Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. J. Cell Biol. ... not only in the formation of cell-cell junctions between contacting cells, but also in directional cell movement in moving ... Cell movement tracking of PDGF-stimulated NIH3T3 cells. Wild-type and afadin-knockdown NIH3T3 cells seeded on the μ-Slide VI ... D) Directional cell movement estimated by the wound-healing assay. Confluent cell monolayers of each type of NIH3T3 cell were ...http://jcs.biologists.org/content/122/23/4319
ERK2 drives tumour cell migration in 3D microenvironments by suppressing expression of Rab17 and Liprin-β2 | Journal of Cell...
A detailed quantitative analysis of cell movement on 3D matrices indicates that ERK2 knockdown impairs cellular motility by ... The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ... on cell motility. A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parson's lab at ... First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, ...http://jcs.biologists.org/content/early/2012/02/08/jcs.092916
"Cell movement is guided by the rigidity of the substrate" by Chun-Min Lo, Hong-Bei Wang et al.
In this study, we demonstrate that cell movement can also be guided by purely physical interactions at the cell-substrate ... It is well known that in these processes cell movements can be guided by gradients of various chemical signals. ... we discovered that cell movement could also be guided by manipulating the flexible substrate to produce mechanical strains in ... In contrast, cells migrating from the stiff side turned around or retracted as they reached the boundary. We call this apparent ...https://escholarship.umassmed.edu/oapubs/269/
Seeing is believing: Powerful new microscopy fuels studies in cell dynamics
Her pursuit will be greatly assisted by advances in live-cell imaging now enabling investigators to track the movement of ... Cell culture and in vivo experiments with mice confirmed that Myosin-VI enhances cell migration and that curbing its expression ... Seeing is believing: Powerful new microscopy fuels studies in cell dynamics. March 2005--Denise Montell has been studying cell ... "Data from a large number of patients confirms that we don't detect it at all in normal cells, but we always see a lot of it in ...https://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/news_events/articles_and_stories/technology/200603_seeing_believing.html
Cell motility assay - Biometric Imaging, Inc.
A. Single-Cell Tracking and Single Cell-Movement Parameters For purposes of tracking the movement of single cells in an assay, ... Examples of tumor cell antigens include CD9, CD10, CD19 and CD20 present on B cell lymphoma cells; tumor cell antigens that are ... in which the cells migrate through a filter that has pore openings that are smaller than the cell diameter. Typically, cells of ... endothelial cells, epithelial cells, neurons, tumor cells, motile gametes (e.g. sperm), motile forms of bacteria (e.g., the ...http://www.freepatentsonline.com/6238874.html
Effect of TGFβ1 on the phenotype, migratory ability, a | Open-i
PBMCs were depleted of CD16+ cells using miniMACS magnetic selection. T ... Cell Movement. *Cell Survival. *Endothelium, Vascular/cytology/immunology. *HLA-DR Antigens/immunology ... A) The cell surface phenotype of these cultured cells was assessed by flow cytometry. Control mAb staining is depicted as a ... A) The cell surface phenotype of these cultured cells was assessed by flow cytometry. Control mAb staining is depicted as a ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196052_20011608f8&req=4
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet- ... Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet- ... Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet- ... Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet- ...http://jcs.biologists.org/content/early/2009/11/03/jcs.048439
Examples of collective cell migration. First column: sc | Open-i
The regions where cells are interacting are depicted ... Examples of collective cell migration. First column: schematic ... Mentions: In multicellular organisms, cells often move in groups rather than as singular cells. Cell migration in loosely or ... Mentions: In multicellular organisms, cells often move in groups rather than as singular cells. Cell migration in loosely or ... in which inhibition of cell protrusion between the cells and presence of large lamellipodia and filopodia in the leader cells ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2927909_gr2&req=4
Cell movement in development | Development
J Cell Sci 2017 130: 3809-3817; doi: 10.1242/jcs.206532. Interkinetic nuclear migration and basal tethering facilitates post- ... TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. Kuisheng Liu, Yan Zhang, ... Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and ...http://dev.biologists.org/content/82/Supplement/115
