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*  microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression
Hypoxia downregulates the expression of miR-18a. To investigate the function of miR-18a in gastric carcinoma cells under ... microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression. * ... microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression. ... microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression'. ...
  https://www.spandidos-publications.com/10.3892/etm.2015.2546
*  Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and...
... not associated with areas of necrosis and also observed in cells immediately adjacent to blood vessels. A significant increase ... In cell lines experiments, the HPV E7 protein seems to be able to enhance Hypoxia Inducible Factor-1 alpha (HIF-1α) activity, ... The E6 and E7 oncogenes from HR HPVs are responsible for the deregulation of p53 and pRB proteins involved in cell cycle and ... normally involved in the response to hypoxia and able to enhance angiogenesis. We studied tumor specimens from 62 OSCC; a ...
  https://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-6-18
*  Regulation of the Chemokine Receptor CXCR4 by Hypoxia | JEM
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63:1138-1143. ... von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as ... Hyp-inducible factor 1; HRE, Hyp responsive element; HUVEC, human umbilical vein endothelial cell; Hyp, hypoxia; MDM, monocyte- ... Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci ...
  http://jem.rupress.org/content/198/9/1391
*  Von Hippel Lindau Syndrome | SpringerLink
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau associated renal cell carcinoma. ... The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells. Proc ... Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor null renal cell carcinoma ... Clinical implications in hypoxia inducible factor in renal cell carcinoma. Urologic Oncology: Seminars and Original ...
  https://link.springer.com/chapter/10.1007%2F978-1-4419-6448-9_22
*  Gastric Cancer: Overexpression of Hypoxia-Inducible Factor 1 as a Prognostic Factor | Springer for Research & Development
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63: 1138-1143.PubMedGoogle Scholar ... Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol. Cell. Biol. 21: 3436-3444. ... Stromal cell-derived factor-1 alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel- ... Overexpression of Hypoxia-Inducible Factor 1 as a Prognostic Factor. In: Hayat M.A. (eds) Gastrointestinal Carcinoma. Methods ...
  https://rd.springer.com/chapter/10.1007/978-1-4020-8900-8_17
*  DiVA - Search result
The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma2005In: ... in particular alveolar epithelial cells, pulmonary neuroendocrine cells and lung cancer cell lines, and they bind to N'- ... Hypoxia-inducible factor-2alpha mRNA expression in human renal cell carcinoma2009In: Acta Oncologica, ISSN 0284-186X, E-ISSN ... Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analyzed by tissue microarray2006In: European Urology, ISSN ...
  http://umu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A5321%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
*  Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2-Driven VHL−/− Renal Cancer | Cancer Research
Hypoxia-inducible factor-2α specifically promotes growth autonomy of renal cell carcinoma cells. VHL loss RCC cells ... Cell and Tumor Biology Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2-Driven VHL−/− Renal ... Hypoxia inducible factor activates the transforming growth factor-α/epidermal growth factor receptor growth stimulatory pathway ... Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nat Cell ...
  http://cancerres.aacrjournals.org/content/65/12/5221
*  Cell proliferation, tumorogenicity, and apoptosis sub-cluster 14
... to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. ... The successful preparation of cells for therapy depends on the characterization of causal factors affecting cell quality. Ultra ... Programmed Cell Death Induced by (-)-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells ... ... As a result, granulosa cell apoptosis causes follicular atresia. In this study, sheep granulosa cells were cultured under ...
  http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-14-p4.html
*  Publications - Mayo Clinic
... enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. ... Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian ... Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem. ... Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell ...
  http://www.mayo.edu/research/SearchPublications/Publications?authid=10584587
*  A Potential Role of Hypoxia-Inducible Factor-1 (HIF-1) in Esophageal Cancer | Springer for Research & Development
... mainly responsible for maintaining oxygen homeostasis in response to reduced oxygen concentration in cells and tissues. The ... Hypoxia-inducible factor-1 (HIF-1) is a regulatory protein, ... of colon carcinoma cell invasion by hypoxia-inducible factor 1 ... Greijer AE, Van der Wall E (2004) The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57 ... Quintero M, Brennan PA, Thomas GJ, Moncada S (2006) Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1 ...
  https://rd.springer.com/chapter/10.1007/978-981-10-6728-0_7
*  Hypoxia Inducible Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous...
