*  Secreted Protein Acidic and Rich in Cysteines-like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal...
The mRNA level of SPARCL1 was barely detectable in most of colorectal tumor cell lines including RKO and SW620 (Supplementary ... 106 viable tumor cells at the site of costal region. Tumor size was measured every 3 days. Tumor volume was calculated on the ... Cell culture and SPARCL1 expression plasmid transfection. Colon cancer cell lines (RKO and SW620) were obtained from American ... Laparotomy was conducted on all the mice at 40 days after the implantation of tumor cells. It revealed that RKO-pLXSN cells ...
  http://clincancerres.aacrjournals.org/content/18/19/5438?rss=1
*  Plus it
... and small cell lung cancer at the 8 and 12 mg/kg, with lesser degrees of tumor shrinkage (stabilization) in several other pts. ... Enter multiple addresses on separate lines or separate them with commas.. You are going to email the following Abstract C67: ... The linker allows SN-38 release from the conjugate at low pH, such as in the tumor microenvironment or lysosomes. IMMU-132 was ... Clin Cancer Res 2011;17:3157-69). A multicenter Phase I clinical trial was initiated in a diverse, metastatic, solid tumor ...
  http://mct.aacrjournals.org/content/12/11_Supplement/C67
*  CD146 suppresses breast tumor invasion via its novel downstream transcriptional target gene, TimpV | OncologyPRO
... the weakly and the highly invasive BC cell lines MCF-7 and MDA-MB-231, respectively. CD146/TimpV association was validated by ... CD146, a marker of endothelial cells, promotes tumor progression of many cancers including melanoma and the prostate. ... it is negatively regulated in melanoma cells, where increased CD146 inhibits TimpV to promote melanoma cell motility. ... 66P - CD146 suppresses breast tumor invasion via its novel downstream transcriptional target gene, TimpV. ...
  http://oncologypro.esmo.org/Topics/Breast-Cancer/CD146-suppresses-breast-tumor-invasion-via-its-novel-downstream-transcriptional-target-gene-TimpV
*  Abstract A130: Joint cell-line (CCLE, Sanger) and patient (TCGA) modeling of drug sensitivity reveals novel molecular...
Cell line based models poorly reflect the extent of molecular heterogeneity and of tumor microenvironment relationships ... 1057 cell lines, 24 drugs), Sanger (790 cell lines, 138 drugs) and TCGA (patients: breast cancer, colorectal cancer, lung ... Abstract LB-B09: Somatic mutation detection via sequencing using circulating tumor cell samples from patients with renal cell ... Abstract LB-B09: Somatic mutation detection via sequencing using circulating tumor cell samples from patients with renal cell ...
  http://mct.aacrjournals.org/content/12/11_Supplement/A130
*  Plus it
Cell lines. The human breast cancer cell lines DU4475, MDA-MB-231, and MDA-MB-435 and mouse myeloma cell lines P3-X63-Ag8.653 ... 3B) proliferation of hypoxic tumor cells in a dose response. A similar result was observed in treatment of the tumor cells with ... reduced tumor cell proliferation, and increased tumor cell apoptosis. Pharmacokinetic/pharmacodynamic studies established a ... Inhibition of tumor cell proliferation. Serum-starved DU4475 cells were treated with desferrioxamine followed by treatment with ...
  http://clincancerres.aacrjournals.org/content/12/21/6573
*  Plus it
Cell Cycle Regulators. *. Abstract LB-C11: HTLV-1 Tax-induced apoptosis to counteract tumor drug resistance ... Results: Silencing of the Efp with siRNA in a MCF‐7 breast cancer cell line resulted in increased expression of the 14‐3‐3 σ. ... Background: 14‐3‐3 sigma (σ) is a negative regulator of the cell cycle and contributes to G2/M arrest. In many malignant tumors ... Abstract A40: MicroRNA-494 inhibits growth of the gastrointesintal stromal tumor by targeting multiple cell cycle regulatory ...
  http://mct.aacrjournals.org/content/8/12_Supplement/A68
*  Plus it
It is overexpressed in a variety of primary tumor cell cultures and tumor cell lines (13, 15-18, 25, 34), whereas normal cells ... PM-RCC cell line). PM-RCC is renal cell carcinoma cell line that has been shown to express IL-13Rα2 chain (13). When breast ... A, RT-PCR analysis for IL-13Rα2 chain transcripts in breast cancer cell lines. Total RNA (2 μg) from five cell lines ... and from 1000 to 320 ng/ml in ZR-75-1 cell line, respectively. Using MCF-7 cell line, we also confirmed that the protein ...
  http://mct.aacrjournals.org/content/3/2/137
*  Tumor Cells Deactivate Human Monocytes by Up-Regulating IL-1 Receptor Associated Kinase-M Expression via CD44 and TLR4 | The...
