Marine Drugs | Free Full-Text | The Marine Fungal Metabolite, Dicitrinone B, Induces A375 Cell Apoptosis through the ROS...
Caspase-9, caspase-8 and caspase-3 were activated during the process, leading to PARP cleavage. The pan-caspase inhibitor, Z- ... cell cycle arrest and apoptosis rate analysis results showed that dicitrinone B significantly induced A375 cell apoptosis. ... Our data for the first time showed that dicitrinone B inhibits the proliferation of tumor cells by inducing cell apoptosis. ... Further studies indicated that the apoptosis was associated with both intrinsic and extrinsic apoptosis pathways under the ...http://www.mdpi.com/1660-3397/12/4/1939/htm
Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe | Disease Models &...
... outcome of our work in the field is that we eventually showed that senescence is an active process that limits tumorigenesis ... We later showed that it plays a role in many physiological settings; for example, in wound repair. ... If you think back to apoptosis, we know that apoptosis at the end of the day is a process that is driven by caspases; these ... awarded for studies on how DNA tumor viruses can transform cells to cancer cells. My work on E1A and apoptosis fit precisely ...http://dmm.biologists.org/content/8/11/1345
Thymoquinone causes multiple effects, including cell death, on dividing plant cells.
BAG genes are known for the regulation of diverse physiological processes in animals, including apoptosis, tumorigenesis, ... It also inhibits proliferation and induces programmed cell death (apoptosis) in human skin cancer cells. The present study ... Thymoquinone causes multiple effects, including cell death, on dividing plant cells.. S.E., Hassanien; A.M., Ramadan; A.Z., ... Thus, TQ has multiple effects, including cell death, on dividing plant cells and plants may serve as a useful system to further ...http://dspace.must.edu.eg/handle/123456789/220
MicroRNA Regulation of Cardiovascular Development | Circulation Research
... apoptosis, stress response, and tumorigenesis. The identification of miRNAs expressed in specific cardiac and vascular cell ... Despite advances in miRNA discovery, the role of miRNAs in physiological and pathophysiologic processes is just emerging. It ... MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008; 2: 219-229. ... such as cell proliferation, differentiation, apoptosis, stress response, and tumorigenesis. In many cancers, miRNAs are ...http://circres.ahajournals.org/content/104/6/724
Cloning-free regulated monitoring of reporter and gene expression | BMC Molecular Biology | Full Text
... cell growth, apoptosis and tumorigenesis. Many different stimuli have been identified that activate the NF-κB pathway such as ... NFκB is a member of the rel family of transcription factors that regulates several important physiological processes, including ... Since many tumor cell lines are high in NF-κB activity , we have observed higher reporter activity in the cell line used in ... The green o red bands of the captured color images of cells consisting of ~1344 × 1024 pixels were processed as follows. The ...https://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-10-20
Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
... c-Myc plays an essential role in the regulation of many physiological processes including cell cycle control, apoptosis, ... Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes ... Cell apoptosis. c-Myc is not only an inducer of cell proliferation, but also has the ability to regulate cell apoptosis via ... Regulation of cell cycle. The primary functions of c-Myc are to promote cell proliferation and to arrest cell differentiation [ ...http://www.ijbs.com/v10p1084.htm
Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy | OMICS International
Cancer is a disease in which normal physiological processes are imbalanced, leading to tumour formation, metastasis and ... to regulate cell survival, proliferation and migration. These processes are dysregulated during tumourigenesis and are critical ... Cancer is a disease in which normal physiological processes are imbalanced, leading to tumour formation, metastasis and ... 2007) Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12: ...https://www.omicsonline.org/inhibitor-of-apoptosis-proteins-promising-targets-for-cancer-therapy-2157-2518.S14-004.php?aid=14011
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
... including the cell cycle, cell differentiation, and apoptosis, and that the binding of Fbxw7 to its substrates depends on their ... suggesting that such cells might be in the process of transdifferentiation to the cholangiocytes by Notch activation. At 50 ... These findings thus suggest that an Fbxw7-SREBP1 axis plays a key physiological role in the regulation of lipid metabolism in ... much attention has focused on the relation between the accumulation of cyclin E due to loss of Fbxw7 function and tumorigenesis ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3007132/
SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
SRC-3 and apoptosis. Apoptosis is a normal physiological process of the cell; altered regulation of apoptosis is common in ... Keywords: Steroid receptor coactivator-3, mice model, tumorigenesis, cell cycle, apoptosis, invasion and metastasis ... SRC-3 is involved in cell cycle control. Cancer is considered to be a disease of the cell cycle, and compromised cell cycle ... Mol Cell Biol. 2002;22:3549-61 70. Li R, Chen Y, Shu WX, Chen Z, Ke WJ. Involvement of SRC-3 in deguelin-induced apoptosis in ...http://www.ijbs.com/v07p0664.htm
