*  Breast cancer classification and prognosis based on gene expression profiles from a population-based study | PNAS
... including genes involved in cell cycle progression such as topoisomerase II α, MCM2, BUB1, and proliferating cell nuclear ... However, the melanoma tumor antigen PRAME was highlighted and should be further investigated in breast cancer as a potential ... Abbreviations: ER, estrogen receptor; RFS, relapse-free survival; BCS, breast cancer survival; PCNA, proliferating cell nuclear ... In our study, cell cycle regulation is clearly important and suggests continued use of antiproliferatives is a rational ...
  http://www.pnas.org/content/100/18/10393?ct=
*  Proliferating cell nuclear antigen - Wikipedia
"Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen". J. Biol. ... "Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control". Progress in cell ... Prelich G, Kostura M, Marshak DR, Mathews MB, Stillman B (1987). "The cell-cycle regulated proliferating cell nuclear antigen ... Shivji KK, Kenny MK, Wood RD (April 1992). "Proliferating cell nuclear antigen is required for DNA excision repair". Cell. 69 ( ...
  https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen
*  MCL1 - Wikipedia
"Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen". J. Biol. ... induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of ... Cell Biol. 6 (5): 443-50. doi:10.1038/ncb1123. PMID 15077116. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM ... Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. The ...
  https://en.wikipedia.org/wiki/MCL1
*  Replication Protein A Links Cell Cycle Progression and the Onset of Neurogenesis in Drosophila Optic Lobe Development | Journal...
... proliferating cell nuclear antigen (PCNA) is important for both DNA synthesis and DNA repair during S phase (Essers et al., ... the rate of cell cycle progression determines whether Notch is inactivated or not. We find that when the cell cycle progression ... To verify that the loss of these cell cycle regulators indeed affected cell cycle progression of NE cells, we used BrdU ... This suggests that cell cycle progression itself may suppress EGFR activity, while slowing down or arresting the cell cycle ...
  http://www.jneurosci.org/content/33/7/2873
*  Bitter Melon Extract Impairs Prostate Cancer Cell-Cycle Progression and Delays Prostatic Intraepithelial Neoplasia in TRAMP...
... proliferating cell nuclear antigen (PCNA), and Bax antibodies (Santa Cruz Biotechnology or Cell Signaling), followed by ... that treatment of prostate cancer cells with BME accumulates cells at the S phase of the cell cycle and induces cell-cycle ... and G2-M phases of the cell cycle. B, population of PC3 and LNCaP cells (%) at different cell-cycle phases is shown by bar ... PC3 and LNCaP cells were treated with BME at indicated time points and cell lysates were prepared for cell-cycle molecules ...
  http://cancerpreventionresearch.aacrjournals.org/content/4/12/2122
*  p21CDKN1A and DNA Repair Systems: Recent Findings and Future Perspectives | IntechOpen
Human proliferating cell nuclear antigen, Poly(ADP-ribose) polymerase 1, and p21waf1/cip1. A dynamic exchange of partners. The ... 112 - Le HV, Minn AJ, Massague J. Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial ... 18 - Prosperi E. The fellowship of the rings: distinct pools of proliferating cell nuclear antigen (PCNA) trimer at work. FASEB ... 127 - Podust VN, Podust L, Goubin F, Ducommun B, Hübscher H. Mechanism of inhibition of proliferating cell nuclear antigen- ...
  https://www.intechopen.com/books/new-research-directions-in-dna-repair/p21cdkn1a-and-dna-repair-systems-recent-findings-and-future-perspectives/
*  Discrimination of cell cycle phases in PCNA-immunolabeled cells
Proliferating cell nuclear antigen (PCNA) is a protein which is involved in DNA replication and has cell cycle dependent ... proteins whose localization varies during the cell cycle are valuable and frequently used markers of cell cycle progression. ... Proliferating cell nuclear antigen (PCNA) is a protein which is involved in DNA replication and has cell cycle dependent ... Nuclear proteins whose localization varies during the cell cycle are valuable and frequently used markers of cell cycle ...
