*  Chimpanzees Use More Varied Receptors and Ligands Than Humans for Inhibitory Killer Cell Ig-Like Receptor Recognition of the...
HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc ... The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors ... Chimpanzees Use More Varied Receptors and Ligands Than Humans for Inhibitory Killer Cell Ig-Like Receptor Recognition of the ... Chimpanzees Use More Varied Receptors and Ligands Than Humans for Inhibitory Killer Cell Ig-Like Receptor Recognition of the ...
  http://www.jimmunol.org/content/182/6/3628.long
*  CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS | Free Medical Textbook
... of Natural Killer Cells Definition Morphology Origin and Tissue Distribution Mechanisms of Natural Killer Cell Functions Cell- ... Mediated Cytotoxicity Production of Cytokines Physiologic Roles of Natural Killer Cells Natural Resistance Regulation of… ... CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS Williams Hematology CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS GIORGIO ... immunoreceptor tyrosine-based inhibitory motif; KIR, killer-cell Ig-like receptors; LCMV, lymphocytic choriomeningitis virus; ...
  https://medtextfree.wordpress.com/2012/01/12/chapter-85-functions-of-natural-killer-cells/
*  Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells...
Gordana Konjević, Ana Vuletić, Katarina Mirjačić Martinović, Natural killer cell receptors: alterations and therapeutic ... NK-mediated effector functions are regulated by a balance between inhibitory and stimulatory signals. NK cells can recognize ... natural killer [NK] cells and NK T cells) and acquired immune cells (T cells),4, 5 but the activation of these immune cells ... CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate ...
  http://onlinelibrary.wiley.com/doi/10.1002/hep.23456/full
*  Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated...
We found an increased frequency of NK cells with high expression of the inhibitory killer cell lectin-like receptor G1 (KLRG1) ... and cell differentiation with inhibitory receptor signaling that may be exploited to enhance NK cell activity during ageing. ... Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With ... Pre-existing AMPK activity is further amplified by ligation of KLRG1 in these cells, which leads to internalization of the ...
  https://www.ndorms.ox.ac.uk/publications/641624
*  Plus it
... promotes natural killer (NK) cell-mediated toxicity. NK cells possess inhibitory killer immunoglobulin-like receptors (KIR; ... encoded by KIR3DL1) that bind to HLA class I molecules, licensing NK cells to target cells lacking self-HLA, but also ... treating neuroblastoma cells with IFNγ to induce HLA class I expression resulted in inhibition of KIR3DL1-high NK cells in the ... presence of 3F8, but had little effect on KIR3DL1-null and KIR3DS1 NK cells. Altogether, these results indicate that ...
  http://cancerdiscovery.aacrjournals.org/content/early/2016/04/27/2159-8290.CD-RW2016-080
*  Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells -...
... how to improve NK cell killing of retrovirus-infected cells. . Biblioteca virtual para leer y descargar libros, documentos, ... activating and inhibitory receptors on their cell surface and often become activated after recognizing virus-infected cells. ... Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells. ... Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells - ...
  http://libros.duhnnae.com/2017/jul7/150076243037-Insufficient-natural-killer-cell-responses-against-retroviruses-how-to-improve-NK-cell-killing-of-retrovirus-infected-cells.php
*  Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. - PubMed - NCBI
Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I ... Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.. Fan QR1, Long EO, Wiley DC. ... We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to ... Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously ...
  https://www.ncbi.nlm.nih.gov/pubmed/11323700
*  Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49...
Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible ... Murine natural killer (NK) cells express inhibitory Ly49 receptors specific for major histocompatibility complex (MHC) class I ... T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen- ... Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature. 402:623-631. ...
  http://jem.rupress.org/content/194/10/1519
*  Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic...
... biological response modifiers and the family of cell adhesion-promoting molecules. ... Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic ... "Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic ...
  https://www.hindawi.com/journals/mi/2012/804043/cta/
*  Frontiers | Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for...
NK cells directly identify and lyse cancer cells. Nascent transformed cells elicit NK cell activation and are eliminated. ... NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... NK cells directly identify and lyse cancer cells. Nascent transformed cells elicit NK cell activation and are eliminated. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00601/full
*  Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural...
Burshtyn DN, Shin J, Stebbins C, Long EO (2000) Adhesion to target cells is. disrupted by the killer cell inhibitory receptor. ... Fan QR, Long EO, Wiley DC (2001) Crystal structure of the human natural. killer cell inhibitory receptor KIR2DL1-HLA-Cw4 ... Natural killer cell signaling pathways. Science. 306: 1517-1519.. 2. Lanier LL (2008) Up on the tightrope: natural killer cell ... role of natural killer cell receptors. Nat Rev Immunol 9: 568-580.. 6. Gleimer M, Parham P (2003) Stress management: MHC class ...
  http://wrap.warwick.ac.uk/3961/
*  Anti-KIR2DL1 + KIR2DL3 + KIR2DL4 + KIR2DS4 antibody [2H6] (ab26251)
KIRs are human natural killer (NK) cell receptors for MHC class I molecules. Most inhibit the activity of NK cells thus ... Killer cell immunoglobulin like receptor 2DL3 antibody. *KKA3 antibody. *Natural killer cell inhibitory receptor antibody ... Two main families of receptors for HLA class I have been discovered on human NK cells: Killer cell Immunoglobulin-like ... The KIR receptors are an extremely diverse family of receptors. In addition to receptors for HLA, NK cells also express pattern ...
