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*  14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport | JCB
... on target proteins such as Raf to control mitogen-activated protein kinase activation, Cdc25 to control G2/M cell cycle ... Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead ... progression, and BAD and FKHRL1 to control apoptosis. The molecular details of how 14-3-3 functions in many of these ... Total cell lysates corresponding to equivalent amounts of total protein from stable cell lines expressing empty vector (lane 1 ...
  http://jcb.rupress.org/content/156/5/817
*  14-3-3 protein sigma / SFN antibody | acris-antibodies.com
It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling ... regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein ... Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2. p73-dependent ... epithelial marker stratifin: a member of a protein family that has been involved in the protein kinase C. signalling pathway.J ...
  https://www.acris-antibodies.com/target/14-3-3-protein-sigma-antibody-sfn-antibody.htm?ab_ag_reactivity=Can
*  YWHAZ - Wikipedia
Garcia-Guzman M, Dolfi F, Russello M, Vuori K (Feb 1999). "Cell adhesion regulates the interaction between the docking protein ... protein transport, and cell cycle regulation. This combination of dependence on phosphorylation and widespread biological ... tumor progression. The protein has been implicated in many cancers, including lung cancer, breast cancer, lymphoma, and head ... This protein family is known for regulating signal transduction pathways primarily through binding phosphoserine proteins, ...
  https://en.wikipedia.org/wiki/YWHAZ
*  ARAF - Wikipedia
A-Raf activates MEK proteins which causes the activation of ERK and ultimately leads to cell cycle progression and cell ... "Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase ... "A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression". Oncogene. 24 (33): ... A-Raf is the only steroid hormone-regulated Raf isoform. In addition, the A-Raf protein has amino acid substitutions in a ...
  https://en.wikipedia.org/wiki/ARAF
*  Plus it
... beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem ... Thus, GLS2 mediates the role of p53 in regulating the mitochondrial TCA cycle and, thus, in regulating mitochondrial ... and progression but also to metabolic reprogramming in cancer cells. This review summarizes the current state of the tumor ... p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 2008;10:611-8 ...
  http://clincancerres.aacrjournals.org/content/18/6/1561
*  Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the...
... cell cycle progression, and angiogenesis (38,39). Activated Akt can activate the cAMP response element binding protein (40,41 ... Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275 : 10761 - ... Annexin-V/propidium iodide-negative cells were counted as viable cells (lower left quadrant). B: Cell survival is expressed as ... LY294002 caused a marked decrease in cell viability compared with growth factor-treated cells. The number of dye-free cells ...
  http://diabetes.diabetesjournals.org/content/52/12/2959
*  Recombinant human CDK1 + Cyclin-A1 protein (ab104617) | Abcam
Ab104617 is an active full length protein produced in Baculovirus infected Sf9 cells and has been validated… ... repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. ... and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for ... By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and ...
  http://www.abcam.com/recombinant-human-cdk1-cyclin-a1-protein-ab104617.html
*  Cyclin B - Wikipedia
B/CDK1 complex also interacts with a variety of other key proteins and pathways which regulate cell growth and progression of ... Cyclin B is necessary for the progression of the cells into and out of M phase of the cell cycle. At the end of S phase the ... However, if DNA damage is detected alternative proteins are activated which results in the inhibitory phosphorylation of cdc25c ... When p53 build-up triggers cell cycle arrest the levels of downstream proteins p21 and WAF1 are increased which prevents ...
  https://en.wikipedia.org/wiki/Cyclin_B
*  Cdk1 / p34cdc2 Antibody - With BSA and Azide - Mouse Monoclonal Antibody [Clone CDK1/873 ] IHC, IF, FC - Buy Now! |Abgent
... protein stability, response to stress, and progression through the cell cycle. ... It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated ... and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for ... Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase, CDK1, CDC2, CDC28A, CDKN1, P34CDC2 ...
