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*  Palifermin - Wikipedia
When patients with blood cancers (leukemia and lymphoma) receive high dose chemotherapy and radiation therapy to undergo bone ... Palifermin reduces the incidence and duration of severe oral mucositis by protecting those cells and stimulating the growth of ... McDonnell AM, Lenz KL (January 2007). "Palifermin: role in the prevention of chemotherapy- and radiation-induced mucositis". ... It was determined that a high intersubject variability was not the cause of dosing errors in previous studies. Study 970276 ( ...
  https://en.wikipedia.org/wiki/Palifermin
*  Companies Related to 'Comparing Imatinib Standard Dose With Imatinib High Dose Induction in Pretreated Chronic Myeloid Leukemia...
Search Results for Comparing Imatinib Standard Dose With Imatinib High Dose Induction in Pretreated Chronic Myeloid Leukemia ( ... cancers undergoing high-dose chemotherapy, with or without radiation, followed by bone marrow transplant. The safety and ... therapeutic platform for high dose, cancer-killing NK cells calibrated to each cancer target while reinforcing immune defenses ... Kepivance™ (palifermin) is indicated to decrease the incidence and duration of severe oral mucositis (mouth sores) in patients ...
  https://www.bioportfolio.com/corporate/companies/?keyword=Comparing+Imatinib+Standard+Dose+With+Imatinib+High+Dose+Induction+in+Pretreated+Chronic+Myeloid+Leukemia+%28CML%29+Patients+in+Chronic+Phase&orderfield=score&orderval=desc
*  Dentistry
... side effect of the conditioning regimens that use high-dose chemotherapy with or without radiation for pediatric bone marrow ... Severe mucositis is a common cause of morbidity in hematopoietic stem cell transplant (HSCT) recipients. Physicians may want to ... side effect of the conditioning regimens that use high-dose chemotherapy with or without radiation for pediatric bone marrow ... Topical Melatonin: Radiation-Induced Oral Mucositis For 21 days post-radiation to the tongue, male Wistar rats were treated ...
  http://lakeelmopharmacy.com/dentistry.html
*  Amgen Submits Biologics License Application for FDA Approval of Palifermin
... duration and severity of oral mucositis in patients with hematologic malignancies undergoing high-dose chemotherapy, with or ... the sensitive cells (mucosa) lining the mouth and digestive tract are damaged by the drugs or radiation used in cancer ... and bone marrow transplant support who received palifermin suffered less ulcerative oral mucositis (grades 2-4) compared to ... 3 pivotal study of palifermin which demonstrated that patients with hematologic malignancies undergoing high-dose chemotherapy ...
  http://www.amgen.com/media/news-releases/2004/06/amgen-submits-biologics-license-application-for-fda-approval-of-palifermin/
*  Rituximab to the Preparative Regimen of Etoposide and Total Body Irradiation in Acute Lymphoblastic Leukemia - Tabular View -...
Its use has been shown to decrease mucositis resulting from high dose chemotherapy used in stem cell transplantation. You may ... and a small amount of bone marrow and bone is withdrawn through a large needle. A bone marrow core (a solid piece from the bone ... Total body irradiation (TBI) uses low level radiation to also interfere with the production of cancer cells at the DNA and RNA ... GVHD occurs when donor cells (graft) attack the stem cell recipient's (host's) cells. The term 'acute' refers to the time it ...
  https://clinicaltrials.gov/ct2/show/record/NCT00427791
*  EUSA Pharma Submits Erwinase Biologics License Application (BLA) for Treatment of Acute Lymphoblastic Leukemia
Caphosol for the treatment of oral mucositis, a common and debilitating side-effect of radiation therapy and high dose ... Asparagine is essential for cell growth, and its removal from the blood inhibits the growth of cells associated with acute ... extent and spread of prostate cancer and Quadramet for the treatment of pain in patients whose cancer has spread to the bones. ... chemotherapy, Collatamp G, a surgical implant impregnated with the antibiotic gentamicin, ProstaScint for imaging the ...
