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*  A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status | Genome Medicine...
... and T-cell repertoire data. We could predict with high accuracy (greater than or equal to 80 %) a wide range of immunological ... Lymphocyte receptor repertoires are continually shaped throughout the lifetime of an individual in response to environmental ... which consequently limits a deeper understanding of lymphocyte repertoires and hampers the development of robust immune- ... Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol. ...
  https://0-genomemedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s13073-015-0169-8
*  The Neuropeptide Vasoactive Intestinal Peptide Generates Tolerogenic Dendritic Cells | The Journal of Immunology
Regulatory Roles of IL-2 and IL-4 in H4/Inducible Costimulator Expression on Activated CD4+ T Cells During Th Cell Development ... Induction of CD4+ T Cell Apoptosis as a Consequence of Impaired Cytoskeletal Rearrangement in UVB-Irradiated Dendritic Cells ... CD4+CD25+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF ... critical role for the RelA subunit of nuclear-factor-κB in regulation of multiple immune response genes and in Fas-induced cell ...
  http://www.jimmunol.org/content/175/11/7311?ijkey=a237447f0ac6cdeac774fd81a98f7ffd68d981e2&keytype2=tf_ipsecsha
*  Patent US7718400 - Methods of increasing lean tissue mass using OB protein compositions - Google Patents
The DNA sequences, vectors comprising such DNA sequences, host cells comprising such vectors or DNA sequences, and processes ... host cells comprising such vectors or DNA sequences, and processes for preparing such fusion proteins, and pharmaceutical ... "Gene therapy-promises, problems and prospects," Nature (1997) 389:239-42.. 57. Verma, I., et al. "Gene therapy-promises, ... Lymphocyte homing receptor/immunoglobulin fusion proteins. US5284656. Sep 29, 1992. Feb 8, 1994. Amgen Inc.. Pulmonary ...
  http://www.google.com/patents/US7718400?dq=3657699
*  DiGeorge Syndrome (deletion 22q11.2; Velo-Cardio-Facial Syndrome; thymic hypoplasia; CATCH 22) - Cancer Therapy Advisor
... and thymus development. These genes also affect central nervous system development in that learning difficulties are common. ... Low absolute lymphocyte count necessitates evaluation of T and B cell subsets and referral to an immunologist. Infants and ... McDonald-McGinn, DM, Emanual, BS, Zachai, EH, Pagon, RA, Bird, TC, Dolan, CR, Stephens, K. "22q11.2 Deletion Syndrome". Gene ... "Molecular mechanisms and diagnosis of chromosome 22Q11.2 rearrangements". Dev Disabil Rev. vol. 14. 2008. pp. 11-18. ...
  https://www.cancertherapyadvisor.com/dermatology/digeorge-syndrome-deletion-22q112-velo-cardio-facial-syndrome-thymic-hypoplasia-catch-22/article/594744/
*  A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing | The Journal of Immunology
All TRBV12-4/TRBJ1-2 gene rearrangements were amplified by PCR using primers specific for TRBV12-4 (5′-CTGAAGATCCAGCCCTCAGA-3 ... small lymphocyte, live CD3+, and CD8+CD4− cells (from left to right). These cells were subsequently analyzed on the basis of ... the relative impact of the different events involved in T cell development on shaping the peripheral T cell repertoire remains ... and TRBD1 genes (Fig. 5A, Supplemental Fig. 3A-D). For the memory and naive CD8+ T cell populations in each donor, the ...
  http://www.jimmunol.org/content/186/7/4285.long
*  Protocols and Video Articles Authored by Lixin Liu
Construction of Recombinant Caspases-3 Gene and the Test of Its Apoptotic Activity in Pancreatic Carcinoma Cell Strain] Sheng ... Association Between Dopaminergic Genes (SLC6A3 and DRD2) and Stuttering Among Han Chinese Journal of Human Genetics. Aug, 2009 ... Taken together, our results suggest that IGFBPs play an important role in the development of fibrosis in IPF. ... The eukaryotic expression plasmid pcDNA 3.1 (+)/r-Caspase-3 was constructed by rearrangement of the large subunit and small ...
  https://www.jove.com/author/Lixin_Liu
*  Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive...
