*  Molecular profile of CD34-lineage- cells differentiated | Open-i
... cells differentiated with IL-15 plus IL-21. Panel A: Molecular features of cytokine-differentiated CD34-lineage- cells. The e ... CD34-lineage- cells cultured with IL-15 and IL-21 harboured un-rearranged TCRγ genes, similar to freshly isolated CD34-lineage ... CD34-lineage- cells cultured with IL-15 and IL-21 harboured un-rearranged TCRγ genes, similar to freshly isolated CD34-lineage ... CD34-lineage- cells expanded by IL-21 in combination with IL-15 acquired lymphoid morphology and killer-cell immunoglobulin- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2743656_1471-2172-10-46-4&req=4
*  Laurie A. Milner, M.D. - Wilmot Cancer Institute - University of Rochester Medical Center
As a model system, they are using embryonic stem (ES) cells to evaluate the role of Notch signaling in hematopoietic cell fate ... they hope to delineate the effects of Notch signaling on lineage specification and self-renewal of progenitors at various ... Chapter Title: Notch in hematopoiesis: Cell fate decisions and self-renewal of progenitors. Book Title: Cell Therapy. Author ... Mammalian hematopoiesis is a unique developmental process in which stem cells continue to generate vast numbers of diverse cell ...
  https://www.urmc.rochester.edu/cancer-institute/team/profile.aspx?urid=23387805
*  Who Needs Pluripotency? - Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons | Stem Cells...
Atkinson Direct conversion of one somatic cell to another somatic cell type, completely bypassing the pluripotent stage through ... the forced expression of lineage specific transcription factors has emerged as a large ... From Cell Stem Cell. By Stuart P. Atkinson. Direct conversion of one somatic cell to another somatic cell type, completely ... The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing ...
  http://www.stemcellsportal.com/content/who-needs-pluripotency-direct-lineage-conversion-terminally-differentiated-hepatocytes
*  In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells |...
In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells ... In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells ... In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells ... In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells ...
  http://dev.biologists.org/content/early/2017/07/21/dev.149989.article-info
*  CELL LINEAGE | Shapiro
Lineage analysis of intestinal epithelial cells. We have developed a method for single cell extraction of epithelial cells from ... In particular, the reconstruction of a cell lineage tree, capturing the cell division history of organism cells, can be ... The reconstructed cell lineage trees of acute myeloid leukemia (AML) patients demonstrated that leukemia cells at relapse were ... Quantifying the ability to reconstruct a cell-lineage tree using somatic mutations. The development of cells within a multi- ...
  http://www.weizmann.ac.il/math/Shapiro/cell-lineage
*  KEGG PATHWAY: Hematopoietic cell lineage - Reference pathway
A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B ... Hematopoietic cell lineage - Reference pathway [ Pathway menu , Organism menu , Pathway entry , Show description , User data ... Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular ... A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and ...
  http://www.genome.jp/kegg-bin/show_pathway?map04640
*  KEGG PATHWAY: Hematopoietic cell lineage - Homo sapiens (human)
Hematopoietic cell lineage - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ... A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B ... Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular ... A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and ...
  http://www.genome.jp/kegg-bin/show_pathway?hsa04640+3674
*  T Cell Lineage Commitment: Identity and Renunciation | The Journal of Immunology
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic ... Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat. Immunol. 8: 845- ... The B-lineage exclusion mechanism must inactivate some crucial B cell function that T and B cells do not share. The B cell- ... early T cells); DN2a, c-Kit++ CD44+ CD25+ DN cells; DN2b, c-Kit+ CD44+ CD25+ DN cells; DN3a, c-Kitlow CD44low CD25+ DN cells; ...
  http://www.jimmunol.org/content/186/12/6649
*  Features of cell lineage in preimplantation mouse development | Development
The cell lineage of the mouse was studied from the 2-cell stage to the blastocyst. Lineage to the 8-cell stage was followed ... Lineage to the blastocyst was followed by injecting oil drops into cells at the 8-cell stage, and then following the ... Between the 8-cell stage and the blastocyst, the deep cells contributed more frequently to the inner cell mass than did the ... Each cell from the 2-cell stage divided to form two daughter cells which remained attached. Subsequently, these two daughters ...
