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*  TIMP-1 induces an epithelial mesenchymal transition via upregulation of the transcription factor Twist in human breast...
This is evidenced by loss of the epithelial cell adhesion molecules E-cadherin and beta-catenin and an increase in the ... a transcription factor known to suppress E-cadherin gene transcription and upregulate mesenchymal markers. SiRNA-mediated Twist ... knockdown restored E-cadherin expression in TIMP-1 overexpressing MCF10A cells, demonstrating a functional significance of ... we have made a novel finding that TIMP-1 expression in MCF10A cells induces phenotypic changes in cell morphology, cell-cell ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/5374
*  Prostaglandin EP2 receptor - Wikipedia
Beta-catenin pathway which regulates not only cell-cell adhesion but also activates the Wnt signaling pathway which, in turn, ... stimulates the transcription of genes responsible for regulating cell migration and proliferation. In many of these respects, ... molecules such as the transcription factor CREB which lead to different types of functional responses depending on cell type. ... dendritic cells, NK cells, TH1 cells, TH2 cells, and fibroblasts in various tissues and on microglia cells in the central ...
  https://en.wikipedia.org/wiki/Prostaglandin_EP2_receptor
*  DIGITAL.CSIC: E-cadherin controls β-catenin and NF-κB transcriptional activity in mesenchymal gene expression
... to be associated with E-cadherin and other cell-adhesion components. Interaction of the NF-kappaB p65 subunit with E-cadherin ... Similar to beta-catenin, NF-kappaB was found, by co-immunoprecipitation and pull-down assays, ... indicating that E-cadherin-sensitive factors are involved in the transcription of these genes. E-cadherin overexpression ... The functional significance of these results was stressed by the stimulation of NF-kappaB transcriptional activity, both basal ...
  http://digital.csic.es/handle/10261/24870
*  anti-CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa)</span...
Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent ... beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin ... translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a ... This antibody reacts with C-terminal part of beta-Catenin, an 88 kDa multifunctional protein involved both in cell adhesion and ...
  https://www.antibodies-online.com/antibody/614788/anti-Catenin+Cadherin-Associated+Protein,+beta+1,+88kDa+CTNNB1+antibody/
*  Exbio antibodies - Mouse Monoclonal to beta-Catenin EM-22 (IgG1)
Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent ... beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin ... translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a ... 1. Immunocytochemistry staining of beta-catenin in human colon adenocarcinoma cell line HT29 using EM-22 antibody (green). Cell ...
  http://www.exbio.cz/products/clone.py?idclone=CLO000000000000375
*  Cell junction - Wikipedia
This allows for homophilic cell-cell adhesion. The β-catenin-α-catenin linked complex at the adherens junctions allows for the ... Signaling Proteins - involved in junctions assembly, barrier regulation, and gene transcription. Regulation Proteins - regulate ... Selectins are cell adhesion molecules that play an important role in the initiation of inflammatory processes. The functional ... Together with an alpha-beta catenin complex, the cadherin can bind to the microfilaments of the cytoskeleton of the cell. ...
  https://en.wikipedia.org/wiki/Cell_junction
*  PTPRT - Wikipedia
PTPrho associates with members of the cadherin and catenin family of cell adhesion molecules as demonstrated by GST-fusion ... by PTPrho in colorectal cancer cells results in a reduction in the total level of transcription of the STAT3 target genes, Bcl- ... beta-catenin, gamma-catenin/plakoglobin, p120 catenin, desmoglein, E-cadherin, N-cadherin, and VE-cadherin. Purified wild-type ... 2010). "Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T". ...
  https://en.wikipedia.org/wiki/PTPRT
*  WikiGenes - MAPRE2 - microtubule-associated protein, RP/EB...
Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin ... As the expression level of the RP1 gene in activated T cells and a spectrum of tumor-derived cell lines correlates with the ... Cell Biol. (2001) [Pubmed]. *Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X- ... Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV ...
  https://www.wikigenes.org/e/gene/e/10982.html
*  SRC gene - Genetics Home Reference - NIH
... cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members ... SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin ( ... Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, ... From NCBI Gene:. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in ...
  https://ghr.nlm.nih.gov/gene/SRC
*  CD44 - Wikipedia
CD44 gene transcription is at least in part activated by beta-catenin and Wnt signalling (also linked to tumour development). ... "The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion". American Journal ... The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the ... CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell ...
  https://en.wikipedia.org/wiki/CD44
*  Multiple oncogenic roles of nuclear β-catenin | SpringerLink
Cellular β-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In... ... "β-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. ... of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene ... Grosschedl R and Birchmeier W 1996 Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382 638- ...
  https://link.springer.com/article/10.1007/s12038-017-9710-9
*  CDH1 cadherin 1 [Homo sapiens (human)] - Gene - NCBI
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem. Regulation of Wnt ... calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA Inferred from Biological aspect of ... Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer. Melo S, et al. Int J Mol Sci ... Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell ...
  https://www.ncbi.nlm.nih.gov/gene/999
*  adenomatous polyposis coli protein
Genomes and Genes, Species, Scientific Experts about adenomatous polyposis coli protein ... GSK3 beta/CKI phosphorylation regulates APC clusters and cell migration independently of cell-cell adhesion and beta-catenin ... Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early ... Cell 103:311-20. 2000. *. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. J Behrens ...
  https://www.labome.org/topics/chemicals/and/proteins/cytoskeletal/adenomatous-polyposis-coli-protein-14404.html
*  WikiGenes - Trans-Activation (Genetics)
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Mosimann, C., ... Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat. ... Functional domains of the human glucocorticoid receptor. Giguère, V., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Cell (1986 ... The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. van de Wetering, M., Sancho, E ...
  http://www.wikigenes.org/e/mesh/e/302.html
*  Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells...
