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*  ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross...
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity ... Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308: 457-460. ... ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross- ... ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross- ...
  http://www.jimmunol.org/content/187/1/55
*  Herpes Simplex Virus (HSV) Amplicon-mediated Codelivery of Secondary Lymphoid Tissue Chemokine and CD40L Results in Augmented...
Mellman I., Steinman R. M. Dendritic cells: specialized and regulated antigen processing machines. Cell, 106: 255-258, 2001. ... nonpolarized memory T cells and dendritic cells (DCs) within lymph nodes and Peyer's patches. CD40L-mediated DC activation ... The elaboration of functional immune responses requires fine-tuned interactions of multiple immune effector cell types, ... Albert M. L., Sauter B., Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. ...
  http://cancerres.aacrjournals.org/content/62/22/6545
*  Human Cytomegalovirus and Autoimmune Disease
... cells destroyed by viruses or by immune attack can further activate dendritic cells and macrophages. Infected tissue and ... SSc is a connective tissue disorder with abnormal fibroblast cell proliferation. Endothelial cell activation leads to vascular ... activated antigen presenting cells (APC) will attract immune cells producing high levels of cytokines and chemokines, which ... cells in vitro has been reported [140]. While HCMV- or immune-mediated cell death is a possible outcome of abortive HCMV ...
  https://www.hindawi.com/journals/bmri/2014/472978/
*  TLR9 - Wikipedia
TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, ... and other antigen presenting cells. TLR9 preferentially binds DNA present in bacteria and viruses, and triggers signaling ... Activation of cells leads to de-methylation, which exposes CpG regions of host DNA, allowing an inflammatory response to be ... Many viruses take advantage of this relationship by inducing certain TLR9 expression patterns to first infect the cell (down- ...
  https://en.wikipedia.org/wiki/TLR9
*  In situ adenovirus vaccination engages T effector cells against cancer
... of the virus could be involved in releasing tumor-specific antigens to dendritic cells and innate and adaptive immune responses ... of MMC cells (Fig. 2F, 2G). Notably, CD3-activation with an agonistic anti-CD3scFv bypasses T cell receptor activation and is ... T cells (regulatory T cells), CD4+FoxP3− (T helper cells), CD8+ T cells and NK cells (Fig. S6). ... T cells (~12% of TIL), whereas CD8+ T cells were only a minor T cell fraction (~2% of TIL). Infiltration of T cells into the ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2727281/
*  WAO Email News and Notes
MCs have emerged as prominent effectors of lymphocyte activation and immune cell migration to draining lymph nodes. To explore ... MC activators may function as vaccine adjuvants by promoting MC-dendritic cell interaction thus boosting protective antigen- ... However, AD cells were unable to mobilize HBD-3 efficiently to kill S aureus. HBD-3 mobilization and the ability to kill S ... of these formulations provides protection against anthrax lethal toxin challenge in vitro and against vaccinia virus challenge ...
  http://www.worldallergy.org/enews/0908/reviews_japanese.html
*  Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1
This cell effectively links the innate recognition of viruses to the generation of an adaptive immune response. However, HIV-1 ... The activation of protective T cell responses depends upon dendritic cells (DC), antigen-presenting cells which have the ... Antigen pathway, Antigen presentation, Antigen processing, Dendritic cells, HIV National Category Medical and Health Sciences ... dendritic cells (DCs) and CD4+ T cells. The complement system, a key component of the innate immune system, is immediately ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:270107
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... viruses efficiently transduce dendritic cells in vitro and generate a strong T cell immune response to our reporter antigen. ... immune cells via CLRs allows for enhanced internalization of antigen and subsequent presentation for further T cell activation ... Dendritic Cells, Immunotherapy, dendritic cell, immunotherapy, vaccine, cell, isolation, flow cytometry, cell culture, clinical ... stable cell line, dendritic cells, vaccine, concatemeric transfection, retrovirus, virus, plasmid, cell culture ...
