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*  Translational Therapeutics of Dipyridamole | Arteriosclerosis, Thrombosis, and Vascular Biology
8 Adenosine is released from vascular wall cells and platelets into the extracellular space as a breakdown product of adenosine ... DP was initially found to increase extracellular levels of adenosine by inhibiting adenosine uptake by red blood cells, thereby ... In circulating blood, free adenosine is rapidly removed from plasma by a specific adenosine carrier into red blood cells. At ... Increased intracellular levels of cGMP in platelets and vascular smooth muscle cell (VSMC) inhibits platelet activation and ...
  http://atvb.ahajournals.org/content/28/3/s39
*  Plus it
... decreased red blood cell sedimentation under low-flow conditions (Defazio et al., 2012), and reduced platelet aggregation ( ... formation from thrombin-stimulated human platelets by sequestering the liberated arachidonic acid in the extracellular space. ... The ability of albumin in inhibiting platelet aggregation by sequestering arachidonic acid released into extracellular space ( ... Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood ...
  http://www.jneurosci.org/content/35/9/3851
*  Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells
... including blood group ligands) may be present on a substantial number of extracellular proteins. Notably, most sites identified ... these data demonstrate that O-glycosylation is a ubiquitous modification of disordered regions in the extracellular space. ... Cell. 2000;103(3):467-479. [PubMed]. 20. McEver RP. Selectins: lectins that initiate cell adhesion under flow. Curr Opin Cell ... and endothelial cells is the maintenance of vascular integrity accomplished through regulation of platelet activation, blood ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5738978/
*  Membrane Potential-Dependent Inhibition of Platelet Adhesion to Endothelial Cells by Epoxyeicosatrienoic Acids |...
... the question whether EETs can be released to the extracellular space from endothelial cells and thus affect platelets, we next ... Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood. 2000; 96: ... Endothelial Cell Culture and Platelet Isolation. Human umbilical vein endothelial cells (HUVEC) were cultivated as described.17 ... EETs inhibited platelet adhesion to endothelial cells under static and flow conditions. Exposure to EETs inhibited platelet P- ...
  http://atvb.ahajournals.org/content/24/3/595
*  Free Radicals and Biomarkers Related to the Diagnosis of Cardiorenal Syndrome | IntechOpen
Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human ... Once MMP are formed, they stay as proenzymes in the ground substance of the extracellular space. However, if met by other ... its function is to release mononuclear cells into the blood flow. After ischemic injury, there seems there to be local ... protein kinase cascades in angiotensin II and platelet-derived growth factor-induced vascular smooth muscle cell proliferation ...
  https://www.intechopen.com/books/free-radicals-and-diseases/free-radicals-and-biomarkers-related-to-the-diagnosis-of-cardiorenal-syndrome/
*  Free Anatomy Flashcards about A&P Lab Ch 3-5
mature bone cells) are trapped in spaces called lacunae. Blood composed of red blood cells, white blood cells, platelets, and ... lipid-storing cells)& little extracellular matrix, Lipid within the adipose cells occupies most of the cell volume. ... the extracellular matrix is packed with elastic fibers, and fibroblasts are found in the spaces between these fibers. ... Long cell projection whip-like motion moves sperm arrector pili bundle of smooth muscle cells attached to the connective tissue ...
  https://www.studystack.com/flashcard-421457
*  ATP-Evoked Sustained Vasoconstrictions Mediated by Heteromeric P2X1/4 Receptors in Cerebral Arteries | Stroke
... purine nucleotides that stored at millimolar range in various cells can leak during their damage into the extracellular space. ... Hydrolysis of extracellular ATP and immune suppression: humans versus mice. Blood. 2008;111:964-965. ... 13,15 In addition, ATP is also released by endothelial cells under shear stress and by degranulated platelets.33 Moreover, ... Interstitial cells from rat middle cerebral artery belong to smooth muscle cell type. J Cell Mol Med. 2009;13:4532-4539. ...
  http://stroke.ahajournals.org/content/45/8/2444
*  Necrotizing enterocolitis - The Clinical Advisor
Complete blood count. The absolute number of white cells may be elevated but is more usually markedly depressed, especially as ... Hyponatremia will result when there is significant "third spacing" of extracellular fluid and loss of sodium within the ... Thrombocytopenia (platelet count , 100,000/μL) occurs due to increased platelet consumption and depressed bone marrow ... due to large third spacing losses. Hematocrit should be monitored and packed red cells provided to replace losses due to ...
  https://www.clinicaladvisor.com/pediatrics/necrotizing-enterocolitis/article/621132/
*  anti-ACTN1 antibody | Rabbit ACTN1 Antibody-NP 001093.1
... extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood ... Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; dendritic spine; extracellular region; ... Cell-Cell Communication Pathway antibodies. Cell-Cell Communication Pathway Diagram. Cell-extracellular Matrix Interactions ... Cell Junction Organization Pathway antibodies. Cell Junction Organization Pathway Diagram. ...
