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*  Implication for Bone Marrow Derived Stem Cells in Hepatocyte Regeneration after Orthotopic Liver Transplantation
... as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas. ... Alternative cell sources have come into focus of research for cell based liver regenerative medicine in order to treat ... N. Fausto, "Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells," Hepatology, vol. 39, no. 6, pp. 1477 ... The most common cell source in liver growth/regeneration is replication of preexisting hepatocytes although liver progenitor ...
  https://www.hindawi.com/journals/ijh/2013/310612/
*  Most recent papers with the keyword Progress in liver transplantation | Read by QxMD
Amniotic epithelial cells (AECs) represent a useful and noncontroversial source for liver-based regenerative medicine, as they ... can differentiate into hepatocytes upon transplantation into the liver. However, the possibility that AECs can differentiate ... BACKGROUND: Liver transplantation (LT) is a successful treatment for both acute liver failure and end-stage liver disease. The ... Drug-induced liver failure is a significant indication for a liver transplant, and unexpected liver toxicity is a major reason ...
  https://www.readbyqxmd.com/keyword/43800
*  Most recent papers with the keyword Donor derived | Read by QxMD
Amniotic epithelial cells (AECs) represent a useful and noncontroversial source for liver-based regenerative medicine, as they ... can differentiate into hepatocytes upon transplantation into the liver. However, the possibility that AECs can differentiate ... a stem cell-based cell replacement therapy seems to be the ideal cure... ... into other liver cell types, such as hepatic sinusoidal endothelial cells (HSECs), has never been assessed. In order to test ...
  https://www.readbyqxmd.com/keyword/120302
*  Human Stem Cell-derived Hepatocytes Regenerate Liver Function: Study
Functional hepatocytes from human stem cells were found to increase the survival of mice with acute liver injury, say ... David C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, U.K., comments on the importance of Vosough et al ... differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based ... Living Donor Liver Transplant: What Are the Risks?. The risk of dying as a result of a living donor liver segment removal is ...
  https://www.medindia.net/news/human-stem-cell-derived-hepatocytes-regenerate-liver-function-study-122716-1.htm
*  Academic Press - Translating Regenerative Medicine to the Clinic - Jeffrey Laurence - 9780128005521 - Schweitzer Online
Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, ... discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle ... Translating Epigenetics to the Clinic.Encompasses the latest innovations and tools being used to develop regenerative medicine ... It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by ...
  https://www.schweitzer-online.de/ebook/Laurence/Translating-Regenerative-Medicine-Clinic/9780128005521/A34439101/
*  Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
... while single base changes occur at very low rates. The cells can readily be converted into functional hepatocytes in vitro and ... regenerative medicine, and gene therapy. show less ... Clonal long-term expansion of primary adult liver stem cells ... We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be ... We now describe conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver. ...
  https://dspace.library.uu.nl/handle/1874/331481
*  'centrifugation density gradient' Protocols and Video...
Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion', 'Generation of Induced Pluripotent ... Cloning and Large-Scale Production of High-Capacity Adenoviral Vectors Based on the Human Adenovirus Type 5', 'Scalable 96-well ... Purification of Biotinylated Cell Surface Proteins from Rhipicephalus microplus Epithelial Gut Cells', 'A Primary Human ... Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular ...
  https://www.jove.com/keyword/centrifugation+density+gradient
*  Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
Liver and pancreas cells grow in a gel-based extracellular matrix (ECM) and a defined medium. The cells can self-organize into ... which could facilitate the study of human biology and allow gene correction for regenerative medicine purposes. The complete ... hepatocytes) and in vivo (hepatocytes and endocrine cells). Genetic modification of these organoids opens up avenues for the ... We provide a detailed protocol that describes how to grow adult mouse and human liver and pancreas organoids, from cell ...
  https://dspace.library.uu.nl/handle/1874/355539
*  Vascularized and functional human liver from an iPSC-derived organ bud transplant. | Yokohama City University
Manipulation of iPSCs holds great promise for regenerative medicine. However, clinical trials of "cell transplantation", that ... Current hepatocyte model systems include primary human hepatocytes harvested from cadavers, immortalized cell lines, hiPSC- ... Prioritization of compounds based on human hepatotoxicity potential is currently a key unmet need in drug discovery. ... During the early liver organogenesis, liver progenitor cells delaminate from the foregut endodermal sheet and form a three- ...
