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*  Regulation of B-Cell Populations | Springer for Research & Development
... which has a uniform antigen-binding capacity for any one B cell. As the body has the potential to produce... ... B cells carry antigen-specific receptors in the form of surface-bound immunoglobulin, ... Coffman RL (1982) Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol ... B cells carry antigen-specific receptors in the form of surface-bound immunoglobulin, which has a uniform antigen-binding ...
  https://rd.springer.com/chapter/10.1007/978-3-642-73855-5_3
*  The Use of Targeted Mutations in ES Cells to Create Novel Immunodeficient Mouse Models | Springer for Research & Development
Davis MM, Bjorkman PJ (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334: 395-401PubMedCrossRefGoogle ... Coffman RL, Weissman IL (1983) Immunoglobulin gene rearrangement during pre-B cell differentiation. J Mol Cell Immunol 1: 31-38 ... in which developing T cells rearrange and express T cell receptor (TCR)-β and -α chain genes (Davis and Bjorkman 1988; Malissen ... Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72: 695-704 ...
  https://rd.springer.com/chapter/10.1007/978-3-642-78438-5_6
*  ATM - Serine-protein kinase ATM - Sus scrofa (Pig) - ATM gene & protein
... of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor ... Also plays a role in pre-B cell allelic exclusion, a process leading to expression ... After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the ... Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent ...
  http://www.uniprot.org/uniprot/Q6PQD5
*  LAT - Linker for activation of T-cells family member 1 - Homo sapiens (Human) - LAT gene & protein
... high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and ... and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity ... immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 ( ... Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development ...
  https://www.uniprot.org/uniprot/O43561
*  BLK - Tyrosine-protein kinase Blk - Homo sapiens (Human) - BLK gene & protein
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. ... Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre- ... B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK ... B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and ...
  http://www.uniprot.org/uniprot/P51451
*  B cell - Wikipedia
Positive selection occurs through antigen-independent signaling involving both the pre-BCR and the BCR. If these receptors do ... each marked by various gene expression patterns and immunoglobulin H chain and L chain gene loci arrangements, the latter due ... T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a ... T cell-derived cytokines bound by B cell cytokine receptors also promote B cell proliferation, immunoglobulin class switching, ...
  https://en.wikipedia.org/wiki/B_cell
*  Lymphoid Hematopoiesis and Lymphocytes Differentiation and Maturation | IntechOpen
... these cells express CD10high, CD38high, CD34, CD79a, TdT and start being called pre‐B I [19, 20]. Immunoglobulin (Ig) gene ... B‐cell antigenreceptor signalling in lymphocyte development. Immunology. 2003;110(4):411-420. DOI: 10.1111/j.1365‐2567.2003. ... NK cells differentiation. [142]. IL‐21. killer immunoglobulin‐like receptors (KIR) expression on final stage of NK cell ... The genes involved in the T cell receptor (TCR) rearrangement are present in the germ cell lineage and are located in the ...
  https://www.intechopen.com/books/lymphocyte-updates-cancer-autoimmunity-and-infection/lymphoid-hematopoiesis-and-lymphocytes-differentiation-and-maturation/
*  Gene expression - Conservapedia
... the cell produces membrane-tethered immunoglobulin (Ig) receptors by transcription and splicing of the entire gene: Long ... Recognition of antigen increases the amount of CStF in the cell, producing a shorter transcript of the gene, which lacks the ... RNAse treatment of pre-mRNA degrades pre-mRNA into heterogeneous ribonucleoprotein fragments. These proteins have a common RNA ... which allows it to be tethered into the cell membrane. However, after the cell has recognised an antigen, it begins to produce ...
  https://www.conservapedia.com/index.php?title=Gene_expression
*  Anti-RAG2 antibody (ab95955) | Abcam
V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T ... The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin ... heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on ... WB: MOLT4 whole cell lysate ICC/IF: Hela cell IHC-P: DLD1 Xenograft Others: 293T, A431, H1299, HeLa, HepG2 and Raji cells ...
  https://www.abcam.com/RAG2-antibody-ab95955.html
*  RAG2 Antibody (C-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, E - Buy Now! |Abgent
V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- ... The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin ... cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one ... Autophagy Receptor Motif Plotter. The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in ...
  http://www.abgent.com/products/AP12445b-RAG2-Antibody-C-term
*  Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis.
