Evidence of Positive Darwinian Selection in Omp85, a Highly Conserved Bacterial Outer Membrane Protein Essential for Cell...
Omp85is a highly conserved outer membrane protein found in all gram-negative bacteria. It is essential for bacterial cell ... Evidence of Positive Darwinian Selection in Omp85, a Highly Conserved Bacterial Outer Membrane Protein Essential for Cell ... plays an integral function in the positioning and folding of other outer membrane proteins into the bacterial outer membrane. ... a Highly Conserved Bacterial Outer Membrane Protein Essential for Cell Viability. Journal of Molecular Evolution, 61 (1). pp. ...http://eprints.maynoothuniversity.ie/667/
Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes | PNAS
... in the outer leaflet (32⇓-34). The inner and outer membranes contain various peripheral and integral membrane proteins that ... 2000) Structure and function of bacterial outer membrane proteins: Barrels in a nutshell. Mol Microbiol 37(2):239-253. ... This method transfers many of the components of the bacterial inner and outer membranes, including transmembrane proteins such ... Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes. Qi Xiao, Srujana S. Yadavalli, ...http://www.pnas.org/content/113/9/E1134.full
Rocky Mountain Spotted Fever
Once it attaches to the endothelial cell membrane through bacterial outer membrane proteins it is phagocytosed and replicates ... it induces host-cell reactive oxygen species formation and actin polymerization to aid in their extrusion from the cell to ... The white blood cell count may be normal, elevated, or decreased; however, there may be an increase in bands. CSF may show a ... Basal cell vacuolization, lymphocytic exocytosis, fibrin thrombi formation, and capillary wall necrosis can be seen in a ...https://www.clinicalpainadvisor.com/dermatology/rocky-mountain-spotted-fever/article/591219/
Biofuel cells without the bio cells
Artist's depiction of purified, electrified bacterial cell outer membrane protein binding with and passing electrons to the ... In purified protein fuel cells, the seal made by the protein coating on the electrode effectively acts in place of the membrane ... Squier and principal authors Yijia Xiong and Liang Shi, PNNL staff scientists, discovered that the proteins, outer membrane c- ... In this purified-protein fuel cell, the seal made by the protein coating on the electrode effectively acts in place of a ...http://www.innovations-report.com/html/reports/life-sciences/report-72407.html
Metabolism of HeLa cells revealed through autofluorescence lifetime upon infection with enterohemorrhagic Escherichia coli
... is translocated into the host cell membrane and consequently interacts with a bacterial outer membrane protein, intimin, and ... b) EHEC infected cells. (c) STS-treated cells. (d) Cells infected with escN-deleted EHEC. (e) JM109-infected cells. (f) cells ... to deliver bacterial effector proteins into host cells to subvert host cell signaling pathways. One of the effector proteins of ... The percentage of cells in each cellular state (viable, early apoptotic cells, late apoptotic cells, or dead cells) is shown ...https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-10/101503/Metabolism-of-HeLa-cells-revealed-through-autofluorescence-lifetime-upon-infection/10.1117/1.JBO.17.10.101503.full
Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review
... cymene has a greater affinity towards bacterial cell membranes and thus may disturb the membrane integrity [16, 157]. The outer ... proteins metabolism, and calcium ion concentrations. Therefore, the permeabilization of inner and outer mitochondrial membranes ... In yeast cells, essential oils establish a membrane potential across the cell membrane and disrupt the production of ATP, which ... membrane-coupled), membrane transport, and other metabolic regulatory functions. The disruption of the cell membrane by ...https://www.hindawi.com/journals/ecam/2016/3012462/
Haemophilus Somnus: Antigen Analysis and Immune Responses | Springer for Research & Development
Bacterial Vaginosis Major Outer Membrane Protein Bovine Endothelial Cell Convalescent Serum Experimental Pneumonia These ... Cole, S.P., Guiney, D.G., and Corbeil, L.B., 1992, Two linked genes for outer membrane proteins are absent in four non-disease ... Tagawa, Y., Haritani, M., Ishikawa, H., and Yuasa, N., 1993a, Antigenic analysis of the major outer membrane protein of ... Tagawa, Y., Haritani, M., Ishikawa, H., and Yuasa, N., 1993b, Characterization of a heat-modifiable outer membrane protein of ...https://rd.springer.com/chapter/10.1007/978-1-4899-0978-7_6
Frontiers | O-Serotype Conversion in Salmonella Typhimurium Induces Protective Immune Responses against Invasive Non-Typhoidal...