Human monocytes were cocultured with different tumor cell lines at a ratio of 1:0.3 (monocytes:tumor cells) for the times ... human hepatoblastoma cell line), and HeLa (human cervical tumor) provided by the American Type Culture. All cell lines were ... Fixed tumor cell lines and soluble factors from cultured cancer cells induce IRAK-M gene expression in human monocytes. To gain ... human breast carcinoma cell line), HL60 (human promyelocytic leukemia cell line), Jurkat (human T cell leukemia), HepG2 ( ...
  http://www.jimmunol.org/content/174/5/3032.long
*  Plus it
Results: In vitro studies showed a pronounced growth inhibitory and pro-apoptotic effect of LBH589 on both HCC cell lines at ... Tumor size and animal weight were determined daily. Tumor samples were obtained for further analysis (immunohistochemistry, RT- ... We therefore investigated the effect of the novel HDACi Panobinostat (LBH589) on human hepatocellular carcinoma cell lines in ... p53wt HepG2 cells were more sensitive than the p53-/- Hep3B cells. Quantitative PCR and western blotting showed an involvement ...
  http://mct.aacrjournals.org/content/6/11_Supplement/B272
*  Wilms' Tumour(tumor) cell lines
... Mr. D.M. Shaw incubus at liverpool.ac.uk Thu Jun 13 09:11:29 EST 1996 *Previous message: A260 ... Hi cell biologists, I am looking for tumour cell lines derived from childhood renal tumours such as Wilms' or the bone marrow ... metastasizing renal tumour of chilhood (BMRTC). Can anyone help? Please send replies vie E-mail incubus at liv.ac.uk Many ...
  http://www.bio.net/bionet/mm/methods/1996-June/045631.html
*  Vascular mimicry in cultured head and neck tumour cell lines.
... by which some genetically deregulated and aggressive tumour cells generat ... Vascuologenesis is the de novo establishment of blood vessels and vascular networks from mesoderm-derived endothelial cell ... cell lines and other aggressive tumour cell lines. We present experimental evidence of vasculogenic mimicry in HNSCC cell lines ... Metastatic HNSCC cells lines were found to have vasculogenic properties similar to HUVEC cell lines when compared to cell lines ...
  http://www.biomedsearch.com/nih/Vascular-mimicry-in-cultured-head/22196216.html
*  Poly A+ RNA, mRNA from Human Tumors and Cell Lines
Cell Line. Poly A Plus RNA samples are enriched through two rounds of oligo(dT) chromatography. Representative populations with ... Human Cell Line ZR75-1 (Breast Carcinoma) Poly A+ RNA 5 ug $538.00 ... Human Cell Line HEP G2 (Hepatoblastoma) Poly A+ RNA 5 ug $538.00 ... Cell Biology * Measure Cell Proliferation. * Measure Cell Death ... Human Cell Line MCF7 (Breast Adenocarcinoma) Poly A+ RNA 5 ug $538.00 ...
  http://www.clontech.com/US/Products/cDNA_Synthesis_and_Library_Construction/RNA/Poly_A_Plus_RNA_Human/Cancer_and_Cell_Line?sitex=10020:22372:US&PROD=1Oq2jpVJto4Uy5ejthsazt3H:S&PROD_pses=ZGDD45B6EAF5C0F611CCCCD9230E168D554257911F27C3A592C132F1605D3BA6AB346B83D2EBD432CCF114AF5D19A3FE964BCCD8FCC3410A26
*  Poly A+ RNA, mRNA from Human Tumors and Cell Lines
Cell Line. Poly A Plus RNA samples are enriched through two rounds of oligo(dT) chromatography. Representative populations with ... Human Cell Line ZR75-1 (Breast Carcinoma) Poly A+ RNA 5 ug $517.00 ... Human Cell Line HEP G2 (Hepatoblastoma) Poly A+ RNA 5 ug $517.00 ... Human Stem Cell Derived Beta Cells * Human Stem Cell Derived ... Human Cell Line MCF7 (Breast Adenocarcinoma) Poly A+ RNA 5 ug $517.00 ...
  http://www.clontech.com/US/Products/cDNA_Synthesis_and_Library_Construction/RNA/Poly_A_Plus_RNA_Human/Cancer_and_Cell_Line?sitex=10020:22372:US&PEBCL1=EgywJCYu5xkKYJ0ltqKTYMJXTP&PEBCL1_pses=ZG9C350B6746E3CFF74C26E275501D41D1F0919BFB6056C7371C40EF44E7779F262EBCC3D289B192A4DF6ED0B8FA43DD390D1A66342065B0A9
*  List of breast cancer cell lines - Wikipedia
Cailleau R, Young R, Olivé M, Reeves WJ Jr (1974). "Breast tumor cell lines from pleural effusions". Journal of the National ... Lasfargues EY, Coutinho WG, Redfield ES (1978). "Isolation of two human tumor epithelial cell lines from solid breast ... 2006). "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes". Cancer Cell. 10 (6): ... "Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery ...
