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*  Cardiac physiology - Wikipedia
In cardiac muscle the T-tubules are only found at the Z-lines. When an action potential causes cells to contract, calcium is ... There are two types of cardiac muscle cell: cardiomyocytes which have the ability to contract easily, and modified ... They are generally much smaller than the contractile cells and have few of the myofibrils or myofilaments which means that have ... Typically, cardiomyocytes have a single, central nucleus, but can also have two or more. Cardiac muscle cells branch freely and ...
  https://en.wikipedia.org/wiki/Cardiac_physiology
*  Myocyte - Wikipedia
A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue. Myocytes are long, tubular cells that ... The striated cells of cardiac and skeletal muscles are referred to as muscle fibers. Cardiomyocytes are the muscle fibres that ... Each muscle fiber contains myofibrils, which are very long chains of sarcomeres, the contractile units of the cell. A cell from ... However muscle cells cannot divide to produce new cells, and as a result we have fewer muscle cells as an adult than a newborn ...
  https://en.wikipedia.org/wiki/Myocyte
*  An approach to endomyocardial biopsy interpretation | Journal of Clinical Pathology
The cellular constituents include fibroblasts, histiocytes, smooth muscle cells, myofibroblasts, mast cells, adipocytes (more ... Nuclear polyploidy is often seen in hypertrophied cardiomyocytes.. Myocardial disease may also arise from myofibril loss ... In addition to the fibroblastic/smooth muscle cell proliferations associated with organisation and fibrosis, the most common ... These may appear in different stages of repair and are often found with myocyte disarray and/or adipocytes (fig 6).31 Thrombus ...
  http://jcp.bmj.com/content/59/2/121
*  Cardiomyopathy
Normally, myofibrils of each cell are aligned end-to-end with myofibrils of the contralateral cardiomyocyte, suggesting that ... Each progenitor cell divides asymmetrically and produces two founder cells that specify individual muscle cell fates and give ... dp53-mediated cell death in cardiomyocytes in stress response. Indeed, it was found that there is massive cell death in the ... contraction requires cell to cell contact, possibly along the ipsilateral domains of cardiomyocytes. This cell surface domain ...
  http://www.sdbonline.org/sites/fly/modelsystem/cardiomyopathy.htm
*  Heart-muscle patches made with human cells improve heart attack recovery
... human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. ... Each patch is a mixture of three cell types -- 4 million cardiomyocytes, or heart-muscle cells; 2 million endothelial cells, ... The sarcomere is the contractile unit in a heart-muscle cell myofibril.. -end- ... found that exosomes released from the large heart-muscle patches appeared to protect the survival of heart-muscle cells.. ...
  https://www.brightsurf.com/news/article/011018447392/heart-muscle-patches-made-with-human-cells-improve-heart-attack-recovery.html
*  Coxsackie virus and adenovirus receptor - Wikipedia
Moreover, CAR expression is not found in normal or tumor cell lines. Expression of CAR in endothelial cells can be regulated by ... reduced density and disorganization of myofibrils, and enlarged mitochondria. Cardiomyocyte-specific deletion of CAR after ... postnatally it is expressed in epithelial cells and in adult cardiac muscle, it is localized at intercalated discs. Knocking ... This was coordinate with the loss of connexin-45 at cell-cell junctions on the sarcolemmal membranes of AV node cells. Mice ...
  https://en.wikipedia.org/wiki/Coxsackie_virus_and_adenovirus_receptor
*  Paxillin - Wikipedia
Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to ... a similar phenomenon is observed in cultured cardiomyocytes. Premyofibrils become nascent myofibrils, which progressively align ... a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion". The Journal of Cell Biology ... During tumor transformation, a consistent finding is that paxillin protein is recruited and phosphorylated. Paxillin plays a ...
  https://en.wikipedia.org/wiki/Paxillin
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Stem Cell Research, Cardiovascular Diseases, Human cardiomyocytes, iPS cells, induced pluripotent stem cells, stem cells, ... contractile fibers house conserved constituents of the muscle cytoarchitecture including densely packed bundles of myofibrils ... We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos. ... Primary Cell Culture, Cell Culture Techniques, Primary Cell Culture, Cell Culture Techniques, Primary Cell Culture, Cell ...
  https://www.jove.com/visualize/abstract/23776695/the-effects-neuregulin-on-cardiac-myosin-light-chain-kinase-gene
*  Propofol-induced Activation of Protein Kinase C Isoforms in Adult Rat Ventricular Myocytes | Anesthesiology | ASA Publications
Lamin B, a protein found in the inner nuclear membrane, has been shown to be involved in the regulation of cell apoptosis37 and ... This is the first study to directly assess the effects of propofol on PKC activation in isolated cardiac muscle cells and to ... The activity of purified PKC from whole cell lysates obtained from control and propofol-treated cardiomyocytes was measured ... 32 Such a position adjacent to sarcoplasmic reticulum ryanodine receptors and myofibrils creates the potential for an intricate ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1922806
*  Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila |...