  https://kops.uni-konstanz.de/handle/123456789/31167
*  Nutrients | Free Full-Text | Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation | HTML
Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell ... Zeng, H.; Davis, C.D. Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest ... Selenium plays a critical role in cell cycle progression; its omission results in G2 cell cycle arrest [56]. Studies have shown ... proliferating cell nuclear antigen, cyclin-dependent kinase (cdk)1, cdk2, cdk4, cyclin B and cyclin D2 mRNA [56]. In addition, ...
  http://www.mdpi.com/2072-6643/5/1/97/htm
*  Antigen, Proliferating Cell Nuclear - Medical Dictionary online-medical-dictionary.org
Antigen, Proliferating Cell Nuclear. Nuclear Antigen with a Role in DNA synthesis, DNA Repair, and Cell Cycle progression. PCNA ... PCNA expression correlates with the proliferation activity of several malignant and non-malignant Cell types. ...
  http://www.online-medical-dictionary.org/definitions-a/antigen-proliferating-cell-nuclear.html
*  Dynamic changes of gene expression profiles during postnatal development of the heart in mice
Results: Various cardiac development related genes involving the cell cycle (cyclin B1, proliferating cell nuclear antigen ( ... According to our microarray analysis, the genes related to cell cycle progression and growth factors were reduced, while the ... and proliferating cell nuclear antigen) and oncogenes (c-myc and Rb) are reportedly involved in cardiac muscle cell cycle ... for proliferating cell nuclear antigen (PCNA), cyclin B1, insulin-like growth factor II (IGF-II), mitogen activated protein ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1768375/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
p21, proliferating cell nuclear antigen (PCNA) and cAMP levels in Hela cells were analyzed by western blot and radioimmunoassay ... Cell proliferation, cell cycle progression and apoptosis were measured by MTS, flow cytometry and terminal deoxynucleotidyl ... Although cell cycle kinetics tend to vary according to cell type, the distribution of cells amongst the four stages of the cell ... cells rejoin the cell cycle in unison. Treatment of the test agent following release from the cell cycle blocking chemical ...
  https://www.jove.com/visualize/abstract/22574207/inhibitory-effects-underlying-mechanism-7-hydroxyflavone-phosphate
*  Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1.
While it has long been appreciated that these cells undergo continual turnover, little is known concerning how adeq ... Mammalian taste buds contain several specialized cell types that coordinately respond to tastants and communicate with sensory ... To identify cycling cells in both G1 and S phases, proliferating cell nuclear antigen (PCNA) was localized by ... we examined the effect of p27 loss on cell cycle progression within CV taste buds. Double-labeling with anti-Proliferating Cell ...
  http://www.biomedsearch.com/nih/Accelerated-turnover-taste-bud-cells/21507264.html
*  Balancing Histone/Protein Acetylation: Gene Regulation and Cancer Therapy | China-Mainland | Sigma-Aldrich
Recent data suggest that the replication factor, PCNA (proliferating cell nuclear antigen), may be acetylated by p300, and that ... down-regulation of genes important for cell cycle progression, such as cyclin A and D, has been observed. Cell cycle arrest ... E2F is required for cell cycle progression [43]. PCAF-acetylated E2F shows stronger DNA binding affinity. Thus, acetylation has ... Thus, the cycle of histone acetylation/deacetylation provides a means for cells to rapidly control gene activities. ...
  https://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/life-science-innovations/mission-shrna-library.html
*  p21 binding to PCNA causes G1 and G2 cell... & related info | Mendeley
... inhibitors is its ability to associate with the proliferating cell nuclear antigen (PCNA), an auxiliary fa... ... Our results suggest that p21 might inhibit cell cycle progression by two independent mechanisms, inhibition of cyclin/CDK ... inhibitors is its ability to associate with the proliferating cell nuclear antigen (PCNA), an auxiliary factor for DNA ... p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. *Cayrol C ...
  https://www.mendeley.com/research-papers/p21-binding-pcna-causes-g1-g2-cell-cycle-arrest-p53deficient-cells/
*  Gene Ontology Classifications
This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory ... and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled ... through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. ...
  http://www.informatics.jax.org/go/marker/MGI:104556
*  p21 Antibody (Monoclonal, HJ21)
This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a ... and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the ... cell cycle regulation of mitotic cell cycle response to UV positive regulation of protein kinase activity regulation of cell ... G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle cellular response to DNA damage stimulus DNA damage ...
  https://www.thermofisher.com/antibody/product/p21-Antibody-clone-HJ21-Monoclonal/AHZ0422
*  OriGene - CDKN1A (NM 078467) cDNA Clone
This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory ... and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the ... ErbB signaling pathwayCell cyclep53 signaling pathwayPathways in cancerGliomaProstate cancerMore Pathways >> ... through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. ...
  http://www.origene.com/Human_cDNA/SC102496.aspx
*  Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear...