  http://dev.biologists.org/content/48/1/53
*  PA-07-127: Cell Lineage and Developmental Studies in Hearing and Balance (R01)
Cell Lineage and Developmental Studies in Hearing and Balance (R01) PA-07-127. NIDCD ... Title: Cell Lineage and Developmental Studies in Hearing and Balance (R01). Announcement Type This is a reissue of PA-04-118, ... Several accomplishments, such as the completion of detailed cell lineage and fate mapping analyses, the identification of key ... Advancement of fate mapping and lineage analysis done at single cell resolution using real-time assessment. ...
  https://grants.nih.gov/grants/guide/pa-files/PA-07-127.html
*  JDB | Free Full-Text | Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells
... and EPDC lineage specification in development and disease. Epicardial cells and subepicardial EPDCs express transcription ... EPDC differentiation into SMC and fibroblast lineages is precisely regulated by a complex network of transcription factors, ... These and other transcription factors also regulate epicardial EMT, EPDC invasion, and lineage maturation. In addition, there ... Determining the function of reactivated epicardial cells in myocardial infarction and fibrosis may improve our understanding of ...
  http://www.mdpi.com/2221-3759/1/2/92
*  Pancreatic cell lineage analyses in mice | Springer for Research & Development
... and genetic labeling of precursor cells (to determine cell lineages). In recent years, in vivo Cre/IoxP-based direct cell ... Lineage analyses allow the identification of progenitor cells from which mature cell types differentiate. Once identified, such ... Understanding pancreatic cell lineages is highly relevant for future cell replacement therapies in diabetic patients, helping ... islet endocrine cells derive from ngn3-expressing progenitor cells, and (iv) insulin cells do not derive from glucagon- ...
  https://rd.springer.com/article/10.1385/ENDO%3A19%3A3%3A267
*  The Allen Discovery Center for Cell Lineage Tracing | www.admissions.caltech.edu
Here, MEMOIR cells were variably activated, as seen by the bright cyan nuclear fluorescence in some cells. The cells recorded ... "A critical step to solving this problem is to be able to track the progeny of cells-that is, their lineage. The funding from ... "The goal is for each cell to be able to tell us its own individual history, including its lineage and the specific molecular ... and work together to map lineage and developmental histories of cells.". "One of the fundamental questions in biology is to ...
  http://www.admissions.caltech.edu/node/1722
*  Cell lineage - Wikipedia
Cell lineage denotes the developmental history of a tissue or organ from the fertilized embryo. Cell lineage can be studied by ... These more variable cell fates are thought to be due to the cells' interaction with the environment. Cell lineage can be ... This causes the cell lineage and cell fate to be highly correlated. Other organisms, such as humans, have variable lineages and ... is activated and permanently labels the cell of interest and its offspring cells, thus the name cell lineage tracing. With the ...
  https://en.wikipedia.org/wiki/Cell_lineage
*  A reaction-diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of...
A schematic diagram of a two-stage cell lineage model. (A) A cartoon of one colonic crypt and the relative location of cells at ... A diagram of an un-branched cell lineage that starts with progenitor cells, regarded as a combination of stem cells and ... Colon crypts, a single sheet of epithelia cells, consist of a periodic pattern of stem cells, transit-amplifying cells, and ... Cell velocity, V, (C) and progenitor cell flux, VC0, (D) are plotted at the time T = 0 (blue dash curve), T = 10 (black dot ...
