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*  Death receptor 3 - Wikipedia
This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed ... The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which ... which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign vs self antigen ... Apo-1/CD95)". Immunity. 6 (1): 79-88. doi:10.1016/S1074-7613(00)80244-7. PMID 9052839. Kitson J, Raven T, Jiang YP, Goeddel DV ...
  https://en.wikipedia.org/wiki/Death_receptor_3
*  Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T...
... gene knockout experiments have established that B7.2 is important for initiating humoral immune responses to foreign antigens ... 1996) Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen ... tolerant B cells that constitutively expressed high levels of B7.2 were not eliminated by antigen-specific T cells (Figs. 2 a ... In contrast to naive B cells stimulated by foreign antigen, tolerant B cells have a selective costimulatory deficit for T cell ...
  http://jem.rupress.org/content/188/4/651
*  JCI - T cell apoptosis and reactive oxygen species
The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity. 1998. 8:265-274. ... While T cells express several different kinds of Bcl-2-like molecules, the role they play in T cell apoptosis has only recently ... To find out whether the ROS caused T cell death by affecting gene transcription, we activated T cells in vivo, isolated the ... Tucek-Szabo, CL, Andjelic, S, Lacy, E, Elkon, KB, Nikolic-Zugic, J. Surface T cell Fas receptor/CD95 regulation, in vivo ...
  https://www.jci.org/articles/view/18007
*  Patent US8076096 - Alteration of cell membrane with FasL - Google Patents
... of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene ... The immune response to foreign antigens is initiated by naive T cells that use clonally-expressed T cell receptors (TCRs) to ... The best characterized death receptor are CD95 ("Fas"), TNFR1 (p55), death receptor 3 (DR3 or Apo3/TRAMO), DR4 and DR5 (apo2- ... Almost all the cells expressed SA-mFasL on day 5 and significant number of cells (,25%) expressed SA-mFasL on day 10, the last ...
  http://www.google.com/patents/US8076096?dq=U.S.+Patent+
*  Memory T cell - Wikipedia
... the term antigen-experienced T cell is often applied. Such T cells can recognize foreign invaders, such as bacteria or viruses ... which strongly express genes for molecules essential to the cytotoxic function of CD8 T cells: effector memory (TEM) effector ... but they also express large amounts of CD95, IL-2Rβ, CXCR3, and LFA-1, and show numerous functional attributes distinctive of ... Memory T cells may be either CD4+ or CD8+ and usually express CD45RO. Memory T cell subtypes: Central memory T cells (TCM cells ...
  https://en.wikipedia.org/wiki/Memory_T_cell
*  Fas ligand - Wikipedia
... pathway are the two main mechanisms by which cytotoxic T lymphocytes induce cell death in cells expressing foreign antigens. ... or CD95, is the most intensely studied member of the death receptor family. The gene is situated on chromosome 10 in humans and ... Its functions include: T-cell homeostasis: the activation of T-cells leads to their expression of the Fas ligand. T cells are ... Immune privilege: Cells in immune privileged areas such as the cornea or testes express Fas ligand and induce the apoptosis of ...
  https://en.wikipedia.org/wiki/Fas_ligand
*  Apoptosis
Thus antigen-reactive T cells, which express Fas, would be killed when they enter these sites. (This is the reverse of the ... cells avoid apoptosis by inhibiting the expression of the gene encoding Apaf-1. *Some cancer cells, especially lung and colon ... Fas ligand (FasL), a molecule that binds to a cell-surface receptor named Fas (also called CD95). The Mechanisms of Apoptosis. ... The immune response to a foreign invader involves the proliferation of lymphocytes - T and/or B cells [Link]. When their job is ...
  http://biology-pages.info/A/Apoptosis.html
*  Cytotoxic T cell - Wikipedia
Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is a molecule capable ... When these cells are infected with a virus (or another intracellular pathogen), the cells degrade foreign proteins via antigen ... There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. Instead, the DNA ... CD95) molecules expressed on the target cell. However, this Fas-Fas ligand interaction is thought to be more important to the ...
  https://en.wikipedia.org/wiki/Cytotoxic_T_cell
*  WikiGenes - Autoimmunity
... we propose a model in which activation with foreign antigens can result in the generation of pathogenic memory T cells that ... Heterozygous mutations in CD95, CD95 ligand or caspase-10 underlie most cases of autoimmune lymphoproliferative syndrome (ALPS ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... is induced in normal mice by the injection of a human monoclonal anti-DNA antibody expressing a common idiotype designated 16/6 ...
  https://www.wikigenes.org/e/mesh/e/5802.html
*  US8119117B2 - Adenoviral expression vector comprising a CD40L fusion protein adapted to elicit cellular immunity -...
Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an ... Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by ... the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing ... Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit ...
  https://patents.google.com/patent/US8119117?oq=6004266
*  Invited Review Molecular and Cellular Mechanisms Associated with Autoimmune Diseases - PDF
However when professional antigen-presenting cells (APC) that express the B7 surface antigen stimulate T cells via CD28- ... Murine strains with lpr/lpr homozygous genes contain mutations in the CD95 gene that render the products nonfunctional. Similar ... Public Health 2004, 1 41 Figure 1: Th/Tc cell activation - Antigen (foreign body) is phagocytosed by antigen presenting cell ( ... Gap junctions between animal cells Cell junctions. Cell-cell recognition Cell Communication Cell Signaling Cell-to-cell ...
  http://healthdocbox.com/Aids_and_Hiv/67459690-Invited-review-molecular-and-cellular-mechanisms-associated-with-autoimmune-diseases.html
*  Patent US20020085996 - Mesenchymal stem cells for prevention and treatment of immune responses in ... - Google Patents
Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host ... The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. ... reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells ... Alloantigens are antigens which differ from antigens expressed by the recipient. Donor tissue, organs or cells to be ...
  http://www.google.com/patents/US20020085996?dq=7,117,286
*  Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway...
... the self-antigen was ubiquitously expressed, whereas in our case the antigen is expressed locally and is cross-presented. Hence ... Fas (CD95)-independent regulation of immune responses by antigen-specific CD4−CD8+ T cells. Int. Immunol. 8:675-681. ... The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity. 8:265-274. ... raising the possibility that a gene(s) causing this phenotype may also impair T cell deletion. Alternatively, as we have ...
  http://jem.rupress.org/content/196/7/947
*  Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance | JEM
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science. 312:1669-1672. doi:10.1126/science ... D) Relative expression of CD23, CD25, CD95, and CD86 on EGFP+ WT or Tnfaip3lsv polyclonal B cells expressing MYD88L265P or ... In the absence of foreign TLR ligands, MYD88L265P was sufficient to drive multiple rounds of B cell division provided the ... activated B cell type diffuse large B cell lymphoma. BCR. B cell receptor. CLL. chronic lymphocytic leukemia. CTV. cell trace ...
  http://jem.rupress.org/content/early/2014/02/11/jem.20131424
*  Apoptosis: cell 'death' reveals creation - creation.com
Programmed cell death is an intricately controlled and irreducibly complex process, without which no multicellular life could ... However, both MCL and CLL cells only rarely express the 'death receptor' protein, Fas(APO1/CD95), in contrast to most other ... the specific recognition of foreign protein (antigen) by a small proportion of the body's circulating lymphocytes, followed by ... The activation of two genes was found to be necessary for apoptosis to occur: ced-3 (cell death gene 3) and ced-4.8 In 1992, it ...
  https://creation.com/apoptosis-cell-death-reveals-creation
*  Plus it
... or antigen-presenting) cell, but also a second, or costimulatory signal supplied by antigen-presenting cell-expressed surface ... The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987;329:512-8. ... The dorsoventral regulatory gene cassette spazel/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell ... CD95; ref. 20). The role of the latter has been shown in a transgenic carcinoembryonic antigen tumor model, where elevated Fas ...
  http://clincancerres.aacrjournals.org/content/11/1/7
*  Chapter 314. Introduction to the Immune System | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill...