The early B lymphopoiesis in mammals is regulated through close interactions with stromal cells and components of the ... and pre-B cells, B progenitor cells might be target for Wnt signaling through these receptors. ... pre-B and immature B developmental stages characterized by successive steps in the rearrangement of immunoglobulin genes and ... In mammals, the early antigen independent phase of B lymphopoiesis takes place in the intersinusoidal spaces in the bone marrow ...
  http://www.biomedsearch.com/nih/Wnt-expression-canonical-signaling-in/16808837.html
*  Somatic mutations in translocated IgH. Analysis of 32,6 | Open-i
... signal sequences targeted by recombination activating genes 1 and 2 during antigen receptor assembly in pre-B cells, suggesting ... Chromosome translocations between oncogenes and the region spanning the immunoglobulin (Ig) heavy chain (IgH) variable (V), ... signal sequences targeted by recombination activating genes 1 and 2 during antigen receptor assembly in pre-B cells, suggesting ... gene segments (Ig V-J(H) region) are found in several mature B cell lymphomas in humans and mice. The breakpoints are ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2118712_jem2042225f04&req=4
*  Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B...
Gene set enrichment analyses suggested impairment of B cell differentiation and survival, as well as enhancement of innate ... Immune markers were blood leukocyte counts, plasma cytokines, serum C-reactive protein and immunoglobulins. Neuroendocrine ... Adolescent CFS is characterized by differential gene expression pattern in whole blood suggestive of impaired B cell ... We identified 176 genes as differentially expressed in patients compared to controls, adjusting for age and gender factors. ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1201-0
*  Immunobiology - NCBI Bookshelf
In these cases the nature of the antigen is the major variable. ... gene segments leads to the formation of a pre-B-cell receptor ... Antigen recognition by T cells*3-10. The antigen receptor on T cells is very similar to a Fab fragment of immunoglobulin ... T-cell receptor gene rearrangement*4-11. The T-cell receptor loci comprise sets of gene segments and are rearranged by the same ... 7-9 Successful rearrangement of heavy-chain immunoglobulin gene segments leads to the formation of a pre-B-cell receptor that ...
  https://www.ncbi.nlm.nih.gov/books/NBK10757/?depth=2
*  Mouse Immunoglobulin Panel | SouthernBiotech
Mouse Immunoglobulin Panel for use as positive reference standards in isotyping and as standards for quantitative studies of ... mouse immunoglobulins in samples such as serum, supernatant, feces, and ascites. ... Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population ... Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice. Genes Immun. 2008;9:137-52. (ELISA Standard ...
  https://www.southernbiotech.com/OtherProductDetails.aspx?catno=5300-01
*  Protein A - Wikipedia
... structural basis for recognition of B-cell receptors and superantigen activity". Proceedings of the National Academy of ... It binds the heavy chain within the Fc region of most immunoglobulins and also within the Fab region in the case of the human ... In addition, protein A has been shown to bind human IgG molecules containing IgG F(ab')2 fragments from the human VH3 gene ... The Bergen group from Norway named the protein "Protein A" after the antigen fraction isolated by Jensen. It has been shown via ...
  https://en.wikipedia.org/wiki/Protein_A
*  Immunoglobulin heavy chain - Wikipedia
"Role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development". Immunology. 101 (4): 435-441. doi: ... The resulting antibodies are designated IgW (also called IgX or IgNARC) and IgNAR ('immunoglobulin new antigen receptor'). The ... Cell. 153 (6): 1379-93. doi:10.1016/j.cell.2013.04.049. PMC 4007204 . PMID 23746848. Fish heavy chain and light chain genes[ ... a variable region that differs between different B cells, but is the same for all immunoglobulins produced by the same B cell ...
  https://en.wikipedia.org/wiki/Immunoglobulin_heavy_chain
*  Anti-Abl SH2 Domain Antibody | 06-465
... to regulation of early B cell development and expression of genes that are central to all phases of antigen receptor gene ... progenitor called a pre-B cell and appear to be arrested in differentiation at the stage of immunoglobulin light chain gene ... FUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ... Abl-mediated transformation, immunoglobulin gene rearrangements and arrest of B lymphocyte differentiation.. Rosenberg, N. ...
  http://www.merckmillipore.com/INTL/en/product/Anti-Abl-SH2-Domain-Antibody,MM_NF-06-465
*  A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in...