  http://www.abgent.com/products/AH12825-Cdk1--p34cdc2-Antibody-With-BSA-and-Azide
*  Protocols and Video Articles Authored by Arne Lindqvist (Translated to Turkish)
... cell cycle progression is arrested and cell cycle-specific transcription is inhibited. However, cell cycle-specific ... and p38 mitogen-activated protein kinase activity indicates that the p38 pathway regulates Cdc25B localisation in different ... Cdc25 phosphatases are essential regulators of the cell cycle. In mammalian cells, the Cdc25B isoform activates cyclin A- and ... a cell should somehow be maintained in its proper cell-cycle phase. This problem is particularly eminent when a cell arrests in ...
  https://www.jove.com/author/Arne_Lindqvist?language=Turkish
*  Plus it
Serine-arginine protein kinases (SRPK) is a family of cell cycle-regulated kinases that phosphorylate serine/arginine (SR) ... 2007) Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival. Mol Biol Cell 18:404-413. ... which mediates cell cycle progression and cell death in neurons (Jang et al., 2009). Moreover, we found that SRPK2 is a caspase ... Serine-arginine protein kinases 2 (SRPK2) is a cell cycle-regulated kinase that phosphorylates serine/arginine domain- ...
  http://www.jneurosci.org/content/32/48/17262
*  Plus it
... to its role in cell-cycle progression and protection of chromosomal stability by regulating translation of cell division cycle ... Indeed, we found that as G0-synchronized cells are stimulated to reenter the cell cycle, CDC27 protein expression is increased ... ubiquitin-activating enzyme; Boston Biochem), 1 μmol/L His-UBCH10 (ubiquitin-conjugating enzyme), 1 μmol/L His-UBE2S (ubiquitin ... As CDC27 is a component of a cell cycle-regulatory complex, we hypothesized that its expression might be regulated in a cell ...
  http://mcr.aacrjournals.org/content/14/7/634
*  A Potential Therapeutic Strategy for Malignant Mesothelioma with Gene Medicine
The typical type of oncolytic Ad is to activate the viral E1A, a transcriptional factor to drive cell cycle progression and to ... The NF2 gene-encoded protein, merlin, regulates several signal cascades, and the defect constitutively activates Yes-associated ... which promotes cell cycle progression. Re-introduction of the defective p14 gene into p14/p16-defective mesothelioma cells ... transduction of mesothelioma cells with the p16 gene decreased pRb phosphorylation levels and inhibited cell cycle progression ...
  https://www.hindawi.com/journals/bmri/2013/572609/
*  Anti-MAPKAP-K2 Antibody, clone 7H4.2 | 04-539
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV ... This led us to investigate mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), a known substrate of p38 MAP ... and exit from the cell cycle. To investigate DNA damage responses mediated by the p38/stress-activated protein kinase (SAPK) ... MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for p38 ...
  http://www.merckmillipore.com/INTL/en/product/Anti-MAPKAP-K2-Antibody-clone-7H4.2,MM_NF-04-539
*  Demethylase - Wikipedia
... cell cycle progression. KDM5B and KDM5C have also shown to interaction with PcG proteins, which are involved in transcriptional ... that KDM6B expression is up-regulated in activated macrophages and dynamically expressed during differentiation of stem cells. ... Phosphorylation of CheB protein enhances its catalytic MCP demethylating activity resulting in adaption of the cell to ... In mammalian studies, KDM6A has been shown to regulate HOX genes as well. Another example of a demethylase is protein-glutamate ...
  https://en.wikipedia.org/wiki/Demethylase
*  Checkpoints couple transcription network oscillator dynamics to cell-cycle progression | Genome Biology | Full Text
The transcription network regulates the temporal expression of many genes, including cyclins, and drives cell-cycle progression ... Further, we demonstrate that the DNA replication checkpoint effector protein, Rad53, acts to arrest a portion of transcript ... suggesting the oscillator can be uncoupled from cell-cycle progression. It is not clear what mechanisms, if any, ensure that ... maintain coupling of the network oscillator to progression during cell-cycle arrest. ...
