Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation...
... for the prevention of TPA-induced neoplastic transformation of JB6 P+ cells was demonstrated using a stable Nrf2-knockdown cell ... Inhibitory effects of SFN on the TPA-induced transformation of JB6 P+ cells. Cells (1 × 105/10-cm dish) were treated with SFN ( ... Cells (1 × 105/10-cm dish) were treated with SFN (0-5.0 μmol/L) for 5 days. The pretreated cells (at a density of 8,000 cells/ ... Knockdown of Nrf2 increases the sensitivity of JB6 P+ cells to TPA-induced cell transformation, a state that is resistant to ...http://cancerpreventionresearch.aacrjournals.org/content/7/3/319
Natural History of Neoplastic Development: Host Effects During Carcinogenesis
... characteristics and mechanisms of the early stages of neoplastic develop- ment-initiation and promotion-were presented as being ... In a later chapter (Chapter 14) the "transformation" of normal cells to cells having distinctive characteristics while cultured ... However, in order to relate such transformation in vitro to the neoplastic process in vivo, the whole animal must be utilized ... mine the neoplastic potential of cells that have been altered in culture. ...http://fx.damasgate.com/natural-history-of-neoplastic-development-host-effects-during-carcinogenesis/
What does cell transformation, neoplastic mean?
... neoplastic. What does cell transformation, neoplastic mean? Information and translations of cell transformation, neoplastic in ... neoplastic in the Definitions.net dictionary. Meaning of cell transformation, ... What does cell transformation, neoplastic mean?. Definitions for cell transformation, neoplastic. Here are all the possible ... cell, constant. Alternative searches for cell transformation, neoplastic:. *Search for Synonyms for cell transformation, ...https://www.definitions.net/definition/cell%20transformation,%20neoplastic
Analysis of differentiation and transformation of cells by lectins.
This is thought to be accompanied by a modulation of cell surface determinants expressed on the outer cell membrane. Vice versa ... During differentiation cells are known to change their biological behavior according to their genotype. ... Cell Differentiation*. Cell Transformation, Neoplastic / analysis*. Lectins / analysis*. Chemical. Reg. No./Substance: 0/ ... 3818125 - Transformation-related changes in the expression of endogenous cell lectins.. 15348415 - Micro and nano-structured ...http://www.biomedsearch.com/nih/Analysis-differentiation-transformation-cells-by/3067975.html
Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and...
Spontaneous cell transformation: karyoplasts derived from multinucleated cells produce new cell growth in senescent human ... endothelial cells, and inflammatory cells [1-4]. Although it is well known that cancer epithelial cells and stromal cells ... Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 2001;15:50-65. ... the giant cells had recovered from H342 toxicity and had generated daughter cells, and the giant cells and daughter cells with ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4918945/
Tumorigenic Transformation and Neoplastic Progression of Human Uroepithelial Cells after Exposure in Vitro to 4-Aminobiphenyl...
Tumorigenic Transformation and Neoplastic Progression of Human Uroepithelial Cells after Exposure in Vitro to 4-Aminobiphenyl ... Tumorigenic Transformation and Neoplastic Progression of Human Uroepithelial Cells after Exposure in Vitro to 4-Aminobiphenyl ... Tumorigenic Transformation and Neoplastic Progression of Human Uroepithelial Cells after Exposure in Vitro to 4-Aminobiphenyl ... Tumorigenic Transformation and Neoplastic Progression of Human Uroepithelial Cells after Exposure in Vitro to 4-Aminobiphenyl ...http://cancerres.aacrjournals.org/content/52/6/1606
Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell...
Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell ... Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell ... Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell ... Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell ...http://cancerres.aacrjournals.org/content/early/2012/01/05/0008-5472.CAN-11-1891
Phase I/II Study of Nilotinib/Ruxolitinb Therapy for TKI Resistant Ph-Leukemia - Full Text View - ClinicalTrials.gov
Cell Transformation, Neoplastic. Carcinogenesis. Neoplastic Processes. Pathologic Processes. To Top. *For Patients and Families ... Precursor Cell Lymphoblastic Leukemia-Lymphoma. Leukemia, Lymphoid. Leukemia, Myeloid, Chronic-Phase. Leukemia, Myeloid, ... Underwent autologous or allogeneic stem cell transplant within 60 days prior to receiving the first dose of Ruxolitinib+ ...https://clinicaltrials.gov/ct2/show/NCT01914484?recr=Open&cond=%22Leukemia%2C+Myelogenous%2C+Chronic%2C+BCR-ABL+Positive%22&rank=9
3-AP and High-Dose Cytarabine in Treating Patients With Advanced Hematologic Malignancies - Full Text View - ClinicalTrials.gov
Cell Transformation, Neoplastic. Carcinogenesis. Neoplastic Processes. Pathologic Processes. Cytarabine. Antimetabolites, ... 3-AP may help cytarabine kill more cancer cells by making them more sensitive to the drug. This phase I trial is studying the ... Drugs used in chemotherapy, such as cytarabine, work in different ways to stop cancer cells from dividing so they stop growing ... Precursor Cell Lymphoblastic Leukemia-Lymphoma. Leukemia, Lymphoid. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Blast ...https://clinicaltrials.gov/ct2/show/NCT00077181
Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic...