Some of these outer membrane proteins induce T-cell-mediated immune responses essential for clearance of the bacterial ... Typhimurium outer membrane proteins (Figure 3E). This seems likely, as antibody responses to outer membrane proteins have been ... Typhimurium (22, 23, 43, 44, 49). Immunization with purified outer membrane proteins from rough S. Typhimurium elicits long- ... Udhayakumar V, Muthukkaruppan V. Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice. ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01647/full
Frontiers | Agrobacterium tumefaciens responses to plant-derived signaling molecules | Plant Science
An Agrobacterium gene involved in tumorigenesis encodes an outer membrane protein exposed on the bacterial cell surface. Gene ... aopB encoding an outer membrane protein, katA encoding a catalase, pckA encoding phosphoenol carboxykinase, and the imp gene ... QS enables a single cell to sense the number of surrounding cells (cell density) and coordinates their collective behavior. In ... The evolution and survival of Agrobacterium as a bacterial species depends on an intricate balance of two populations of cells ...https://www.frontiersin.org/articles/10.3389/fpls.2014.00322/full
RCSB PDB - Protein Feature View - Adhesin YadA - P0C2W0 (YADA2 YEREN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Collagen-binding outer membrane protein forming a fibrillar matrix on the bacterial cell surface. Promotes initial attachment ... domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell ... The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion ...http://www.rcsb.org/pdb/protein/P0C2W0
E. coli infection mechanism - Stock Image C002/5829 - Science Photo Library
The formation of these pedestals is catalysed by the bacterial outer membrane protein intimin, which is yellow. - Stock Image ... The intestinal cell's nucleus is the large blue object. Bacterial DNA (deoxyribonucleic acid) is also blue. Actin protein ... Here the actin filaments are causing protrusions on the cells' membranes known as pedestals, which help this pathogenic ... Immunofluorescence deconvolution micrograph of Escherichia coli bacteria (rods) infecting an intestinal cell. ...http://www.sciencephoto.com/media/90082/view
Listeria - Wikipedia
The comet forms in a polar manner and aids the bacterial migration to the host cell's outer membrane. Gelsolin, an actin ... It induces directed polymerization of actin by the ActA transmembrane protein, thus pushing the bacterial cell around. L. ... Once at the cell surface, the actin-propelled Listeria pushes against the cell's membrane to form protrusions called filopods ... For treatment to be effective, the antibiotic must penetrate the host cell and bind to penicillin-binding protein 3 (PBP3). ...https://en.wikipedia.org/wiki/Listeria
NMR STUDIES OF BACTERIAL TYPE III SECRETION APPARATUS NEEDLE AND TIP PROTEINS AND THE NMR STRUCTURE OF THE HANTAVIRUS...
The TTSA basal body spans the bacterial inner and outer membranes, and the external needle is topped with a tip complex that ... functions like a syringe to inject proteins through an external needle and into a target cell's membrane and cytosol. ... NMR STUDIES OF BACTERIAL TYPE III SECRETION APPARATUS NEEDLE AND TIP PROTEINS AND THE NMR STRUCTURE OF THE HANTAVIRUS ... The tip complex is assembled by SipD, the tip protein in Salmonella, and BipD, the tip protein in Burkholderia. We also ...https://kuscholarworks.ku.edu/handle/1808/5438
Transmembrane protein - Wikipedia
Outer membrane auxiliary proteins (polysaccharide transporter)  - α-helical transmembrane proteins from the outer bacterial ... Alpha-helical proteins are present in the inner membranes of bacterial cells or the plasma membrane of eukaryotes, and ... that includes outer membrane protease OmpT and adhesin/invasin OpcA protein  Outer membrane protein G porin family (n=14,S= ... Virulence-related outer membrane protein family (OmpX) Outer membrane protein W family (OmpW) Antimicrobial peptide resistance ...https://en.wikipedia.org/wiki/Transmembrane_protein
An Alternative Approach to Protein Folding
"Fiber formation across the bacterial outer membrane by the chaperone/usher pathway," Cell, vol. 133, no. 4, pp. 640-652, 2008. ... Z. Peng and L. C. Wu, "Autonomous protein folding units," Advanced in Protein Chemistry, vol. 53, pp. 1-30, 2000. View at ... Here, an approaching chaperone complex triggers a response by which outer membrane usher passage unblocks. Applying the ... Also, many protein folding simulations such as molecular dynamics (MD) require large amounts of CPU time for protein structure ...https://www.hindawi.com/journals/bmri/2013/583045/
Discovery of iron-acquisition pathway suggests new treatments for drug-resistant Staph. infections - UChicago Medicine
... acquires iron from its host's red blood cells, a critical step in causing disease. The discovery suggests new ways to combat ... The bacteria first secrete hemolysin, a toxin that punches a hole in the outer membrane of red blood cells. Then the protein ... located within the bacterial cell wall. The proteins IsdD, IsdE and IsdF transport the heme groups through the rigid cell wall ... transport them across the bacterial membrane and extract the iron. They also found that the human pathogens Anthrax and ...http://www.uchospitals.edu/news/2003/20030206-staph-get-iron.html
... research lab is known for determining the structure of transporter proteins embedded in the outer membranes of bacterial cells ... Transporter proteins direct the passage of virtually every molecule across plant cell membranes, including water, nutrients and ... How Cells Repurpose their Garbage Disposal Systems to Promote Inflammation *Initiative for Digital Exploration of Arts and ... Natural variations in transport proteins allow farmers to selectively breed crops for a variety of desirable traits. In one ...https://ucsdnews.ucsd.edu/index.php/feature/crop_cure
More reason to use Meningococcal B vaccine - it could also cut the Clap
... of bacterial membrane from the outside of the bacterial cell wall. These structures, known as Outer Membrane Vesicles (OMV), ... OMVs include a range of immunogenic proteins. Some are well characterised, others less so, which means there are many angles to ...http://www.familyplanning.org.nz/news/2017/more-reason-to-use-meningococcal-b-vaccine-%E2%80%93-it-could-also-cut-the-clap
Microbiology Society Journals | Virulence determinants of Moraxella catarrhalis: distribution and considerations for vaccine...
