Accumulation of LDL in Rat Arteries Is Associated With Activation of Tumor Necrosis Factor-α Expression | Arteriosclerosis,...
... followed by activation of endothelial expression of leukocyte adhesion molecules, such as vascular cell adhesion molecule-1 and ... Intercellular adhesion molecule-1 gene expression in human endothelial cells: differential regulation by TNF-α and phorbol ... To determine whether the vascular expression of TNF-α in response to LDL was associated with a local activation of TNF-α gene ... Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of ...http://atvb.ahajournals.org/content/20/10/2205
MicroRNA Profiling Response to Acupuncture Therapy in Spontaneously Hypertensive Rats
... miRNA-339 has been shown to have a central role in regulating the expression of intercellular cell adhesion molecule-1 . ... "Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells," PloS One, vol. 9, no ... The MAPK signaling molecules have been recognized as important mediators in directing cellular responses to a diverse array of ... miR-145 has been proposed to inhibit human embryonic stem cell self-renewal, represses expression of pluripotency genes, and ...https://www.hindawi.com/journals/ecam/2015/204367/
Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review
There was enhanced total release of intercellular cell adhesion molecule 1 (ICAM-1), CD14, and LPL but not of osteoprotegerin, ... The ratio of gene expression in fat cells to nonfat cells ranged from 0.06 to 128 (Table 2). However, if in vitro ... Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. Journal of ... vascular cell adhesion cell molecule 1 (VCAM-1) and NGFβ in addition to VEGF and amyloid A. A number of inflammatory adipokines ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2874930/
Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbits | Stroke
Cytokines produced during SAH stimulate the expression of adhesion molecules, including intercellular adhesion molecule-1 (ICAM ... polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem. 1995;270:11176-11180. ... Handa Y, Kubota T, Kaneko M, Tsuchida A, Kobayashi H, Kawano H, Kubota T. Expression of intercellular adhesion molecule 1 (ICAM ... H2O2 and tumor necrosis factor-α activates intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis- ...http://stroke.ahajournals.org/content/32/1/225
Junctional Adhesion Molecule-1 Is Upregulated in Spontaneously Hypertensive Rats | Hypertension
Ebnet K, Suzuki A, Ohno S, Vestweber D. Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci. ... intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 genes were tested in this study; primer ... Collagen I and III mRNA gene expression and cell growth potential of skin fibroblasts in patients with essential hypertension. ... and Vascular Cell Adhesion Molecule-1 Gene Expression in the NTS of WKY Rats and SHRs. With the heightened mRNA of JAM-1 in the ...http://hyper.ahajournals.org/content/49/6/1321
Fluid Shear Stress Increases the Production of Granulocyte-Macrophage Colony-Stimulating Factor by Endothelial Cells via mRNA...
30 intercellular cell adhesion molecule-1,31 and VCAM-1.32 More recently, cis-acting elements and transcriptional factors ... Ando J, Kamiya A. Flow-dependent regulation of gene expression in vascular endothelial cells. Jpn Heart J. 1996;37:19-32. ... Actions of molecules which regulate hemopoiesis on endothelial cells: memories of common ancestors? Pathol Res Pract. 1994;190: ... Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells ...http://circres.ahajournals.org/content/82/7/794
... the ability of endothelial cells to adhere to vitronectin and to up-regulate intercellular adhesion molecule 1 and vascular ... decreases in adhesion molecules expressed by endothelial cells that may further limit angiogenesis. These distinct pathways ... Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study. Gene ... In particular, IL-12 helps to prime T cells and increases their survival, enhances T cell, NK cell, and NK-T cell effector ...http://clincancerres.aacrjournals.org/content/13/16/4677
Table of Contents - April 01, 1996, 156 (7) | The Journal of Immunology
TNF-alpha stimulates monocyte adhesion to glomerular mesangial cells. The role of intercellular adhesion molecule-1 gene ... Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. T von der Weid, N Honarvar and J ... Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those ... Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 ...http://www.jimmunol.org/content/156/7
Aspirin (5 mmol/L) Inhibits Leukocyte Attack and Triggered Reactive Cell Proliferation in a 3D Human Coronary In Vitro Model |...