Cell Transformation, Neoplastic. Carcinogenesis. Neoplastic Processes. Pathologic Processes. Eosinophilia. Leukocyte Disorders ... Post stem cell transplant allowed provided completion ≥ 4 months prior to study entry and no evidence of active acute or ... Drugs used in chemotherapy, such as flavopiridol, work in different ways to stop the growth of cancer cells, either by killing ... Precursor Cell Lymphoblastic Leukemia-Lymphoma. Leukemia, Lymphoid. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Blast ...https://clinicaltrials.gov/ct2/show/NCT00101231?cond=%22Acute+monoblastic+leukemia%22&rank=19
Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients...
Cell Transformation, Neoplastic. Carcinogenesis. Neoplastic Processes. Pathologic Processes. Fludarabine. Fludarabine phosphate ... The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor ... Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving ... before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's ...https://clinicaltrials.gov/ct2/show/NCT00036738?recr=Open&cond=%22Leukemia%22&rank=17
Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate ...
Cell Transformation, Neoplastic. Carcinogenesis. Neoplastic Processes. Pathologic Processes. Decitabine. Imatinib Mesylate. ... Patients who had received hematopoietic stem cell transplantation within 6 weeks of Day 1 decitabine therapy ...https://clinicaltrials.gov/ct2/show/NCT00042003
SOX2 gene | Cancer Genetics Web
Neoplastic Cell Transformation. Tag cloud generated 14 December, 2014 using data from PubMed, MeSH and CancerIndex. Notable (4) ... 3D cell cultures prolonged the survival and in vitro proliferation of neoplastic IDH1(R132H)-positive cells, however, did not ... Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10.. Mol Cell Biol. 2014 ... Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self- ...http://www.cancerindex.org/geneweb/SOX2.htm
TCF7L1 | Cancer Genetics Web
Neoplastic Cell Transformation. *Nerve Tissue Proteins. *Cancer Gene Expression Regulation. *Repressor Proteins ... cells were detected in the ALDHpos FA‑HNSCC cells and not in the ALDHneg cells. FA‑HNSCC cell lines revealed enhanced in vitro ... Nat Cell Biol. 2015; 17(5):545-57 [PubMed] Related Publications How embryonic stem cells (ESCs) commit to specific cell ... PCA decreased cell viability in a dose-dependent manner in HCT116 and SW480 cells. In addition, PCA reduced cell viability in ...http://www.cancerindex.org/geneweb/TCF7L1.htm
MYD88 | Cancer Genetics Web
TLR4 expression was present in all ovarian epithelium (normal and neoplastic), whereas MyD88 was restricted to neoplastic cells ... suggesting a multistep transformation of clonal B cells that, albeit benign (ie, IgM MGUS and smoldering WM), already harbor ... Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 ... Next, the role of TLR4 in cell proliferation and migration was assessed using the TLR4-positive (TLR4(+)) melanoma cell lines ...http://www.cancerindex.org/geneweb/MYD88.htm
FHL2 | Cancer Genetics Web
Neoplastic Cell Transformation. *Cell Nucleus. *Wnt Proteins. *p300-CBP Transcription Factors. *Chromosome 2 ... Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein ... Cell cycle and growth were assessed. The interaction between FHL2 and G0/G1 cell cycle and growth was evaluated by flow ... We also found high levels of TMED2 expression in BeWo but not in JEG-3 choriocarcinoma cell line. We used the BeWo cell line to ...http://www.cancerindex.org/geneweb/FHL2.htm
SKIL | Cancer Genetics Web
Neoplastic Cell Transformation. *Transforming Growth Factor beta. *Tumor Suppressor Proteins. *Transcription Factors ... Cell proliferation was analyzed by the Cell Counting Kit‑8 (CCK‑8) and cell apoptosis was investigated by flow cytometry. In ... cell cycle arrest - chromatin binding - cytoplasm - DNA binding - gene expression - lens fiber cell differentiation - ... METHODS: The patterns of sno/scaRNA expression in highly purified CD19+ B-cells of 211 CLL patients and in 18 normal B-cell ...http://www.cancerindex.org/geneweb/SKIL.htm
FSCN1 | Cancer Genetics Web