... of hypoxia-inducible factor-1α in the susceptibility to γ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells ... Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells. Cancer Res ... Dysregulation of hypoxia inducible factor-1α in head and neck squamous cell carcinoma cell lines correlates with invasive ... Targeted replacement of hypoxia-inducible factor-1α by a hypoxia-inducible factor 2α knock-in allele promotes tumor growth. ...
  http://clincancerres.aacrjournals.org/content/16/19/4732
*  Restricting Anaerobic Glycolysis Reliance (Warburg effect): Novel Natural Products Based Therapeutic Strategy for Cancer...
... represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway. Toxicol Lett ... Bavachinin (21) hinders the increase in HIF-1α activity in human KB carcinoma and HOS osteosarcoma cells in hypoxia [23]. ... Hypoxia Inducible Factor-1 (HIF-1) is a vital transcription factor that plays a major role in the metabolic programing of tumor ... clear cell renal cell carcinoma (CCRCC) cell proliferation and the P-gp mediated localization of carminomycin I (34) in CCRCC ...
  http://www.alliedacademies.org/articles/restricting-anaerobic-glycolysis-reliance-warburg-effect-novel-natural-products-based-therapeutic-strategy-for-cancer-treatment-8060.html
*  Hypoxia Inducible Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous...
Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous Cell Carcinoma. Gui ... When OSCC cells were cultured at 5% O2, only HIF-2α contributed to the expression of vascular endothelial growth factor. At 1% ... Hypoxia Inducible Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous ... Hypoxia Inducible Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous ...
  http://clincancerres.aacrjournals.org/content/early/2010/09/16/1078-0432.CCR-10-1408
*  Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model - Semantic Scholar
Tumor cells metastasize from the primary renal tumor to the lungs, liver and mesentery mimicking the progression of RCC in ... The KCI-18 RCC cell line was generated from a patient with papillary renal cell carcinoma. Following orthotopic renal ... we used the orthotopic metastatic KCI-18 renal cell carcinoma (RCC) model established in our laboratory. ... implantation of KCI-18 RCC cells and serial in vivo kidney passages in nude mice, we have established a reliable and ...
  https://www.semanticscholar.org/paper/Progression-of-renal-cell-carcinoma-is-inhibited-by-Hillman-Wang/18033d45505e2b3c3ae5b8825d78e0022050e273
*  Table of Contents | Cancer Research
Activated by Hypoxia-Inducible Factor-1α Overproduces Proopiomelanocortin in von Hippel-Lindau-Mutated Renal Cell Carcinoma ... S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and Cap43 Expression in Mouse Epidermal Cl41 Cells ... Cell and Tumor Biology Parathyroid Hormone-Related Protein Is an Essential Growth Factor for Human Clear Cell Renal Carcinoma ... Cell and Tumor Biology Inhibition of Tumorigenicity and Metastasis of Human Melanoma Cells by Anti-Cathepsin L Single Chain ...
  http://cancerres.aacrjournals.org/content/64/1
*  AIDA | Cancer Genetics Web
Expression of hypoxia-inducible factor-1alpha protein predicts survival in patients with transitional cell carcinoma of the ... high-metastatic-potential squamous cell carcinoma cells (SAS-Ly) and low-metastatic-potential squamous cell carcinoma cells ( ... Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in ... Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma.. ...
  http://www.cancerindex.org/geneweb/AIDA.htm
*  CiNii 論文 - 機能性RNAの変遷を通して, siRNAによる肝疾
Effect of ionization on the expression of hypoxia-inducible factor-1 alpha and VEGF in hepatocellular carcinoma HepG2 cells ... Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines SIMIANTONAKI N ... Immunohistochemical expression of vascular endothelial growth factor (VEGF) in intestinal type gastric carcinoma AICA M ... Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl (2) in cultured cancer cells DAI M ...