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol. 1992;140:665-673. ... During the last 6 hours of aspirin incubation, the expression of adhesion molecules was stimulated by adding TNF-α. ... at the level of gene transcription involving the binding of nuclear factor-κB (NF-κB).6 7 8 9 Recently, Kopp and Sankar10 ... Functional analysis of the human vascular cell adhesion molecule-1 promotor. J Exp Med. 1992;176:1583-1593. ...http://circ.ahajournals.org/content/103/12/1688
Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases
Subjecting aortic endothelial cells to in vitro shear stress for 4 h reduced the expression of vascular cell adhesion molecule- ... intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), iNOS, cyclooxygenase-2 (COX-2), and ... S. M. Wasserman, F. Mehraban, L. G. Komuves et al., "Gene expression profile of human endothelial cells exposed to sustained ... and duration of exercise training induces downregulation of the expression of inflammatory and atherogenic adhesion molecules ...https://www.hindawi.com/journals/omcl/2016/7239639/
Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
... is a 90-kDa cell surface glycoprotein that is known to be a member of the immunoglobulin gene superfamily of adhesion molecules ... K. Maeda, S.-M. Kang, T. Sawada et al., "Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer," ... Adhesion molecules that maintain cell-cell contact in the differentiated tumour cells, such as E-cadherin, are downregulated in ... Carnosic acid showed IC50 values in the range of 24-96 μM against Caco-2, HT29, and LoVo cell lines. It inhibited cell adhesion ...https://www.hindawi.com/journals/bmri/2018/4154185/
MicroRNA-146a Decreases High Glucose/Thrombin-Induced Endothelial Inflammation by Inhibiting NAPDH Oxidase 4 Expression
... biological response modifiers and the family of cell adhesion-promoting molecules. ... intercellular adhesion molecule 1 (ICAM-1), and E-selectin (SELE) were as follows: GAPDH: Forward primer: 5′- ... gene expression studies reported that Nox4 was the dominant isoform expressed in endothelial cells [23, 24]. In endothelial ... ROS are important signaling molecules that participate in endothelial inflammation . Previous studies reported that Nox4 ...https://www.hindawi.com/journals/mi/2014/379537/
Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin...
Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H: Intercellular adhesion molecule- ... and cell surface adhesion molecules. Because it can modulate the expression of these targets, curcumin is now being used to ... Gene expression analysis by real-time RT-PCR. Gene expression analysis was performed by real-time reverse transcription ... Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Tesch GH: Intercellular adhesion molecule-1 deficiency is protective against ...https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-8-35
Reduced Leukocyte Migration, but Normal Rolling and Arrest, in Interleukin-8 Receptor Homologue Knockout Mice | IOVS | ARVO...
In contrast, IL-8 does not affect the expression of intercellular adhesion molecule (ICAM)-1 or E-selectin on the endothelial ... The sensitivity of light-evoked responses of retinal ganglion cells is decreased in nitric oxide synthase gene knockout mice ... Because IL-8 regulates expression of both P-selectin andβ 2-integrins, molecules implicated in rolling and arrest, respectively ... All pieces were stained with anti-platelet-endothelial cell adhesion molecule (PECAM) antibody to visualize vessels. In ...https://iovs.arvojournals.org/article.aspx?articleid=2123667
Mouse Aorta Smooth Muscle Cells Differentiate Into Lymphoid Tissue Organizer-Like Cells on Combined Tumor Necrosis Factor...
... and for the interferon-γ-inducible genes gbp3, gbp6, and mpa2l (Figure 2). Hyperinduced mRNA included adhesion molecules vcam1 ... and intercellular adhesion molecule-1. TNFR-1/LTβR cross-talk resulted in augmented secretion of lymphorganogenic chemokine ... However, evidence that macrophage/foam cells/dendritic-like cells (DC)7 and T cells may mediate antigen-dependent T-cell ... Figure 3. Induction kinetics of inflammatory and lymphorganogenic chemokine and vascular cell adhesion molecule-1 mRNA. SMC ...http://atvb.ahajournals.org/content/30/3/395
Myth: "One High-Saturated Fat Meal Can Be Bad"
If the variation in adhesion molecule expression by cells incubated in different sources of HDL particles can be completely ... Effect of different isofoms of tocopherols on expression of intercellular adhesion molecule-1 in human umbilical vein ... stimulated these isolated cells to produce inflammatory adhesion molecules by adding a compound called TNF-alpha to the cells, ... Vitamin E mediates cell signaling and regulation of gene expression. Ann NY Acad Sci, 2004 Dec; 1031:86-95.. 12. Fan Y, Liu ML ...http://www.cholesterol-and-health.com/One-High-Saturated-Fat-Meal-Can-Be-Bad-Carrot-Cake-Coconut-Oil.html
Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid...