Neoplastic Cell Transformation. *Microfilament Proteins. *Gene Knockdown Techniques. Tag cloud generated 15 March, 2017 using ... cell junction - cell migration - cell motility - cell proliferation - cytoplasm - cytoskeleton - cytosol - drug binding - ... Re-introduction of miR-133b in GC cells can inhibit cell proliferation, cell migration and invasion. In contrary, knockdown of ... miR-133b inhibitors were also introduced in GES cells to investigate its role on regulating cell proliferation, cell migration ...http://www.cancerindex.org/geneweb/FSCN1.htm
PRSS1 | Cancer Genetics Web
Neoplastic Cell Transformation. *Genotype. *Genetic Testing. *Pancreatitis, Chronic. *Pancreatitis. *Young Adult. *Pedigree ... and P gene in cultured human RPE cells and uveal melanoma cells.. METHODS: RPE cells were isolated and cultured from three ... without cell surface receptor linked signal transduction, neuroactive ligand-receptor interaction, cell-cell signaling, and ... In uveal melanoma cells, melanin content per cell remained stable, and melanin production could be detected in each passage. ...http://www.cancerindex.org/geneweb/PRSS1.htm
EEF1A1 | Cancer Genetics Web
Squamous Cell Carcinoma. *Neoplastic Cell Transformation. *Transcription Factors. *Ovarian Cancer. *Protein Biosynthesis ... The effect on ribosome biogenesis, cell growth, cell cycle, and induction of apoptosis and autophagy in glioma cells during the ... We selected 20 overexpressed genes related to cell cycle, cellular movement and growth, proliferation and cell-to-cell ... in alkalinization-induced cell growth. In all cell lines tested (NIH3T3, HEK293, and HeLa), cell growth was affected by the ...http://www.cancerindex.org/geneweb/EEF1A1.htm
USP6 | Cancer Genetics Web
USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary ... and cell transformation. The first DUB to be identified as an oncogene was TRE17/Ubiquitin-specific protease 6 (USP6)/Tre-2. In ... USP6 and CDH11 rearrangements were restricted to spindle cells in the ABC and were not found in multinucleated giant cells, ... Microscopically both lesions demonstrated bland fibroblastic cells with intricate vasculature and inflammatory cells. Both ...http://www.cancerindex.org/geneweb/USP6.htm
DNAJB4 | Cancer Genetics Web
Non-Small Cell Lung Cancer. *Drug Evaluation, Preclinical. *Neoplasm Metastasis. *Neoplastic Cell Transformation ... Aurin exposure caused caspase-dependent cell death in a panel of human malignant melanoma cells (A375, G361, LOX-IMVI) but not ... Lung Cancer, Non-Small Cell. DNAJB4 and Non-Small Cell Lung Cancer. View Publications. 3. ... Metabolic rates of cancer cells are faster compared to normal cells. This faster rate yields aberrant protein folding and ...http://www.cancerindex.org/geneweb/DNAJB4.htm
Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells.
Cell Death / genetics*, physiology. Cell Transformation, Neoplastic / metabolism. Gene Expression Regulation, Neoplastic. ... However, the manifestations of cell morphologies characteristic of cell necrosis suggest necrotic cell death, apoptotic cell ... Effect of IRS-1 on oxidative stress-mediated cell fate. (A) Control cells and cells overexpressing IRS-1 were treated with 5 mU ... C) Control cells and cells overexpressing IRS-1 were treated with 5 or 10 mU/ml GO for 6 h. Cells were collected by ...http://www.biomedsearch.com/nih/Insulin-receptor-substrate-1-prevents/22788551.html
Jeffrey Townsend, PhD | Yale School of Public Health
Algorithms; Bacteria; Bacterial Infections and Mycoses; Beer; Bread; Cell Transformation, Neoplastic; Coccidioidomycosis; ... Tools from evolutionary theory have the potential to parse those mutations that are selected within cells on the path to cancer ...https://medicine.yale.edu/ysph/people/jeffrey_townsend-2.profile
Program Members > Yale Cancer Center | Yale School of...
Cell Transformation, Neoplastic; CRISPR-Cas Systems; Genetics; Immunity; Lung Neoplasms; Neoplasm Metastasis; Stem Cells ... Cell Biology; Genetics, Medical; Human Genome Project; Musculoskeletal Diseases; Skin and Connective Tissue Diseases ...http://yalecancercenter.org/research/programs/genetics/people/
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