*  Faculty Research Page | Department of Molecular & Cell Biology
How is the polarity of epithelial cells established and maintained?. Epithelial cells constitute the most widespread and ... Cell polarity and proliferation appear coupled in a number of contexts, and disruption of epithelial polarity correlates with ... Cell, 147: 603-614. (cf commentary in Cell, Nature Reviews Molecular and Cell Biology, AAAS Science Podcast, NIH Radio) ... Developmental Cell, 9 (5): 687-98. (cf commentary in Current Biology). Bilder D. (2004). Epithelial polarity and proliferation ...
  http://mcb.berkeley.edu/faculty/CDB/bilderd.html
*  IJMS | Free Full-Text | Expression of Partitioning Defective 3 (Par-3) for Predicting Extrahepatic Metastasis and Survival...
We first confirmed that Par-3 was abundantly expressed in HCC cell lines by Western blot analysis. We used immunohistochemistry ... controls cell polarity and contributes to cell migration and cancer cell epithelial-to-mesenchymal transition. However, the ... Differential mRNA Expression Levels of Human Histone-Modifying Enzymes in Normal Karyotype B Cell Pediatric Acute Lymphoblastic ...
  http://www.mdpi.com/1422-0067/14/1/1684/notes
*  VackvSuG: BMP4 and Wnts niche successior Crumbs.
In the control of both apico-basal polarity and cell proliferation attributed to defective endocytosis. These results suggest ... either 2 daughter cells [2.] with stem cell loss, or 2 stem cells and eventual clone dominance, underlying stem cell function ... BMP signaling generate different astrocytic[2.] cell types a link between their lateral and apical components and related to ... In adult flies, is located at the apical-lateral membrane boundary, isoform S97 expression is localized to the cell borders, ...
  http://lnwme.blogspot.com/2008/09/bmp4-and-wnts-niche-successior-crumbs.html
*  Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization | Circulation
Endothelial cells forming the sprout must develop front-rear polarity to allow sprout extension. The adaptor proteins Nck1 and ... Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization. Alexandre Dubrac, Gael Genet, Roxana ... Here we show that the Nck adaptors are required for endothelial cell front-rear polarity and migration downstream of the ... Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization. Alexandre Dubrac, Gael Genet, Roxana ...
  http://circ.ahajournals.org/content/early/2015/12/09/CIRCULATIONAHA.115.017537
*  Exclusion of a Proton ATPase from the Apical Membrane Is Associated with Cell Polarity and Tip Growth in Nicotiana tabacum...
Adams, C.L., Chen, Y.-T., Smith, S.J., and James Nelson, W. (1998). Mechanisms of epithelial cell-cell adhesion and cell ... A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125: 535-548. ... Pollen tubes are cells that display an extreme example of cellular polarity and growth control, growing exclusively at the tip ... Here, we show that cell polarity in Nicotiana tabacum pollen is associated with the exclusion of a novel pollen-specific H+- ...
  http://www.plantcell.org/content/20/3/614.full
*  Rab14 regulates apical targeting in polarized epithelial cells - UQ eSpace
Epithelial cells. Polarity. Rab14 Q-Index Code C1 Q-Index Status Provisional Code ... Epithelial cells display distinct apical and basolateral membrane domains, and maintenance of this asymmetry is essential to ... Rab14 regulates apical targeting in polarized epithelial cells. Kitt, Khameeka N., Hernandez-Deviez, Delia, Ballantyne, Sarah D ... Rab14 regulates apical targeting in polarized epithelial cells. Traffic, 9 7: 1218-1231. doi:10.1111/j.1600-0854.2008.00752.x ...
  https://espace.library.uq.edu.au/view/UQ:315767
*  Numb is Required for the Production of Terminal Asymmetric Cell Divisions in the Developing Mouse Retina | Journal of...
2D,E). Since the increased cell death and disrupted neuroepithelium polarity are observed after the initial reduction of RPC ... E, Cell-cycle exit index (number of BrdU+/Ki67− cells divided by total number of BrdU+ cells) is reduced in the cDKO retina (n ... The cell-cycle time in hours was calculated using the following formula: 2 h × (PCNA+ cells/BrdU+ only cells), as described in ... The number of cells expressing markers of RGCs (Brn3b and Pax-6), horizontal cells (Lim-1), amacrine cells (Pax-6), bipolar ...
  http://www.jneurosci.org/content/32/48/17197
*  The in vivo function of mammalian cell and tissue polarity regulators - how to shape and maintain the epidermal barrier |...