The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ... dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen ... dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen ... dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen ...
  http://jcs.biologists.org/content/early/2006/03/21/jcs.02868
*  A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. - Zurich Open Repository and Archive
... of this factor interacts directly with proliferating cell nuclear antigen (PCNA), and critical regions for this interaction on ... Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of ... of this factor interacts directly with proliferating cell nuclear antigen (PCNA), and critical regions for this interaction on ... Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of ...
  http://www.zora.uzh.ch/id/eprint/846/
*  RCSB PDB - 1VYJ: Structural and biochemical studies of human PCNA complexes provide the basis for association with CDK/cyclin...
... complexes and with proliferating cell nuclear antigen (PCNA) regulate and coordinate the processes of cell-cycle progression ... complexes and with proliferating cell nuclear antigen (PCNA) regulate and coordinate the processes of cell-cycle progression ... Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin ... PROLIFERATING CELL NUCLEAR ANTIGEN. A, C, E, G, I, K. 261. Homo sapiens. Gene Names: PCNA. ...
  https://www.rcsb.org/structure/1VYJ
*  CDC45L & CDKN1A Protein Protein Interaction Antibody Pair - (DI0092) - Products - Abnova
This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a ... and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the ... CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like,CDC45-like,CDC45-related protein,cell division cycle 45-like 2,human ... through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=DI0092
*  CDKN1A & SKP2 Protein Protein Interaction Antibody Pair - (DI0568) - Products - Abnova
This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a ... and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the ... through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. ... HeLa cells were stained with anti-CDKN1A rabbit purified polyclonal antibody 1:1200 and anti-SKP2 mouse purified polyclonal ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=DI0568
*  Proliferating cell nuclear antigen
E2F proteins control cell cycle progression by predominantly acting as either activators or repressors of transcription. How ... proliferating cell nuclear antigen)- and DNA polymerase alpha-encoding genes in both cultured cell and transgenic fly systems. ... Proliferating cell nuclear antigen REGULATION. Promoter Structure The major transcription initiation site (cap site) of PCNA is ... The proliferating-cell nuclear antigen (PCNA) promoter function resides within a 192-bp region (-168 to +24 with respect to the ...
  http://www.sdbonline.org/sites/fly/polycomb/pcna3.htm
*  G2/M-Phase-Specific Transcription during the Plant Cell Cycle Is Mediated by c-Myb-Like Transcription Factors | Plant Cell
... proliferating cell nuclear antigen (Travali et al., 1991), and cyclin A (Müller et al., 1999), all of which are important for ... From yeast to humans, progression through the cell cycle is associated with the phase-specific transcription of defined sets of ... Koch, C., and Nasmyth, K. (1994). Cell cycle regulated transcription in yeast. Curr. Opin. Cell Biol. 6, 451-459. ... The accumulation of NtmybB mRNA was cell cycle independent in BY2 cells and in meristems. Thus, NtmybA1 and A2 genes themselves ...
  http://www.plantcell.org/content/13/8/1891?ijkey=3178cf16a30a2de9807a4722265a9afec64ae871&keytype2=tf_ipsecsha
*  Ircinin-1 induces cell cycle arrest and apoptosis in human melanoma cells | Cancer Research
... of pRb protein and increased the co-association of pRb or proliferating cell nuclear antigen with p21WAF1/CIP1 in these cells. ... Flow cytometric analysis revealed that ircinin-1 resulted in G1 arrest in cell cycle progression which was associated with a ... Ircinin-1 induces cell cycle arrest and apoptosis in human melanoma cells. Hye Joung Choi, Yung Hyun Choi, Su-Bok Yee, Eunok Im ... Ircinin-1 induces cell cycle arrest and apoptosis in human melanoma cells ...
  http://cancerres.aacrjournals.org/content/64/7_Supplement/1147.5