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*  Fluorescent Dye Monitoring of Mitochondrial Changes Associated with Malignant Cell Transformation
The fluorescent dyes, rhodamine 6G and 123, which specifi-cally stain mitochondria, were used to examine changes in mitochondria that follow malignant transformation. The spatial distribution and shapes of mitochondria differ in untransformed and malignant-transformed cells. In untransformed C3H/10T1/2 clone 8 cells, the mitochondria were distributed radially around the nucleus, and each had a fibrous shape. In chemically transformed MCA clone 16 cells, the mitochondria were distributed randomly in the cytoplasm, and each was shaped like a short rod. Another important mitochondrial change after malignant transformation was the change in the time course of fluorescence emission from the rhodamine present in the mitochondria. A slow increase in fluorescence, which was instantaneous at the time of excitation irradiation occurred in untransformed but not in transformed ...
  https://www.jstage.jst.go.jp/article/csf1975/12/6/12_6_525/_article
*  Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo- p-dioxin...
The potential role of arachidonic acid metabolism in the enhancement (promotion) of malignant transformation of C3H/M2 mouse fibroblasts by the tumor promoter 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated using inhibitors of cyclooxygenase and lipoxygenase activities. The promoting effects of TCDD (1.5 pM) and of the reference tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 0.4 mM) on carcinogen (N-methyl-N′-nitro-N-nitrosoguanidine or 3-methylcholanthrene)-pre-treated fibroblasts was abolished by cotreatment with indomethacin, hydrocortisone, caffeic acid or nordihydroguaiaretic acid. A differential inhibition was found with N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide, a selective inhibitor of the cyclooxygenase isoenzyme COX-2: the promoting effect of TPA, but not that of TCDD, was abolished. Therefore, the role of the cyclooxygenase isoenzymes COX-1 and COX-2 during chronic exposure to TCDD was studied in more detail. Long-term treatment with TCDD (4-7 ...
  http://oxfordindex.oup.com/view/10.1093/carcin/21.1.15
*  Plus it
Cell clones derived from undifferentiated 3T3 T mesenchymal stem cells show a low rate of spontaneous transformation but can be efficiently transformed by a variety of carcinogens. In contrast, it is now reported that cell clones derived from nonterminally differentiated 3T3 T stem cells are highly resistant to neoplastic transformation induced by physical and chemical carcinogens. Differentiation-induced resistance to neoplastic transformation is evident in both in vitro and in vivo transformation assays and can be stably expressed for ,50 population doublings. These results establish that resistance to neoplastic transformation can be regulated in mammalian stem cells by the process of nonterminal differentiation.. ...
  http://cancerres.aacrjournals.org/content/49/4/1008
*  Malignant Transformation - Guo Lab
Cancer is believed to be driven by genetic mutations. However, mouse models and human patients with cancer-predisposing germ line mutations show that only a small fraction of their cells become malignant, suggesting mutations themselves are not sufficient to cause transformation and additional determinants must exist. There are two prevailing, non-exclusive models to account for the additional determinants. One is that full transformation requires accumulation of multiple genetic mutations, which posits transformation occurs only when all mutations have been acquired. The recent success in reprogramming malignant cells into pluripotent stem cells indicates that normal cells of essentially all lineages can exist in the presence of replete cancer mutations. The second model ...
  http://www.guolab.net/hematopoiesis
*  Ezrin function is required for ROCK‐mediated fibroblast transformation by the Net and Dbl oncogenes | The EMBO Journal
The small GTPase RhoA controls many cytoskeletal processes, including actin polymerization, F‐actin bundling, myosin‐based contractility, formation of focal adhesions and formation of the contractile ring at cytokinesis (for a review see Van Aelst and D'Souza‐Schorey, 1997). In addition, RhoA plays a less well understood role in the control of cell cycle progression, transformation and tumour cell invasiveness. In fibroblasts, activated RhoA is sufficient to induce DNA synthesis (Olson et al., 1995), and cooperates with activated Raf in focus formation assays (Khosravi‐Far et al., 1995; Qiu et al., 1995). Activated Rho GDP/GTP exchange factors (GEFs) are potent oncogenes in focus assays (for a review see Whitehead et al., 1997), and it has been proposed that their ability to induce anchorage‐independent growth arises because they mimic signalling by adhesion receptors (Schwartz et al., 1996). Rho activity is required for ...
  http://emboj.embopress.org/content/19/17/4565
*  Lymph nodes - not lymphoma - Progressive transformation of germinal centers
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
  http://pathologyoutlines.com/topic/lymphnodesPTGC.html
*  Plus it
Carcinogenesis is caused by a cumulative, multistage process that mainly consists of initiation, promotion, and progression. ROS, which are produced as a result of the metabolism of molecular oxygen via biochemical reactions in cells, play a key role in tumor promotion. Some tumor promoters accelerate/induce the conversion of initiated cells (carcinogen-mediated mutation or potential "stem cells") into tumorigenic cells possibly via the production of oxidative/inflammatory responses (30, 31). TPA (12-O-tetradecanoylphorbol-13-acetate), a phorbol ester, is a tumor promoter that induces the neoplastic/tumorigenic transformation of preneoplastic JB6 cells through the overproduction of ROS (32). In this study, we investigated the inhibitory effect of SFN on ...
  http://cancerpreventionresearch.aacrjournals.org/content/7/3/319
*  Metals | Free Full-Text | Method to Evaluate the Kinetics of Bainite Transformation in Low-Temperature Nanobainitic Steel Using...
