Faculty Research Page | Department of Molecular & Cell Biology
How is the polarity of epithelial cells established and maintained?. Epithelial cells constitute the most widespread and ... Cell polarity and proliferation appear coupled in a number of contexts, and disruption of epithelial polarity correlates with ... Cell, 147: 603-614. (cf commentary in Cell, Nature Reviews Molecular and Cell Biology, AAAS Science Podcast, NIH Radio) ... Developmental Cell, 9 (5): 687-98. (cf commentary in Current Biology). Bilder D. (2004). Epithelial polarity and proliferation ...http://mcb.berkeley.edu/faculty/CDB/bilderd.html
IJMS | Free Full-Text | Expression of Partitioning Defective 3 (Par-3) for Predicting Extrahepatic Metastasis and Survival...
We first confirmed that Par-3 was abundantly expressed in HCC cell lines by Western blot analysis. We used immunohistochemistry ... controls cell polarity and contributes to cell migration and cancer cell epithelial-to-mesenchymal transition. However, the ... Differential mRNA Expression Levels of Human Histone-Modifying Enzymes in Normal Karyotype B Cell Pediatric Acute Lymphoblastic ...http://www.mdpi.com/1422-0067/14/1/1684/notes
VackvSuG: BMP4 and Wnts niche successior Crumbs.
In the control of both apico-basal polarity and cell proliferation attributed to defective endocytosis. These results suggest ... either 2 daughter cells [2.] with stem cell loss, or 2 stem cells and eventual clone dominance, underlying stem cell function ... BMP signaling generate different astrocytic[2.] cell types a link between their lateral and apical components and related to ... In adult flies, is located at the apical-lateral membrane boundary, isoform S97 expression is localized to the cell borders, ...http://lnwme.blogspot.com/2008/09/bmp4-and-wnts-niche-successior-crumbs.html
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization | Circulation
Endothelial cells forming the sprout must develop front-rear polarity to allow sprout extension. The adaptor proteins Nck1 and ... Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization. Alexandre Dubrac, Gael Genet, Roxana ... Here we show that the Nck adaptors are required for endothelial cell front-rear polarity and migration downstream of the ... Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization. Alexandre Dubrac, Gael Genet, Roxana ...http://circ.ahajournals.org/content/early/2015/12/09/CIRCULATIONAHA.115.017537
Exclusion of a Proton ATPase from the Apical Membrane Is Associated with Cell Polarity and Tip Growth in Nicotiana tabacum...
Adams, C.L., Chen, Y.-T., Smith, S.J., and James Nelson, W. (1998). Mechanisms of epithelial cell-cell adhesion and cell ... A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125: 535-548. ... Pollen tubes are cells that display an extreme example of cellular polarity and growth control, growing exclusively at the tip ... Here, we show that cell polarity in Nicotiana tabacum pollen is associated with the exclusion of a novel pollen-specific H+- ...http://www.plantcell.org/content/20/3/614.full
Viruses | Free Full-Text | High Throughput Method to Quantify Anterior-Posterior Polarity of T-Cells and Epithelial Cells
One measure of cell polarity induced by both IS or VS formation is the repositioning of the microtubule organizing center (MTOC ... We also show that the system can be adapted to score anterior-posterior polarity establishment of epithelial cells. This ... Here we describe an automated, high throughput system to score repositioning of the MTOC and thereby cell polarity ... This polarization resembles anterior-posterior cell polarity induced by immunological synapse (IS) formation, which is more ...http://www.mdpi.com/1999-4915/3/12/2396/xml
Numb is Required for the Production of Terminal Asymmetric Cell Divisions in the Developing Mouse Retina | Journal of...
2D,E). Since the increased cell death and disrupted neuroepithelium polarity are observed after the initial reduction of RPC ... E, Cell-cycle exit index (number of BrdU+/Ki67− cells divided by total number of BrdU+ cells) is reduced in the cDKO retina (n ... The cell-cycle time in hours was calculated using the following formula: 2 h × (PCNA+ cells/BrdU+ only cells), as described in ... The number of cells expressing markers of RGCs (Brn3b and Pax-6), horizontal cells (Lim-1), amacrine cells (Pax-6), bipolar ...http://www.jneurosci.org/content/32/48/17197
Non-Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation | Circulation...