  https://www.yokohama-cu.ac.jp/en/20130701-takebe-vascularized-and-functional-human-liver-from-an-ipsc-derived-organ-bud-transplant/
*  RegenerativeMedicine.net - Article Archives
... of regenerative medicine research and therapies as reviewed by the experts at the McGowan Institute for Regenerative Medicine ... Reprograms Human Liver Cells Spread of Cancer Cells May Be Slowed by Targeting of Protein New Technique Could Make Cell-Based ... 1) the promise found in the ability to generate hepatocyte-like cells (HLCs) from cells called pluripotent stem cells (iPSCs); ... Via Regenerative Medicine Therapy Human Blood Cell Found Through Regenerative Medicine Work at Stanford Regenerative Medicine ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=25452&qCat=USN
*  Isolation, Characterization, and Differentiation to Hepatocyte-Like Cells of Nonparenchymal Epithelial Cells from Adult Human...
Dimitry A. Chistiakov, Liver Regenerative Medicine: Advances and Challenges, Cells Tissues Organs, 2012, 196, 4, 291. CrossRef ... human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell ... Catherine A. Lombard, Julie Prigent, Etienne M. Sokal, Human Liver Progenitor Cells for Liver Repair, Cell Medicine, 2013, 5, 1 ... Side Population Cells from an Immortalized Human Liver Epithelial Cell Line Exhibit Hepatic Stem-Like Cell Properties, Cell ...
  http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2006-0664/abstract
*  Cellular Dynamics Licenses Technology Fr... ( MADISON Wis. April 13 2011 /- Nick S...)
CDI will apply this patented methodology in the development and production of iCell® Hepatocytes, iPSC-derived liver cells. ... The Company is funded in part through the support of the California Institute for Regenerative Medicine. ... Our therapy is based on pancreatic beta cell progenitors (Pro-Islet™) derived from human pluripotent stem cells. These cells ... Biology NewsMedicine NewsBiology ProductsMedicine ProductsBiology DefinitionMedicine DefinitionBiology TechnologyMedicine ...
  http://www.bio-medicine.org/biology-technology-1/Cellular-Dynamics-Licenses-Technology-From-ViaCyte-19140-1/
*  Recent advances in three-dimensional multicellular spheroid culture for biomedical research - Lin - 2008 - Biotechnology...
A multiple-funnels cell culture insert for the scale-up production of uniform cell spheroids, Regenerative Therapy, 2017, 7, 52 ... Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems ... Dagmar Kulms, Friedegund Meier, Skin Tissue Models for Regenerative Medicine, 2018, 57. CrossRef ... Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids ...
  http://onlinelibrary.wiley.com/doi/10.1002/biot.200700228/abstract
*  Articles Added on February 5, 2013
... methods for efficient and reliable cell seeding into these and tissue-engineering constructs used for regenerative medicine ... few cases have shown selective enrichment of hESC-derived hepatocytes and their integration into host liver tissues. Here ... ... Here, we describe a capillary force-based method for seeding the human prostate cancer cell lines M12 ... ... Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to ... ...
  http://www.biomedsearch.com/added/20130205.html
*  आयुष दर्पण: 2013-07-21
... differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based ... David C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, U.K., comments on the importance of Vosough et al ... transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to ... This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease ...
  http://ayushdarpan.blogspot.com/2013_07_21_archive.html
*  HCV Research and News: 07/26/13
... differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based ... David C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, U.K., comments on the importance of Vosough et al ... Liver Basics Liver Cancer Liver Damage Liver Disease Liver Disease Progression Liver Enzymes Liver Failure Liver fibrosis ... Liver Stiffness Liver Stiffness Measurement Liver toxicity Liver Transplant Liver Tumours Living Donor Living-donor liver ...
  http://hepatitiscresearchandnewsupdates.blogspot.com.es/2013_07_26_archive.html
*  IQ4I Research and Consultancy Published New Pipeline Analysis on 'Non-Alcoholic SteatoHepataitis (NASH)'
medicines covering small molecules, antibodies, stem cell therapies, recombinant proteins and RNA-based therapeutics, but ... hepatocyte injury and fibrogenesis and may worsen into fibrosis or cirrhosis, liver failure and rarely into liver cancer. ... regenerative ... With fact-based insights and accurate market forecasts, we ... NASH, if untreated can progress to liver-destroying cirrhosis and potentially cancer. Majority of the NASH pipeline drugs are ...
