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*  Subpressor infusions of angiotensin II alter glomerular binding, prostaglandin E2, and cyclic AMP production. | Hypertension
II in rats enhances the contractile response of the glomerular mesangial cell through effects on the cell's surface receptor ... ability of ANG II to reduce glomerular capillary surface area through an effect on ANG II binding to glomerular mesangial cells ... a method of measuring mesangial cell contractility. The sensitivity and magnitude of ANG II-induced decrements in glomerular ... The ability of ANG II to influence function was tested by assessing its effect on glomerular surface area in vitro by image- ...
  http://hyper.ahajournals.org/content/9/6_Pt_2/III49
*  ANP-induced signaling cascade and its implications in renal pathophysiology | Renal Physiology
... may act on glomerular epithelial and mesangial cells (21, 66). The receptor NPR-A has been localized to the surface of ... where it acts in a paracrine fashion by binding to a separate receptor; natriuretic peptide receptor-B (NPR-B) regulates cell ... Characterization of atrial natriuretic factor receptors in human glomerular epithelial and mesangial cells. Am J Physiol Renal ... Mesangial cells express NPR-A and respond to ANP, with strong elevations in intracellular cGMP (10). ANP may also relax ...
  http://ajprenal.physiology.org/content/308/10/F1047?ijkey=b3785440e42a3c3bb59171b4cfd069e3d4db2637&keytype2=tf_ipsecsha
*  Plus it
Two types of cell surface receptors mediate these varied physiological effects of kinins and are designated as B1 and B2. Most ... 11) demonstrated the presence of B2 receptors on rat cultured mesangial cells. Although a marked decrease in Kf alone is ... For example, there is an increase in mRNA expression of glomerular B2 receptors over the first week of postnatal life in rat ... 1990) Characterization of a B2-bradykinin receptor in rat mesangial cells. Eur J Pharmacol 190:381-392. ...
  http://ajpregu.physiology.org/content/281/4/R1311
*  Suppressors of Cytokine Signaling Regulate Fc Receptor Signaling and Cell Activation during Immune Renal Injury | The Journal...
... in many cell types, including glomerular mesangial cells (MC) (17, 30, 31). ... Tec kinases associate with multiple cell surface receptors, including Ag receptor and FcεR (17, 18), and are able to interact ... SOCS can also associate with different receptors, such as growth hormones, T cell and B cell Ag receptors (6, 7, 8, 9, 10, 11, ... Both kinases are implicated in signaling via T cell and B cell Ag receptors and IgG receptors (FcγR) (17, 18), thus suggesting ...
  http://www.jimmunol.org/content/172/11/6969
*  Prostaglandin - Wikipedia
Prostaglandins ligate a sub-family of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors ... specialised smooth muscle cells) in the glomerulus of the kidney to increase glomerular filtration rate acts on parietal cells ... regulate hormones control cell growth acts on thermoregulatory center of hypothalamus to produce fever acts on mesangial cells ... DP1-2 receptors bind to PGD2). The diversity of receptors means that prostaglandins act on an array of cells and have a wide ...
  https://en.wikipedia.org/wiki/Prostaglandin
*  The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance | SpringerLink
Cultured stem cells express NTPDase2 and functional P2 receptors. Agonists of P2Y1 and P2Y2 receptors augment cell ... Cell surface-located catabolism of extracellular nucleotides and potential activation of receptors for nucleotides (P2 ... Kapojos JJ, VandenBerg A, Borghuis T et al (2004) Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells ... in human endothelial cells in-vitro is increased by aspirin [93] and glomerular 'ecto-ATP diphosphohydrolase' immunoreactivity ...
  https://link.springer.com/article/10.1007%2Fs11302-006-9003-5
*  Inflammation in Diabetic Nephropathy
... biological response modifiers and the family of cell adhesion-promoting molecules. ... including mesangial, glomerular, endothelial, dendritic, and renal tubular cells [35-38]. TNF-. expression is increased in the ... Receptor activation by various stress stimuli on the cell surface trigger intracellular signalling involving a cascade of ... It is produced by various cells in the kidney, including monocyte-macrophages, mesangial cells, podocytes, and tubular cells [ ...
  https://www.hindawi.com/journals/mi/2012/146154/
*  C-peptide - Wikipedia
C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal ... March 2005). "C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats". Nephrol. Dial. ... C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells. ii Patients ... tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2+-dependent ...