Non-Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation. Helen M. ... Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol. 2006; 17: 194-203. ... Non-Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation ... Non-Cell-Autonomous Roles for the Planar Cell Polarity Gene Vangl2 in Development of the Coronary Circulation ...http://circres.ahajournals.org/content/102/5/615.long
The in vivo function of mammalian cell and tissue polarity regulators - how to shape and maintain the epidermal barrier |...
Polarity comes in two main forms: cell polarity and tissue polarity. In cell polarity, asymmetry is achieved in individual ... 2008). Cell polarity and cancer-cell and tissue polarity as a non-canonical tumor suppressor. J. Cell Sci. 121, 1141-1150. doi: ... 2010). Cell polarity in eggs and epithelia: parallels and diversity. Cell 141, 757-774. doi:10.1016/j.cell.2010.05.011. ... 2009). Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr. Opin. Cell Biol. 21, 694-700. ...http://jcs.biologists.org/content/125/15/3501
VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog)
... apical-basolateral polarity regulator, spe-39 homolog), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... intracellular protein transport spermatogenesis endosome to lysosome transport endosome to lysosome transport cell ... VIPAS39 63894 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. ... intracellular protein transport spermatogenesis endosome to lysosome transport endosome to lysosome transport cell ...http://atlasgeneticsoncology.org/Genes/GC_VIPAS39.html
Putting cell polarity on the map | JCB
Genetics and biochemistry have been used to map many of the individual pathways that establish and maintain cell polarity in ... Because the machinery of cell polarity development is highly conserved from yeast to humans, the newly described interactions ... the authors assayed the universe of likely protein-protein interactions involved in cell polarity development. The resulting ... which is essential for establishing and maintaining cell polarity. Still other interactions suggest direct connections between ...http://jcb.rupress.org/content/154/3/478.1
ZFIN Person: Reugels, Alexander
We are interested in the mechanisms underlying the establishment of cellular polarity and the generation of neuronal cell ... the putative cell fate determinant Numb and the role of the Par-3/Par-6/aPKC complex in setting up apicobasal polarity and ... We were able to show that neurulation in zebrafish embryos is characterised by oriented cell divisions and the progressive ... Proper spatial and temporal specification of cells during development is crucial for the generation of cellular diversity in ...https://zfin.org/ZDB-PERS-001206-1
Download a Free Excerpt from Cell Polarity:. Preface. Role of Polarity Proteins in the Generation and Organization of Apical ... Phosphoinositides and Membrane Targeting in Cell Polarity. Gerald R. Hammond and Yang Hong. The Crumbs3 Polarity Protein. Ben ... Making Heads or Tails of It: Cell-Cell Adhesion in Cellular and Supracellular Polarity in Collective Migration. Jan-Hendrik ... Cell Polarity. Book Series: A Cold Spring Harbor Perspectives in Biology Collection. Subject Area(s): Developmental Biology; ...https://cshlpress.com/default.tpl?action=full&cart=1512675988600415264&--eqskudatarq=1159
Cell Polarity in the Preimplantation Mouse Embryo | SpringerLink
The union of two highly polarized cells, the sperm and the egg, initiates a series of dramatic cellular transformations that ... 8-cell blastomere polarity-inducing ability of a variety of embryonic cells and non-cellular materials, J. Cell Biol. 101: 343a ... The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early ... Nuccitelli, R., 1983, Transcellular ion currents: Signals and effectors of cell polarity, in: Modern Cell Biology, Vol. 2 (J.R ...https://link.springer.com/chapter/10.1007/978-1-4684-5332-4_2
Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases
The planar cell polarity (PCP) pathway is a highly conserved signaling pathway that mediates changes in cell polarity and cell ... Noncanonical Wnt pathways, also called the planar cell polarity (PCP) signaling pathway, work on planar cell polarity in ... strongly suggesting that this is a defect in cell polarity and/or cell movement, rather than some other aspect of cell behavior ... The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and ...https://www.hindawi.com/journals/bmri/2011/589414/
Cell Polarity and Subcellular RNA Localization : Dietmar Richter : 9783540411420
Cell Polarity and Subcellular RNA Localization by Dietmar Richter, 9783540411420, available at Book Depository with free ... Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity ... Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity ... 4 CREB Protein Moves from the Dendrite to the Cell Nucleus.- 5 Potential Importance of Dendritic CREB in Modulating.- Neuronal ...https://www.bookdepository.com/Cell-Polarity-Subcellular-RNA-Localization-Dietmar-Richter/9783540411420?ref=bd_ser_1_1