Antigens-foreign or self-molecules that are recognized by the adaptive and innate immune systems resulting in immune cell ... Immune responses by these cells are based on specific antigen recognition by clonotypic receptors that are products of genes ... B lymphocytes-bone marrow-derived or bursal-equivalent lymphocytes that express surface immunoglobulin (the B cell receptor for ... on the surface of cells [e.g., tumor necrosis factor (TNF) receptors, CD95] leads to a signaling cascade that involves ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727113
*  Plus it
A rVV has been developed that contained the CEA gene in its genome and expressed its gene product in infected cells; another ... Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are ... An approach to the second hypothesis would be to use superagonists that form higher affinity TCR/foreign-peptide MHC-I ... This strategy should also offer protection from apoptosis because the CD95 ligand signaling will be stimulatory. Once a ...
  http://clincancerres.aacrjournals.org/content/9/9/3222
*  WikiGenes - Fasl - Fas ligand (TNF superfamily, member 6)
Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen ... In support of this hypothesis, cytokine gene-engineered DCs expressed higher levels of MHC and costimulatory molecules, as well ... Foreign antigens that stimulate the BCR acutely cause CD40L and FasL to promote clonal proliferation [12]. ... The recombinant gld FasL expressed in COS cells could not induce apoptosis in cells expressing Fas [3]. ...
  http://www.wikigenes.org/e/gene/e/14103.html
*  Macrophages Are the Ultimate Multitaskers | The Scientist Magazine®
... there seems to be no job that the immune cells can't tackle. ... is expressed by certain immune cells to trigger the process in ... Their specific antigens might be accidentally flagged as foreign, but tissue-resident macrophages in the testis produce ... The CD95 receptor and its ligand are best known for triggering cell death, or apoptosis, in response to viral infections, ... "It didn't tell us at all what these macrophages were doing, because the list of genes that they were [expressing] were ...
  https://mobile.the-scientist.com/article/50446/macrophages-are-the-ultimate-multitaskers
*  Estrogen directly activates AID transcription and function | JEM
Humoral immune responses triggered by foreign antigens require B cell activation. The activated B cell undergoes antibody ... Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 192:1833-1840 ... We generated a DT40 cell line (a cell line derived from a chicken B cell lymphoma that constitutively expresses AID and ... Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Mol. Cancer Res. 1:300- ...
  http://jem.rupress.org/content/206/1/99
*  Nucleic acid molecules encoding TNF-.alpha. ligand polypeptides having a CD154 domain - Patent # 7786282 - PatentGenius
... cell expressing a TNF.alpha. receptor, inducing activation of an immune system cell and treating neoplastic cells, by ... that is expressed on the surface of the cell. ... introducing into the cell of interest an isolated ... receptor on the surface of a cell. The chimeric TNF.alpha. is therefore useful in methods for inducing apoptosis of a ... cells that are not naturally capable of presenting antigen to the immune systembut may be genetically engineered with the genes ...
  http://www.patentgenius.com/patent/7786282.html
*  others Flashcards by Anthos Christofides | Brainscape
1. maturity of immun system of the host (neonatal do not respond well to foreign antigens 2. structure and dose of antigen ( ... immunodeficiency resulting from a defect in expression of HLA class II antigens on the surface of antigen presenting cells ... both HIV genes: Tat plays a role in viral replication. Nef decreases expression of MHC class I protein on the surface of ... B cells produce antibodies with increased affinity for antigen during the course of an immune response ...
  https://www.brainscape.com/flashcards/others-5178666/packs/7620266
*  Protocols and Video Articles Authored by Patrick C. Wilson
B-cell (BND) compartment. Antigen receptors expressed by these cells are polyreactive and have N-region additions, Vh usage, ... Ab genes from single cells of three donors were cloned, sequenced, and expressed as recombinant hmAbs. Of 26 cloned H chain Ab ... Here, we examined the characteristics of post-GC foreign antigen-specific B cells from SLE patients and healthy controls by ... CD95 and CD40. The apoptosis frequency of cells bearing these markers were assessed. Also, the apoptosis capability of cultured ...
  https://www.jove.com/author/Patrick++C._Wilson
*  Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of...
4D). However, compared with lymph node B cells of the same CD38hi CD95lo phenotype, spinal cord B cells expressed elevated ... 2D2 T cells, OTII mice in which the great majority of T cells express an irrelevant TCR against the foreign Ag OVA were used as ... Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5: 647 ... To induce a T and B cell autoimmune response targeting MOG-self-antigen we used a novel fusion protein Ag based on the ...
  http://www.jimmunol.org/content/199/2/449