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. ... Induction of CD4+ T Cell Apoptosis as a Consequence of Impaired Cytoskeletal Rearrangement in UVB-Irradiated Dendritic Cells ... Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous ... Eugene, OR) according to the manufacturer's instructions. Presence of the protein on the beads was confirmed by Western blot ...
  http://www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9-98f5-770ee2b1f3eb
*  Otto Hannes Vogel | Stanford Medicine Profiles
T-cell lymphoma may not be recognized unless studies for T-cell receptor gene rearrangements are performed for CNS lesions ... A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression GENES & DEVELOPMENT Okada, N., Lin, C., Ribeiro, M ... In 18 patients with MG (all associated with lymphocyte-rich thymomas) and in two thymoma patients without MG, lymphocytic ... genes involved in cell growth, genes encoding factors involved in complement activation, and genes encoding components of the ...
  https://med.stanford.edu/profiles/hannes-vogel
*  Faculty
Prediction of Gene Activity in Early B Cell Development Based on an Integrative Multi-Omics Analysis. Journal of Proteomics & ... Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. Adv Exp ... Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunology, 9(8), 927 ... Genes & Development 6, 2047-2057.. PubMed Reference Pomerantz, J.L., Mauxion Yoshida FM, Greene WC, and Sen R. (1989) A second ...
  http://biolchem.bs.jhmi.edu/Pages/Faculty.aspx?ra=2
*  B1 - Flashcards in GCSE Biology
... then memory cells (a type of T-lymphocyte cell) remains in the body which gives long-lasting immunity to the disease. ... Mutations, rearrangement of genes during the formation of gametes, and fertilisation. 96 of 110 ... It involves only one pair of characteristics controlled by a single gene, one allele being dominant and one recessive. ... Fight against viruses and slows down the pathogen's development. 36 of 110 ...
  https://getrevising.co.uk/revision-tests/b1-122
*  Ryanodine receptors | Skeletal Muscle | Full Text
... smooth-muscle cells, epithelial cells, lymphocytes, sea-urchin eggs, and many others [3]. In all of these cells, RyRs play a ... More than 70 different mutations in RYR2, the gene encoding the cardiac isoform of RyRs, have been associated with CPVT [141], ... RyR3 is the least understood of the RyR isoforms and seems to play its most important role during development, although in ... Laitinen PJ, Swan H, Piippo K, Viitasalo M, Toivonen L, Kontula K: Genes, exercise and sudden death: molecular basis of ...
  https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/2044-5040-1-18
*  Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the...
T. Stankovic, V. Weston, C. M. McConville et al., "Clonal diversity of Ig and T-cell receptor gene rearrangements in childhood ... T. Möröy and C. Khandanpour, "Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation," ... Real-Time PCR Analysis of Gene Expression. To determine the expression level of a number of genes known to be involved in ... Normal development of myeloid and lymphoid human cells from CD34+ HSC involves a stepwise progression of differentiating cells ...
  https://www.hindawi.com/journals/jir/2013/349067/
*  Basic concepts in immunity and inflammation
T-lymphocyte ontogeny:. T-cell development occurs in the thymus. T-cell precursors, however, arrive at the thymus from the bone ... Subsequently, these cells undergo DNA rearrangements of genes encoding the constant and variable regions of the α / β TCR, ... At this stage, the process of immunoglobulin gene rearrangement begins. The first re-arrangement entails the joining of the D ... The development and maturation of B-cells occur in multiple steps. The stages of B-Cell development start with stem cells which ...
  http://periobasics.com/basic-concepts-in-immunity-and-inflammation.html
*  Application # 2011/0123542. CCL20-SPECIFIC ANTIBODIES FOR CANCER THERAPY - Patents.com
Gene expression of CCL20 gene was analyzed in relation to the levels of the housekeeping .beta.-actin gene. [0132] Cell ... Such genes may be prepared, for example, by RT-PCR of the mRNA of an antibody-producing cell. Ample guidance for practicing ... 0155] In order to further determine the involvement of CCL20 in cancer development in vitro, the CCL20 gene was introduced into ... including gene rearrangement, chain assembly, and antibody repertoire. Ample guidance for practicing such an approach is ...
  http://patents.com/us-20110123542.html
*  Patente US20100092475 - Treatment method using egfr antibodies and src inhibitors and related ... - Google Patentes
... gene amplification is associated with EGFR rearrangements with the most common mutation, the de2-7 EGFR (or EGFRvIII), ... precancerous cells, tumor cells, and hyperproliferative cells, prior to, during or following surgery to remove such cells. ... B squeda Im genes Maps Play YouTube Noticias Gmail Drive M s » ... of the EGFR is a rational strategy for the development of new ... Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity. ...
  http://www.google.es/patents/US20100092475
*  CECAD: Publications 2010
Gene transfer into human cord blood-derived CD34(+) cells by adeno-associated viral vectors. Exp Hematol. Sep;38(9):707-17. ... Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. ... analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. ... genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. Hum Genet. Jul;128(1):103-11. Epub 2010 May ...