  https://en.wikipedia.org/wiki/C-peptide
*  Plus it
2C). The microscopic lesions noted in the DM+RAGE (+/+) mice consisted of glomerular cell proliferation, mesangial expansion, ... Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial cells. Biochem Biophys Res Commun 245 : ... is known to be regulated by binding to heparan sulfate on the cell surface or the extracellular matrix, which promotes or ... 5E), glomerular tuft area (Fig. 5G), glomerular cell number (Fig. 5H), and glomerular sclerosis index (Fig. 5I) when compared ...
  http://diabetes.diabetesjournals.org/content/55/9/2510
*  PTPRO gene - Genetics Home Reference - NIH
These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation ... protein tyrosine phosphatase, receptor type O. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and ... Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial ...
  https://ghr.nlm.nih.gov/gene/PTPRO
*  Mesangial cell - Wikipedia
... mesangial cells to the glomerular basement membrane can alter capillary flow by changing glomerular ultrafiltration surface ... B and mesangial cells have receptors for PDGF. This induces mesangial cells to attach to endothelial cells causing developing ... Mesangial cells can be categorised as either extraglomerular mesangial cells or intraglomerular mesangial cells, based on their ... Mesangial cells form a glomerular functional unit with glomerular endothelial cells and podocytes through interactions of ...
  https://en.wikipedia.org/wiki/Mesangial_cell
*  Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Chemokine and chemokine receptor expression in a novel human mesangial cell line. J Am Soc Nephrol 1999;10:2314-2322.. ... present on the surface of podocytes, mesangial cells, and proximal tubular epithelial cells, degrades Ang II into Ang III [16, ... such as mesangial, glomerular epithelial, and proximal tubular epithelial cells [20,21]. In addition, MCP-1 is synthesized and ... Some studies show that Ang III activates NF-κB in cultured mesangial cells, mainly via AT2 receptors [18], and contributes to ...
  http://www.kjim.org/journal/view.php?number=169540
*  Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells | The Journal of Immunology
Cutting edge: cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse ... Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: possible ... Cell lines. SV40-transformed murine mesangial cell line, Mes13, purchased from American Type Culture Collection (Manassas, VA) ... T cells (17, 18), and dendritic cells (19), but also in other cell types, e.g., dermal endothelial cells (20), intestinal ...
  http://www.jimmunol.org/content/169/4/2026.long
*  Atrial natriuretic peptide - Wikipedia
They are all cell surface receptors and designated: guanylyl cyclase-A (GC-A) also known as natriuretic peptide receptor-A ( ... Dilates the afferent glomerular arteriole, constricts the efferent glomerular arteriole, and relaxes the mesangial cells. This ... and relaxes the mesangial cells. This increases pressure in the glomerular capillaries, increasing the glomerular filtration ... When the cells are stimulated, pro-ANP is released and converted to the 28-amino-acid C-terminal mature ANP on the cell surface ...
  https://en.wikipedia.org/wiki/Atrial_natriuretic_peptide
*  Endothelin-1 Increases Glomerular Permeability and Inflammation Independent of Blood Pressure in the Rat | Hypertension
Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates β-adrenergic-mediated cyclic adenosine ... ETB receptors clear ET-1 from the circulation and protect against ETA receptor-dependent vasoconstriction, cell proliferation, ... They went on to conclude that ET-1 activates the podocyte cytoskeleton and modifies surface expression of nephrin, thus ... Sections were stained for CD68-positive cells (monocytes/macrophages; A through C) or CD3-positive cells (T cells; D through F ...
  http://hyper.ahajournals.org/content/56/5/942
*  Role of Inflammation in the Pathogenesis of Diabetic Nephropathy
TNF-α and its receptors are expressed by activated native kidney cells (glomerular mesangial, epithelial and endothelial cells ... adipocytes and endothelial cells [24]. TNF-α is cleaved from the cell surface by a disintegrin and mettaloprotease protein-17 ( ... in mesangial cells. Finally, TNF-α appears to have a direct apoptotic and cytotoxic effect on glomerular cells [30, 35].. Some ... glomerular mesangial, epithelial and endothelial cells, and tubular epithelial cells) and also in activated monocytes- ...
  https://scidoc.org/IJDVR-2328-353X-03-602.php
*  Expression of PDGFB in cancer - Summary - The Human Protein Atlas
GO:0072126 [positive regulation of glomerular mesangial cell proliferation]. GO:0072255 [metanephric glomerular mesangial cell ... GO:0008284 [positive regulation of cell proliferation]. GO:0009611 [response to wounding]. GO:0009986 [cell surface]. GO: ... G-protein coupled receptors. Mapped to UniProt SWISS-PROT. Nuclear receptors. Plasma proteins. Potential drug targets. ... Reliability score cells (ICC). - ANTIBODY VALIDATION -. Protein array (PA). Western blot (WB). Immunohistochemistry (IHC). ...