The multifunctional beta-catenin protein functions in cell-cell adhesion by binding cadherins. It also binds to the Wnt signal ... Among the most highly enriched functional gene groups were terms involved in innate immune response, defense response, and the ... a protein complex that contains beta-catenin and the transcription factor TCF7L2 that is also known as TCF4. ... TBP were reference genes for A549 cells, genes tef1, gpdA for A. fumigatus and 18S rRNA gene and the tub2 gene for A niger.. ...
  https://link.springer.com/article/10.1186%2Fs12864-018-4895-3
*  CDH1 (gene) - Wikipedia
Dobrosotskaya IY, James GL (April 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion ... increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671-7 ... "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345-55. doi:10.1016/j ... Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ...
  https://en.wikipedia.org/wiki/CDH1_(gene)
*  Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial...
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol. Cell 15: ... Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2:461-472 ... Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J. Cell Sci. 114:2043- ... Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20:539-550. ...
  https://mcb.asm.org/content/26/16/6024
*  William Nelson | Stanford Medicine Profiles
beta-Catenin has important roles in cell-cell adhesion and in the regulation of gene transcription. Mutations that stabilize ... Spatial and functional organization of cells in tissues is determined by cell-cell adhesion, thought to be initiated through ... beta-catenin, and alpha-catenin regulates actin-dependent cell-cell adhesion. alpha-Catenin can bind beta-catenin and F-actin, ... WNT-1 MODULATES CELL-CELL ADHESION IN MAMMALIAN-CELLS BY STABILIZING BETA-CATENIN BINDING TO THE CELL-ADHESION PROTEIN CADHERIN ...
  https://med.stanford.edu/profiles/w-james-nelson
*  MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of beta-catenin-mediated transcription. Brain ... suppressing transcription. While E-cadherin has a widely acknowledged role in cell-cell adhesion, it also functions as an ... β-catenin is an important functional target for miR-200a in gastric adenocarcinoma SGC7901 cells and glioblastoma U251 cells. ... Vandewalle C, Comijn J, De Craene B, et al: SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell ...
  https://www.spandidos-publications.com/ijo/40/4/1162
*  產品文獻集
RT-PCR revealed that MEHP exposure primarily influenced genes in cell adhesion and transcription in NT2/D1 cells. Gap junction ... while claudin-6 and beta 1-catenin expression levels were up-regulated. This study provides insight into mechanisms that may ... Functional analysis showed that mutant pri-mir-125a can enhance endometrial stromal cells (ESCs) invasive capacity and increase ... We profiled the gene expression of the stem cells or progenitor cells, the inner ear progenitor cells, and hair cells using ...
  http://www.phalanx.com.tw/DataCenter/Publication.php?TYPE=DEV
*  IQGAP1 - Wikipedia
Actin - cytoskeletal structure ARF6 APC Beta-catenin-cell adhesion and WNT signaling: transcription B-raf - MAPK pathway CD44 ... a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 ... This domain is highly similar to the functional subunit of Ras GTPase-activating proteins (GAPs) and was thus thought to have ... b-catenin, and E-cadherin, weakening these junctions and thus decreasing cell-cell adhesion. IQGAP weakens cell adhesion by ...
  https://en.wikipedia.org/wiki/IQGAP1
*  MUC1 - Wikipedia
"Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion". J. Biol. Chem. 272 (19): ... "Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response". Cancel Cell. 7 (2): 167- ... 2013 Peterson JA, Scallan CD, Ceriani RL, Hamosh M (2002). "Structural and functional aspects of three major glycoproteins of ... In cancer cells, increased expression of MUC1 promotes cancer cell invasion through beta-catenin, resulting in the initiation ...
  https://en.wikipedia.org/wiki/MUC1
*  Protocols and Video Articles Authored by Sandrine Etienne-Manneville (Translated to Norwegian)
... by downregulating beta-catenin and thereby controlling gene transcription and cell proliferation. However, APC is clearly a ... p120catenin regulates a wide range of cellular processes such as cell-cell adhesion, cell polarity and cell proliferation and ... The functional coordination between neighboring cells is at the heart of collective migration, during which cells migrate with ... cells interact with a microenvironment composed of extracellular matrix and neighbouring cells. Cell-cell adhesions ensure ...
  https://www.jove.com/author/Sandrine_Etienne-Manneville?language=Norwegian
*  Faculty Advisors | Stanford Medicine | Stanford Medicine
... cadherin-based cell adhesion and its regulation, 2) the Wnt signaling pathway, including how beta-catenin is degraded in the ... Alejandro Sweet-Cordero: Our laboratory is interested in the discovery and functional analysis of genes involved in the ... My lab focuses on the molecular mechanisms of transcription factors that govern the transformation of normal mammalian cells to ... the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for ...
  http://med.stanford.edu/cbio/faculty.html
*  CTNNB1 - Beta-catenin - Sus scrofa (Pig) - CTNNB1 gene & protein
... beta-catenin-TCF7L2 complex, catenin complex, cell cortex, cell junction, cell periphery, cell-cell adherens junction, cell- ... Apoptotic cleavage of cell adhesion proteins. R-SSC-375170. CDO in myogenesis. R-SSC-3769402. Deactivation of the beta-catenin ... positive regulation of transcription by RNA polymerase II Source: UniProtKB. *protein localization to cell surface Source: ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR011989. ...
  http://www.uniprot.org/uniprot/Q8WNW4