LAT - Linker for activation of T-cells family member 1 - Homo sapiens (Human) - LAT gene & protein
... high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and ... and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity ... immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 ( ... Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development ...https://www.uniprot.org/uniprot/O43561
CXCR4 acts as a costimulator during thymic beta-selection. - PubMed - NCBI
... beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene ... Tcrb) and formation of a pre-TCR on the surface of CD4(-)CD8(-) thymocytes. How other receptors influence betabeta-selection is ... Migration of pre-T cell lines SCIET27 (pre-TCR-deficient) and SCB29 (pre-TCR-expressing) to 20nM SDF-1α or BSA (n=5). Data in a ... Bar graphs show percentage of migrated DN3 cells as a fraction of total cell input, ± s.d. (n=2). (h) DN3 thymocytes pre- ...https://www.ncbi.nlm.nih.gov/pubmed/20010845?access_num=20010845&link_type=MED&dopt=Abstract
Enhanced Cytotoxicity of Natural Killer Cells following the Acquisition of Chimeric Antigen Receptors through Trogocytosis
Viral vectors have been used to genetically modify in vitro expanded NK cells to express chimeric antigen receptors (CARs), ... A K562 cell line expressing high levels of anti-CD19 CARs was generated as a donor cell to transfer the anti-CD19 CARs onto NK ... Anti-CD19 CAR expression was observed in expanded NK cells after these cells were co-cultured for one hour with freeze/thaw- ... Acquisition of anti-CD19 CARs via trogocytosis enhanced NK cell-mediated cytotoxicity against the B-cell acute lymphoblastic ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109352
ZIOPHARM Announces Sleeping Beauty Non-Viral Gene Transfer Technology Featured in Nature Medicine
... today announced that its Sleeping Beauty non-viral gene transfer technology was featured in a perspectives article in the ... include chimeric antigen receptor T cell (CAR-T) and other adoptive cell based approaches that use non-viral gene transfer ... is a unique non-viral system for introducing genes encoding T-cell receptors and chimeric antigen receptors into lymphocytes ... TCR and NK cell-based therapies, or any of our other therapeutic candidates will advance further in the pre-clinical or ...https://www.cnbc.com/2016/01/11/globe-newswire-ziopharm-announces-sleeping-beauty-non-viral-gene-transfer-technology-featured-in-nature-medicine.html
Medigene and academic partners publish a method to identify T cell receptors against viral antigens - 'Human Gene Therapy'...
Human Gene Therapy' (DOI: 10.1089/hum.2017.122). The research results show how a platform like Medigene's also serves to ... announces that a scientific article on a method to identify T cell receptors (TCRs) specific for novel and immunodominant ... The TCR technology aims at arming the patient's own T cells with tumor-specific T-cell receptors. The receptor-modified T cells ... Medigene concentrates on the development of personalized T cell-based therapies, with associated projects currently in pre- ...http://irnews.pressetext.com/news/20171011007
Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer...
Overexpressed genes in TMPRSS2-ERG fusion-positive prostate cancer cells; 4) miRNA mediated regulation of the androgen receptor ... It is important to understand the activation or repression of target genes and proteins in response to various stimuli and the ... Accordingly, we divide this multi-component review ofprostate cancer cells into several segments: 1) The role of TMPRSS2-ERG ... Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common ...https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-14-34
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. - Semantic...
... these abnormal B-cell antigen receptors might engage in ligand-independent signalling. Normal pre-B-cell development requires ... the presence of the pre-B-cell receptor, formed by the association of mu heavy chains with two polypeptides--so-called ... pre-B cells develop normally. To determine whether this pre-B-cell development requires surrogate light chains, we backcrossed ... Our results show that the truncated heavy chain, but not the normal chain, is able to promote pre-B-cell development in the ...https://www.semanticscholar.org/paper/Pre-B-cell-development-in-the-absence-of-lambda-5-a-Corcos-Dunda/5e238fdea92e8bcb5eba3b9a92be7cdf0d99a2f9
Lymphoid Development and Function in IL-7R-Deficient Mice | SpringerLink
... antigen receptor gene rearrangement, and cytokine responsiveness. For... ... and T-cell progenitor development have been thoroughly defined on the basis of cell surface marker expression, ... Status of xL chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J. Immunol ... Expression of cytokine receptors in cultured neuronal and glial cells. Neurosci. Lett. 160, 131-134.PubMedCrossRefGoogle ...https://link.springer.com/chapter/10.1007/978-1-4757-2753-1_3
Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus, Arthritis Research &...