We find that the size of individual muscles correlates with the number of nuclei per muscle cell and with increasing nuclear ... whether they regulate the nuclear ploidy of muscle cells; (3) whether this is important for cell growth; and (4) whether muscle ... body wall muscles (see Fig. 1A) grow dramatically in∼ 5 days, via sarcomere assembly and the addition of novel myofibrils, ... the atrophic and hypertrophic programs in human skeletal muscles and cardiomyocytes, and display complementary gene expression ...
  http://dev.biologists.org/content/136/6/983
*  SORBS2 - Wikipedia
ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin ... suggesting that ArgBP2 may be involved in myofibril assembly and Z-band signaling in cardiomyocytes, though functional studies ... Cell Res. 310 (1): 88-98. doi:10.1016/j.yexcr.2005.06.026. PMID 16125169. Kioka N, Ueda K, Amachi T (Feb 2002). "Vinexin, CAP/ ... The SOHO domain interacts with flotillin found in lipid rafts. The subcellular localization of this protein in epithelial and ...
  https://en.wikipedia.org/wiki/SORBS2
*  SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton | Development
... to mark cardiomyocytes, DAPI to mark cell nuclei, and either anti-phospho histone H3 (pH3) (1:200; Upstate) to mark cells in M ... we found that inclusion of the pharmacological ROCK inhibitor Y27632 after the onset of cell spreading (40 minutes following ... result from a block in striated muscle α-actin expression and subsequent cardiac muscle differentiation. It is also possible ... SHP-2N308D leads to alterations in cardiac myofibril formation. (A-I) Transverse sections of stage 37 hearts from uninjected (A ...
  http://dev.biologists.org/content/139/5/948
*  MYH10 - Wikipedia
NM-IIB, along with the other non-muscle myosin isoforms IIA and IIC, play a role in cell-cell and cell-matrix adhesion, cell ... "Differential localization of myosin-II isozymes in human cultured cells and blood cells". Journal of Cell Science. 107 (11): ... In adult cardiomyocytes, NM-IIB redistributes from a diffuse cytoplasmic pattern in development to a localized Z-disc and ... Sanger JW, Kang S, Siebrands CC, Freeman N, Du A, Wang J, Stout AL, Sanger JM (2005). "How to build a myofibril". Journal of ...
  https://en.wikipedia.org/wiki/MYH10
*  Cardiac muscle - Wikipedia
Various stem cell lineages have been shown to be able to differentiate into cardiomyocytes, including bone marrow stem cells. ... the fundamental contractile units of muscle cells. The regular organisation of myofibrils into sarcomeres gives cardiac muscle ... It is an involuntary, striated muscle that is found in the walls of the heart. This muscle tissue is known as myocardium, and ... Cardiac muscle cells or cardiomyocytes are the contracting cells which allow the heart to pump. Each cardiomyocyte needs to ...
  https://en.wikipedia.org/wiki/Cardiac_muscle
*  Cardiac myocyte | definition of Cardiac myocyte by Medical dictionary
Also found in: Dictionary, Thesaurus, Encyclopedia.. Related to Cardiac myocyte: cardiac muscle, Cardiomyocytes car·di·ac mus· ... the one or two nuclei of each cell are centrally located and the longitudinally arranged myofibrils have considerable ... The muscle forming the myocardium, consisting of anastomosing transversely striated muscle fibers formed of cells united at ... cardiac muscle. a type of vertebrate muscle found only in the HEART, which appears to be halfway between INVOLUNTARY MUSCLE and ...
  http://medical-dictionary.thefreedictionary.com/Cardiac+myocyte
*  Differentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes | Circulation Research
With maturation, ES cell-derived cardiomyocytes become elongated with well-developed myofibrils and sarcomeres. Beating cells ... Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods Mol ... The gene trap approach in embryonic stem cells: the potential for genetic screens in mice. Ciba Found Symp. 1992; 165: 277-288. ... cell lines that are not as pluripotent as ES cells.73. Kehat et al12 have studied cardiomyocytes from hES cells. Cardiomyocytes ...
  http://circres.ahajournals.org/content/91/3/189
*  Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in...