The aim of this work was to develop a method to evaluate the kinetics of bainite transformation by theoretical deduction and thermal dilatation curve analysis. A Gleeble-3500 thermomechanical simulator and dilatometer (DIL805A) were employed to study the isothermal transformation in deformed (360 ∘ C , 600 ∘ C , and 860 ∘ C ) and undeformed conditions. The thermal dilatation information during isothermal transformation was recorded, and the dilatation curves were well smoothed. By taking a derivative of the dilation curve with respect to the transformation time, the peak time of transformation rate (PTTR) was obtained, which can serve as the essence of isothermal transformation time. The relative change of length ( Δ L / L ) due to phase transformation was theoretically deduced, and the effect of temperature was taken into consideration. Combing ...
  http://www.mdpi.com/2075-4701/7/9/330
*  Patent US4414685 - Method and apparatus for pattern recognition and detection - Google Patents
Image analyzing apparatus and methods are disclosed for analyzing 3-dimensional as well as 2-dimensional images. The pixels of the 3-D images may be represented by multivalued digital data signals which are analyzed in one or more programmable neighborhood transformation stages. In the preferred embodiment, each stage is programmed with selected contribution values associated with each pixel in the neighborhood. The values of the data signals for each pixel are modified by these contribution values and the maximum value thereof is selected as the transformation output of the stage. A series of dilation/erosion transformations may be used to transform the original image matrix in such a manner so as to locate the position and/or identify the shape of particular objects contained in the original image.
  http://www.google.com/patents/US4414685?dq=Dirks++%233,242,466
*  AC-'s top 3 transformation tips / Resource | Monster Supplements
AC's top 3 transformation tips - After my recent 7 week transformation, many people have been asking me for tips on achieving a rapid transformation in muscle size and fat loss. There are no single tips that will ensure success in everyone as it totally depends on the person as to how good the results will be. However there are some helpful tips that I can offer that will help ensure success in anyone wanting to make a body transformation. So here are my top 3 tips: 1. Plan the full transformation before you start. With any transformation I do with a client I plan literally every workout before we even start. I do this on a spreadsheet that can be updated and adapted as time goes on. However the main thing is to know exactly what you are doing every day of every week. This will keep you incredibly focused and you will know what to expect from training each week. It also makes it incredibly easy to progress ...
  https://monstersupplements.com/resource/2012/06/ac-s-top-3-transformation-tips/
*  C8-D1A [Astrocyte type I clone] ATCC ® CRL-2541™ Mus musculu
Clonal permanent cell lines with astrocytic or microglial properties have been established from explant cultures of 8-day postnatal mouse cerebella after in vitro spontaneous transformation. The cell lines were derived in a multistage process. Slowly proliferating foci with several morphologies appeared 4 months after initiation of the cultures and became progressively enriched by cells with a homogeneous appearance.
  https://www.atcc.org/products/all/CRL-2541.aspx?p=1&rel=%7B0%7D
*  Cyclooxygenase
COX-1 and -2 gene expression can be regulated at both the transcriptional and the posttranscriptional levels, and species differences may exist at both levels. Transcription induced in murine or chicken embryo fibroblasts by mitogens or by oncogene-induced transformation occurs rapidly, and maximal levels are seen at 15-30 min, followed shortly by COX-2 mRNA and protein […] ...
  http://www.levelofhealth.com/tag/cyclooxygenase
*  Plus it
The proliferative features of ANSCs, characterized as having a long lifespan and continuous self-renewal, make their behavior similar to that of tumor cells. Accordingly, ANSCs have been recently proposed as precursors to cancer in the brain ( 4, 8), and, as a consequence, a major criticism raised against their therapeutic applications is their potential propensity to undergo rapid and spontaneous transformation. In fact, a single previous report has proposed that the extensive culturing of ANSCs by the NSA ( 11) might select for aggressive cell clones. These cells were apparently able to overgrow the rest of the native stem cells generating a mutated population, which grew indefinitely in culture and was endowed with neoplastic potential ( 7).. To bypass this drawback, several groups have proposed using ANSC lines grown for very few ...
  http://cancerres.aacrjournals.org/content/67/8/3725
*  Plus it
Activated oncogenes are the dominant drivers of malignant progression in human cancer, yet little is known about how the transformation from proto-oncogene to activated oncogene drives the expression of transformed phenotypes. An isogenic model of HER2-mediated transformation of human mammary epithelial cells was used along with HER2-amplified human breast cancers to investigate how HER2 activation alters its properties as a signaling molecule and changes the networks of HER2-regulated genes. Our results show that full oncogenic activation of HER2 is the result of a transition in which activated HER2 acquires dominant signaling properties that qualitatively alters the network of genes regulated by the activated oncogene as compared to the proto-oncogene. As a result, gene expression programs related to ...
