Mechanisms of Lymphocyte Activation and Immune Regulation X: Innate Immunity, Book by Sudhir Gupta (Paperback) | chapters...
Buy the Paperback Book Mechanisms of Lymphocyte Activation and Immune Regulation X by Sudhir Gupta at Indigo.ca, Canada's ... Antigen Processing and Presentation by Dendritic Cells: Cell Biological Mechanisms.- Human Thymic Stromal Lymphopoietin ... Role of TRAF6 in the Immune System.- The Innate Functions of Dendritc Cells in Peripheral Lymphoid Tissues.- The Mannose- ... Binding Lectin: An Infection Susceptibility Gene.- Immunotherapy Via Dendritic Cells.- Ontogeny of Langerhans Cells and Graft ...https://www.chapters.indigo.ca/en-ca/books/mechanisms-of-lymphocyte-activation-and/9781441937001-item.html
Lymph node stromal cell - Wikipedia
The lymph tissue in the lymph nodes consists of immune cells (95%), for example lymphocytes, and stromal cells (1% to 5%) The ... Lymph node stromal cells express peripheral tissue-restricted antigens (PTAs) on their surface. The Transcription factor Aire ( ... An adaptive immune response takes place in response to the presence of the antigen in the lymph node. Antigen-presenting cells ... Crosstalk LEC, lymphoid tissue inducer cells and mesenchymal stromal organizer cells initiate the formation of lymph nodes. ...https://en.wikipedia.org/wiki/Lymph_node_stromal_cell
CD169 mediates the capture of exosomes in spleen and lymph node | Blood Journal
Exosomes are a potential source of self-antigen for modulating the immune response against self-tissues, including tumors.1,2 ... are sialic acid binding molecules expressed on a variety of leukocytes and stromal cells. CD169 (Sialoadhesin), the first ... antigen presenting cells (APCs) in the marginal zone (MZ) of the spleen11 and follicular dendritic cells (DCs) in the B-cell ... sinus-lining cells to limit antigen entry into the red pulp.35 Such partitioning of antigen may optimize antigen availability ...http://www.bloodjournal.org/content/123/2/208?sso-checked=true
Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... professional antigen presenting cells (dendritic cells, macrophages, and B lymphocytes), and NK cells via direct cell-to-cell ... Mesenchymal stromal cells (MSCs) are multipotent and self-renewable cells that reside in almost all postnatal tissues. In ...https://www.hindawi.com/journals/sci/2015/989473/abs/
Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation | Gut
IgA secreting plasma cells, innate lymphoid cells and stromal cells such as fibroblasts. Antigen presenting cells in Peyer's ... Lymphoid tissue inducer (LTi) cells, assigned to group 3 ILCs, interact with stromal cells and induce lymph node organogenesis ... Innate lymphoid cells (ILCs) resemble lymphocytes, but lack the key characteristics of adaptive immune cells, namely an antigen ... The base of the crypts also contains the IEC stem cell populations. Immune cells can be found in organised tissue such as ...http://gut.bmj.com/content/62/11/1653
Changes of tumor infiltrating lymphocyte subtypes before and after neoadjuvant endocrine therapy in estrogen receptor-positive...
... in which the host immune response to tumor antigens changed in consequence of an interaction between tumor and stromal cells in ... The CD8+/Treg ratio in breast cancer tissue can be a potential surrogate marker in surgical pathology specimens for predicting ... not only incorporating features of carcinoma cells as in Ki-67 LI but also those of adjacent stromal cells in the tumor ... Tumor-stromal interactions involve continuous crosstalk and interactions among different cell types and play pivotal roles in ...https://www.sigmaaldrich.com/catalog/papers/23280127
Aida Habtezion MD MSc. | Stanford Medicine Profiles
Dendritic cells (DCs) are 'professional' antigen-presenting cells that are key in the regulation of immune responses. Here we ... Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to ... and stromal cells controls leukocyte recruitment and microenvironmental localization in intestine and in the gut-associated ... Immune cells and immune-based therapy in pancreatitis. Immunologic research Xue, J., Sharma, V., Habtezion, A. 2014; 58 (2-3): ...https://med.stanford.edu/profiles/aida-habtezion
Follicular dendritic cells and B cell tolerance - Robert Rickert
... are recognized as critical stromal components of the secondary lymphoid tissues that retain antigen and immune complexes, but ... are recognized as critical stromal components of the secondary lymphoid tissues that retain antigen and immune complexes, but ... 2013) Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol 191:1082-90 ... In the proposed work, we will: (i) Characterize the late B cell development block imposed by FDC-bound self-antigen. (ii) Use ...http://grantome.com/grant/NIH/R21-AI098304-02
Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions | Science...
