Neural Stem Cells in the Diabetic Brain
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... TACs rapidly divide symmetrically to amplify the availability of neural and glial precursors and finally differentiate into one ... "Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions," Cell Stem Cell, vol. 3 ...https://www.hindawi.com/journals/sci/2012/820790/
Neural stem cell - Wikipedia
These neurospheres can differentiate to form the specified neurons, glial cells, and oligodendrocytes. In previous studies, ... or stem cell niche. Some neural cells are migrated from the SVZ along the rostral migratory stream which contains a marrow-like ... both daughter cells are also stem cells. In asymmetric division, a stem cells produces one stem cell and one specialized cell. ... Neural stem cells are more specialized than ESCs because they generate only neural cells (neurons or glial cells). During ...https://en.wikipedia.org/wiki/Neural_stem_cell
Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche | Journal of Neuroscience
In contrast to the predominant view, adult neural stem cells in nonmammalian vertebrates show more neuroepithelial than glial ... 4E,G). However, a few cells were displaced laterally from the stem cell niche and later differentiated into glia (Figs. 2B, 4B ... the cerebellar stem cell niche, in zebrafish.. We show that neural stem cells are maintained in a highly specialized niche in ... Stem cells in this niche are bipotent, and express neural stem cell and upper rhombic lip markers. It is thought but has not ...http://www.jneurosci.org/content/29/19/6142
Frontiers | Activation of endogenous neural stem cells for multiple sclerosis therapy | Neuroscience
... the activation of either the parenchymal oligodendrocyte progenitor cells or the subventricular zone-derived neural stem cells ... aim to promote the activation of either the parenchymal oligodendrocyte progenitor cells or the subventricular zone-derived ... neural stem cells (NSCs). Less studied but highly potent, is the strategy of neuronal regeneration with endogenous NSCs that ... NSCs are multipotent cells that have the ability to self-renew and differentiate into neurons or glial cells (Gage, 2000). ...https://www.frontiersin.org/articles/10.3389/fnins.2014.00454/full
DiVA - Search result
These stem cells dwell in a niche at the tooth apex where they produce a variety of differentiated derivatives. Cells ... Glial cells generate multipotent mesenchymal stem cells that produce pulp cells and odontoblasts. By combining a clonal colour- ... giving rise to pulp cells and odontoblasts derive from neural crest cells after their migration in the early head and formation ... Internal calcium oscillations induced by alpha-haemolysin in a renal epithelial cell line stimulated production of cytokines ...http://kth.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%2215036%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes | The EMBO Journal
Instead of migrating to the OB and becoming neurons, they migrate to the lesion area and differentiate mainly into glial cells ... Fuentealba LC, Obernier K, Alvarez‐Buylla A (2012) Adult neural stem cells bridge their niche. Cell Stem Cell 10: 698-708. ... A specialized vascular niche for adult neural stem cells. Cell Stem Cell 3: 279-288. ... Nam HS, Benezra R (2009) High levels of Id1 expression define B1 type adult neural stem cells. Cell Stem Cell 5: 515-526. ...http://emboj.embopress.org/content/34/22/2804
9783642005121: 205: The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes (Advances in Anatomy,...
Embryology and Cell Biology) by JP David at AbeBooks.co.uk - ISBN 10: 3642005128 - ISBN 13: 9783642005121 - Springer - 2009 - ... The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes (Advances in Anatomy, ... which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate ... cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells ...https://www.abebooks.co.uk/9783642005121/NEUROENDOCRINE-LEYDIG-CELLS-STEM-CELL-3642005128/plp
Frontiers | Molecular Mechanisms Governing the Stem Cell's Fate in Brain Cancer: Factors of Stemness and Quiescence | Frontiers...
Cancer stem cells have been extensively studied in most malignancies, including glioma. Here, the aberrant niche activities ... maintain and gear stem cells towards re-activation. Cancer stem cells have been extensively studied in most malignancies, ... molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem cell ... molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem cell ...https://www.frontiersin.org/articles/10.3389/fncel.2018.00388/full
Isolation of neural stem cells from neural tissues using the neurosphere technique.
... and expansion of neural stem cell (NSC) lines from the adult mouse subventricular zone (mNSCs), embryonic mouse brain and from ... Removal of growth factors and plating cells on an adherent substrate allows cells to differentiate into neurons, astrocytes, ... 8325244 - Development and organization of glial cells in the peripheral nervous system of drosoph.... 18379434 - Class iii beta ... NSCs niches) of the central nervous system (CNS) and grown in suspension. By using this methodology, NSCs form spherical ...http://www.biomedsearch.com/nih/Isolation-neural-stem-cells-from/21049474.html
Frontiers | SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche | Frontiers in...