Cell movement explained by molecular recycling
Scientists at The University of Manchester have identified the method by which cells control the recycling of molecules, a ... By studying the movement of fibroblast cells using sophisticated imaging techniques, Dr Morgan and the team identified the role ... The next step will be to investigate how Syndecan-4 can be manipulated to control cell movement with a view to developing novel ... Once they have been used by the cell, integrins are moved from the surface to a store inside the cell. When the time is right ...https://www.nanowerk.com/news2/biotech/newsid=29308.php
Cellular 'racetrack' accurately clocks brain cancer cell movement | EurekAlert! Science News
... of human brain tumor cell movement along a small glass 'track.' The assay, so far tested on the cells of 14 glioblastoma ... Cellular 'racetrack' accurately clocks brain cancer cell movement. Johns Hopkins Medicine. Journal. Cell Reports. Funder. NIH/ ... of human brain tumor cell movement along a small glass "track." The assay, so far tested on the cells of 14 glioblastoma ... They tested PDGF to see if it would prime the glioblastoma cells for movement rather than growth by growing the glioblastoma ...https://www.eurekalert.org/pub_releases/2016-06/jhm-ca060716.php
Cell movement tale told by bacterial tail protein | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...http://science.sciencemag.org/content/269/5220/30
SAS Team Discovers Protein Needed for Cell Movement | School of Arts & Sciences
The findings deepen the understanding of how cells initiate movement, and have implications for conditions dependent on cell ... A new multi-disciplinary study at Penn illuminates a crucial step in the process of cell movement. The protein they examined, ... Exo70, induces a reshaping of the cell's plasma membrane, a necessary step in how a cell migrates from one location to another ... underscoring the importance of the molecule in helping cells make directed movements. ...http://www.sas.upenn.edu/news/sas-team-discovers-protein-needed-cell-movement
Finding sheds new light into mysterious process of cell movement during development
What begins as a disordered, chaotic motion changes into an orderly movement. As this happens the cells also change from a ... Finding sheds new light into mysterious process of cell movement during development. 15.08.2002 ... By labeling the nerve cells with fluorescent protein, the biologists determined that the trilobite cells moved much slower and ... the researchers report the discovery that a single protein facilitates the movements of cells within the developing embryo of ...http://www.innovations-report.com/html/reports/life-sciences/report-12095.html
New understanding of cell movement may yield ways to brake cancer s spread
From birth until death, our cells migrate: nerve cells make their vital connections, embryonic cells move to the proper places ... the molecular machinery needed for cell movement begins accumulating at the leading edge, or front of a cell in response to a ... New understanding of cell movement may yield ways to brake cancer s spread. 01.08.2005 ... Cell growth and cell differentiation as well as the release and efficacy of hormones such as insulin depend on the presence of ...https://www.innovations-report.com/html/reports/life-sciences/report-47265.html
Experts and Doctors on cell movement in Tianjin, Tianjin Shi, China
Locale about Experts and Doctors on cell movement in Tianjin, Tianjin Shi, China ... hep g2 cells*neoplasm grading*group iv phospholipases a2*lim kinases*enhancer of zeste homolog 2 protein*tumor stem cell assay* ... Experts and Doctors on cell movement in Tianjin, Tianjin Shi, China. Summary. Locale: Tianjin, Tianjin Shi, China ... You are here: Locale , China , Tianjin Shi , Experts and Doctors on cell movement in Tianjin, Tianjin Shi, China ...http://www.labome.org/locale/china/tianjin/experts-and-doctors-on-cell-movement-in-tianjin--tianjin-shi--china-194113.html
TRPM7 regulates polarized cell movements | Biochemical Journal
TRPM7 regulates polarized cell movements. Li-Ting Su, Wei Liu, Hsiang-Chin Chen, Omayra González-Pagán, Raymond Habas, Loren W. ... TRPM7 regulates polarized cell movements. Li-Ting Su, Wei Liu, Hsiang-Chin Chen, Omayra González-Pagán, Raymond Habas, Loren W. ... and the ability of cells to form lamellipodia and to execute polarized cell movements. A pulldown-purification assay revealed ... is also effective in restoring the change in cell morphology, disruption of the cytoskeleton and directional cell motility ...http://www.biochemj.org/content/434/3/513
