptive cell therapy, & cytokines. Take Quiz. Targeting inhibitors of immune responses & nonspecific ... Pathology & clinical presentation of small cell lung cancer. Take Quiz. Staging & imaging of small cell lung cancer. Take Quiz ... Induce cells in the microenvironment to release substances that suppress immune responses and promote cancer cell proliferation ...https://www.mdedge.com/oncologypractice/quiz/5772/immunotherapy/adoptive-cell-transfer-immune-checkpoint-modulators
Journal for ImmunoTherapy of Cancer | 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer ...
Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing ... Combination radioimmunotherapy with adoptive NK transfer targets cancer stem cells in canine models of bone and soft tissue ... Efficacy of adoptive transfer of expanded fetal liver-derived precursor syngeneic and allogeneic murine NK cells against solid ... Interaction between effector and memory cd8+ t cells enhances melanoma adoptive immunotherapy Authors: Amanda Contreras, Andrew ...https://jitc.biomedcentral.com/articles/supplements/volume-3-supplement-2
MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy | Cancer Research
We also detected CD73 upregulation in melanoma patients progressing under adoptive T-cell transfer or immune checkpoint ... In a mouse model of T-cell immunotherapy, CD73 was induced in relapse melanomas, which acquired a mesenchymal-like phenotype. ... which marked both nascent and full activation of a mesenchymal-like melanoma cell state program. Proinflammatory cytokines like ... Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we found that induction of CD73, the ...http://cancerres.aacrjournals.org/content/77/17/4697?utm_source=sep117&utm_medium=carousel2&utm_campaign=170395
Cancers | Free Full-Text | The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy | HTML
Cytotoxic ionizing radiation is known to trigger pro-inflammatory signaling cascades and immune activation secondary to cell ... Immunotherapies such as the dendritic cell (DC) vaccine, heat shock protein vaccines, and epidermal growth factor receptor ( ... have been observed in patients with melanoma receiving adoptive T-cell transfers expressing genetically altered T-cell ... Transfer of tumor reactive T-cells to patients with melanoma have led to objective responses of 34%-50% [119,120]. Objective ...https://www.mdpi.com/2072-6694/6/4/1953/htm
Characterization of the cDNA coding for the recognized | Open-i
A) M170.48 TNF responses to COS-7 cells (E/T ratio = 1:3) transfected with the indicated plasmi ... MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency. ... MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency. ... Mentions: We screened a cDNA library derived from the M134 melanoma cell line (20) in COS-7 cells cotransfected with pHLA-A* ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2571940_jem2052673f02&req=4
... combination virotherapy for melanoma with tumor antigen-expressing vesicular stomatitis virus and adoptive T-cell transfer. ... T cells, CD8+ T cells, or NK cells (Fig. 6). It was seen that both CD8+ T cells and NK cells were required for the therapeutic ... T cells but not NK cells or CD4+ T cells also significantly enhanced viral replication, indicating this cell lineage was ... 5); and (iii) depletion of either CD8+ T cells, IFNγ or NK cells (but not CD4+ T cells) resulted in loss of the therapeutic ...http://clincancerres.aacrjournals.org/content/21/24/5543
The New Yorker Digital Edition : Apr 23, 2012
In the latest of three trials of pa- tients with melanoma who underwent adoptive cell transfer at the National Can- cer ... adoptive cell transfer;' in which T -cells are taken from a patient's tumor and given immune stimulants such as interleukin-2, ... Today, none of the melanoma remains. 'My T -cells, they were fiery,' Breidenbach concluded. But there was one permanent side ... He ex- plained that Breidenbach's T -cells could be stimulated to recognize and attack melanoma. 'Dr. Rosenberg basically told ...http://archives.newyorker.com/?iid=61780&startpage=page0000030
Mouse model exposes a new type of T cell to target melanoma | EurekAlert! Science News
... on cancer cells and destroy them before they grow into tumors. Cancer cells, for their part, evolve constantly to evade such ... Most are nipped in the bud by the immune response, not least by its T cells, which detect telltale molecular markers--or ... were combined with a cutting-edge therapy known as adoptive T cell transfer to eradicate advanced melanoma tumors in mice. ... Now they wanted to see if adding T cell transfer to the mix would further improve outcomes. T cell transfer is an investigative ...https://www.eurekalert.org/pub_releases/2012-10/lifc-mme102312.php
In This Issue | Cancer Discovery
Immunotherapy with adoptive T-cell transfer (ACT) achieves responses in patients with melanoma, but most patients develop ... Adoptive transfer of MART1-specific T cells induced tumor regression in a patient with melanoma. ... Melanoma Cell Dedifferentiation Induces Resistance to T-cell Therapy. *Antitumor Activity of NY-ESO-1c259 Autologous T Cells in ... FATP1 is overexpressed in melanoma and promotes lipid transfer from adipocytes to melanoma cells. ...http://cancerdiscovery.aacrjournals.org/content/8/8/899?rss=1