Polarity comes in two main forms: cell polarity and tissue polarity. In cell polarity, asymmetry is achieved in individual ... 2008). Cell polarity and cancer-cell and tissue polarity as a non-canonical tumor suppressor. J. Cell Sci. 121, 1141-1150. doi: ... 2010). Cell polarity in eggs and epithelia: parallels and diversity. Cell 141, 757-774. doi:10.1016/j.cell.2010.05.011. ... 2009). Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr. Opin. Cell Biol. 21, 694-700. ...
  http://jcs.biologists.org/content/125/15/3501
*  VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog)
... apical-basolateral polarity regulator, spe-39 homolog), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... intracellular protein transport spermatogenesis endosome to lysosome transport endosome to lysosome transport cell ... VIPAS39 63894 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. ... intracellular protein transport spermatogenesis endosome to lysosome transport endosome to lysosome transport cell ...
  http://atlasgeneticsoncology.org/Genes/GC_VIPAS39.html
*  ZFIN Person: Reugels, Alexander
We are interested in the mechanisms underlying the establishment of cellular polarity and the generation of neuronal cell ... the putative cell fate determinant Numb and the role of the Par-3/Par-6/aPKC complex in setting up apicobasal polarity and ... We were able to show that neurulation in zebrafish embryos is characterised by oriented cell divisions and the progressive ... Proper spatial and temporal specification of cells during development is crucial for the generation of cellular diversity in ...
  https://zfin.org/ZDB-PERS-001206-1
*  Cell Polarity in the Preimplantation Mouse Embryo | SpringerLink
The union of two highly polarized cells, the sperm and the egg, initiates a series of dramatic cellular transformations that ... 8-cell blastomere polarity-inducing ability of a variety of embryonic cells and non-cellular materials, J. Cell Biol. 101: 343a ... The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early ... Nuccitelli, R., 1983, Transcellular ion currents: Signals and effectors of cell polarity, in: Modern Cell Biology, Vol. 2 (J.R ...
  https://link.springer.com/chapter/10.1007/978-1-4684-5332-4_2
*  Putting cell polarity on the map | JCB
Genetics and biochemistry have been used to map many of the individual pathways that establish and maintain cell polarity in ... Because the machinery of cell polarity development is highly conserved from yeast to humans, the newly described interactions ... the authors assayed the universe of likely protein-protein interactions involved in cell polarity development. The resulting ... which is essential for establishing and maintaining cell polarity. Still other interactions suggest direct connections between ...
  http://jcb.rupress.org/content/154/3/478.1
*  Cell Polarity: Uniklinik Essen
Analyses of cell-polarity organizing processes in human hematopoietic stem and progenitor cells. ... Freshly isolated hematopoietic stem and progenitor cells (HSPCs) are small, round cells which adopt a polarized cell shape upon ... we have started to study the impact of these proteins on the cell fate of human CD34+ cells in parallel. ... defect proteins Par3 and Par6 as well as with the rho-GTPase Cdc42 and this complex has been found to organize cell polarity in ...
  https://www.uk-essen.de/en/transfusionsmedizin/forschung/wg-giebel/research/cell-polarity/
*  establishment of T cell polarity QuickView - Correlation Engine
... signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. ... The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center… ...
  http://www.nextbio.com/b/search/ov/establishment%20of%20T%20cell%20polarity?id=31351&type=biogroup
*  Coordinating Cell Polarity - May 2014 | The Company of Biologists
... even within individual organisms it is apparent that multiple different strategies may be used to coordinate cell polarities, ... great progress has been made by experimental biologists towards understanding how during plant and animal morphogenesis cells ... as diverse a group as possible of experimental and theoretical biologists who are interested in mechanisms of coordinated cell ... Coordinating Cell Polarity - May 2014. Coordinating Cell Polarity. Organisers: Enrico Coen and David Strutt ...
  http://www.biologists.com/workshops/coordinating-cell-polarity-may-2014/
*  Prickle3 - Prickle planar cell polarity protein 3 - Mus musculus (Mouse) - Prickle3 gene & protein
Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in ... pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and ... the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By ... Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during ...
  http://www.uniprot.org/uniprot/Q80VL3
*  Cell polarity - Wikipedia
Epithelial polarity Cell migration Embryogenesis Embryonic development Asymmetric cell division 3D cell culture Cell culture ... cell migration, cell-cell signalling and fertilization. Cell polarity is an example of the self-organization property that all ... Cell polarity refers to spatial differences in shape, structure, and function within a cell. Almost all cell types exhibit some ... "Cell Polarity in Eggs and Epithelia: Parallels and Diversity". Cell. 141 (5): 757-774. doi:10.1016/j.cell.2010.05.011. PMID ...