... findings indicate that peripheral therapeutic vaccination to HPV antigens can induce a robust tissue-localized effector immune ... T cell infiltrates in both the stromal and epithelial compartments, suggest an effector response to vaccination. ... and that analyses of immune responses at sites of antigen are likely to be much more informative than analyses of cells that ... High-throughput T cell receptor sequencing of unmanipulated specimens identified clonal expansions in the tissue that were not ...http://stm.sciencemag.org/content/6/221/221ra13.short?rss=1
The malignant transplantable elements are only the lymphoblastic round cells and not mesenchymal stromal elements. Antigen- ... Homologous and heterologous immune sera may inactivate leukemic cells in vitro. Cytoplasmic constituents of leukemic cells are ... Preliminary experiments have suggested that noncellular extracts of either leukemic tissue or of embryonic cells from a high ... Resistance to homologous transplantation of leukemic cells may be overcome by inoculation of large doses of cells into very ...http://cancerres.aacrjournals.org/content/11/10/741
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Short Talk: Tumor-Associated Stromal Cells Contribute to Immune Dysfunction Via Antigen-specific Deletion of CD8+ T Cells and ... Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissues Meeting has ended...abstracts no longer viewable online. ... Imaging the Immune Cell-Stromal Interface in Lymphoid Tissues and Beyond. Fiona M. Watt, King's College London School of ... stromal cells support the migration of and interactions between antigen-presenting cells and naïve T and B cells during the ...http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1405
Patent US5478739 - Three-dimensional stromal cell and tissue culture system - Google Patents
The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three- ... the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue. ... Three dimensional vaginal tissue model containing immune cells. US20080058956 *. Oct 25, 2007. Mar 6, 2008. Badylak Stephen F. ... As the hematopoietic cells replicate and mature they will be educated to see the recipient cell antigens as "self", thereby can ...http://www.google.com/patents/US5478739?dq=5,960,411
Peter P. Lee, M.D., Chair, Dept. of Immuno-oncology, Beckman Research Institute in Los Angeles | City of Hope in Southern CA
... to dissect the complex interplay between immune/stromal cells and cancer cells within tumors, tumor-draining lymph nodes (TDLNs ... Whether these defects are due to improper T cell activation by dysfunctional antigen presenting cells, suppression by the tumor ... In addition she recruited patients into research studies, and procured and processed tissue specimens for study purposes. Diana ... Diana is interested in learning more about immune-tumor-stromal cell intereactions in the setting of breast cancer and how the ...https://www.cityofhope.org/chinese/people/lee-peter
Telocytes as potential targets in a cyclophosphamide-induced animal model of premature ovarian failure
... of cardiac stromal cells from the endothelium to mesothelium and contribute to vascular regeneration of myocardial tissues ... telocytes affect antigen presentation, immune activation and immune tolerance, via the release of microvesicles during synapses ... other types of cell, including ovarian stromal cells, ovarian epithelial cells and ovarian microvascular endothelial cells are ... Telocyte-like cells were observed in the stroma of ovarian tissues in mice of the WT group; these cells had a triangular cell ...https://www.spandidos-publications.com/mmr/14/3/2415
Celiac Disease and Autoimmune-Associated Conditions
... rather than because they are specific for an epithelial cell antigen. Only cells that up-regulate IL-15 and nonclassical MHC ... These lymphocytes trigger a Th1 response, with a predominance of IFN and the absence of IL-10, and the release by stromal cells ... These antibodies in the liver and in other extraintestinal tissues could modify other external- or self-antigens and generate ... Myocardial injury can also be attributed to immune response cross-reactivity against antigens present in the small intestine ...https://www.hindawi.com/journals/bmri/2013/127589/
Patente US5478739 - Three-dimensional stromal cell and tissue culture system - Google Patentes
The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three- ... the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue. ... Three dimensional vaginal tissue model containing immune cells. US20030236574 *. 11 Mar 2003. 25 Dic 2003. Sulzer Innotec Ag. ... As the hematopoietic cells replicate and mature they will be educated to see the recipient cell antigens as "self", thereby can ...http://www.google.es/patents/US5478739?dq=flatulence
Localization of igm in plasma cells in the iris of a patient with iridocyclitis and juvenile rheumatoid arthritis.
Radiographs of the knees showed normal findings except for soft tissue swelling; histocompatibility antigen typing revealed A2 ... She continued to have intermittent stiffness and swell- Figure 2. Electron microscopy photomicrograph of a stromal plasma cell ... No immune complexes were detected by a Clq binding assay (10). Total hemolytic complement and DNA antibody determinations were ... Light microscopy revealed scattered plasma cells and pigment cells within the iris stroma (Figure 1). Occasional plasma cells ...https://www.docme.ru/doc/2166321/localization-of-igm-in-plasma-cells-in-the-iris-of-a-pati..