Distribution and organization of desmin in cultured adult cardiac muscle cells: reflection on function. J. Muscle Res. Cell ... Granger, B. L. and Lazarides, E. (1979). Desmin and vimentin coexist at the periphery of the myofibril Z disc. Cell 18, 1053- ... Different behaviour of the non-sarcomeric cyoskeleton in neonatal and adult rat cardiomyocytes. J. Mol. Cell. Cardiol. 30, 19- ... Additionally, we found that the acetylated microtubule arrays (Ac-MTs), which largely overlap with Glu-MTs, also appeared ...
  http://jcs.biologists.org/content/117/15/3175
*  Heart - Histology & Clinical Aspects | Kenhub
... including the cells and conduction system. Learn this topic now at Kenhub! ... As opposed to the unbranched linear appearance of muscle cells in skeletal muscle tissue, cardiomyocytes are arranged in a ... Bundles of myofilaments (myofibrils) extend across the length of the cell. The myofilaments are bordered on either side by ... Endocardium: simple squamous epithelium with the subendocardial tissue found underneath. Myocardium: cardiomyocytes are ...
  https://www.kenhub.com/en/library/anatomy/histology-of-the-heart
*  Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo | Development
... at specialized adherens junctions that mechanically couple myofibrils across cell membranes of neighboring cardiomyocytes ( ... and has also been found in nonmuscle cells, such as the stress fibers of cultured cells (Pellegrin and Mellor, 2007) and the ... Importantly, we found that immature myofibrils (i.e. myofibrils that had started to incorporate muscle myosin but that did not ... Sarcomeres are chained into linear myofibrils spanning the entire muscle fiber. In mammalian body muscles, myofibrils are ...
  http://dev.biologists.org/content/144/7/1261
*  Myocyte - Wikipedia
A myocyte (also known as a muscle cell)[1] is the type of cell found in muscle tissue. Myocytes are long, tubular cells that ... The striated cells of cardiac and skeletal muscles are referred to as muscle fibers.[3] Cardiomyocytes are the muscle fibres ... A cell from the biceps brachii muscle may contain 100,000 sarcomeres.[11][verification needed] The myofibrils of smooth muscle ... However muscle cells cannot divide to produce new cells, and as a result we have fewer muscle cells as an adult than a newborn. ...
  https://en.wikipedia.org/wiki/Muscle_fiber
*  ACTG1 - Wikipedia
... is found in non-muscle cells in the cytoplasm, and in muscle cells at costamere structures, or transverse points of cell-cell ... myofibril-to-sarcolemma attachment sites". Cell Motility. 3 (5-6): 449-62. doi:10.1002/cm.970030513. PMID 6420066. Pardo JV, ... "Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes". The Journal of Cell Biology. 118 (6 ... "A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly". Experimental Cell Research. 297 (1): 82-96. doi ...
  https://en.wikipedia.org/wiki/ACTG1
*  Plakoglobin - Wikipedia
"A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". Journal of Cell Science. 116 (Pt 24): 4985 ... within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. ... Studies investigating the role of plakoglobin in disease pathology have found that suppression of desmoplakin expression by ... with loss of cardiomyocytes, fibrosis and cardiac dysfunction, as well as alterations in desmosome protein content and gap ...
  https://en.wikipedia.org/wiki/Plakoglobin
*  Cardiomyopathy in Transgenic myf5 Mice | Circulation Research
Large numbers of infiltrating desmin-negative cells were evident, suggesting that they were not of muscle origin. The cells ... Speculatively, the initial synthesis of skeletal muscle proteins within a myocardial cell could lead to dysfunction and perhaps ... Cardiac myofibrils were purified using established methods.35 Ca2+-activated ATPase activity of cardiac myofibrils was measured ... This finding might be expected, since several cardiac-specific genes contain the E-box motif within their promoters.16 17 ...
  http://circres.ahajournals.org/content/78/3/379
*  Cardiac Hypertrophy Cell Biology - Cell Biology of Disease and Exercise
Tethering myocytes and myofibrils together in proper alignment. *Providing architectural support for muscle cells ... It is also known that both are expressed in cardiomyocytes to regulate CTGF levels, but miR-30 found in cardiac fibroblasts ... AGING Cell Bio. a. AGING Exercise. BREAST CANCER Cell Bio. a. Breast Cancer Exercise. METABOLIC SYNDROME Cell Bio. a. Metabolic ... STROKE Cell Bio. a. Stroke Exercise. MUSCULAR DYSTROPHY Cell Bio. a. Muscular Dystrophy Exercise. MULTIPLE SCLEROSIS Cell Bio. ...
  http://pt851.wikidot.com/cardiac-hypertrophy-cell-biology
*  Isoform Composition and Gene Expression of Thick and Thin Filament Proteins in Striated Muscles of Mice after 30-Day Space...
The authors also thank the Head of Laboratory of cell cultures and cell engineering (Institute of Cell Biophysics RAS), ... NT-isoforms of titin were recently found in striated muscles of mammals [31]. The content of NT-titin in mouse striated muscles ... I. V. Ogneva, M. V. Maximova, and I. M. Larina, "Structure of cortical cytoskeleton in fibers of mouse muscle cells after being ... A. Borbély, I. Falcao-Pires, L. Van Heerebeek et al., "Hypophosphorylation of the stiff N2B titin isoform raises cardiomyocyte ...
  https://www.hindawi.com/journals/bmri/2015/104735/