  https://www.drugs.com/nda/erwinase_101109.html
*  Patente US6025326 - Compositions and methods for the prevention and treatment of oral mucositis - Google Patentes
The present invention provides methods and compositions suitable for treating oral mucositis in animals, including humans, with ... Due to these complications, oral mucositis can be a dose-limiting toxicity of radiation or chemotherapy treatment resulting in ... very aggressive chemotherapy protocols used in bone marrow transplant being associated with a high incidence of oral mucositis ... as well as in animal cells, insect cells and plant cells. Indeed, modified plant cells can be used to regenerate plants ...
  http://www.google.es/patents/US6025326?hl=es&dq=flatulence
*  Prise en charge des foyers infectieux bucco-dentaires | Journal of Oral Medicine and Oral Surgery
Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation : a randomised ... hematopoietic cell transplantation, and/or radiation. Pediatr Dent 2008;30(Suppl 7) :219-25. [Google Scholar] ... Periodontal infection in cancer patients treated with high-dose chemotherapy. Support Care Cancer 2002;10 :466-73. [CrossRef] [ ... The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy. Int J Radiat ...
  https://www.jomos.org/articles/mbcb/ref/2012/03/mbcb120027/mbcb120027.html
*  Mucositis - Wikipedia
... mucositis affects almost all patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT), 80 ... is a mouth rinse which has been shown to prevent and treat oral mucositis caused by radiation and high-dose chemotherapy. ... Seventy-five to eighty percent of bone marrow transplantation recipients experience mucositis, of which oral mucositis is the ... registry trial to prevent and reduce the severity of oral mucositis caused by radiation and high-dose chemotherapy. In the ...
  https://en.wikipedia.org/wiki/Mucositis
*  Habers Pharmacy
Therapy for Mucositis Caused by Chemotherapy or Radiation. Patients with cancer are at high risk for numerous oral problems. ... Cytotoxic chemotherapy, radiation to the head and neck, and immunosuppression prior to bone marrow transplantation commonly ... These results suggest that BMS may be treated with lower doses of a combination of medications rather than higher doses of a ... Furthermore, women with the highest red blood cell levels of EPA had a remarkable 73% decreased risk of breast cancer, compared ...
  http://www.haberspharmacy.com/blog/
*  A Phase I Dose Escalation Study with Anti-CD44v6 Bivatuzumab Mertansine in Patients with Incurable Squamous Cell Carcinoma of...
In the mid dose, exfoliation was predominantly located at the femoral region. In the high dose, exfoliation progressed to scabs ... As a corollary, radiation absorption will also be relatively small in small tumor cell clusters, and therefore ... whereas just a small proportion of patients experienced mucositis. In general, mucositis was less severe than experienced by ... The role of adjuvant chemotherapy for this group of patients is limited, and therefore the development of an effective adjuvant ...
  http://clincancerres.aacrjournals.org/content/12/20/6064
*  News For Parents.org - Bone Marrow Transplant
... up to two weeks of high doses of potentially lethal chemotherapy or radiation therapy (or both) that cause side effects for one ... Higher levels of radiation, used to kill cancerous cells, can also threaten important bone marrow and necessitate a bone marrow ... That s why chemotherapy commonly causes side effects like hair loss, mouth sores, vomiting and diarrhea (called mucositis), and ... the standard doses of chemotherapy or radiation therapy fail to cure their disease. If too much chemotherapy is given, the bone ...
  http://www.newsforparents.org/expert_bone_marrow_transplant.html
*  1554-Soft tissue sarcoma locally advanced or metastatic DOXOrubicin | eviQ
... prior mediastinal radiation, hypertensive cardiomegaly, concurrent therapy with high dose cyclophosphamide and some other ... Small cell lung cancer. *Sarcoma*Soft tissue sarcoma. *Bone sarcoma. *Upper gastrointestinal*Gastric and oesophageal ... and high dose chemotherapy followed by a blood and marrow transplant (BMT). ... Mucositis and stomatitis. Grade 2. Delay treatment until toxicity has resolved to Grade 1 or less and reduce the dose for ...