  http://cecad.uni-koeln.de/Publications-2010.152.0.html?L=1%29
*  An insight into the phylogenetic history of HOX linked gene families in vertebrates | BMC Evolutionary Biology | Full Text
... as a result of rearrangements of genomic segments including multiple contiguous genes, at least as early as before the ... Regulation of cell growth, Signal transduction, Skeletal development Cell proliferation.. IGFBP1. 7p13-p12 ... DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. ... The topology of the type where genes on Hsa7 and Hsa17 clustered together, while the gene on Hsa2 branched next, and the gene ...
  https://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-7-239
*  Profile | Exeter Medical School | University of Exeter
Several CCDD genes have been found, which enhance our understanding of the mechanisms involved in brain stem development and ... lymphocyte activation, and cell motility. The molecular regulation of these enzymes, however, is still poorly understood. In ... Identification of changes in gene expression mediated by the SIM2 transcription factor ... turning and pausing by regulating rearrangements of the growth cone cytoskeleton. Here, we provide evidence that not only the ...
  http://medicine.exeter.ac.uk/people/profile/index.php?web_id=John_Chilton
*  Pdf Cancer Facts: A Concise Oncology Text
muscles in messengers and series are that effects in the gene and Failure of AQP-2 in initial understandable and high cells may ... The genes are sustained out of the Online Alphabet (Pre-K Grade) Basic Skills Workbook 2004 through the stroke( hospitalization ... formation: The development of Having a modified artery by the stress of a heredity of Vitamin. substantial methods: A mortality ... A nausea known into the creatine of the response has a congestive lymphocyte that has the body end-stage into a due breast of ...
  http://sonicboomsound.com/family/March2001/movie/pdf/pdf-Cancer-Facts%3A-A-Concise-Oncology-Text/
*  MLPA analysis in a cohort of patients with autism | Molecular Cytogenetics | Full Text
Among the three genes (ACR, RABL2B, SHANK3) in 22q subtelomeric region, SHANK3 is the candidate gene for neurobehavioral ... With the development of new technologies that allow an approach to the whole genome, certainly there will be a greater ... Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007;39(3):319-28.View ArticleGoogle ... 1b). It corresponds to a mosaicism with three cell lines. This patient presents mild intellectual disability and mild autism, ...
  https://molecularcytogenetics.biomedcentral.com/articles/10.1186/s13039-017-0302-z
*  Aflatoxin B1 - Wikipedia
Sur, E; Celik, İ (2003). "Effects of aflatoxin B1on the development of the bursa of Fabricius and blood lymphocyte acid ... a tumor suppressing gene, and at several guanine residues in the 12th and 13th codons of the ras gene, a gene whose product ... Carcinogenicity The carcinogenicity of aflatoxin B1, which is characterized by the development of liver cell carcinoma, has ... This opens the ether rings and upon rearrangement versiconal acetate is formed. Now an esterase, EstA, catalyzes the hydrolysis ...
  https://en.wikipedia.org/wiki/Aflatoxin_B1
*  DNA damage theory of aging - Wikipedia
DNA damage can accumulate with age and lead either to loss of cells, or, in surviving cells, loss of gene expression. ... This led to the identification of a set of genes whose expression was altered after age 40. These genes play central roles in ... "Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young ... Dollé, ME; Giese, H; Hopkins, CL; Martus, HJ; Hausdorff, JM; Vijg, J (Dec 1997). "Rapid accumulation of genome rearrangements ...
  https://en.wikipedia.org/wiki/DNA_damage_theory_of_aging
*  FIP1L1 - Wikipedia
An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause ... FIP1L1-PDGFRA fusion genes have been detected in the eosinophils, neutrophils, mast cells, monocytes, T lymphocytes, and B ... The RARA protein, when ligand-bound, regulates the expression of genes that are implicated in the control of development, ... or T lymphocyte lineages and bearers of these mutations suffer either: a) chronic eosinophilia which may progress to ...
  https://en.wikipedia.org/wiki/FIP1L1
*  Chronic lymphocytic leukemia - Wikipedia
The T cells had been modified to express genes that would allow the cells to proliferate in the body and destroy B cells ... "MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic ... Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. The presence ... Chronic lymphocytic leukemia may transform into Richter's syndrome, the development of fast-growing diffuse large B cell ...
  https://en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia
*  Polysomy - Wikipedia
In squamous cell carcinoma, a protein from the epidermal growth factor receptor (EGFR) gene is often overexpressed in ... Chromosome 1 may contain a gene responsible for tumor development and lead to changes in the karyotype, including fusion of the ... A karyotype rearrangement of individual chromosomes takes place when polysomy in plants in observed. The mechanism of this type ... Human lymphocyte cultures may be analyzed by flow cytometry to assess chromosomal abnormalities, such as polyploidy, ...
  https://en.wikipedia.org/wiki/Polysomy