  http://www.proteinatlas.org/ENSG00000100311-PDGFB/pathology
*  Acute poststreptococcal glomerulonephritis
... shows diffuse mesangial hypercellularity and inflammatory infiltrate of the glomerular tuft with polymorphonuclear cells. ... Red blood cell casts or dysmorphic red blood cells on microscopic analysis of urine ... Angiotensin-converting enzyme (ACE) Inhibitors and angiotensin-receptor blockers (ARBs) should generally be avoided in the ... and rheumatogenic strains of strepococcus that are defined by their surface M protein. Immune complex formation results in ...
  https://www.neurologyadvisor.com/pediatrics/acute-poststreptococcal-glomerulonephritis/article/622018/
*  Pathophysiology and classification of kidney diseases - IFCC
... mesangial and epithelial glomerular cells. This process is facilitated by the cell-cell adhesion and costimulatory molecules. ... They interact through their surface receptor/CD3 complex with antigens presented in the clefts of MHC molecules of endothelial ... CD4-positive T cells and CD3 T cells carrying chemokine receptors CCR5 and CxCR3 are closely associated with renal function. ... nonproliferative (without cell proliferation) glomerular diseases without glomerular inflammation and without deposition of ...
  http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2009-vol-20/vol-20-n-1/pathophysiology-and-classification-of-kidney-diseases/
*  Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A...
Ellis V, Pyke C, Eriksen J, Solberg H, Dano K. The urokinase receptor: involvement in cell surface proteolysis and cancer ... Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus. Biochem J ... This study was designed to evaluate the association of uPA/uPAR/PAI-1 expression with glomerular pathology in immunoglobulin A ... Madsen CD, Sidenius N. The interaction between urokinase receptor and vitronectin in cell adhesion and signalling. Eur J Cell ...
  http://www.kjim.org/journal/view.php?number=169257
*  Acid increases NHE8 surface expression and activity in NRK cells | Renal Physiology
pH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3−. Am J Physiol Cell ... ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells. Am J Physiol Renal Physiol 280: F34-F42, 2001. ... Sulfo-NHS-SS-acetate blocks all cell surface NHS-reactive sites so that NHE8 on the cell surface is blocked. The cells were ... Cell culture.. Normal rat kidney cells (NRK cells) were purchased from American Type Culture Collection (Manassas, VA). Cells ...
  http://ajprenal.physiology.org/content/302/4/F495.long
*  Free Radicals and Biomarkers Related to the Diagnosis of Cardiorenal Syndrome | IntechOpen
... primarily not only located in renal tubular cell [161-163] but also found in glomerular mesangial cells [164, 165]. ... AT1-receptor antagonists abolish glomerular MCP-1 expression in a model of mesangial proliferative glomerulonephritis. Exp ... In mammals, there are two isoforms of ACE: somatic ACE, abundant on the surface of pulmonary endothelial cells, and testicular ... like in mesangial cells [97], vascular smooth muscle cells [98, 99], endothelial cells [100], glomerular epithelial podocytes [ ...
  https://www.intechopen.com/books/free-radicals-and-diseases/free-radicals-and-biomarkers-related-to-the-diagnosis-of-cardiorenal-syndrome/
*  Most recent papers in the journal ISRN Nephrology | Read by QxMD
Glomerular mesangial cells (MC), like most cell types secrete hyaluronan (HA), which attached to the cell surface via CD44, is ... Hyaluronan is not a ligand but a regulator of toll-like receptor signaling in mesangial cells: role of extracellular matrix in ... www.readbyqxmd.com/read/24967246/hyaluronan-is-not-a-ligand-but-a-regulator-of-toll-like-receptor-signaling-in-mesangial-cells- ... HA fragments were reported to trigger innate immunity via Toll-like receptor-(TLR-) 2 and/or TLR4 in immune cells. We ...
  https://www.readbyqxmd.com/journal/48620
*  FCGR3A - Wikipedia
"Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney International. 46 (6): 1627-34. ... It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules. GRCh38: Ensembl release 89: ... "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
  https://en.wikipedia.org/wiki/FCGR3A
*  Course of preeclamptic glomerular injury after delivery | Renal Physiology
... along with mesangial cell interposition and subendothelial fibrinoid deposits. These findings were computed to lower glomerular ... and this excess is thought to inhibit VEGF receptors, which are present on glomerular endothelial cells and podocytes. It has ... Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat ... Changes in glomerular endothelial cells that are remarkably similar to those observed in preeclamptic humans have been induced ...
  http://ajprenal.physiology.org/content/294/3/F614