JCI - The FGF system has a key role in regulating vascular integrity
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am. J. Pathol. ... These activities are critical to a wide variety of physiological as well as pathological processes including angiogenesis (6), ... Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev. 16:179-186. View this article via: CrossRef ... At day 5, endothelial cells lost cell-cell contacts and gaps formed between cells. Scale bars: 10 μm. (B) Mouse carotid artery ...https://www.jci.org/articles/view/35298
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Generation of human secondary cardiospheres as a potent cell processing strategy for cell-based cardiac repair. ... is a cytoprotective agent in a variety of cells including hepatocytes as well as an inducer of apoptosis in cancer cells. In ... AEG-1 co-localized with Ki-67, indicating a role in cell proliferation, as previously revealed in tumorigenesis. Taken together ... AEG-1 is also implicated in diverse physiological and pathological processes, such as development, inflammation, ...https://www.jove.com/visualize?author=Yoo-Wook%20Kwon%20
Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human...
The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein ... the quintessential moonlighting protein in normal cell function and in human disease. [Michael A Sirover;] -- Glyceraldehyde-3- ... Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis ... GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival --. Moonlighting GAPDH and age-related ...http://www.worldcat.org/title/glyceraldehyde-3-phosphate-dehydrogenase-gapdh-the-quintessential-moonlighting-protein-in-normal-cell-function-and-in-human-disease/oclc/988291290
Carcinogenesis - Wikipedia
... and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues ... Mutations in genes that regulate cell division, apoptosis (cell death), and DNA repair may result in uncontrolled cell ... Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed ... Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist ...https://en.wikipedia.org/wiki/Carcinogenesis
... whether PMA mimics a physiological process is not known. Ovarian cancer cells in the patient might produce LPA either ... Miao J. Y., Kaji K., Hayashi H., Araki S. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J. Biochem. ... implicating it in ovarian tumorigenesis (2, 3, 4, 5, 6) . Because LPA levels are higher in ascitic fluid than in plasma, it has ... We found that ovarian cancer cells, in contrast to normal ovarian epithelial cells or breast cancer cells, produce LPA either ...http://clincancerres.aacrjournals.org/content/6/6/2482
Protocols and Video Articles Authored by Mattia Boeri
... are small noncoding RNAs that actively modulate cell physiological processes as apoptosis, cell-cycle control, cell ... In this review we summarize the current knowledge on the role of miRNAs and their target genes in lung tumorigenesis and ... significantly decreased cell proliferation and cell cycle perturbation associated with upregulation of p21 and p27 cell-cycle ... We screened a panel of human tumor samples and cancer cell lines and identified that the YAP1 amplification event is actually ...https://www.jove.com/author/Mattia_Boeri
Trends in Stem Cell Proliferation and Cancer Research | Springer for Research & Development
... stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell ... Functions and Dysfunctions of Physiological Processes Involved in Tumor Genesis and Malignancy. * Front Matter Pages 337-337 ... BH3-Only Proteins in Cancer and Apoptosis Fabio Ghiotto, Claudya Tenca, Franco Fais, Silvia Bruno ... stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell ...https://rd.springer.com/book/10.1007/978-94-007-6211-4
Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells | SpringerLink
... as appropriate model cells to pinpoint the mechanism of the progress of neurodegenerative disorders. In the present study, we ... Recently our group used oligodendrocyte progenitor cells (OPCs) ... Therefore OPN therapy may be considered as a feasible process ... Protective role of OPN, as a negative regulator of tumorigenesis, has already been clarified. Human embryonic stem cell-derived ... involved in a number of physiological events including bone formation and remodeling, immune responses, and tumor progression. ...https://link.springer.com/article/10.1007/s10571-017-0563-4
Ph.D. | Einstein/Montefiore Department of Medicine
Programmed cell death is a genetically controlled physiological process that rids the body of unwanted or malfunctioning cells ... Direct Activation of BAX by BTSA1 Ovecomes Apoptosis Resistance in Acute Meyloid Leukemia. Cancer Cell 2017, 32: 490-505 ... signaling pathways can lead to uncontrolled cell growth and proliferation leading to malignant transformation and tumorigenesis ... of major cell death and cell survival pathways to enable us to manipulate cell signaling and fate desicion in physiological and ...http://www.einstein.yu.edu/departments/medicine/faculty/profile.asp?id=12958
IJMS | Free Full-Text | Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear ...