  https://www.jove.com/visualize/abstract/24886790/immature-dengue-virus-is-infectious-human-immature-dendritic-cells
*  Protocols and Video Articles Authored by Jeanette Boudreau (Translated to Dutch)
IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-infected Dendritic Cells Cancer ... strategy for tumor immunotherapy due to their ability to activate both antigen-specific T-cell immunity and innate immune ... The ability of dendritic cells (DCs) to provide all three signals required for T-cell activation makes them an ideal cancer ... Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive ...
  https://www.jove.com/author/Jeanette_Boudreau?language=Dutch
*  Vitamin D metabolism and signaling in the immune system | SpringerLink
... and recent work has revealed that it has several roles in control of human immune system function. Vitamin D was originally... ... Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344-9.CrossRefGoogle ... Immune-modifying properties of topical vitamin D: focus on dendritic cell and T cells. J Ster Biochem Mol Biol. 2010;121:247-9. ... Micobiota regulates immune defense against respiratory tract influenza A virus infection. Proc Nat Acad Sci U S A. 2011;108: ...
  https://link.springer.com/article/10.1007%2Fs11154-011-9195-z
*  Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury | Journal of Neuroscience
B cells interact with T cells and dendritic cells to mount immune responses against virus and bacteria. Of paramount importance ... Impaired antigen-specific immunity after high-level SCI is a result of mature B lymphocyte cell death and impaired B-cell ... Vaccines are designed to elicit B-cell activation and stimulate antibody production. We showed previously that splenic B-cell ... Splenic atrophy and B-cell loss could result from death of mature B cells (Lucin et al., 2007), impaired B-cell genesis ( ...
  http://www.jneurosci.org/content/33/32/12970
*  Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen | Science Immunology
Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation ... is critical for efficient pathogen encounter and antigen presentation. Epstein-Barr virus-induced gene 2 (EBI2) has been ... Programming dendritic cells with cholesterol. Strategic positioning of immune cells at sites of pathogen encounter plays a ... Research ArticleDENDRITIC CELLS. Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the ...
  http://immunology.sciencemag.org/content/2/10/eaal5237
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The activation status can be tracked by changes in cell surface antigens, gene expression and cell signaling pathways. ... Dendritic cells (DCs) can be considered sentinels of the immune system which play a critical role in its initiation and ... viruses have evolved intricate strategies to evade and exploit host immune signaling for survival and propagation. Viral immune ... Immunology, Issue 10, Natural Killer T cells, NKT cells, CD1 Tetramers, antigen presentation, glycolipid antigens, CD1d, ...
  https://www.jove.com/visualize/abstract/19936255/genome-wide-analysis-immune-activation-human-t-b-cells-reveals
*  Pharmaceuticals | Free Full-Text | Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications | HTML
... from either myeloid or epithelial origin expressed in a majority of tissues with broad-spectrum antibacterial and immune ... Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and ... Many peptides are shown to be actively involved in chemotaxis and activation of immune cells, regulation of dendritic cell ... Enveloped and non-enveloped viruses such as human immunodeficiency virus (HIV-1), influenza A virus (IAV), cytomegalovirus (CMV ...
  http://mdpi.com/1424-8247/7/3/220/htm
*  Viruses | Free Full-Text | Dendritic Cells and HIV-1 Trans-Infection
... transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the ... This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro ... Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious ... Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, ...
  http://www.mdpi.com/1999-4915/2/8/1704
*  T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to...
Superantigen-specific T cells start to show signs of activation within 65 h of virus injection ((29)). T cell proliferation ... It is also similar to findings in secondary immune responses, where the highest amount of switch transcript per antigen- ... Cells other than interdigitating dendritic cells that might influence the very early differentiation of Th cells in primary ... Sites of specific B cell activation in primary and secondary responses to T-cell-dependent and T-cell- independent antigens. ...
  http://jem.rupress.org/content/187/8/1193
*  Generation of Human Monocyte-derived Dendritic Cells from Whole Blood | Protocol
... we demonstrate how monocytes are isolated by magnetic bead separation from peripheral blood mononuclear cells after density... ... Dendritic cells (DCs) are the most important specialized antigen-presenting cells of our immune system. Immature DCs (iDCs) ... Mills, K. H. TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol. 11, 807-822 (2011). ... Dendritic cells (DCs) recognize foreign structures of different pathogens, such as viruses, bacteria, and fungi, via a variety ...