  http://cancerres.aacrjournals.org/content/early/2010/08/21/0008-5472.CAN-10-1529
*  Vol 5: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation. - pdf descargar
Vol 5: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jun2/149656193585-Vol-5-OCT4-as-a-target-of-miR-34a-stimulates-p63-but-inhibits-p53-to-promote-human-cell-transformation-Ng-W-L-Chen-G-Wang-M-Wang-H-Story-.php
*  "Malignant transformation induced by incorporated radionuclides in balb" by P K. Lemotte, S J. Adelstein et al.
Lemotte, P K.; Adelstein, S J.; and Little, J B., "Malignant transformation induced by incorporated radionuclides in balb/3t3 mouse embryo fibroblasts." (1982). Subject Strain Bibliography 1982. 54 ...
  https://mouseion.jax.org/ssbb1982/54/
*  Natural History of Neoplastic Development: Host Effects During Carcinogenesis
In the last chapter, characteristics and mechanisms of the early stages of neoplastic develop- ment-initiation and promotion-were presented as being the result of cellular and molecular changes induced by specific ...
  http://fx.damasgate.com/natural-history-of-neoplastic-development-host-effects-during-carcinogenesis/
*  Global Digital Transformation Market 2017- GE, Alpha Water Systems Inc, Toray, Shuangliang Eco-Energy Systems Company Limited,...
This report examines the Digital Transformation market standing and opportunity of global plus major regions, from plans of manufacturers, regions, product types and end industries; this report investigates the best manufacturers in global and major regions and splits the Digital Transformation market by product type and applications/end industries. The Global Digital Transformation market is considered…
  http://www.eontarionow.com/2017/09/12/global-digital-transformation-market-2017-ge-alpha-water-systems-inc-toray-shuangliang-eco-energy-systems-company-limited-wellthy-corporation-ampac/
*  Live ZetaTalk Chat Jan 18, 2003
AGreenspan) 1.Are we to believe, that entities more than twice as smart as a genious level human, who are overseen by even more massive souls, would fail at such an important task, unless you are not being, shall I say, "fully forthcoming"? Furthermore, if one is to comprehend ZT, it is clear that THE HIGHER THE DEATH TOLL AMONG HUMANS THE FASTER THE TRANSFORMATION CAN OCCUR - are you therefor operating against yourselves ...
  http://zetatalk.com/index/cjan1803.htm
*  Pglo Transformation Lab Report Essay - 1470 Words
Transformation Lab Report Introduction Transformation is the transfers of virulence from one cell to another, through the transferring of genetic material
  http://www.studymode.com/essays/Pglo-Transformation-Lab-Report-922044.html
*  hep-th/0312154] Nonabelian Bundle Gerbes, their Differential Geometry and Gauge Theory
Abstract: Bundle gerbes are a higher version of line bundles, we present nonabelian bundle gerbes as a higher version of principal bundles. Connection, curving, curvature and gauge transformations are studied both in a global coordinate independent formalism and in local coordinates. These are the gauge fields needed for the construction of Yang-Mills theories with 2-form gauge potential ...
  https://arxiv.org/abs/hep-th/0312154
*  Eclipse Community Forums: M2T (model-to-text transformation)
Whenever an Xtend function is invoked - whether for M2M Xtend transformations or M2T Xpand templates, a Java Model Exception is thrown ...
  http://www.eclipse.org/forums/index.php/sf/thread/24/1/640/
*  The Chemistry Development Kit / Mailing Lists
On Tue, Aug 11, 2009 at 2:24 PM, Mark Rijnbeek,markr@..., wrote: ,, MDL molfiles have the (0,0) coordinate in the lower left corner, as we ,, explored a couple of years ago... This made MDL molfiles draw in other ,, drawing application shown upside down. The old JChemPaint had horrible ,, code to fix this (combination of a translation *and* a mirroring). ,, This was one of the design goals of the new JChemPaint when we started ,, two(?) years ago, using proper Java2D and affine transformations. ,, Correction of the (0,0) is just one of those transformations applied ,, when converting world coordinates into screen coordinates. ,, , But why wasn't a solution for the molfile display incorporated during , the redesign of that horrible code then? It *was* incorporated... if it indeed is missing now, it was lost somewhere in time... , Did people just forget about the upside down effect perhaps? Dunno... this is a good example explaining my unit test fetish... ,,, Also (probably ...
  https://sourceforge.net/p/cdk/mailman/message/23312635/
*  Gamma variables and transformations
If Y is uniformly distributed over the interval (0,1), i.e. f(y) = 1 for 0| y | 1. Show that U = -2 loge(Y) has a negative exponential
  http://mathhelpforum.com/advanced-statistics/60643-gamma-variables-transformations.html