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*  Department of Biochemistry and Molecular Biology | UMass Amherst
... where they couple the exact specificity of antibodies to the specialized effector functions of different immune cells. Fc ... site on the antibody. In the case of mast cells, the high affinity IgE Fc receptor (FcεRI) binds the IgE antibody, and the ... Antibody-receptor interactions: Fc receptors are found on the surface of immune cells, ... These receptors function in cell adhesion, entry into host cells, and immune system evasion. Due to their accessibility on the ...
  http://www.umass.edu/biochem/faculty/scott-garman
*  Similar - Books on Google Play
Cells and Molecules of the Innate Immune System; The Adaptive Immune System; Antibodies; The Antibody Response; The T Cell ... providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the ... dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments ... in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, ...
  https://play.google.com/store/books/collection/books_clusters_mrl_rt_4E6B214D_6F4FBEC9_E3220E3E
*  The Specificity and Function of Follicular CD4 T Cells in Response to Protein Vaccination and Influenza Infection - Projects -...
... and effector phenotype in order to determine if this is the best predictor and correlate of a protective antibody response to ... and transcription factors that identify antigen TfH and so it is now feasible to track this particular cell type during immune ... Thus far, analysis of CD4 T cells specificity and function in humans has involved analysis of unfractionated CD4 T cells of ... T follicular helper cell models. TfH localize to B cell zone of secondary lymphoid organs, and supply cognate help to B cells ...
  https://www.urmc.rochester.edu/labs/sant/projects/the-specificity-and-function-of-follicular-cd4-t-c.aspx
*  Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions | Cancer...
... connects the fine-specificity of the antibody with immune cells that mediate antibody-triggered effector functions. The nature ... which connects the fine specificity of an antibody with immune cells that mediate antibody-triggered effector functions through ... It is likely that the expression levels of the therapeutic target on effector immune cells, regulatory immune cells, or the ... antitumor antibodies of the msIgG2a subclass potently activate effector cells to kill msIgG2a antibody-opsonized target cells, ...
  http://cancerimmunolres.aacrjournals.org/content/3/7/704
*  Raif Geha, MD | Research + Innovation | Boston Children's Hospital
Raif Geha is a researcher for the Geha Laboratory focusing on Immune deficiencies. ... is the mechanism by which a B cell goes from producing one type of antibody to another while maintaining antigenic specificity ... the structural framework of the cell. The Geha lab is now studying the role of WASP and WIP in immune cell functions that ... TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33): ...
  http://www.childrenshospital.org/research-and-innovation/research/researchers/g/raif-geha
*  Immunology | Weizmann Institute of Science
... raising of catalytic antibodies; studies of the repertoire and specificity of the T-cell receptor in autoimmune models for ... and effector functions of the immune system to the role of these processes in autoimmune disorders, allergies and cancer. ... immune cell adhesion and migration; the control of inflammatory processes; development of hematopoietic stem cells and T-cells ... Role and mechanism of tolerance induction by activated CD8 T cells: A novel cell therapy for chimerism induction, stem cell ...
  https://www.weizmann.ac.il/pages/research-activities-current-research-activities/faculty-biology/immunology
*  Barbara BOHLE, PhD
Moreover, we characterize the specificity and effector functions of different allergen-specific antibody subclasses.. Our ... To understand the immune mechanisms of IgE-mediated hypersensitivity we characterize allergen-specific T cells isolated from ... One major goal is to understand and influence the interaction of T lymphocytes and antigen-presenting cells. In parallel, ... Our long-term research interest is to understand the immune mechanisms that regulate the development and maintenance of allergy ...
  https://www.meduniwien.ac.at/hp/phd-immunologie/research-laboratories/barbara-bohle-phd/
*  High‐resolution definition of humoral immune response correlates of effective immunity against HIV | Molecular Systems Biology
Stem Cell Technologies) effectors at an E:T ratio of 5:1. Following a 4‐h incubation at 37°C and antibody at 20 μg/ml, cells ... We evaluated antibody specificity across 41 different HIV protein variants, and innate immune recruiting capacity by ... Effector function assays. The functional activity of HIV‐specific antibodies was determined in a number of cell‐based assays ( ... Antibody effector functions including antibody‐dependent complement deposition (ADCD), antibody‐dependent neutrophil ...