Cell polarity and membrane dynamics
... 26-31 May 2019 , Sant Feliu de Guixols, Spain ...http://events.embo.org/coming-soon/index.php?EventID=w19-09
Cell Polarity: Uniklinik Essen
Analyses of cell-polarity organizing processes in human hematopoietic stem and progenitor cells. ... Freshly isolated hematopoietic stem and progenitor cells (HSPCs) are small, round cells which adopt a polarized cell shape upon ... we have started to study the impact of these proteins on the cell fate of human CD34+ cells in parallel. ... defect proteins Par3 and Par6 as well as with the rho-GTPase Cdc42 and this complex has been found to organize cell polarity in ...https://www.uk-essen.de/en/transfusionsmedizin/forschung/wg-giebel/research/cell-polarity/
establishment of T cell polarity QuickView - Correlation Engine
... signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. ... The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center… ...http://www.nextbio.com/b/search/ov/establishment%20of%20T%20cell%20polarity?id=31351&type=biogroup
Helicobacter pylori Usurps Cell Polarity to Turn the Cell Surface into a Replicative Niche
We utilized live-cell imaging and a cell culture model of polarized epithelial cells to address why Hp attaches to the cell ... which is injected directly into host cells by the bacteria. We found that CagA's ability to perturb cell polarity is important ... We discovered that Hp is able to grow on the surface of epithelial cells, even in conditions where the free-swimming bacteria ... The bacteria live in close proximity to the epithelial lining and can adhere directly to the host cell membrane and deliver ...https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000407
Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis | Science
Using high-resolution live-cell imaging in chick neural tube, we uncover a form of cell subdivision that abscises apical cell ... Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis ... Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis ... Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis ...http://science.sciencemag.org/content/343/6167/200
Coordinating Cell Polarity - May 2014 | The Company of Biologists
... even within individual organisms it is apparent that multiple different strategies may be used to coordinate cell polarities, ... great progress has been made by experimental biologists towards understanding how during plant and animal morphogenesis cells ... as diverse a group as possible of experimental and theoretical biologists who are interested in mechanisms of coordinated cell ... Coordinating Cell Polarity - May 2014. Coordinating Cell Polarity. Organisers: Enrico Coen and David Strutt ...http://www.biologists.com/workshops/coordinating-cell-polarity-may-2014/
Cell Polarity In Development And Disease, Book by Douglas W Houston (Paperback) | chapters.indigo.ca
Buy the Paperback Book Cell Polarity In Development And Disease by Douglas W Houston at Indigo.ca, Canada's largest bookstore ... 3. Pluripotency and cell polarity. 4. The role of cell polarity in adult stem cell maintenance. 5. Integration of cell polarity ... Hepatic cell polarity and disease. 14. Epidermal cell polarity and disease. 15. Cell polarity and sensory cell defects ... 6. Cell polarity and the onset and progression of cancer. 7. Cell division and cell polarity. 8. Polarized membrane/vesicle ...https://www.chapters.indigo.ca/en-ca/books/cell-polarity-in-development-and/9780128024386-item.html
Prickle3 - Prickle planar cell polarity protein 3 - Mus musculus (Mouse) - Prickle3 gene & protein
Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in ... pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and ... the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By ... Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during ...http://www.uniprot.org/uniprot/Q80VL3
DiVA - Search result
The mobile revolution is here to stay, and today most people have (at least) one cell phone at home. Some even a PDA (Personal ... In a second model, two polarities and three levels of certainty are applied on diagnostic statements from an emergency ... After a couple of failures in the development process, almost every cell phone has support for mobile Internet today. Instead ... And what kind of obstacles lies in the way of making this service available for everyone that uses a cell phone - not only the ...http://www.diva-portal.org/smash/resultList.jsf?p=2901&fs=false&language=en&searchType=SIMPLE&query=&af=%5B%5D&aq=%5B%5B%7B%22organisationId%22%3A%22507%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all