CIM seminar: "Mechanisms of activation of innate immune responses in viral RNA and virus infection stimulated human cells" |...
Mechanisms of activation of innate immune responses in viral RNA and virus infection stimulated human cells' Host: Malin ... CIM seminar: 'Mechanisms of activation of innate immune responses in viral RNA and virus infection stimulated human cells'. ... "Mechanisms of activation of innate immune responses in viral RNA and virus infection stimulated human cells" ...http://ki.se/en/medh/calendar/cim-seminar-mechanisms-of-activation-of-innate-immune-responses-in-viral-rna-and-virus
Viruses | Free Full-Text | The Dual Role of Exosomes in Hepatitis A and C Virus Transmission and Viral Immune Activation
Paradoxically, both viral exosomes can also be detected by plasmacytoid dendritic cells (pDCs) leading to innate immune ... Hepatitis A virus (HAV; a picornavirus) and Hepatitis C virus (HCV; a flavivirus) two single strand plus-sense RNA viruses, in ... activation and type I interferon production. This article will review recent findings regarding these two viruses and outline ... proteins and lipids between different cells. Many studies have found that exosomes also play various roles in viral ...http://www.mdpi.com/1999-4915/7/12/6707
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... dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection. ... Influenza A virus PB1-F2 is involved in regulation of cellular redox state in alveolar epithelial cells. ... Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. ... The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=24799673
Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection - Velazquez - 2012 -...
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119: ... Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection†‡. ... Hepatitis C virus infection involves CD34(+) hematopoietic progenitor cells in hepatitis C virus chronic carriers. Blood 1998; ... cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection ...http://onlinelibrary.wiley.com/doi/10.1002/hep.25904/references?globalMessage=0
Frontiers | Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like...
... in local and systemic NK cell activation following respiratory IAV infection despite the presence of redundant innate IAV- ... in local and systemic NK cell activation following respiratory IAV infection despite the presence of redundant innate IAV- ... Strikingly, respiratory IAV infection also primed splenic NK cells for IFN-γ production, degranulation and target cell lysis, ... Strikingly, respiratory IAV infection also primed splenic NK cells for IFN-γ production, degranulation and target cell lysis, ...https://www.frontiersin.org/articles/10.3389/fimmu.2018.00245/full
Quantitative profiling of innate immune activation by viral infection in single cells - Integrative Biology (RSC Publishing)
... and other molecules that typically initiate virus replication and activate cellular ant ... Cells infected by viruses can exhibit diverse patterns of viral and cellular gene expression. The patterns arise in part from ... Quantitative profiling of innate immune activation by viral infection in single cells A. C. Timm, J. W. Warrick and J. Yin, ... Quantitative profiling of innate immune activation by viral infection in single cells ...http://pubs.rsc.org/en/content/articlelanding/2017/ib/c7ib00082k
Polarity of human parainfluenza virus type 3 infection in polarized human lung epithelial A549 cells: role of microfilament and...
... is an airborne pathogen that infects the epithelial cells of the respiratory tract. In the present study we investigated the ... had no effect on virus entry, disruption of the microtubule but not the microfilament inhibited HPIV-3 release. ... interaction of HPIV-3 with the type II alveolar human lung polarized epithelial A549 cells. Although HPIV-3 entry and budding ... Activation of innate immune antiviral response by NOD2. *Ahmed Sabbah, Te Hung Chang, +5 authors Santanu Bose ...https://www.semanticscholar.org/paper/Polarity-of-human-parainfluenza-virus-type-3-in-of-Bose-Malur/7bfa9769113552a9c1df1a85bae4e529ca98bcea
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Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection ... GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis ...http://www.jimmunol.org/content/by/section/INNATE%20IMMUNITY%20AND%20INFLAMMATION
Viruses | Free Full-Text | Filovirus Research in Gabon and Equatorial Africa: The Experience of a Research Center in the Heart...