  https://www.ncbi.nlm.nih.gov/pubmed/22849824?access_num=22849824&link_type=MED&dopt=Abstract
*  IJMS | Free Full-Text | Ultraviolet B (UVB) Irradiation-Induced Apoptosis in Various Cell Lineages in Vitro
... in tumor and normal cells. Several studies have demonstrated that UVB-induced cell death occurs through the generation of ... Human chondrocytes and C2C12 skeletal muscle cells, known to be more resistant to damage, were also considered. All of them, ... Differently, in chondrocytes and in skeletal muscle cells, oligonucleosomic DNA fragmentation did not appear, even if a certain ... In this review, we investigated UVB apoptotic action in various cell models by using ultrastructural, molecular and ...
  http://mdpi.com/1422-0067/14/1/532/xml
*  Stem cell lineage database - Wikipedia
The Stem Cell Lineage Database (SCLD) is a database of resources used to identify cell lineages. The Stem Cell Lineage Database ... "about cell type gene expression, cell lineage maps and stem cell differentiation protocols for both human and mouse stem cells ... A stem cell lineage database for the annotation of cell types and developmental lineages". Nucleic Acids Research. 39 (Database ... The Stem Cell Lineage Database could help compare stem cell information around the world and eliminate taking a global gene ...
  https://en.wikipedia.org/wiki/Stem_cell_lineage_database
*  Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL) - Full Text View -...
Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL). The safety and ... B-cell, Chronic Waldenstrom Macroglobulinemia Mantle Cell Lymphoma Burkitt Lymphoma B-cell Lymphoma ... This study evaluates ADCT-402 in patients with Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL). Patients ... Male or female patients, ages 18 years or older with pathologically confirmed relapsed or refractory B-cell lineage NHL who ...
  https://clinicaltrials.gov/ct2/show/NCT02669017
*  JAIRO | Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System
Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous SystemNeuronal Differentiation in Schwann Cell Lineage ...
  http://jairo.nii.ac.jp/0006/00023265
*  Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
B cells, myeloid cells, and innate lymphoid-like cells... (More). Natural killer (NK) cells are cytotoxic lymphocytes and play ... B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment ... B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment ... Cell Press}, series = {Immunity}, title = {Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal ...
  https://lup.lub.lu.se/search/publication/7840590
*  Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute...
Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute ... Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute ... can help to control newly diagnosed B-Cell Lineage ALL. The safety of this drug will also be studied. ... every cycle to help raise your blood cell counts. ...
  http://www.centerwatch.com/clinical-trials/listings/99870/leukemia-hyper-cvad-regimen-sequential-combination/?&radius=50
*  Cell lineage analysis of KIT D816V and NRAS G12D activating mutations in aggressive systemic mastocytosis (36.25) | The Journal...
Cell lineage analysis of KIT D816V and NRAS G12D activating mutations in aggressive systemic mastocytosis (36.25). Yun Bai, ... Unlike other mature lineages, mast cell survival is dependent on KIT and the presence of these two mutations may have a greater ... Cell lineage analysis of KIT D816V and NRAS G12D activating mutations in aggressive systemic mastocytosis (36.25) ... Cell lineage analysis of KIT D816V and NRAS G12D activating mutations in aggressive systemic mastocytosis (36.25) ...
  http://www.jimmunol.org/content/184/1_Supplement/36.25
*  Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion |...
Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion ... Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion ... Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion ... Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion ...
  http://dev.biologists.org/content/122/1/151
*  GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment | Journal of Cell Science
The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ... GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment ... GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment ... GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment ...
  http://jcs.biologists.org/content/early/2014/08/07/jcs.150227
*  Int J Dev Biol - Cell number control and timing in animal development: the oligodendrocyte cell lineage.
... which together control cell survival and cell division. As the cells seem to compete for limiting amounts of both survival ... but it is still unclear how the level of this protein is controlled over time in the dividing cells. The timing of cell-cycle ... The timing of cell-cycle exit, and therefore the onset of differentiation, seems to depend in part on the progressive ... Both cell number and the timing of differentiation depend on intracellular programs and extracellular signals, ...
  http://www.ijdb.ehu.es/web/paper/9654007/cell-number-control-and-timing-in-animal-development-the-oligodendrocyte-cell-lineage