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*  Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties | JEM
The transmembrane CD45 protein is expressed on all human hematopoietic cells, acting as a regulator of antigen receptor ... The follicular versus marginal zone B lymphocyte cell fate decision. Nat. Rev. Immunol. 9:767-777. doi:10.1038/nri2656. ... The extracellular domain of NOTCH2 contains 36 epidermal growth factor (EGF) repeats involved in ligand binding and three Lin/ ... Furthermore Notch2 haploinsufficiency in the B cell lineage compromises MZB cell differentiation, with the numbers of MZB cells ...
  http://jem.rupress.org/content/early/2014/04/08/jem.20132203
*  HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B...
... alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions-the B and F pockets-of ... Supertypes are groups of human leukocyte antigen (HLA) ... 1a) and a higher level of population differentiation than B7 ... Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific ... functional and evolutionary interactions with T cells. Cold Spring Harb Symp Quant Biol 54(Pt 1):529-543CrossRefPubMedGoogle ...
  https://link.springer.com/article/10.1007/s00251-015-0875-9
*  Plasma cell - Wikipedia
... sometimes called T helper cells). These T cells bind to the MHC II-antigen molecule and cause activation of the B cell. This is ... received from the T cell during differentiation.[6] Differentiation through a T cell-independent antigen stimulation ( ... and internalizes offending antigens, which are taken up by the B cell through receptor-mediated endocytosis and processed. ... Lymphocyte. *Organelles. *White blood cell. References[edit]. *^ http://global.britannica.com/EBchecked/topic/463540/plasma- ...
  https://en.wikipedia.org/wiki/Plasma_cells
*  Publikacje...
Lukasiuk K., Kaczmarek L., Condorelli D.F., Transcription factors NF-kB DNA binding activities in rat brain cells cultured in ... receptor is modulated by the palmitoylation of its C-terminal domain. Biochmica et Biohysica Acta - Molecular Cell Research, ... Cell Death and Differentiation, 14:1255-1258, 2007.. 133. Knapska E., Radwanska K., Werka T., Kaczmarek L., Functional internal ... Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo. FEBS Lett., 312: 179-182, 1992.. 16. ...
  https://neurogene.nencki.gov.pl/?page_id=59
*  JCI - Volume 127, Issue 5
T cells isolated from human peripheral blood mononuclear cells. The regulation of CD4+ T cell differentiation was mediated at ... Here, we have described a relationship among the B cell receptor (BCR), TLR9, and cytokine signals that regulate B cell ... A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. ... prevented lymphocyte infiltration into regenerated islets, and sharply elevated the expression of the β cell markers pancreatic ...
  https://hzyouma.com.www.mobile.jci.org/127/5
*  The Neuropeptide Vasoactive Intestinal Peptide Generates Tolerogenic Dendritic Cells | The Journal of Immunology
... was used to block nonspecific binding to Fc receptors. After extensive washing, the cells were fixed in 1% paraformaldehyde. ... the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 ... Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood 105: 1162-1169. ... 104 cells/well) to purified PCCF-specific Tg CD4 T cells (5 × 105 cells/well) in the presence of PCCF. One week later, T cells ...
  http://www.jimmunol.org/content/175/11/7311?ijkey=a237447f0ac6cdeac774fd81a98f7ffd68d981e2&keytype2=tf_ipsecsha
*  IL-33 Signaling in Lung Injury
IL-33 first binds to a receptor complex, which is composed of ST2L and IL-1RAP. Signaling is induced through the cytoplasmic ... IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proceedings of the ... from activation of cytoplasmic Toll-interleukin receptor domain which attracts the adaptor molecule myeloid differentiation ... Serumand oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. ...