  https://www.eviq.org.au/medical-oncology/sarcoma/soft-tissue-sarcoma/1554-soft-tissue-sarcoma-locally-advanced-or-metas
*  TLR Signaling Modulates Side Effects of Anticancer Therapy in the Small Intestine | The Journal of Immunology
Intestinal mucositis occurs in up to 100% of patients undergoing high-dose chemotherapy with stem cell or bone marrow ... R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/β-catenin pathway. ... Murine model of chemotherapy-induced intestinal mucositis. A common murine model of chemotherapy-induced mucositis was applied ... were exposed to a common model of chemotherapy-induced intestinal mucositis by systemically administering high-dose MTX, as ...
  http://www.jimmunol.org/content/194/4/1983
*  Autologous hematopoietic cell transplantation - Renal and Urology News
... to be used after high-dose chemotherapy and/or radiation therapy. This is now the most common source of stem cells used in the ... the reinfused stem cells are derived from the patient's own bone marrow and collected from the peripheral blood. These cells do ... Mucositis, nausea and anorexia. Regimen related toxicity often results in severe oral mucositis, nausea, and anorexia. Patients ... collection of stem cells upon recovery and then high dose chemotherapy and stem cell transplant. ...
  https://www.renalandurologynews.com/hematology/autologous-hematopoietic-cell-transplantation/article/597176/
*  Neuroblastoma - ONA
High dose chemotherapy, surgical resection of primary tumor, myeloablative chemotherapy with autologous stem cell rescue and ... "Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation and cis- ... Chemotherapy and radiation therapy can both be associated with late sequelae in disease survivors. The chemotherapy-related ... The acute toxicities of chemotherapy in general most commonly include alopecia, nausea and vomiting, mucositis and pancytopenia ...
  https://www.oncologynurseadvisor.com/pediatrics/neuroblastoma/article/622664/
*  DOXORUBICIN HYDROCHLORIDE 2 MG/ML SOLUTION FOR INFUSION | Drugs.com
local death of cells of tissue. • loss of renal function may lead to renal failure. • high uric acid level in blood. • absence ... decreased activity in bone marrow leads to reduced. blood cells. • cardiomyopathy (heart disease in which your heart. muscle ... deficiency in blood cells causing infection. • nausea and/or vomiting (feeling and /or being sick). • mucositis (inflammation ... For single dose use only. Any unused solution should. be discarded immediately after initial use.. Do not use this medicine if ...
  https://www.drugs.com/uk/doxorubicin-hydrochloride-2-mg-ml-solution-for-infusion-leaflet.html
*  chronobiology
This is when the cells in the bone marrow and cells in the gut make the least new DNA. Dosing these drugs during this slow ... By reducing drug toxicity higher and more effective doses of chemotherapy can be used. In another study of colorectal cancer ... of the standard dosed group. Only 14% of the circadian patients developed mucositis compared to 76% of the standard dosed ... vii] Here's one that says timing of radiation treatments also makes a difference. [viii] The thing is that current science is ...
  http://www.denvernaturopathic.com/news/chronobiology.html
*  Chemotherapy - Wikipedia
Chemotherapeutic drugs may be used at high doses to permanently remove the recipient's bone marrow cells (myeloablative ... Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or ... in the dose-adjusted group, and the incidence of severe mucositis was reduced from 15% to 0.8%. The FOLFOX study also ... "Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow ...
  https://en.wikipedia.org/wiki/Chemotherapy
*  News Release | Investor Center | Jazz Pharmaceuticals
... a common and debilitating side-effect of radiation therapy and high dose chemotherapy, Collatamp®, a surgical implant ... Asparagine is essential for cell growth, and its removal from the blood inhibits the growth of cells associated with acute ... These include Erwinase/Erwinaze and Kidrolase® for the treatment of ALL, Caphosol® for the treatment of oral mucositis, ... for the treatment of pain in patients whose cancer has spread to the bones. EUSA Pharma also has several product candidates in ...