  https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0446-7
*  MAPK6 - Wikipedia
"Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression". J. Biol. Chem ... Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. The protein encoded by this gene ... MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades ... Robinson MJ, Xu Be BE, Stippec S, Cobb MH (2002). "Different domains of the mitogen-activated protein kinases ERK3 and ERK2 ...
  https://en.wikipedia.org/wiki/MAPK6
*  Hippo signaling pathway - Wikipedia
These kinases are known regulators of cell cycle progression, growth, and development. Two proteins are known to facilitate the ... When activated, YAP and TAZ can bind to several transcription factors including p73, Runx2 and several TEADs. YAP regulates the ... which promotes cell cycle progression, and diap1 (Drosophila inhibitor of apoptosis protein-1), which, as its name suggests, ... "Salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and is Mutated in Human Cancer Cell Lines". Cell. 110 (4): ...
  https://en.wikipedia.org/wiki/Hippo_signaling_pathway
*  Plus it
Kelly PA, Rahmani Z. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, ... tumor progression, and angiogenesis (1, 2, 12, 17). FOXOs are regulated by a broad variety of external stimuli, such as ... Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol 2002;22:7842-52 ... The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007; ...
  http://clincancerres.aacrjournals.org/content/15/3/752
*  Plus it
... an important regulator of cell cycle progression (8) .. Estrogens activate ERα and ERβ, which are ligand-activated ... It was therefore possible that ICI was regulating cyclin D1 mRNA levels and that IGF-I was regulating cyclin D1 protein ... In addition to directly regulating cell cycle progression, there is evidence that both E and antiestrogens influence growth ... Cells in medium containing 5% FBS served as a control population of cycling cells. Expression of the transfected proteins and ...
  http://cancerres.aacrjournals.org/content/62/14/3985
*  Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro | Annals of the...
Mast cell activation in arthritis; detection of alpha- and beta-tryptase, histamine and eosinophilic cationic protein in ... 17 presumably provided by mast cells of OA synovial tissue4 or possibly by activated chondrocytes,19 although its unequivocal ... an observation which may reflect preferential expression of specific receptors or their position in the cell cycle. ... Evidence presented here shows that histamine up regulates both MMP-13 and MMP-3 production by chondrocytes. Both these MMPs are ...
  http://ard.bmj.com/content/61/8/737
*  IJMS | Free Full-Text | The Role of F-Box Proteins during Viral Infection | HTML
... have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete their infection cycle. ... The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination ... On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box ... of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several ...
  http://www.mdpi.com/1422-0067/14/2/4030/htm
*  Plus it
Next, we evaluated its detailed subcellular localization during cell cycle progression by synchronizing ETK-1 cells with ... we identified RAD51AP1 as a commonly up-regulated gene in ICCs and showed abundant accumulation of RAD51AP1 protein in a great ... are activated in premalignant cells, as well as cancerous cells (29, 30). Highly proliferating cancer cells are likely to ... Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 2003;193:91 ...
  http://clincancerres.aacrjournals.org/content/14/5/1333
*  A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle...
M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell ... cell cycle arrest and miRNA expression profiles and enhances pro-apoptotic survivin-2B expression in renal cell carcinoma cell ... A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M ... A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/ ...
  http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=14644&path%5B%5D=46711
*  no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila | Development
... so cell cycles are regulated by post-transcriptional mechanisms. At cycle 14, the embryo cellularizes and initiates zygotic ... eukaryotic cells have developed checkpoints, regulatory pathways that delay cell-cycle progression until completion of prior ... ATM and ATR substrates include checkpoint kinases CHK1 and CHK2, which phosphorylate proteins that mediate cell-cycle arrest. ... Syncytial embryos are considered to be unusual in that they activate CHK2 but not CHK1 in response to DNA-damaging agents ( ...
  http://dev.biologists.org/content/136/3/449