  http://transpopmed.org/articles/tppm/tppm-2016-3-037.php
*  Sodium Channels | Identification and Characterization of Inhibitors of Human Apurinic
Latest antigen publicity of mucosal T and B cells induces proliferation and differentiation of the cells (14, 25). The turned ... a membrane bound form of TGF-β [12]. These LAP+ CD4 T cells lack FoxP3 expression but can inhibit proliferative activities of T ... LHR2A antibody In vitro assay of secreting antibody in the lymphocyte supernatant (i.e., the ALS assay) is definitely capable ... VIP Receptors *Vitamin D Receptors Recent Posts. * Ramifications of retinoids and inhibitors of arachidonic acidity rate of ...
  http://dansukyoshitsu-park.com/category/sodium-channels/
*  CHO-K1/Lag3 Stable Cell Line Molecule - GenScript
... cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000[3]. LAG-3 is a... ... Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene.[1] LAG3, which was ... LAG-3 is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as ... Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene.[1] LAG3, which was ...
  https://www.genscript.com/molecule/M00532-CHO_K1_Lag3.html
*  CECAD: Publications 2008
Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding. Dev Cell. May; ... self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. Oct 15;181(8):5748-59 ... Yttrium-90 ibritumomab tiuxetan-induced complete remission in a patient with classical lymphocyte-rich Hodgkin's Lymphoma. ... osteoclastogenesis by IKKbeta-null precursors is a result of RANKL-induced JNK-dependent apoptosis and impaired differentiation ...
  http://www.cecad.uni-koeln.de/index.php?id=155&type=0
*  P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small...
T lymphocyte survival and differentiation, transcription factor activation, and cell death [29]. Here, we found that ... The human P2X7 receptor and its role in innate immunity. Tissue Antigens. 2011;78:321-32.View ArticlePubMedGoogle Scholar. ... such as Toll-like receptors (TLRs) or nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), detect the ... Culture of FHs 74 Int cells. A non-transformed human fetal small intestinal epithelial cell line (FHs 74 Int cells) was ...
  https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2573-y
*  Macrophage - New World Encyclopedia
The processed antigen is then presented in MHCII on the surface of the B-cell. TH1 receptor that has proliferated recognizes ... When a B-cell in the lymph node recognizes the same unprocessed surface antigen on the bacterium with its surface bound ... into the phagocytosing macrophage cell after they migrate from the bloodstream into the tissue and undergo differentiation. ... The human immune system: The lymphocyte story. New Scientist March 24, 1988. Retrieved October 15, 2007. ...
  http://www.newworldencyclopedia.org/entry/Macrophage
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... dendritic cells and fibroblast cells via GPCR Gαi proteins and MMP-9 5. For TLR receptors, our data indicate that Neu1 ... To study the molecular events that regulate human T lymphocyte migration, we have utilized an in vitro system to analyze cell ... sialidase is already in complex with TLR-2, -3 and -4 receptors, and is induced upon ligand binding to either receptor. ... transporting of antigens and other soluble factors to lymph nodes 19, and (c) modulating lymphatic endothelial cell ...
  https://www.jove.com/visualize/abstract/20657647/mmp-9-upar-cathepsin-b-silencing-downregulate-integrins-human-glioma
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
T cells, induced pluripotent stem cells, differentiation, Notch signaling, T cell receptor, adoptive cell transfer ... Immunology, Issue 98, nanoparticle, vaccine, biomaterial, subunit antigen, adjuvant, cytotoxic CD8+ T lymphocyte, whole animal ... Impedance or opposition to an electric current occurs when adherent tumor cells bind to electrode plates. Tumor cells detach ... T cells can be engineered ex vivo to express chimeric antigen receptors specific for glioma antigens (CAR T cells). The ...
  https://www.jove.com/visualize/abstract/26079374/combination-id2-knockdown-whole-tumor-cells-checkpoint-blockade
*  Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006; ... Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi ... such as those binding TLR2, can favor Treg expansion both in vitro and in vivo (Liu et al., 2006; Sutmuller et al., 2006a) ... Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+T cells. Mucosal ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2712925/?lang=en-ca
*  Cluster of Differentiation
... in conjunction with the International Workshops on Leukocyte Differentiation Antigens ... Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice. Int ... to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor- ... The surrogate light chain is a component of the preB cell receptor that plays a critical role in early B cell differentiation ...