Since the reemergence of Ebola virus in Central Africa, the CIRMF ... The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J ... Genus/Virus *. Origin/Country **. Year. Host. Genetics/virus isolates ***. Filoviridae. Ebolavirus/Ebola virus ****. Mayibout 2 ... Genetic characterization by partial or total sequencing/Virus isolation on cell culture; all Ebola virus strains are of the " ...http://www.mdpi.com/1999-4915/4/9/1592/htm
Most recent papers with the keyword thirumala-devi kanneganti | Read by QxMD
Innate sensing of influenza virus infection induces activation of programmed cell death pathways. We have recently identified Z ... is-a-transcriptional-regulator-of-zbp1-promoting-nlrp3-inflammasome-activation-and-cell-death-during-influenza-virus-infection ... Innate immune sensing of influenza A virus (IAV) induces activation of various immune effector mechanisms, including the ... Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. ...https://www.readbyqxmd.com/keyword/109997
DVIDS - News - Turning Bat Genes Into Future Vaccines
Alternatively, in bat cells there is a robust innate immune response to the infection, which results in lower virulence without ... DGE can be used to identify immune response genes that are expressed after cells are infected with a virus mutated at a known ... Basler utilized these heat maps to demonstrate that filovirus proteins can successfully suppress activation of human immune ... present in the virus particle is key to the virus's ability to evade the host immune response, but were unclear how it ...https://www.dvidshub.net/news/251116/turning-bat-genes-into-future-vaccines
Selective Killing of Vaccinia Virus by LL-37: Implications for Eczema Vaccinatum | The Journal of Immunology
Innate immunity to viruses: control of vaccinia virus infection by γδ T cells. J. Immunol. 166:6784. ... These processes include antimicrobial proteins, complement activation, macrophages, NK cells, numerous cytokines, CTLs, ... Resolution of infection and protection against reinfection with viruses depend on cooperation between innate and adaptive ... Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes. J. Gen. Virol. ...http://www.jimmunol.org/content/172/3/1763
Browsing Immunology by Subject "Immunology"
Dermal resident versus recruited γδ T cell response to cutaneous Vaccinia virus infection Davis, Amanda Swale Woodward ... Virus recognition and response by the innate immune system are critical components of host defense against infection. ... Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus ... ... 33D1+ Dendritic Cells in Tolerance and Immunity STOLLEY, James M. CD4+ Foxp3+ regulatory T cells (Tr cells) are potent anti- ...https://digital.lib.washington.edu/researchworks/handle/1773/4930/browse?value=Immunology&type=subject
HIV-1 ANTIBODIES: Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues ... initiated infection after adoptive transfer into naïve hosts. These data demonstrate that bNAb-mediated protection against a ... HIV-1 ANTIBODIES: Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus. ... However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We ...https://insights.ovid.com/scie/201609020/00007529-201609020-00056
Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection
... genes encoding virus interacting proteins, and evidence of active anti-oxidant and cell-mediated innate immune response. Taken ... we discovered strong transcriptional regulation of genes involved in inflammasome activation, ... In a human challenge study using live influenza (H3N2/Wisconsin) viruses, we conducted a clinically uninformed (unsupervised) ... by the identification of 42 biomarkers whose expression patterns best differentiate early from late phases of infection. In ...http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002234
Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans | JEM
T cells before EBV infection. During acute infection, activation resulted in a mean of 65.4 ± 25.6% CD38+/DR+ and 74.1 ± 25.6% ... In summary, we studied natural infection with a common virus that induces robust innate and adaptive immune responses in humans ... T cells) because it has been reported that IFN can cause T cell activation of bystander T cells (McNally et al., 2001; ... Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans. Oludare A. Odumade, Jennifer A. ...http://jem.rupress.org/content/early/2012/02/29/jem.20112401
Browsing UT Electronic Theses and Dissertations by Department "Cellular and Molecular Biology"
... initiates host cell defense mechanisms including activation of the innate immune system in an effort to clear an infection. As ... Human immunodeficiency virus reverse transcriptase (HIV RT) is a virally encoded polymerase responsible for replicating the HIV ... Cell proliferation is a fundamental biological process, and the ability of human cells to transition from a quiescent to ... The cell lines of Old Man Cactus and Bunny Ear Cactus have been developed by previous researchers and are well maintained in ...https://repositories.lib.utexas.edu/handle/2152/11/browse?order=ASC&rpp=20&sort_by=-1&value=Cellular+and+Molecular+Biology&etal=-1&offset=20&type=department
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing | PNAS
Intracellular detection of virus infections is a critical component of innate immunity carried out by molecules known as ... 2005) Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific ... A549 human lung carcinoma cells were infected with a high MOI of SeV-C or PR8ΔNS1 viruses. Infections were allowed to proceed ... 2010) RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140:397-408. ...http://www.pnas.org/content/107/37/16303
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Natural Killer (NK) cells are important in early innate immune responses to viral infections. Activation of NK cells, in part, ... Natural killer (NK) cells are a vital component of the innate immune response to virus-infected cells. It is important to ... Embryonic Stem Cells, ESCs, ES Cells, Hematopoietic Stem Cells, HSC, Pluripotent Stem Cells, Induced Pluripotent Stem Cells, ... Immunology, Issue 82, Blood Cells, Respiratory Syncytial Virus, Human, Respiratory Tract Infections, Paramyxoviridae Infections ...https://www.jove.com/visualize/abstract/22216211/enrichment-variations-kir3dl1s1-kir2dl2l3-among-h1n109-icu-patients
B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein...