  https://www.jove.com/video/54968/generation-of-human-monocyte-derived-dendritic-cells-from-whole-blood
*  Frontiers | Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection | Immunology
Following activation, CD8 T cells can migrate to sites of infection and kill infected cells, whereas CD4 T cells contribute to ... immunity against various viral infections by generating effector cells that cooperate to eliminate antigens and memory cells ... CD4 T cells contribute to the elimination of pathogens by trafficking to infected tissues and providing help to innate immune ... Following activation, CD8 T cells can migrate to sites of infection and kill infected cells, whereas ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00531/full
*  Early Differentiation of Human CD11c+NK Cells with γδ T Cell Activation Properties Is Promoted by Dialyzable Leukocyte Extracts
... immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... "Both conventional and interferon killer dendritic cells have antigen-presenting capacity during influenza virus infection," ... Figure 3: Stromal cell activation by DLE increases the emergent innate immune cell differentiation. MS-5 stromal cells were ... Figure 6: Activation of γδ T cells as a result of DLE-associated CD11c+ NK cell emergent production. γδ T cells from healthy ...
  https://www.hindawi.com/journals/jir/2016/4097642/
*  Application # 2018/0050098. COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS -...
Described herein are compositions and methods for treating cancer through the combination of tumor antigen-pulsed dendritic ... cells and Dengue Virus. The combination of the two forms of therapeutic int ... immune cells, etc.). In some instances, peptides/antigens from tumor cells and tumor supporting cells induce dendritic cells or ... exposing the dendritic cells to the tumor cells or tumor cell lysate 105, also referred to as "pulsing" the dendritic cells, to ...
  http://patents.com/us-20180050098.html
*  Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes, Nature Communications | 10.1038/s41467...
"Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes, Nature Communications" on DeepDyve, ... Renal dendritic cells sample blood-borne antigen and guide T-cell migration to the kidney by means of intravascular processes ... Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral ... Analysis of TNF-mediated recruitment and activation of glomerular dendritic cells in mouse kidneys by compartment-specific flow ...
  https://www.deepdyve.com/lp/springer_journal/effector-cd4-t-cells-recognize-intravascular-antigen-presented-by-uuDUqUxoGL
*  Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. | CHAVI-ID
T cell response. We demonstrate a key role for virus-induced GCN2 activation in programming dendritic cells to initiate ... Porichis, Filippos, et al. "Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells." J Immunol. 201.3 ( ... Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.. Mon, 02/03/2014 - 9:28am -- ... Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.. ...
  http://chavi-id.org/publications/vaccine-activation-nutrient-sensor-gcn2-dendritic-cells-enhances-antigen-presentation
*  Immune Response | Encyclopedia.com
... viruses, fungi, and other foreign or disease-causing agents. All organisms have nonspecific defenses (or innate defenses) that ... Immune Response Among the many threats organisms face are invasion and infection by bacteria, ... TC cells) and B cells. Like TH cells, each TC cell and B cell has receptors that match one antigen. This is why the immune ... dendritic cells, and B cells. These cells encounter the foreign invader and present the invader's antigens to a group of T ...
  https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/immune-response
*  RFA-AI-07-008: Immune Mechanisms of Viral Control (R21)
Immune Mechanisms of Viral Control (R21) RFA-AI-07-008. NIAID ... Cells of the innate immune system, such as dendritic cells (DC ... antigen persistence, cell turnover kinetics, and cytokines necessary for T and B cell memory to viruses ... the innate response leads to activation of the adaptive immune system, and expansion of viral antigen-specific T and B cells. ... cells, NK T cells, γδ-T cells, neutrophils, and B-1 B cells. Many soluble effectors produced by cells of the innate immune ...
  https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-07-008.html
*  HAVCR2 - Hepatitis A virus cellular receptor 2 precursor - Homo sapiens (Human) - HAVCR2 gene & protein
Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes ... Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells ... Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune ... Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of ...
  http://www.uniprot.org/uniprot/Q8TDQ0