  https://en.wikipedia.org/wiki/List_of_breast_cancer_cell_lines
*  Halichondrin B - Wikipedia
"NCI-60 DTP Human Tumor Cell Line Screen". Developmental Therapeutics Program, National Cancer Institute. Archived from the ... "60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard ... these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and ...
  https://en.wikipedia.org/wiki/Halichondrin_B
*  DAOY (biology) - Wikipedia
Sep 2003). "Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and ... Sep 2016). "Top-down proteomic characterization of DAOY medulloblastoma tumor cell line". EuPA Open Proteomics. 12: 13-21. ... DAOY is a widely used human primary medulloblastoma cell line. It has epithelial morphology and was obtained from a 4-year-old ... Srivastava VK, Nalbantoglu J (Oct 2008). "Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer ...
  https://en.wikipedia.org/wiki/DAOY_(biology)
*  Tumor necrosis factor superfamily - Wikipedia
It can cause cytolysis of certain tumor cell lines; it is involved in the induction of cachexia; it is a potent pyrogen, ... FASL, a cell surface protein involved in cell death. 4-1BBL, an inducible T cell surface molecule that contributes to T-cell ... two related cytokines produced by lymphocytes that are cytotoxic for a wide range of tumor cells in vitro and in vivo. T cell ... The tumor necrosis factor (TNF) superfamily refers to a superfamily of cytokines that can cause cell death (apoptosis). The ...
  https://en.wikipedia.org/wiki/Tumor_necrosis_factor_superfamily
*  Interleukin 10 - Wikipedia
Expression of IL-10 from transfected tumor cell lines. in IL-10 transgenic mice. or dosing with IL-10 leads to control of ... mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. IL-10 can be produced ... In melanoma cell lines, IL-10 modules the surface expression of NKG2D ligands. Knockout studies in mice suggested the function ... it is also stimulatory towards certain T cells (Th2) and mast cells and stimulates B cell maturation and antibody production. ...
  https://en.wikipedia.org/wiki/Interleukin_10
*  Myeloid-derived suppressor cell - Wikipedia
Tumor cell lines overexpressing colony stimulating factors (e.g. G-CSF and GM-CSF) have long been used in in vivo models of ... Similar to other myeloid cells, MDSCs interact with other immune cell types including T cells, dendritic cells, macrophages and ... These MDSCs infiltrate inflammation sites and tumors, where they stop immune responses by inhibiting T cells and NK cells, for ... MDSC (myeloid-derived suppressor cells) are a heterogenous group of immune cells from the myeloid lineage (a family of cells ...
  https://en.wikipedia.org/wiki/Myeloid-derived_suppressor_cell
*  BARD1 - Wikipedia
"Genetic analysis of BRCA1 function in a defined tumor cell line". Molecular Cell. 4 (6): 1093-9. doi:10.1016/S1097-2765(00) ... "Genetic analysis of BRCA1 function in a defined tumor cell line". Molecular Cell. 4 (6): 1093-9. doi:10.1016/S1097-2765(00) ... Inhibiting cancer cells' BRCA1/BARD1 heterodimer from relocating to DNA damage sites would induce tumor cell death rather than ... Jin Y, Xu XL, Yang MC, Wei F, Ayi TC, Bowcock AM, Baer R (Oct 1997). "Cell cycle-dependent colocalization of BARD1 and BRCA1 ...
  https://en.wikipedia.org/wiki/BARD1
*  TUSC3 - Wikipedia
Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been ... Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. This gene is a candidate tumor ... "Entrez Gene: TUSC3 tumor suppressor candidate 3". Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of ... Cell. 12 (1): 101-11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896. Anderson NL, Polanski M, Pieper R, et al. (2004). "The ...
  https://en.wikipedia.org/wiki/TUSC3
*  Kendomycin - Wikipedia
It also has strong cytotoxicity against various tumor cell lines. Because of its potent biological activities, kendomcyin has ...
  https://en.wikipedia.org/wiki/Kendomycin
*  Capillin - Wikipedia
Whelan LC, Ryan MF (2004). "Effects of the polyacetylene capillin on human tumour cell lines". Anticancer Research. 24 (4): ... Capillin exhibits cytotoxic activity and could cause apoptosis of certain human tumor cells. "Showing metabocard for Capillin ( ...
  https://en.wikipedia.org/wiki/Capillin
*  CCL7 - Wikipedia
It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large ... Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). "Structural and functional identification of two human, tumor-derived ... 1999). "Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling". J. ... 1997). "Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells". Eur. Cytokine Netw. 8 (3): 271- ...
  https://en.wikipedia.org/wiki/CCL7