... plays a key role in promoting activation of autoimmune B cells. This cytokine may be expressed in and secreted by salivary ... In autoimmune diseases, PKR may be an interesting target for preventing BAFF following the induction of innate immunity. ... but retinoic acid-inducible gene I silencing mRNA had a slight effect observed following infection with dsRNA reovirus-1. ... by 2-aminopurine completely abolished both BAFF mRNA and protein production after reovirus-1 infection and poly(I:C) ...https://www.semanticscholar.org/paper/B-cell-activating-factor-expressions-in-salivary-on-Ittah-Miceli-Richard/7015c16cb4076d3d61166a6eff285282424bd955
Pandemic H1N1 2009 Influenza A Virus Induces Weak Cytokine Responses in Human Macrophages and Dendritic Cells and Is Highly...
We have studied the activation of innate immune responses in pandemic virus-infected human monocyte-derived dendritic cells (DC ... Virus infection experiments. To study the kinetics of virus infection in macrophages and DCs, the cells were infected with A/ ... DCs and macrophages activate virus-destroying NK cells and T cells with the cytokines they secrete and via direct cell-to-cell ... The pandemic virus as well as two recent seasonal H1N1 viruses induced a relatively weak innate immune response in these cells ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2812319/
NK Cell Response to Vaccinia Virus Is Regulated by Myeloid-Derived Suppressor Cells | The Journal of Immunology
NK cells are critical for the innate immune control of poxviral infections. Previous studies have shown that NK cells are ... Depletion of MDSCs enhances NK cell activation and function. NK cells are pivotal for the control of VV infection as well as ... Innate immune CD11b+Gr-1+ cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating ... that NK cell response to VV infection is also negatively regulated by G-MDSCs. This tight control of NK cell activation could ...http://www.jimmunol.org/content/189/4/1843.long
Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated...
It appears, then, that the complex interaction of a greater-than-normal innate response (mediated by type I interferons) and ... T-cell activation in the setting of HIV-1 infection leads to CD4+ T-cell depletion. We hypothesized that if chronic CD4+ T-cell ... T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis ... Chronic HIV-1 infection is characterized by massive and chronic activation of CD4+ T cells (29, 41, 63). This activation is ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2258719/?lang=en-ca
Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro. -...
This is concomitant with the activation and modulation of monocyte-mediated innate immune responses by latent virus. These ... Upon binding and entry of the virus, tegument proteins most likely aid in remodeling the cell for latent carriage of the virus ... activation of innate immune responses and the modulation of protein and lipid synthesis to accommodate latent HCMV infection. ... Genome-wide expression profiling of latently infected monocytes demonstrates activation of innate immune responses. RNA ...https://www.ncbi.nlm.nih.gov/pubmed/24920803
Frontiers | Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses |...
These include metabolic functions of IRF9 as well as the regulation of NK cell activity by kinase-dead TYK2 and different ... Our review summarizes the contribution of noncanonical JAK-STAT signaling to the innate antimicrobial immunity imparted by IFN ... These include metabolic functions of IRF9 as well as the regulation of NK cell activity by kinase-dead TYK2 and different ... Our review summarizes the contribution of noncanonical JAK-STAT signaling to the innate antimicrobial immunity imparted by IFN ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00029/full