... increased infiltration of antigen-presenting cells is supported by gene expression data whereas other immune cells of both the ... Infiltration of antigen-presenting cells was supported by increased expression of the Pattern Recognition Receptors (PRR), Toll ... although there was increased expression of immunoglobulin J chain. As myeloid-derived suppressor cells (MDSC) immune ... Subsequent to the increased expression of HLA-class II genes, co-stimulatory markers of antigen-presenting cells (CD83) and the ...
  https://rd.springer.com/article/10.1186/bcr3409
*  KIR2DL4 - Wikipedia
Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene. Killer cell ... "Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103". Tissue Antigens. 49 (6 ... "Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia". Eur. J. Immunol. 32 (1): 18-29. doi:10.1002/ ... "Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4". Carosella ED, Favier B, ...
  https://en.wikipedia.org/wiki/KIR2DL4
*  Resources | Free Full-Text | Recent Research Progress and Potential Uses of the Amphibian Xenopus as a Biomedical and...
... transgenesis approach to Xenopus have allowed for in vivo studies of the impact of loss and gain of function of specific genes ... thereby providing a unique model to study whole genome duplication and its effects thereof on individual genes. To better ... mediated rearranging immunoglobulin receptors (Ig) and T cell receptors (TCR), MHC class I and II genes, and activation-induced ... Pre-metamorphic tadpoles. Stage 50-57, 30-50 mm long, 2-6 weeks post-fertilization. *. Thymus and spleen, mature B and T cells; ...
  http://www.mdpi.com/2079-9276/2/3/167/htm
*  Plus it
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J 2002;21:5611- ... Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 2008;28: ... as assessed by rearrangement of the immunoglobulin heavy chain (IGH) gene, and express low levels of surface B-cell receptor ( ... Because cell-surface expression of myeloid antigens is not sufficient to attest to the myeloid nature of a progenitor cell, we ...
  http://cancerdiscovery.aacrjournals.org/content/4/9/1088
*  RAG 1 and 2 info
RAG1 and RAG2 are two proteins necessary for immunoglobulin and T-cell receptor gene recombination. RAG stands for ... RAG1 and RAG2 have different levels of expression during different stages of B-cell and T-cell antigen receptor assembly. ... In thymocytes, the presence of the pre-T-cell receptors triggers the repression of RAG expression during the proliferative ... a complex of enzymes that work together to join gene segments of B-cell and T-cell receptor genes (Janeway et al., 2005). All ...
  http://www.bio.davidson.edu/courses/Immunology/Students/spring2006/Rogers/RAG1_2.html
*  Lisa Wagar | Stanford Medicine Profiles
Gene expression in activated CD4 T cells at the time of the peak response identified gene modules related to cell cycle ... Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens NATURE Khodadoust, M. S., Olsson, N ... T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one ... Pre-existing human CD4(+) and CD8(+) T cells from healthy donors were shown to recognize and respond to these neopeptides. One ...
  https://med.stanford.edu/profiles/lisa-wagar?tab=bio
*  B Cell Differentiation: From Stem Cell to an Antibody Producing Plasma Cell - Maine Biotechnology
Once HC Ig gene rearrangement has successfully initiated, the cells become precursor B (or pre-B) cells. During the pre-B cell ... B cells present antigen to the T cells and those that are specific for that antigen will activate the B cell to become an ... gene rearrangement takes place to generate a fully functional B cell receptor (BCR, which is a membrane bound antibody). At ... In the pro-B cells heavy chain (HC) immunoglobulin (Ig) rearrangement begins which is the beginning of antibody production. ...
  http://mainebiotechnology.com/b-cell-differentiation/