  https://www.mybiosource.com/prods/Antibody/ACTN1/datasheet.php?products_id=1403
*  Outcome 5 Hemopoietic System Flashcards by Sarah sharp | Brainscape
as blood circulates around the body, our blood plasma moves into the extra cellular spaces, bathes the cells in nutrients, ... cleans the blood by removing aged and defective blood cells and platelets -stores blood making components such as iron and ... during this some of the blood plasma remains behind in the extracellular spaces. -the "escaped" plasma is called interstitial ... Platelets also release several hormones and chemicals that trigger coagulation and the release of more platelets 3) BLOOD ...
  https://www.brainscape.com/flashcards/outcome-5-hemopoietic-system-5551912/packs/8394453
*  Nouvelle Cuisine: Platelets Served with Inflammation | The Journal of Immunology
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood 123: 3818-3827. ... can release them to the extracellular space. (6) Immune interactions with platelets can lead to severe thrombocytopenic states ... Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood 111: 3684-3691. ... Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 13: 463-469. ...
  http://www.jimmunol.org/content/194/12/5579
*  Body Bio-chemicals 1 Test Kit
... made by certain white blood cells; naturally produced by virus-infected host cells that induce unaffected cells to synthesize ... Accumulates in extra-cellular spaces of many organs in association with different disease processes; inhibits elastase (enzyme ... In parts of the brain, blood platelets, lining of digestive tract; concerned with conscious processes, involved in controlling ... Extra-cellular, viscous material that binds cells together, lubricates joints and maintains shape of the eye ball; may help ...
  https://www.lifeworkpotential.com/products/Body-Bio-chemicals-1-Test-Kit
*  COL1A1 (human)
... extracellular space; Golgi apparatus; secretory granule Molecular Function: extracellular matrix structural constituent; ... platelet activation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive ... Biological Process: blood coagulation; blood vessel development; cellular response to epidermal growth factor stimulus; ... Cellular Component: collagen type I trimer; endoplasmic reticulum lumen; extracellular matrix; extracellular region; ...
  https://www.phosphosite.org/proteinAction?id=7512&showAllSites=true
*  The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes
... an integrin on the surface of blood platelets (thrombocytes) responsible for attachment to fibrin within a developing blood ... To provide a larger space to allow for cell proliferation and generation of new ECM, we found that a COLII scaffold composed of ... Regulation of cell shape and signaling from cell-cell and cell-ECM interactions are vital to the maturation of chondrocytes. ... The integrins are a large family of heterodimeric cell adhesion receptors involved in cell-cell and cell-matrix interactions [ ...
  https://www.hindawi.com/journals/bmri/2014/648459/
*  Mesangial cell - Wikipedia
Mesangial cells are separated by intercellular spaces containing extracellular matrix called the mesangial matrix that is ... Endothelial precursor cells secrete platelet-derived growth factor (PDGF)-B and mesangial cells have receptors for PDGF. This ... Mice lacking the growth factor PDGF-B or PDGFRβ do not develop mesangial cells. When mesangial cells are absent the blood ... The mesangial cell population accounts for approximately 30-40% of the total cells in the glomerulus. Mesangial cells can be ...
  https://en.wikipedia.org/wiki/Mesangial_cell
*  Why all migraine patients should be treated with magnesium | SpringerLink
Routine blood tests do not reflect true body magnesium stores since ,2 % is in the measurable, extracellular space, 67 % is in ... Soriani S, Arnaldi C, De Carlo L et al (1995) Serum and red blood cell magnesium levels in juvenile migraine patients. Headache ... Baudouin-Legros M, Dard B, Guichency P (1986) Hyperreactivity of platelets from spontaneously hypertensive rats. Role of ... Abraham GE, Lubran MM (1981) Serum and red cell magnesium levels in patients with premenstrual tension. Am J Clin Nutr 34:2364- ...
  https://link.springer.com/article/10.1007%2Fs00702-012-0790-2
*  Extracellular fluid - Wikipedia
... does not contain red blood cells or platelets as they are too large to pass through but can contain some white blood cells to ... substance between the cells throughout the body. These substances occur in the extracellular space, and are therefore all ... The main component of the extracellular fluid is the interstitial fluid that bathes cells. Extracellular fluid is the internal ... white blood cells and cell waste-products. This solution accounts for 26% of the water in the human body. The composition of ...