... recognize self-antigens via their B cell receptors (BCR). however, methylated histones have also been identified as In B cells ... After quality control, using the sum gene score approach, and gene score pre-phasing of genotypes was performed using SHA- ... The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor ... recognize self-antigens via their B cell receptors (BCR). however, methylated histones have also been identified as In B cells ...https://www.deepdyve.com/lp/springer_journal/genome-wide-association-study-meta-analysis-identifies-five-new-loci-LCO4Ifjix1
Regulation of B-Cell Populations | Springer for Research & Development
... which has a uniform antigen-binding capacity for any one B cell. As the body has the potential to produce... ... B cells carry antigen-specific receptors in the form of surface-bound immunoglobulin, ... Coffman RL (1982) Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol ... B cells carry antigen-specific receptors in the form of surface-bound immunoglobulin, which has a uniform antigen-binding ...https://rd.springer.com/chapter/10.1007/978-3-642-73855-5_3
Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy
Gene engineered chimeric antigen receptor (CAR) T cells also show promise in B-cell malignancy, and as they induce apoptosis ... chimeric antigen receptors, CAR T cells, T cell therapy, immunotherapy, CD19, Bcl-2 family inhibitors, B cell malignancies ... CAR T cells targeting CD19 were generated from healthy donors as well as from pre-B-ALL (precursor-B acute lymphoblastic ... B cell-stimulated CAR T cells showed increased proliferation and an antigen-driven accumulation of CAR+ T cells. 3G CAR T cells ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:641359
Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia | SpringerLink
... ensuring the life-long supply of mature haematopoietic cells and forming a reservoir to... ... Haematopoietic stem cells (HSC) are situated at the apex of the haematopoietic differentiation hierarchy, ... and the relationship between them was further confirmed via Ig and T cell antigen receptor (TCR) deletions analysis. This ... also defined as pre-leukaemic state . These genes are involved in DNA methylation such as DNA methyltransferase 3 alpha ( ...https://link.springer.com/article/10.1007%2Fs00109-017-1535-3
Anti-Mouse (Murine) LAT antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development ... high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and ... Gene ID 27040 UniProt O43561 Research Area Signaling, Adaptive Immunity Pathways TCR Signaling, Fc-epsilon Receptor Signaling ... Antigen Linker For Activation of T Cells (LAT) Antibodies show synonyms for this antigen * LAT ...http://www.antibodies-online.com/tcr-signaling-pathway-12/lat-antibody-839/mouse-ihc-p-6706/
Table of Contents - November 03, 1997, 186 (9) | JEM
Subunit Composition of Pre-T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not ... Novel Mutants Define Genes Required for the Expression of Human Histocompatibility Leukocyte Antigen DM: Evidence for Loci on ... Wound Healing Is Accelerated by Agonists of Adenosine A2 (Gαs-linked) Receptors M. Carmen Montesinos, Pratap Gadangi, Michael ... Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose-dependent Manner and Promotes Receptor ...http://jem.rupress.org/content/186/9
Precursor B Cell Receptor-Dependent B Cell Proliferation and Differentiation Does Not Require the Bone Marrow or Fetal Liver...
... chain gene loci (2) (3) (4). The precursor B cell receptor (pre-BCR), consisting of a μH chain associated with the surrogate ... Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors. ... 1998) Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk ... B cell receptor; B6, C57BL/6; cμ, cytoplasmic μH chain; pre-B cell, precursor B cell; pro-B cell, progenitor B cell; sIg, ...http://jem.rupress.org/content/191/1/23
CTL019 therapy induced response in CLL, ALL
... refractory pre-B-cell acute lymphoblastic leukemia, according to study results presented at the ASH Annual Meeting and ... Chimeric antigen receptor-expressing T cells that target CTL019 induced clinical response and long-term B-cell aplasia in ... NEW ORLEANS - Chimeric antigen receptor-expressing T cells that target CTL019 induced clinical response and long-term B-cell ... Disclosure: The researchers report advisory board roles with, research funding from, and royalties on CART19 and cell and gene ...https://www.healio.com/news/online/%7Be7604bbc-ec0c-44db-a154-dce62fb89f38%7D/ctl019-therapy-induced-response-in-cll-all
B cell - Wikipedia
Positive selection occurs through antigen-independent signaling involving both the pre-BCR and the BCR. If these receptors do ... but others need T cell help. Upon antigen binding, the memory B cell takes up the antigen through receptor-mediated endocytosis ... From here, their development into B cells occurs in several stages (shown in image to the right), each marked by various gene ... T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a ...https://en.wikipedia.org/wiki/B_cell
Viruses | Free Full-Text | Measles to the Rescue: A Review of Oncolytic Measles Virus
Successful attempts to retarget MV by inserting genes for tumour-specific ligands to antigens such as carcinoembryonic antigen ... receptor CD46 in many tumour cells may direct the virus to preferentially enter transformed cells and there is increasing ... The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with ... The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with ...http://www.mdpi.com/1999-4915/8/10/294
Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia | The Medical...