  https://www.medindia.net/health-press-release/IQ4I-Research-and-Consultancy-Published-New-Pipeline-Analysis-on-Non-Alcoholic-SteatoHepataitis-NASH-379426-1.htm
*  Stem Cells Treatment For Liver Disorders In India
... like fatty liver, liver failure, liver cirrhosis etc. are noted to be growing problems and is identified to be a leading cause ... discovery of stem cells and the science of regenerative medicine reveals the possibility of delayed progression of liver damage ... The resident stem cell quota that is present in liver named to be hepatocytes, are responsible for normal wear and tear of the ... Although, embryonic stem cells are proven to be the most potent candidates for cell based therapy, their adult counterparts ...
  http://www.sooperarticles.com/health-fitness-articles/diseases-articles/stem-cells-treatment-liver-disorders-india-1604372.html
*  Muse cell - Wikipedia
... they could provide an ideal source of pluripotent stem cells for regenerative medicine and cell-based therapy. Currently, Life ... and human anti-trypsin-expressing hepatocytes in the liver, human dystrophin-expressing cells in the muscle, neurofilament and ... When mesenchymal cells (sometimes called mesenchymal stem cells) are separated into Muse and non-Muse cells by SSEA-3 cell ... Therefore, Muse cells are double positive for pluripotent and mesenchymal stem cell markers. Cell isolation by SSEA-3 cell ...
  https://en.wikipedia.org/wiki/Muse_cell
*  Learn about the World Regenerative Medicine Market
... p090567/World-Regenerative-Medicine-Market.htmlThis report analyzes the worldwide markets for Regenerative Medicine in Millions ... research report related to the Pharmaceutical industry industry is available in its catalogue.World Regenerative Medicine ... 13 Type-2 Regenerative Medicine II-13 Therapies Based on Human Cells and Tissues II-13 Type-3 Regenerative Medicine II-15 Based ... Diabetes III-3 Market for Liver and Pancreas Transplantation III-4 Implantable Regenerative Products Take Over Sports Medicine ...
  http://www.marketwired.com/press-release/learn-about-the-world-regenerative-medicine-market-872472.htm
*  KAKEN - Researchers | KASAI Shinichi (40091566)
... hybrid artificial liver,G-CSF,無アルブミンラット,肝不全, # of Research Projects ... Artificial liver support based on the regenerative medicinePrincipal Investigator. *. Principal Investigator. KASAI Shinichi ... hepatocytes / 胎児膵 / 肝機能障害 / artificial liver support / liver failure / bone marrow cells / severe sepsis / Neuropeptide Y (NPY ... Hepatocyte Groth Factor / liver regeneration / 肝非実質細胞 / モノクローナル抗体 / 親指化膜 / Entrapped
  https://nrid.nii.ac.jp/nrid/1000040091566/
*  Biofabrication with Stem Cells | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation Liliang Ouyang1,2,6, Rui ... Biofabrication with Stem Cells Curator: Larry H. Bernstein, MD, FCAP Biofabrication Special Issue: Dec 2015; 7(4). http:// ... Cellular self-assembly based on cell-to-cell communication is a well-known tissue organizing process in living bodies. Hence, ... regenerative medicine, stem cell expansion and biology studies. ... into hepatocyte-like cells for the generation of mini-livers in ...
  https://pharmaceuticalintelligence.com/2015/11/07/biofabrication-with-stem-cells/
*  Frontiers | A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts...
... the liver, but is also manifested in skin fibroblasts. Transcriptome data enabled the generation of a regulatory network based ... the liver, but is also manifested in skin fibroblasts. Transcriptome data enabled the generation of a regulatory network based ... consumption results in an increase of insulin and insulin resistance that can lead to the accumulation of fat in the liver. ... consumption results in an increase of insulin and insulin resistance that can lead to the accumulation of fat in the liver. ...
  https://www.frontiersin.org/articles/10.3389/fphys.2012.00339/full
*  Grant of the Month 2018
Medicine and UPMC Health System have established the McGowan Institute for Regenerative Medicine which serves as a single base ... stem cell therapy, medical devices and other techniques to repair damaged or diseased tissues and organs. The University of ... of operations for the university's leading scientists and clinical faculty working to develop regenerative medicine therapies. ... Title: A New Molecular Mechanism to Bioengineering a Liver. Description: Hepatocyte transplantation has many potential ...
  http://www.mirm.pitt.edu/category/grant-of-the-month/grant-of-the-month-2018/
*  The AMEDEO Literature Guide
Amedeo offers weekly literature overviews in scientific medicine. Select a topic, define your favourite journals, and you will ... Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes.. Cell Stem Cell. 2018 Jun 7. pii: S1934- ... CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges.. Cell Stem Cell. 2018;22:801-805.. ... Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.. Cell Stem Cell. ...
  https://amedeo.com/medicine/stc/cellstce.htm