... to inhibit cell apoptosis, to prevent protein unfolding and to promote cholesteatoma growth. ... The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. ... It participates in various physiological functions, such as stress response, cell differentiation, cell proliferation, ... mRNA metabolic process. negative regulation of transcription. protein folding. regulation of cell cycle. response to unfolded ...http://www.mdpi.com/1422-0067/14/7/14439/htm
Waldman, Scott - Philadelphia University + Thomas Jefferson University - Thomas Jefferson University
Beyond cell autonomous processes within epithelial cells, non-autonomous interactions with underlying mesenchymal elements ... The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of ... Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. This novel role in ... Conversely, GCC signaling restores survival circuits in colon cancer cells, decelerating the cell cycle and switching from ...https://www.jefferson.edu/university/jmc/departments/pharmacology/faculty_staff/faculty/waldman.html
Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling...
Results of apoptosis assay in SW403 cells. We next determined the effect of ZJW extracts on cell apoptosis. Flow cytometry ... accumulating preclinical and clinical evidences have pointed out that 5-HT not only plays a role in physiological cell mitosis ... 5-HT and 5-HTRs may be a potential factor in the tumorigenesis and tumor progression. It has been found that the agonists of 5- ... but also has a close correlation with cancers . Certain subtypes of 5-HTRs have been reported in the process of different ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-2006-7
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma |...
Most physiological, biochemical, and behavioral processes in mammals follow circadian rhythm, which is generated by an ... cell differentiation, cell migration, cell apoptosis, cell cycle, and proliferation (Fig. 4C). To identify potential Bmal1 ... Apoptosis was evaluated by flow cytometry of SCC9/Bmal1 and SCC9/vehicle cells stained with Annexin V and PI. D, Cell-cycle ... between SCC9/Bmal1 cells and SCC9/vehicle cells. C, Gene ontology (GO) assignment of the top 15 biological processes (BP) ...http://cancerres.aacrjournals.org/content/77/2/532
Apoptosis in neural development and disease | ADC Fetal & Neonatal Edition
INHIBITION OF APOPTOSIS. As apoptosis is a highly regulated physiological process, a window of opportunity exists for ... Apoptosis in the developing nervous system. Programmed cell death by apoptosis occurs in many developmental processes, ... Dysregulation of apoptosis is seen after cellular insults or in neurodegeneration as well as in tumourigenesis. Strategies ... 1996) Integrated control of cell proliferation and apoptosis by oncogenes In: Thomas NSB, ed. Apoptosis and cell cycle control ...http://fn.bmj.com/content/77/3/F165
Netrin‐1 Preserves Blood‐Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling...
... is involved in both physiological and pathological processes such as apoptosis, inflammation, neurogenesis, and tumorigenesis ... Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 2006;172: ... 1 in mesenchymal stem cells. Cell Death Dis. 2013;4:e563. ... J Cell Biol. 2005;169:941-952.. OpenUrlAbstract/FREE Full Text ... Arrow indicates that NTN‐1 (B) and DCC (C) were expressed in endothelial cells. *P,0.05 vs sham. Scale bar=50 μm. ...http://jaha.ahajournals.org/content/6/5/e005198
The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis - Tabular View - ClinicalTrials.gov
... and several other important physiological processes. Interestingly, the influence of IL-6 in human cancers is varied depending ... In principle, cancer cells can spread within the body by different mechanisms, such as direct invasion of surrounding tissues ( ... Additionally, recent study supports the hypothesis that IL-6 facilitates tumorigenesis of cervical cancer via VEGF-mediated ... Increased levels of COX-2 may contribute to carcinogenesis by modulating xenobiotic metabolism, apoptosis, immune surveillance ...https://clinicaltrials.gov/ct2/show/record/NCT00173381?view=results