... were used to analyze the effect of vitamin C in neural stem cells. Both cell types expressed functional SVCT2 in vitro, and ... were used to analyze the effect of vitamin C in neural stem cells. Both cell types expressed functional SVCT2 in vitro, and ... However, BrdU-positive cells also expressed SVCT2, suggesting a role of vitamin C in neural progenitor proliferation. Primary ... However, BrdU-positive cells also expressed SVCT2, suggesting a role of vitamin C in neural progenitor proliferation. Primary ...https://www.frontiersin.org/articles/10.3389/fncel.2013.00119/full
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function. ... Instead, they differentiate into HSC niche-forming MSCs, helping to establish the HSC niche by secreting Cxcl12. Perineural ... in the developing bone marrow HSC niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells ... Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow ...https://www.jove.com/visualize?author=Andr%C3%A9s%20Garc%C3%ADa-Montero%20
Isolation and characterization of GFAP-positive porcine neural stem/progenitor cells derived from a GFAP-CreERT2 transgenic...
... whereas serum treatment induced cell differentiation into reactive astrocytes and neurons. Collectively, these results indicate ... Here, we isolated GFAP-positive porcine neural stem cells (NSCs) from the brain explant of a transgenic piglet, with expression ... there is lack of information about neural progenitor cells derived from this model. ... Quiescent and activated stem cells coexist in the adult stem cell niche , and play critical roles in maintenance, ...https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1660-4
Stem Cells and Neuroprotection: Understanding the Players
... undifferentiated neural stem cells show low ROS when compared to more differentiated cells, while generally differentiating ... glial, and oligodendroglial . Cell types, within the stem cell hierarchy that include precursors and progenitors, can be ... 8. Ninkovic J, Gotz M. Signaling in adult neurogenesis: From stem cell niche to neuronal networks. Curr. Opin. Neurobiol. 2007; ... Neural stem cells provide a renewable source of replacement cells, and increased proliferation of neural stem cells can act as ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2956095/
The roles and regulation of multicellular rosette structures during morphogenesis | Development
... is composed of multiple cell types and acts as a niche for adult neural stem cells that give rise to neurons and glial cells. ... type-B2 cells (astrocyte-like cells that do not contact the ventricle), and type-A cells (more differentiated neuroblasts). The ... 2008). Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3 ... 2012). Adult neural stem cells bridge their niche. Cell Stem Cell 10, 698-708. doi:10.1016/j.stem.2012.05.012. ...http://dev.biologists.org/content/141/13/2549.long
IJMS | Free Full-Text | Epidermal Stem Cells in Orthopaedic Regenerative Medicine | HTML
Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the ... In this review, we will summarize the biological characteristics of epidermal stem cells, and their potential in orthopedic ... Although controversies and unknown issues remain, epidermal stem cells possess an immune-privileged property in transplantation ... These studies reported various subpopulations and differentiations existing in the epidermal stem cell. ...http://mdpi.com/1422-0067/14/6/11626/htm
Myc increases self-renewal in neural progenitor cells through Miz-1 | Journal of Cell Science
Stem cell maintenance is affected by the cues provided by the environment including the stem cell niche (Li and Neaves, 2006; ... of NPCs towards neural or glial fate but causes cell cycle exit delay and can affect the morphology of the differentiated cells ... Li, L. and Neaves, W. B. (2006). Normal stem cells and cancer stem cells: the niche matters. Cancer Res. 66, 4553-4557. ... The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ...http://jcs.biologists.org/content/121/23/3941
Regenerative Neurosurgery and Neuro-Oncology: Terry C. Burns - Mayo Clinic Research
Niche tropism. Co-culturing neural stem cells with explants of neurogenic regions facilitates research on neural stem cell ... Differentiating embryonic stem cell colony. When encouraged to differentiate toward a neuronal lineage, embryonic stem cells ... This image of a microdissected mouse SVZ stained with nestin (red), glial fibrillary acidic protein (blue) and laminin - a ... suggesting a possible role for stem cell therapies in these diseases. Here, transplanted embryonic stem cell-derived cells ( ...http://www.mayo.edu/research/labs/regenerative-neurosurgery-neuro-oncology/
The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue | Development
2004). Neural stem cells in the mammalian eye: types and regulation. Semin. Cell Dev. Biol. 15, 53-62. doi:10.1016/j.semcdb. ... 2014). Stem cell decisions: a twist of fate or a niche market? Semin. Cell Dev. Biol. 34, 116-123. doi:10.1016/j.semcdb.2014.02 ... 2009). From progenitors to differentiated cells in the vertebrate retina. Annu. Rev. Cell Dev. Biol. 25, 45-69. doi:10.1146/ ... 1999). p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell 99, 499-510. doi:10.1016/ ...http://dev.biologists.org/content/143/7/1099.long
Frontiers | The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging | Frontiers in...
SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate ... The production of new cells in the SVZ decreases during aging, affecting the incorporation of new neurons into the OB. However ... The production of new cells in the SVZ decreases during aging, affecting the incorporation of new neurons into the OB. However ... SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate ...https://www.frontiersin.org/articles/10.3389/fncel.2013.00147/full
Ependymal cell development and repair | Open Biology
2008 A specialized vascular niche for adult neural stem cells. Cell Stem Cell 3, 279-288. (doi:10.1016/j.stem.2008.07.025). ... including different subtypes of radial glial progenitors and more differentiated CSF-cNs (figure 1j). However, despite the ... 2008 Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3, ... 2011 Neural stem/progenitor cells from the adult human spinal cord are multipotent and self- renewing and differentiate after ...http://rsob.royalsocietypublishing.org/content/7/11/170139
Adult stem cells reprogrammed in the brain : Stem Cells - This Is MS Multiple Sclerosis Community: Knowledge & Support
... stem cell researchers have become very adept at manipulating the fate of adult stem cells cultured in the lab. Now, ... ... Adult stem cells reprogrammed in the brain, hopes for diseases such as Multiple Sclerosis 01 July 2008 In recent years, ... When pampered and cosseted in a petri dish, adult neural stem cells can be nudged to differentiate into any kind of brain cell ... "As a result we don't know much about the actual plasticity of neural stem cells within their adult brain niche." To test ...http://www.thisisms.com/forum/stem-cells-f25/topic5801.html
Frontiers | The Long Adventurous Journey of Rhombic Lip Cells in Jawed Vertebrates: A Comparative Developmental Analysis |...
... giving rise to Purkinje cells and other inhibitory cerebellar cell types, and an atoh1 expressing upper rhombic lip giving rise ... eurydendroid cells) from ptf1a expressing VCP cells, the sequential activity of various atoh1 paralogues and the incomplete ... The fate of the ptf1a expressing ventral LRL zone which gives rise to (excitatory cells of) the inferior olive (climbing fiber ... The fate of the ptf1a expressing ventral LRL zone which gives rise to (excitatory cells of) the inferior olive (climbing fiber ...https://www.frontiersin.org/articles/10.3389/fnana.2011.00027/full
Resistance of glia‐like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction-differential...
Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7: 150-161. ... Kriegstein A, Alvarez‐Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32: 149-184 ... SVZ stem cells from hGFAP‐SDHD animals were able to differentiate into Tuj1+ neurons in vitro; however, survival of these newly ... Suda T, Takubo K, Semenza GL (2011) Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9: ...http://embor.embopress.org/content/16/11/1511
Progenitor cell - Wikipedia
... between stem cells and fully differentiated cells. The kind of potency they have depends on the type of their "parent" stem ... Radial glial cells found in developing regions of the brain, most notably the cortex. These progenitor cells are easily ... cell and also on their niche. Some progenitor cells were found during research, and were isolated. After their marker was found ... Intermediate progenitor cells formed in the subventricular zone. Some of these transit amplifying neural progenitors migrate ...https://en.wikipedia.org/wiki/Progenitor_cell
New Jersey Commission Science and Technology Grants - Stem Cell Institute of New Jersey
Regulation of microRNA gene expression in differentiating neural stem cells. The key to transforming human stem cells into ... "Stem Cell Therapeutics: PDGF-Directed Glial Migration." This study will focus on engineering stem cells so that they home into ... objective is to use the knowledge gained to develop targeted therapy against cancer stem cells and/or their supportive niches. ... Modulation of recovery from neural trauma by neural stem cells. Neural stem cells give rise to neurons and glia during ...http://rwjms.umdnj.edu/scinj/research/Compendium.html