  https://en.wikipedia.org/wiki/Extracellular_fluid
*  Coronary Artery Atherosclerosis: Practice Essentials, Background, Anatomy
These cellular elements include endothelial cells, smooth muscle cells, platelets, and leukocytes. Interrelated biologic ... In a type IV lesion, lipid exudes into the extracellular space and begins to coalesce to form the lipid core. ... Fluid shear stresses generated by blood flow influence the phenotype of the endothelial cells by modulation of gene expression ... The thin subendothelial space in between contains thin elastin and collagen fibers along with a few smooth muscle cells (SMCs). ...
  https://emedicine.medscape.com/article/153647-overview
*  NAVBO Newsletter - Announcing New Councilors
Original Articles: Coagulation and Fibrinolysis; Cellular Haemostasis and Platelets; Blood Cells, Inflammation and Infection; ... the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively ... MicroRNA-93 in control of peripheral blood mononuclear cell VEGF-A expression in Kawasaki disease Pediatrics Research ... driven by recruitment of circulating inflammatory cells and their interactions with resident vascular cells, and ...
  https://myemail.constantcontact.com/NAVBO-Newsletter---Announcing-New-Councilors.html?soid=1123122143395&aid=noL-fgsRgeA
*  VEGF-B elisa kit | Mouse Vascular Endothelial cell Growth Factor B ELISA Kit-NP 003368.1
Mouse Vascular Endothelial cell Growth Factor B ELISA Kit-NP_003368.1 (MBS726544) product datasheet at MyBioSource, ELISA Kits ... Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: heparin binding; protein binding; ... platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of endothelial cell ... The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is ...
  https://www.mybiosource.com/prods/ELISA-Kit/Mouse/Vascular-Endothelial-cell-Growth-Factor-B/VEGF-B/datasheet.php?products_id=726544
*  Fibrinogen elisa and antibody
Cellular Component: cell cortex; cell surface; cytoplasm; external side of plasma membrane; extracellular space; fibrinogen ... Was originally thought to be essential for platelet aggregation. >>>. , based on in vitro studies using anticoagulated blood. ... Cellular Component: cell surface; external side of plasma membrane; extracellular region; extracellular space; fibrinogen ... Biological Process: blood coagulation; cell-matrix adhesion; cellular protein complex assembly; extracellular matrix ...
  https://www.mybiosource.com/protein_family.php?root=fibrinogen
*  Gene Info
BP] platelet activation *[BP] platelet degranulation *[BP] signal transduction *[CC] cell junction *[CC] extracellular space *[ ... BP] blood coagulation *[BP] cell adhesion *[BP] cell recognition *[BP] diapedesis *[BP] glomerular endothelium development *[BP ... Cell lines only *Tissues and cell lines *SAGE Digital Northern *Monochromatic SAGE/cDNA Virtual Northern *Two-dimensional array ... Cell to Cell Adhesion Signaling *Monocyte and its Surface Molecules *Neutrophil and Its Surface Molecules ...
  https://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=514412&LLNO=5175
*  The Role of Clostridium perfringens Toxins in Gas Gangrene - microbewiki
Platelets are tiny blood cells that forms clots to help stop bleeding. If more platelets in addition to the normal amount are ... PFO, like the alpha toxin, plays a similar role in the build up of leukocytes inside blood vessels and the extracellular space ... Red blood cells are important machinery of humans that carry oxygen through the blood vessels to our tissues. If our red blood ... Because leukocytes are bigger than red blood cells, if they build up they will also block the red blood cells from passing. ...
  https://microbewiki.kenyon.edu/index.php/The_Role_of_Clostridium_perfringens_Toxins_in_Gas_Gangrene
*  Chapter 40 Basic Priciples of Animal Form and Function by R. Aaron Ramey on Prezi
red blood cells. that carry oxygen, white blood cells. that fight infection/cancer/foreign material, and platelets. that can ... Composed of cells separated by an extracellular matrix (ECM). ECM composition. Protein fibers. : collagen. that is strong and ... fills in the rest of the space between the fibers in the ECM. ECM fibers loosely weaved together. Functions to bind epithelium ... Structure defined by two criteria, number of cell layers and cell shape. Cell layers. Simple. : one. Stratified. : more than ...
  https://prezi.com/8ee4rpcorw34/chapter-40-basic-priciples-of-animal-form-and-function/
*  Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists |...
"Giant platelets" refers to the finding in blood smears of a percentage of platelets larger than erythrocytes ... to the BM spaces enriched in sinusoids, the vascular niche [13]. Mk migration is driven by a positive gradient of stromal cell- ... resulted in a TPO-R normally expressed on cell surface that was unable to bind TPO via canonical extracellular binding sites. ... Platelet transfusion. Transfusion of platelet concentrates is highly effective in increasing platelet count, but it exposes ...
  https://link.springer.com/article/10.1007/s12185-013-1351-7