  https://ci.nii.ac.jp/naid/10021939025
*  SIAH1 gene cDNA ORF clone, Homo sapiens(human) - GenScript
Siah-1 is associated with expression of hypoxia-inducible factor-1? in oral squamous cell carcinoma.. Aga M, Kondo S, Wakisaka ... STAT3 Potentiates SIAH-1 Mediated Proteasomal Degradation of ?-Catenin in Human Embryonic Kidney Cells.. Shin M, Yi EH, Kim BH ... Siah-1 is associated with expression of hypoxia-inducible factor-1? in oral squamous cell carcinoma.. Auris, nasus, larynx44(2) ... Title: Siah-1 is associated with expression of hypoxia-inducible factor-1? in oral squamous cell carcinoma. ...
  https://www.genscript.com/gene/other/6477/siah1.html
*  VHL | Cancer Genetics Web
We report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible ... hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a ... Reciprocal regulation of hypoxia-inducible factor 2α and GLI1 expression associated with the radioresistance of renal cell ... Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells.. FEBS Lett. 2014; ...
  http://www.cancerindex.org/geneweb/VHL.htm
*  Hypoxia-inducible factor legal definition of Hypoxia-inducible factor
What is Hypoxia-inducible factor? Meaning of Hypoxia-inducible factor as a legal term. What does Hypoxia-inducible factor mean ... Definition of Hypoxia-inducible factor in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Effects of hypoxia inducible factor-1[alpha] (HIF-1[alpha]) on the growth & adhesion in tongue squamous cell carcinoma cells ... Hypoxia-inducible factor legal definition of Hypoxia-inducible factor https://legal-dictionary.thefreedictionary.com/Hypoxia- ...
  https://legal-dictionary.thefreedictionary.com/Hypoxia-inducible+factor
*  Iliopoulos Lab - Massachusetts General Hospital, Boston, MA
Discovery and Development of Hypoxia Inducible Factor 2a (HIF2a) inhibitors for treatment of Renal Cell Carcinoma and other ... The main function of this protein in the cells is to keep Hypoxia Inducible Factor 2 (HIF2a) under physiologic control; VHL ... We use Renal Cell Carcinoma (RCC) as a model disease of altered cancer metabolism and angiogenesis mechanisms. Cancer cells ... allows the expression of HIF2a only when the cells lack nutrients or the oxygen level drops within a cell (hypoxia). HIF2a is a ...
  https://www.massgeneral.org/research/researchlab.aspx?id=1180
*  JCI - Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model
Hypoxia-inducible factors, stem cells, and cancer. Cell. 2007;129(3):465-472.. View this article via: PubMed CrossRef Google ... Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. ... Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40(2):294-309.. View this article via: PubMed ... Differential roles of hypoxia-inducible factor 1alpha (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol. 2003;23(24 ...
  https://www.jci.org/articles/view/73665
*  Gene expression - The Full Wiki
"Effects of hypoxia inducible factor-1alpha (HIF-1alpha) on the growth & adhesion in tongue squamous cell carcinoma cells". ... The daughter cells change into the many cell types of the mature embryo. These include neurones, muscle cells, epithelium, ... totipotent stem cells become the various cell lines of the embryo, which in turn become fully differentiated cells. In other ... the expression of HMGA2 in cancer cells is linked to poor prognosis in cancer patients, but also with these cells' sensitivity ...
  http://www.thefullwiki.org/Gene_expression
*  NEDD9 - Wikipedia
... enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells ... based on binding to T-cell factor (TCF) factors in the promoter region. NEDD9 is induced by hypoxia and loss of VHL, based on ... and renal cell carcinoma cells. A non-coding RNA, named B2, extending from 10 kb upstream of NEDD9 exon 1 to exon 4 has been ... Tikhmyanova N, Tulin AV, Roegiers F, Golemis EA (2010). "Dcas supports cell polarization and cell-cell adhesion complexes in ...
  https://en.wikipedia.org/wiki/NEDD9
*  CEA: Combination-based gene set functional enrichment analysis (pdf) | Paperity
... of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer ... Mesnil, M. & Yamasaki, H. Cell-cell communication and growth control of normal and cancer cells: evidence and hypothesis. Mol ... Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma. Anticancer Res 29, 4337-4343 (2009). ... between hypoxia-inducible factor-2alpha and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma ...
  http://paperity.org/p/152469662/cea-combination-based-gene-set-functional-enrichment-analysis