  http://investor.jazzpharma.com/phoenix.zhtml?c=210227&p=irol-newsArticle&ID=1688148
*  Glossary of Terms - Children's National Health System
Chemotherapy: Treatment for cancer using chemical substances designed to kill cancer cells. It is used in large doses to help ... A procedure by which a sample of bone marrow is taken from the hip bone. Cardiomyopathy: Heart damage that can occur after high ... T cells are also the cells responsible for graft rejection and graft-versus-host disease. Total Body Irradiation: Radiation - ... Mucositis: Inflammation of the mucous membranes inside the mouth, tongue, gums, throat, stomach or intestines; commonly called ...
  https://childrensnational.org/Departments/Center-for-Cancer-and-Blood-Disorders/Blood-and-Marrow-Transplantation/Glossary-of-Terms
*  Frontiers | Feasibility of Induction Docetaxel, Cisplatin, 5-Fluorouracil, Cetuximab (TPF-C) Followed by Concurrent Cetuximab...
Grade 3/4 mucositis was observed in 6 (31.6%) patients. At a median follow up of 19 months, 13 patients were alive and 9 (40.9 ... In addition, we performed mutation analysis for PIK3CA genes and high-risk HPV-DNA detection using PCR. Results: Median follow- ... During TPF-C, Grade 3 and 4 toxicities occurred in 8 patients (36.4%), dose modifications in 7 (31.8%), delays in 1 (4.5%), and ... Grade 3/4 mucositis was observed in 6 (31.6%) patients. At a median follow up of 19 months, 13 patients were alive and 9 (40.9 ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00005/full
*  Preclinical Pharmacologic Basis for Clinical Use of rhIL-11 as an Effective Platelet-Support Agent | Cancer Network | The...
high-dose chemotherapy (ct) with autologous peripheral blood stem. cell reinfusion (abstract). Proc Am Soc Clin Oncol 18:584a, ... dose-dependent increase in absolute numbers of femoral bone marrow. progenitor cells, including multipotential progenitor cells ... with combined chemotherapy and radiation. Lab Invest 75:33-42, 1996.. 38. Du X, Liu Q, Yang Z, et al: Protective effects of ... ulcerative mucositis in hamsters. Cytokine 9:605-612, 1997.. 34. Fiore NF, Ledniczky G, Liu Q, et al: Comparison of interleukin ...
  http://www.cancernetwork.com/review-article/preclinical-pharmacologic-basis-clinical-use-rhil-11-effective-platelet-support-agent
*  Common side effects of treatment
... and cells that make up the tissues in your mouth, gut and bone marrow. The side effects of chemotherapy occur as a result of ... is often recommended if having radiation therapy. Chemotherapy and radiation therapy makes your skin more vulnerable to the ... This is usually expected 10 to 14 days after having your chemotherapy. During this time you will be at a higher risk of ... Mucositis (sore mouth). Mucositis is an inflammation of the lining of the mouth, throat or gut and is a common and ...
  https://www.leukaemia.org.nz/information/about-blood-cancers/treatments/common-side-effects-of-treatment/
*  Acute Lymphocytic Leukemia (ALL): Radiation Therapy - AHealthyMe - Blue Cross Blue Shield of Massachusetts
... radiation can help with bone pain caused by the growth of leukemia cells in bone marrow. Killing the cancer cells can ease the ... Special shields will be used to protect certain organs from high-dose radiation. These include your lungs, heart, and kidneys. ... or brain and spine to destroy any cells that may be hiding or not reached with chemotherapy. ... Sore mouth (mucositis), if the head and neck are treated. * Skin irritation ...
  http://www.ahealthyme.com/Library/DiseasesConditions/Adult/Liver/34,BALLT8