... reduced complexity of the T-cell receptor repertoire suggested a reduced capacity to respond to a diverse spectrum of antigens ... γ chain of several interleukin receptors; mutations affecting the γc gene cause SCID-X1). Gene-modified cells (equivalent to ... Pre-activation of cells with cytokines: CD34+ cells were cultured in gas-permeable bags (Baxter, Deerfield, Ill) in a purpose- ... T-cell receptor repertoire. PCR-based analysis of T-cell receptor diversity among αβ T cells revealed expression of all 28 Vβ ...https://www.mja.com.au/journal/2005/182/9/treatment-infant-x-linked-severe-combined-immunodeficiency-scid-x1-gene-therapy
Function of the pre-T-cell receptor a chain in T-cell development and allelic exclusion at the T-cell receptor b locus. ... DEVELOPMENTAL REGULATION OF T CELL ANTIGEN RECEPTOR EXPRESSION AND FUNCTION. , http://www.fccc.edu/research/reports/current/ ... either the pre-TCR, TCR, or CD3 are needed to transcribe the TCRA gene (Mancini et al., 2001). ... so-called because the T cell lacks both CD4 and CD8 co-receptors) to the double positive stage (CD4 +CD8 +). From here, the ...http://www.bio.davidson.edu/courses/Immunology/Students/spring2006/Heeren/pTalpha.html
Cytotoxic T cell - Wikipedia
Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is a molecule capable ... some of which are presented by MHC Class I to the T cell antigen receptor (TCR) on CD8+ T cells. The activation of cytotoxic T ... CD8+ T cells are recognized as TC cells once they become activated and are generally classified as having a pre-defined ... There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. Instead, the DNA ...https://en.wikipedia.org/wiki/Cytotoxic_T_cell
T cell - Wikipedia
... cells typically express a large number of self derived pMHC on their cell surface and although the T cell antigen receptor can ... A T cell becomes a CD4+ cell by down-regulating expression of its CD8 cell surface receptors. If the cell does not lose its ... Although these signals require this pre-TCR at the cell surface, they are independent of ligand binding to the pre-TCR. These ... which are produced from the independent T cell receptor alpha and beta (TCRα and TCRβ) genes. The other proteins in the complex ...https://en.wikipedia.org/wiki/T_cell
KIR2DL4 - Wikipedia
"NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains". ... "Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103". Tissue Antigens. 49 (6 ... "Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia". Eur. J. Immunol. 32 (1): 18-29. doi:10.1002/ ... Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene. Killer cell ...https://en.wikipedia.org/wiki/KIR2DL4
Polyomaviridae - Wikipedia
Each region is transcribed by the host cell's RNA polymerase II as a single pre-messenger RNA containing multiple genes. The ... The early genes - comprising at minimum the small tumor antigen (ST) and large tumor antigen (LT) - are expressed first, from a ... The polyomavirus life cycle begins with entry into a host cell. Cellular receptors for polyomaviruses are sialic acid residues ... the JC virus is believed to require interaction with the 5HT2A receptor and the Merkel cell virus with heparan sulfate. However ...https://en.wikipedia.org/wiki/Polyomaviridae
Thymocyte - Wikipedia
... the T cell receptor is made up of a series of alternative gene fragments. In order to create a functional T cell receptor, the ... The ability of T cells to recognize foreign antigens is mediated by the T cell receptor (TCR), which is a surface protein able ... The key disadvantage in a gene rearrangement process for T cell receptors is that by random chance, some arrangements of gene ... TCRβ is capable of pairing with pre-Tα to generate the pre-TCR, and that the pre-TCR can interact on the cell surface with the ...https://en.wikipedia.org/wiki/Thymocyte