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement | Development
... showing an unknown mode of collective cell movement with dynamic 'cell-mixing'. Mosaic analysis, which enabled us to monitor ... Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement Message Subject (Your Name) ... Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Satoshi Arima, Koichi ... Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Satoshi Arima, Koichi ...http://dev.biologists.org/content/early/2011/09/28/dev.068023
NIH and UNC researchers define role of protein vinculin in cell movement - Healthcanal.com : Healthcanal.com
... in regulating cell movement? Studies with knockout models that deactivated vinculin show that the cell still can move without ... Cell movement plays an important role in cancer research because of the role of metastasis in tumor development. In many ... "Vinculin makes cells almost smarter, in a way. It really helps the cells decide if they are going to stay put or if they are ... "By helping us better understand how cell movement occurs, we can better understand metastasis," said Thompson. Media contact: ...https://www.healthcanal.com/medical-breakthroughs/41873-nih-and-unc-researchers-define-role-of-protein-vinculin-in-cell-movement.html
Where are they going? Directed cell movement in morphogenesis | Genome Biology | Full Text
Spring Meeting of the British Societies for Cell and Developmental Biology, University of Sussex, Brighton, UK, 3-6 April, 2001 ... and it also reduces cell polarity. By expressing the cytoplasmic domain of the α4 integrin in Jurkat T cells, cell migration is ... In an astrocyte cell-layer model, cells at the leading edge polarize and extend protrusions towards a scratched 'wound'. ... Cells lacking myosin II function cannot move under highly concentrated agarose, whereas wild-type cells can, suggesting that ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2001-2-6-reports4014
Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.
... Huang H., Lu F.I., Jia S., Meng ... Knockdown of amotl2 expression delays epiboly and impairs convergence and extension movement, and amotl2-deficient cells in ... These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos. ... Angiomotin (Amot), the founding member of the Motin family, is involved in angiogenesis by regulating endothelial cell motility ...http://www.uniprot.org/citations/17293535
The Snail genes as inducers of cell movement and survival: implications in development and cancer | Development
To conclude, these data together therefore suggest that Snail regulates cell movement and adhesion rather than cell fate. ... Cells move together even though Snail still functions as an E-Cadherin repressor. Cell-cell adhesion is reduced but maintained ... Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr. Opin. Genet. ... FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell 1, 37-49 ...http://dev.biologists.org/content/132/14/3151?ijkey=d251441f1d0d41652edc68def529d08f2c98eb44&keytype2=tf_ipsecsha
talks.cam : Signals regulating cell fates and cell movements in the vertebrate embryo
Signals regulating cell fates and cell movements in the vertebrate embryo. Add to your list(s) Download to your calendar using ... University of Cambridge , Talks.cam , Developmental Biology Seminar Series , Signals regulating cell fates and cell movements ... Epigenetic regulation of antibody production and the formation of B cell memory to acute and chronic infections ...https://talks.cam.ac.uk/talk/index/104620
Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation | JCB
A compromise in cell-cell interactions could disrupt the coherent movement of neighboring cells and the ability of cells to ... Defects in cell movements in pcdh19 and ncad morphants. To characterize cell movements in vivo, we used transgenic embryos ... Video 2 shows cell movements in an embryo injected with morpholinos directed against pcdh19. Video 3 shows cell movements in a ... disrupting both the directedness of cell movements and the coherence of movements among neighboring cells. Our results suggest ...http://jcb.rupress.org/content/191/5/1029
'Chase and Run' Cell Movement Mechanism Explains...
Healthy cells of the body try to escape from tumor cells, but are followed by malignant cells because the healthy cells produce ... Similarly the neural crest cells follow the placode cells, but placode cells move away when touched by neural crest cells.". ... Now, using embryonic cells called 'neural crest cells' (which are similar to cancer cells in term of their invasive behaviour) ... Chase and Run' Cell Movement Mechanism Explains Metastasis News Jun 20, 2013 ...https://www.technologynetworks.com/genomics/news/chase-and-run-cell-movement-mechanism-explains-metastasis-190413