GITR Ligand-Mediated Local Expansion of Regulatory T Cells and Immune Privilege of Corneal Allografts | IOVS | ARVO Journals
... stromal, and endothelial cells) express no MHC class II and only weak MHC class I antigens. 13 -15 Second, anterior chamber- ... naive C3H-T cells). After a 6-hour incubation, corneal endothelial cell death was detected by staining unfixed tissue with PI ... α-B6/BALB-T cells) or third-party C3H/He antigens (α-C3H/BALB-T cells), or from the spleens of naive BALB/c (naive BALB-T cells ... α-B6/BALB-T cells) or third-party C3H/He antigens (α-C3H/BALB-T cells), or from the spleens of naive BALB/c (naive BALB-T cells ...https://iovs.arvojournals.org/article.aspx?articleid=2126970
Asthma Lancet 2013 | Asthma | T Helper Cell
TSLP=thymic stromal lymphopoietin. TGFβ1=transforming growth-factor β1. TCR=T-cell receptor. Treg=regulatory T cell. Th=T- ... epithelial cells interact with mesenchymal cells to coordinate remodelling of tissue architecture in response to the mechanical ... Mast cell Figure 4: Major immune pathways involved in asthma pathogenesis Innate and adaptive components of allergic ... Interleukin33 Interleukin 13 IL33R Interleukin 13 Smooth muscle cells TSLP CD14 TLR MHC class II IL4Rα TCR Antigen Interleukin ...https://www.scribd.com/document/204879911/Asthma-Lancet-2013
Immune tolerance - Wikipedia
... other antigen presenting cells, or in certain conditions surrounding tissue. Treg cells are not the only cells that mediate ... recognized that tumors are a complex and dynamic population of cells composed of transformed cells as well as stromal cells, ... tumor antigens, alloantigens, and self-antigens in inflamed tissue. Immune recognition of non-self-antigens typically ... FasL expression by immune privileged tissues can result in activation-induced cell death of T cells. The involvement of T cells ...https://en.wikipedia.org/wiki/Immune_tolerance
Detecting Avian Influenza Virus (H5N1) in Domestic Duck Feathers - Volume 14, Number 10-October 2008 - Emerging Infectious...
Virus antigens were detected in feather epidermal cells from days 3 through 6 pi, and in a few stromal cells in the feather ... The epidermis, the outer layer of the feather, is a tissue that has poor host immune response against viral replication (8). As ... Chua TH, Ellis TM, Wong CW, Guan Y, Ge SX, Peng G, Performance evaluation of five detection tests for avian influenza antigen ... selecting the sample with higher viral load and antigens in tissues, such as feathers, can increase the detection rate obtained ...https://wwwnc.cdc.gov/eid/article/14/10/08-0415_article
Epithelial Cells in the Female Reproductive Tract: a Central Role as Sentinels of Immune Protection - Wira - 2005 - American...
Separating underlying tissues from luminal antigens, polarized epithelial cells of the cervix, uterus and Fallopian tubes have ... Acting both directly and indirectly through underlying stromal cells, estradiol and progesterone regulate epithelial cell ... Epithelial Cells in the Female Reproductive Tract: a Central Role as Sentinels of Immune Protection. Authors. *. Charles R. ... Cell and Tissue Research, 2015, 359, 2, 655. CrossRef. *20. Li Zhou, Jie-Liang Li, Yu Zhou, Jin-Biao Liu, Ke Zhuang, Jian-Feng ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2004.00248.x/abstract?globalMessage=0
Human being mesenchymal stromal cells (MSC) possess immunosuppressive and antimicrobial results - Aurora Kinases as Druggable...
Major Cells Human being bone tissue marrow-derived MSC had been ready, spread, and characterized as described  previously. ... During coevolution with its particular sponsor, human being CMV offers created many immune system evasion strategies [16C18]. ... For example, CMV offers been reported to inhibit the upregulation of MHC course II antigens. Furthermore, it was discovered ... Mesenchymal stromal cells and embryonic come cells are capable to hinder T-cell reactions and many systems including the ...http://www.exposed-skin-care.net/2018/02/06/human-being-mesenchymal-stromal-cells-msc-possess-immunosuppressive-and-antimicrobial-results/
Waldman, Scott - Philadelphia University + Thomas Jefferson University - Thomas Jefferson University
This is particularly relevant in tumors derived from mucosal tissues such as colorectal cancer, in which antigens that are ... reveal a previously unappreciated role for GCC and cGMP signaling in directing epithelial cell remodeling of the stromal ... We have explored a novel class of tumor-associated antigens fulfilling these criteria by exploiting immune compartmentalization ... Thus, a novel paradigm suggests that targeting self-antigens expressed by normal mucosal tissues and by derivative neoplasms ...https://www.jefferson.edu/university/jmc/departments/pharmacology/faculty_staff/faculty/waldman.html
... or by blocking heterotypic signaling between tumor cells and the surrounding stromal tissue or blood vessels. Enhancing immune ... Immune response modulation Most tumors express antigens that could potentially elicit an immune response due to the expression ... Several mechanisms protect tumor cells from immune surveillance. Tumor cells can down-regulate the expression of major ... We carried out dropout screens for shRNAs that affect cell proliferation and viability in cancer cells and normal cells (205, ...http://elledgelab.med.harvard.edu/?page_id=305