  http://msb.embopress.org/content/14/3/e7881
*  Frontiers | Antibody Engineering for Pursuing a Healthier Future | Microbiology
... such as engaging immune effector functions, effective development of fusion proteins, efficient tumor and tissue penetration, ... Furthermore, recent advances in antibody engineering techniques together with antibody fragments, display technologies, ... Furthermore, recent advances in antibody engineering techniques together with antibody fragments, display technologies, ... such as engaging immune effector functions, effective development of fusion proteins, efficient tumor and tissue penetration, ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.00495/full
*  Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn - WORKPLACESAFETYEXPERTS.COM E-books
... supplying specificity to quite a lot of innate effector cells. moreover, they supply a suggestions loop to control the nature ... within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune structures, ... Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. Lancet ... of the immune reaction through interactions with B cells and antigen-presenting cells. ...
  http://workplacesafetyexperts.com/books/antibody-fc-linking-adaptive-and-innate-immunity
*  Download PDF by Margaret Ackerman, Falk Nimmerjahn: Antibody Fc. Linking Adaptive and Innate Immunity - Home Books
... supplying specificity to quite a lot of innate effector cells. moreover, they supply a suggestions loop to control the nature ... within the organic task of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, ... Immune complex-induced enhancement of bacterial antigen presentation requires Fcγ receptor III expression on dendritic cells. ... of the immune reaction through interactions with B cells and antigen-presenting cells. ...
  http://umgtravel.com/lib/antibody-fc-linking-adaptive-and-innate-immunity
*  Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application | SpringerLink
Therapeutic antibodies have revolutionised treatment of some cancers and improved prognosis for many patients. Over half of ... which can trigger powerful immune responses through strong affinity for their particular receptors on effector cells, could be ... Our laboratory has examined this concept by evaluating two chimaeric antibodies of the same specificity (MOv18) but different ... neu-expressing tumour cells but also activated effector cells to kill tumour cells by different mechanisms. On-going efficacy, ...
  https://link.springer.com/article/10.1007%2Fs00262-011-1162-8
*  T-Cell Immunotherapy, A Novel Advancement For the Treatment Of Cancer | US Financial News Today
... of a monoclonal antibody. The domain includes T-cell receptor CD3-zeta chain, which graft specificity into an immune effector ... CAR T-cells are the modified T-cells used to express CARs, which recognize specific antigens present on targeted cell. CARs are ... T-cell immunotherapy pipeline in 2016. The study analyzed that the T-cell immunotherapy pipeline comprised of 139 therapeutic ... It mediates T-cell cytotoxicity and activation when bound to a target cell. ...
  http://www.usfinancialnewstoday.com/story/109528/tcell-immunotherapy-a-novel-advancement-for-the-treatment-of-cancer.html
*  Technology Offers | Bayerische Patentallianz
LiCADs comprise binding sites with specificity for a tumor cell, for an effector cell and for a checkpoint molecule ... Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint ... lead to strong expansion of effector T cells (memory T cells) and are much more stable compared to other DC vaccination ... ‍Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing ...
  https://www.baypat.de/technology-offers
*  Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral...
... immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... pursuit of cancer-cell surface directed antibodies recruiting and activating immune effectors such as FcR positive immune cells ... Checkpoint inhibitors only unleash the effector functions of preformed T cell specificities. This has motivated the ... Figure 3(d)), effector T cells of a CMV+ donor were expanded using peptide loaded autologous iDCs. K562-A2 cells were ...
  https://www.hindawi.com/journals/jir/2016/9540975/
*  Chimeric antigen receptor - Wikipedia
... are engineered receptors which graft an arbitrary specificity onto an immune effector cell (T cell). Typically, these receptors ... "Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity". Transplantation Proceedings ... neuroblastoma cells). To target malignant B cells, investigators have redirected the specificity of T cells using a chimeric ... The T cells, which can then recognize and kill the cancer cells, are reintroduced into the patient. Modification of T-cells ...