... whereas all cell lines expressed MUC18/melanoma cell adhesion molecule and intercellular adhesion molecule-1, two members of ... Among the cell surface molecules that mediate cell-substratum adhesion, integrins play a predominant role in cancer metastasis ... it might be necessary to transfect these cells with this important costimulatory molecule together with cytokine genes, such as ... and the epithelial cell adhesion molecule E-cadherin, and they lacked markers of BM-derived cells. The tumor origin of the cell ...http://cancerres.aacrjournals.org/content/59/1/241?ijkey=b43f44d1d22b8000794ddab9b79bb9946ad32559&keytype2=tf_ipsecsha
Frontiers | Role of inositol phospholipid signaling in natural killer cell biology | Immunology
NK cells from mice with deletion in different members of the PI3K signaling pathway have defective development, natural killer ... NK cells from mice with deletion in different members of the PI3K signaling pathway have defective development, natural killer ... At a molecular level NK cells undergo an education process to prevent autoimmunity. Mouse models have shown important roles for ... At a molecular level NK cells undergo an education process to prevent autoimmunity. Mouse models have shown important roles for ...https://www.frontiersin.org/articles/10.3389/fimmu.2013.00047/full
DSCAM - Wikipedia
"Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion". Brain Res Mol Brain Res. 79 (1-2): 118- ... DSCAM and Dscam are both abbreviations for Down syndrome cell adhesion molecule. In humans, DSCAM refers to a gene that encodes ... Cell aggregation assays show that cell adhesion molecules, such as DSCAM, belonging to the immunoglobulin superfamily bind ... "Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion". Molecular Brain Research. 79 (1-2): 118 ...https://en.wikipedia.org/wiki/DSCAM
ICAM-1 - Wikipedia
"Entrez Gene: intercellular adhesion molecule 1". Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG (Apr 1998). "The ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system ... The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the ...https://en.wikipedia.org/wiki/ICAM-1
CLEC4M - Wikipedia
2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly ... This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript ... liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that ... This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 ...https://en.wikipedia.org/wiki/CLEC4M
Xenotransplantation - Wikipedia
... as well as expression of leukocyte adhesion molecules such as E-selectin, intercellular adhesion molecule-1 (ICAM-1), and ... stimulated by CD4+ T cells) and NK cells (stimulated by the release of Il-2). Thus, the role of MHC molecules and T cell ... 3 galactosyl transferase gene knockouts - These pigs don't contain the gene that codes for the enzyme responsible for ... Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells. The strength of ...https://en.wikipedia.org/wiki/Xenotransplantation
Desmoglein-1 - Wikipedia
Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule ... is related to the cadherin family of cell adhesion molecules". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4796-800. doi:10.1073/ ... "Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion". J. Cell Sci. 111 (4 ... These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been ...https://en.wikipedia.org/wiki/Desmoglein-1
ICAM2 - Wikipedia
"Entrez Gene: ICAM2 intercellular adhesion molecule 2". Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August ... ICAM-2 molecules regulate spermatid adhesion on Sertori cell on the apical side of the blood-testis barrier (towards the lumen ... Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the ... The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I ...https://en.wikipedia.org/wiki/ICAM2
Epithelial cell adhesion molecule - Wikipedia
... as compared to some other adhesion molecules, such as classic cadherins. EpICD is required for EpCAM to mediate intercellular ... end of the EpCAM gene causes epigenetic inactivation of the MSH2 gene by hypermethylating the promoter region of the MSH2 gene ... 1997). "Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins". J Cell Biol ... "Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule". Mol Cell Biol. 18 (8 ...https://en.wikipedia.org/wiki/Epithelial_cell_adhesion_molecule