  http://www.abcam.com/kir2dl1-kir2dl3-kir2dl4-kir2ds4-antibody-2h6-ab26251.html
*  NK Receptor | SpringerLink
Natural cytotoxicity receptors (NCR); Natural killer cell group (NKG) Natural Killer (NK) cells are a major... ... Killer immunoglobulin-like receptors (KIR); Killer lectin-like receptors (KLR); ... Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol. 2001;2:452-60. ... Killer immunoglobulin-like receptors (KIR); Killer lectin-like receptors (KLR); Natural cytotoxicity receptors (NCR); Natural ...
  https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_421
*  Vav1 Phosphorylation Is Induced by β2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft...
Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J. Exp. ... Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). Immunol. Rev. 181: ... Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19:197-223. ... Target cell lysis by NK cells is activated by a number of receptors that bind to ligands expressed on tumor cells and virus- ...
  http://jem.rupress.org/content/198/3/469
*  Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members...
Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. J. Immunol. 1998. 161: 1299- ... Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members ... Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members ... Fan, Q. R., Long, E. O. and Wiley, D. C., Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor. J ...
  http://onlinelibrary.wiley.com/doi/10.1002/eji.200323710/references
*  Frontiers | Molecular Recognition of Paired Receptors in the Immune System | Microbiology
... either inhibitory or stimulatory. These receptors are designated as paired receptors. Paired receptors often recognize not only ... the cell membrane. Interestingly, accumulating evidence clearly reveals that the members of cell surface receptor families have ... either inhibitory or stimulatory. These receptors are designated as paired receptors. Paired receptors often recognize not only ... the cell membrane. Interestingly, accumulating evidence clearly reveals that the members of cell surface receptor families have ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full
*  Frontiers | The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy | Immunology
NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells ... In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on ... NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells ... cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01124/full
*  KIR2DS4 - Wikipedia
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets ... Fan QR, Long EO, Wiley DC (2000). "Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor". J. Biol ... 1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875-82. ... 2001). "Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail ...
  https://en.wikipedia.org/wiki/KIR2DS4
*  CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence | JEM
The cell biology of the human natural killer cell CD94/NKG2A inhibitory receptor. Mol. Immunol. 42:485-488. ... Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease. Clin. Exp. Immunol. ... Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat. Immunol. 2:452-460. ... HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc. Natl. Acad. Sci. USA. 95:5199-5204. ...
  http://jem.rupress.org/content/205/3/725
*  Isolation of Cells from the Feto‐Maternal Interface - Current Protocols
... with invading placental cells (trophoblast) of fetal origin ... cell inhibitory receptors on human uterine natural killer cells ... Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J. Exp. Med. 198:1201‐1212. ... with invading placental cells (trophoblast) of fetal origin. Of particular interest are uterine natural killer cells, which ... Killer Ig‐like receptor expression in uterine NK cells is biased toward recognition of HLA‐C and alters with gestational age. J ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0740.html?quicktabs_cp=toc
*  CiNii 論文 - Methylprednisolone induces preferential and rapid differentiation of CD34^+ cord...
NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the ... Analysis of natural killer cells isolated from human decidua : evidence that 2B4 (CD244) functions as an inhibitory receptor ... Unravelling natural killer cell function : triggering and inhibitory human NK receptors MORETTA L. ... Phenotypic and functional analysis of the HLA-class I-specific inhibitory receptors of natural killer cells isolated from ...
  https://ci.nii.ac.jp/naid/10021240721
*  KIR2DL1 - Wikipedia
Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets ... "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors". Nature. 389 (6646): 96 ... Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 ... Fan QR, Long EO, Wiley DC (2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 ...
  https://en.wikipedia.org/wiki/KIR2DL1
*  HLA-C - Wikipedia
Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 ... MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which ... "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. ... "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337-44. doi:10.1016/ ...
  https://en.wikipedia.org/wiki/HLA-C
*  Increased Frequency of CD4+ Cells Expressing CD161 in Cancer Patients | Clinical Cancer Research
... attention has focused on the expression of activating and inhibitory receptors of natural killer (NK) cells on T-cell subsets. ... Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A 2004;101: ... In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J Exp Med ... Both types of NK receptors, namely killer cell immunoglobulin-like receptors and C-type lectin receptors, have been detected on ...
  http://clincancerres.aacrjournals.org/content/12/23/6901
*  Frontiers | Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity | Immunology
Natural killer (NK) cells, which express PKCtheta, play a prominent role in this process, mainly by elimination of tumor cells ... while others show that it is implicated in NK cell functional activation mediated by certain killer activating receptors (KAR ... Natural killer (NK) cells, which express PKCtheta, play a prominent role in this process, mainly by elimination of tumor cells ... while others show that it is implicated in NK cell functional activation mediated by certain killer activating receptors (KAR ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2012.00187/full