  https://en.wikipedia.org/wiki/Cell_polarity
*  Cell Polarity In Development And Disease, Book by Douglas W Houston (Paperback) | chapters.indigo.ca
Buy the Paperback Book Cell Polarity In Development And Disease by Douglas W Houston at Indigo.ca, Canada's largest bookstore ... 3. Pluripotency and cell polarity. 4. The role of cell polarity in adult stem cell maintenance. 5. Integration of cell polarity ... Hepatic cell polarity and disease. 14. Epidermal cell polarity and disease. 15. Cell polarity and sensory cell defects ... 6. Cell polarity and the onset and progression of cancer. 7. Cell division and cell polarity. 8. Polarized membrane/vesicle ...
  https://www.chapters.indigo.ca/en-ca/books/cell-polarity-in-development-and/9780128024386-item.html
*  Recent Articles | Planar-cell Polarity And Genetics & Genomics | The Scientist Magazine®| Page 5
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until ... T-cell therapies are not just for cancer. Researchers are also advancing immunotherapy methods to protect bone marrow ... From single-cell analysis to whole-genome sequencing, this year's best new products shine on many levels. ... tags: planar-cell polarity x genetics & genomics x The Scientist. » planar-cell polarity and genetics & genomics ...
  https://www.the-scientist.com/?articles.list/tagNo/2480,9/tags/planar-cell-polarity,genetics--amp--genomics/pageNo/5/
*  Recent Articles | Planar-cell Polarity And Genetics & Genomics | The Scientist Magazine®| Page 9
Daily News Stem Cell Vaccine Protects Mice From Cancer Stem cells and cancer cells have enough molecular similarities that the ... In a first, scientists reanimate the fish using embedded gold nanoparticles that heat up cells by absorbing laser light. ... Two freely available databases include data on hundreds of human cancer cell lines. ... tags: planar-cell polarity x genetics & genomics x The Scientist. » planar-cell polarity and genetics & genomics ...
  https://www.the-scientist.com/?articles.list/tagNo/2480,9/tags/planar-cell-polarity,genetics--amp--genomics/pageNo/9/
*  Recent Articles | Planar-cell Polarity And Disease/Medicine | The Scientist Magazine®| Page 59
Stem Cells: Safe Haven For TB. By Nsikan Akpan , February 5, 2013 ... The first human trial of a treatment using induced pluripotent stem cells has received conditional approval from an ... Tuberculosis bacteria find shelter from drugs and the body's defenses in bone marrow stem cells. ... tags: planar-cell polarity x disease/medicine x The Scientist. » planar-cell polarity and disease/medicine ...
  https://www.the-scientist.com/?articles.list/tagNo/2480,6/tags/planar-cell-polarity,disease-medicine/pageNo/59/
*  Apical targeting of syntaxin 3 is essential for epithelial cell polarity | JCB
Instead, cells form tumor-like cell structures that lack tight junctions and exhibit no apparent cell polarity. Bars, 5 μm. (B ... For unknown reasons, cell polarity is more severely affected when MDCK cells are cultured in 3D collagen. In the case of ... Expression of mistargeted syntaxin 3 causes disruption of cell polarity. (A) MDCK cells stably transfected for wt-syntaxin 3 or ... PATJ regulates tight junction formation and polarity in mammalian epithelial cells. J. Cell Biol. 168:705-711. ...
  http://jcb.rupress.org/content/173/6/937
*  Recent Articles | Planar-cell Polarity And Cell & Molecular Biology | The Scientist Magazine®| Page 2
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until ... Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, ... Single-cell analyses from mouse samples detail the changes in cell distribution during infections. ... Opinion: How to Define Cell Type. By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage , November 1, 2017 ...
  https://www.the-scientist.com/?articles.list/tagNo/2480,4/tags/planar-cell-polarity,cell--amp--molecular-biology/pageNo/2/
*  Mob2p: coordinating cell polarity and the cell cycle | Journal of Cell Science
Mob2p: coordinating cell polarity and the cell cycle Message Subject (Your Name) has sent you a message from Journal of Cell ... Cells can tightly couple changes in polarity to the cell cycle. New-end take off (NETO) in fission yeast provides a good ... The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ... a kinase whose relatives regulate cell polarity in several species. The authors demonstrate that Mob2p and Orb6p form a complex ...
  http://jcs.biologists.org/content/116/1/e105
*  Wnt4 overexpression promotes thymoma development through a JNK‑mediated planar cell polarity‑like pathway
Cells in Q2 are undergoing advanced apoptosis, cells in Q3 are normal live cells and cells in Q4 are viable apoptotic cells. ... viable apoptotic cells are Annexin V+/PI− cells (Q4); and advanced apoptotic cells and dead cells are Annexin V+/PI+ cells (Q2 ... Different cells can be distinguished from the four quadrant diagram: Normal live cells are Annexin V−/PI− cells (Q3); ... Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS One. 6: ...
  https://www.spandidos-publications.com/ol/15/1/83