  http://sciencegateway.org/resources/prow/guide/574153212_g.htm
*  DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses
Regulation of B-lymphocyte activation, proliferation, and differentiation. Ann N Y Acad Sci, 505: 82-89. *DOI ... DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell, 100: 587-597. *DOI ... Dendritic cells (DCs) are professional antigen-presenting cells that act as a bridge between peripheral mucosal and lymphoid ... C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol, 2: 77-84. *DOI ...
  http://www.virosin.org/html/32/05/10.1007s12250-017-4034-3.htm
*  Rituximab - Wikipedia
The antibody binds to the cell surface protein CD20. CD20 is widely expressed on B cells, from early pre-B cells to later in ... It increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen). ... with enhanced binding to Fc gamma receptors, which increase ADCC (antibody-dependent cellular cytotoxicity).[55] This strategy ... differentiation, but it is absent on terminally differentiated plasma cells. CD20 does not shed, modulate or internalise. ...
  https://en.wikipedia.org/wiki/Rituximab
*  A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing | The Journal of Immunology
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc. Natl. Acad. Sci. USA 103 ... small lymphocyte, live CD3+, and CD8+CD4− cells (from left to right). These cells were subsequently analyzed on the basis of ... Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. ... Another interpretation is that asymmetric division and differentiation after Ag encounter result in T cells bearing the same ...
  http://www.jimmunol.org/content/186/7/4285.long
*  NYOH - Drug Dictionary
EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors. After binding to the ... Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and ... the DCR ligand moiety of this vaccine targets receptors on dendritic cells (DCs), thereby presenting the antigens to DCs which ... thereby inhibiting IL-2 binding and IL-2-mediated lymphocyte activation, a critical cellular immune response pathway. Check for ...
  http://newyorkoncology.com/disease-drug-info/drug-dictionary/D/
*  Chapter 326. The Vasculitis Syndromes | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical
Sequence analysis of the T cell receptor of tissue-infiltrating T cells in lesions of giant cell arteritis indicates restricted ... and orchestrate macrophage differentiation. T cells recruited to vasculitic lesions in patients with giant cell arteritis ... Etanercept, a dimeric fusion protein containing the 75-kDa TNF receptor bound to human IgG1, was not found to sustain remission ... T lymphocytes in a manner similar to antigen-presenting macrophages. Endothelial cells can secrete IL-1, which may activate T ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727127
*  The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts | JCB
... it has been proposed that a membrane-bound OC factor on stromal cells would stimulate differentiation of OC progenitors as well ... 1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-179, ... 1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323, ... 5, D and E). To demonstrate the specificity of this antibody, excess antigen was preincubated with the antibody before ...
  http://jcb.rupress.org/content/145/3/527
*  Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived...
... toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645-1651 [PMC free article ... 4. Domínguez P. M., Ardavín C. (2010) Differentiation and function of mouse monocyte-derived dendritic cells in steady state ... In a model of Th2 lymphocyte recruitment in asthma, activated mast cells release lipid mediators LTB4 and PGD2, which recruit ... C to eliminate nonspecific binding of mAb to the FcγII/IIIR followed by hamster anti mouse CD11c-FITC or CD11c-PE (BD ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3675565/
*  3D ADCC NK FACS ASSAY - Patent application
Patent applications in class Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor ... FCS and the percentage of the CD56 positive but CD3 negative cell fraction within the lymphocyte scatter gate was analyzed ... differentiation, proliferation and survival. [0038] In one embodiment the method for the generation of three dimensional ... dead Raji-cells. Panel A: Raji-cells only, panel B: Raji-cells and NK cells at a ratio of 1:1, panel C: Raji-cells and NK-cells ...
  http://www.patentsencyclopedia.com/app/20120309016