Moraxella catarrhalis is a human-restricted opportunistic bacterial pathogen of the respiratory mucosa. It frequently colonizes ... Role of Moraxella catarrhalis outer membrane protein CD in bacterial cell morphology and autoaggregation. Res Microbiol 2013; ... The Moraxella catarrhalis porin-like outer membrane protein CD is an adhesin for human lung cells. Infect Immun 2004;72: 1906- ... Outer membrane protein UspA1 and lipooligosaccharide are involved in invasion of human epithelial cells by Moraxella ...http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000523
Microbiology Society Journals | Maximal adherence and invasion of INT 407 cells by Campylobacter jejuni requires the CadF outer...
Given the relationship between the pericellular Fn matrix and the cytoskeleton, the involvement of host cell cytoskeletal ... jejuni infection of INT 407 cells. Collectively, these data suggest CadF promotes the binding of C. jejuni to Fn, which in turn ... jejuni wild-type isolate for host cell receptors. ... is mediated by a 37 kDa outer-membrane protein termed CadF for ... jejuni major outer membrane protein and a 59-kDa protein are involved in binding to fibronectin and INT 407 cell membranes. ...http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.25820-0
Prediction of bacterial proteins carrying a nuclear localization signal and nuclear targeting of HsdM from Klebsiella...
... pathogenic mechanism whereby bacterial proteins can interact with nuclear molecules and alter the physiology of host cells. The ... Nuclear targeting of bacterial proteins is an emerging ... Acinetobacter baumannii outer membrane protein A targets the ... Nuclear targeting of bacterial proteins is an emerging pathogenic mechanism whereby bacterial proteins can interact with ... A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 290, 354-357.CrossRef ...https://link.springer.com/article/10.1007/s12275-009-0217-4
Protocols and Video Articles Authored by Kirk Manson (Translated to Norwegian)
Many bacterial pathogens utilise outer membrane vesicles (OMVs) for delivery of virulence factors into host cells. In the ... jejuni 11168H OMVs identified 151 proteins including periplasmic and outer membrane-associated proteins, but also many ... Campylobacter Jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial ... identified a novel bacterial protein present in an extract of cell culture medium aspirated from heavily infected in vitro cell ...https://www.jove.com/author/Kirk_Manson?language=Norwegian
Type II secretion system - Wikipedia
In the type II secretion system GspD creates a pore in the outer membrane of the bacterial cell through which proteins can be ... These are the outer membrane complex, the inner membrane complex, the secretion ATPase and the pseudopilus. The outer membrane ... This secretin forms a hydrophilic channel in the outer membrane which allows the proteins to exit the cell. Once outside of the ... Each bacterial cell will contain a number of type II secretion systems and these are found embedded in the inner and outer ...https://en.wikipedia.org/wiki/Type_II_secretion_system
Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen
Beyond the outer cell surface, AMPs interact with the plasma membrane. Furthermore, fungal membranes contain mostly ... A. Ben Nasr, H. Herwald, W. Muller-Esterl, and L. Bjorck, "Human kininogens interact with M protein, a bacterial surface ... The proteins were further transferred onto nitrocellulose membranes (Hybond-C, Amersham Biosciences, UK). The membrane was ... B. Bechinger, "A dynamic view of peptides and proteins in membranes," Cellular and Molecular Life Sciences, vol. 65, no. 19, pp ...https://www.hindawi.com/journals/ijpep/2011/761037/
Protocols and Video Articles Authored by Toru Kariu (Translated to Hindi)
Oct, 2011 , Pubmed ID: 21875077 Among bacterial cell envelopes, the Borrelia burgdorferi outer membrane (OM) is structurally ... In this study, we demonstrate that BBA52 is an outer membrane surface-exposed protein and that disulfide bridges take part in ... the complexome is dominated by the frequent occurrence of a limited diversity of membrane proteins, most notably P13, outer ... mass spectrometric analysis for a global characterization of protein-protein interactions as well as to identify protein ...https://www.jove.com/author/Toru_Kariu?language=Hindi