  https://en.wikipedia.org/wiki/Chimeric_antigen_receptor
*  PAR-16-115: Optimization of Monoclonal Antibodies for Eliminating the HIV Reservoir (R01)
Optimization of Monoclonal Antibodies for Eliminating the HIV Reservoir (R01) PAR-16-115. NIAID ... Improved Fab function to increase specificity, potency, avidity and breadth. * Improved Fc effector function to eliminate cells ... activating cytotoxic immune effector mechanisms, delivering cytotoxic payloads, or otherwise causing the infected cells to die ... Rather, they must bind with high specificity, potency and avidity to cells producing HIV proteins, and then eliminate these HIV ...
  https://grants.nih.gov/grants/guide/pa-files/PAR-16-115.html
*  Jing Wang's Faculty Profile | School of Medicine | University of Colorado Denver
... antigen-appropriate effector functions to antibody molecules and is, therefore, a process important for productive immune ... Eventually AID-mediated DNA alterations enhance antibody diversity and specificity. Given that AID is a potent DNA mutator, its ... This is likely because B cells extensively shuffle their genomic DNA during immune responses. Upon immunizations and infections ... These mutations cause small changes in the protein sequence of antibodies and lead to increased antibody affinity for specific ...
  http://www.ucdenver.edu/academics/colleges/medicalschool/programs/Molbio/faculty/WangJ/Pages/default.aspx
*  Genetic and Immunologic Biomarkers in Type 1 Diabetes
The immune response expands as effector cells are drawn to the site of inflammation and initiate beta cell destruction, PAGE 14 ... A utoantibodies to self antigens are produced by B cells; in humans, auto antibodies to insulin is most often the first to ... 14 releasing additional epitopes and driving a broader attack by cells with diverse antigen specificities. ... includi ng T effector cells, B cells, dendritic cells, natural killer cells, and eosinophils but is only constituitively ...
  http://ufdc.ufl.edu/UFE0045760/00001
*  53BP1 is required for class switch recombination | JCB
This isotype switching allows antibodies to change their effector functions while maintaining their antigen specificity (Honjo ... T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16: ... DNA DSBs occur as part of the normal development of the immune repertoire in B and T lymphocytes. During the process of V(D)J ... B cells to undergo switching to IgG1 in vitro with LPS and IL-4. Cells were also labeled with CFSE to track cell divisions by ...
  http://jcb.rupress.org/content/165/4/459
*  Immune Response | Encyclopedia.com
Immune Response Among the many threats organisms face are invasion and infection by bacteria, viruses, fungi, and other foreign ... the B cells begin to multiply and produce cells that make antibody (plasma cells). This antibody is directed against the same ... These T cells become activated, recognizing specific antigens from the pathogen and become effector cells; helper T cells (TH1 ... This is why the immune system can recognize millions of antigens with specificity. The cells with the appropriate receptor ...
  https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/immune-response
*  Plus it
These two signals allow T cells of the appropriate antigen specificity toproliferate and attain effector function, which may ... Irradiation of tumor cell lines induces several changes in expression of critical molecules involved in immune recognition and ... Tonegawa S. Somatic generation of antibody diversity. Nature 1983;302:575-81. ... Because most proteins found in tumor cells are identical to ones found in normal tissues, most possible antigenic specificities ...
  http://clincancerres.aacrjournals.org/content/11/1/7
*  Protocols and Video Articles Authored by Gene S. Tan
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies' ... Epitope Specificity Plays a Critical Role in Regulating Antibody-dependent Cell-mediated Cytotoxicity Against Influenza A Virus ... and that cross-talk among antibodies of varying specificities determines the magnitude of Fc receptor-mediated effector ... neutralizing antibodies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes (ICs). This ...
  https://www.jove.com/author/Gene+S._Tan
*  Organ-specific antigen | definition of organ-specific antigen by Medical dictionary
T-dependent antigen one that requires the presence of helper T cells to stimulate antibody production by B cells; most antigens ... Similarly the antibody or effector lymphocyte produced by the response combines only with the one antigenic determinant. A ... an antigen which both stimulates the immune response and reacts with the products, e.g. antibody, of that response, cf. hapten. ... Two types of organ specificity have been proposed: (1) first-order or tissue specificity is attributed to the presence of an ...
  http://medical-dictionary.thefreedictionary.com/organ-specific+antigen
*  Patent US6020153 - Chimeric antibodies - Google Patents
... mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric ... The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or ... processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these ... antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, ...
  http://www.google.com/patents/US6020153?dq=6734022