PTGS1 - Wikipedia
Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (June 1991). "Human platelet/erythroleukemia cell prostaglandin G/H ... released from membrane phospholipids at the sn-2 ester binding site by the enzymatic activity of phospholipase A2, to ... Cyclooxygenase 1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 ... Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is the key enzyme in prostaglandin biosynthesis ...https://en.wikipedia.org/wiki/PTGS1
Prostaglandin receptor - Wikipedia
Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as ... Phospholipase C (PLC) which when activated is responsible for forming Inositol trisphosphate (IP3) and diacylglycerol secondary ... There is indirect evidence for a second PGI2 receptor in BEAS-2B human airway epithelial cells but this finding has not been ... IUPHAR GPCR Database - Prostanoid receptors Prostaglandin Receptors at the US National Library of Medicine Medical Subject ...https://en.wikipedia.org/wiki/Prostaglandin_receptor
KAKEN - Research Projects | Leukotriene receptors and new lipid ligands (KAKENHI-PLANNED-22116002)
Journal Article] Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. ... BLT1 defines dendritic cell subsets with different characteristics in differentiation and proliferation of T cells.2015. *. ... Presentation] Distinct roles of BLT1hi DCs and BLT1lo DCs in activating T cells.2015. *. Author(s). Koga T, Sasaki F, Saeki K, ... Presentation] BLT1 as a potential marker of mouse dendritic cell subsets2011. *. Author(s). Koga T., Sasaki F., Saeki K., Okuno ...https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22116002/
Cellular Compartmentalization of the Biosynthesis and Function of PGE2 and PGI2 in the Renal Medulla | SpringerLink
It is clear from studies conducted in a number of laboratories that the biosynthesis of prostaglandins in the kidney is ... of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells. J Biol ... Bohman SO: Demonstration of prostaglandin synthesis in collecting duct cells and other cell types of the rabbit renal medulla. ... Thus one of the major goals of studies on renal prostaglandin biochemistry has been that of localization-to define which cells ...https://link.springer.com/chapter/10.1007/978-1-4684-4277-9_3
The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under...
... which is liberated from cell membranes by phospholipase A2, into prostaglandin H2 (PGH2). PGH2 then acts as a substrate for a ... LMWF-5A affects prostaglandin release by cytokine-stimulated OA synovial fibroblasts. Cell culture media was collected from OA ... Levels of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) in the media were quantified by competitive ELISA. ... Prostaglandin enzyme-linked immunosorbent assays (ELISAs). Conditioned media for the two prostaglandin assays used in this ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5613771/
Patent US5187263 - Expression of biologically active PDGE analogs in eucaryotic cells - Google Patents
Eucaryotic cells transformed with these DNA constructs are also disclosed. Methods of promoting the growth of mammalian cells, ... comprising incubating the cells with a biologically active PDGF analog expressed by a eucaryotic host cell transformed with ... The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and ... secretion of biologically active PDGF analogs in eucaryotic cells. The DNA construct contains a transcriptional promoter ...http://www.google.com.au/patents/US5187263
The sPLA2 Inhibition to Decrease Enzyme Release After Percutaneous Coronary Intervention (SPIDER-PCI) TrialClinical Perspective...
Prostaglandin production in human coronary artery endothelial cells is modulated differentially by selective phospholipase A(2 ... Type II secretory phospholipase A2 binds to ischemic flip-flopped cardiomyocytes and subsequently induces cell death. Am J ... Secretory phospholipase A2 (sPLA2) may play a key role in the promotion of myocardial injury associated with PCI, its activity ... Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans. Cardiovasc Res. 2002; ...http://circ.ahajournals.org/content/122/23/2411
The elmiric acids: biologically active anandamide analogs
Prostaglandins and cannabis--VIII. Elevation of phospholipase A2 activity by cannabinoids in whole cells and subcellular ... Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? Cell Signal. 2002;14:573-583. [PubMed ... Prostaglandins and cannabis--VI. Release of arachidonic acid from HeLa cells by delta1-tetrahydrocannabinol and other ... 2. Cell proliferation effects. In view of the reported inhibition of cell proliferation by anandamide (vide supra), it was ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2621443/?lang=en-ca
Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo...
3The enzyme activity of the cyclo-oxygenase/prostaglandin E (PGE) isomerase was measured in cell membranes from control cells ... in dexamethasone-treated cells as compared to control cells. Thus, glucocorticoids inhibit not only phospholipase A2 in these ... Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo- ... When the cells were preincubated with dexamethasone (10−7 and 10−6m) overnight, prostaglandin synthesis was inhibited by 66.5 ...http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1989.tb12676.x/abstract
PLA2G5 - Wikipedia
2000). "Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells". ... and chorionic cell lines". Prostaglandins Other Lipid Mediat. 60 (4-6): 119-25. doi:10.1016/S0090-6980(99)00057-X. PMID ... "Entrez Gene: PLA2G5 phospholipase A2, group V". Otha, Shin (15 June 2013). "Group V secretory phospholipase A2 is involved in ... 2003). "Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human ...https://en.wikipedia.org/wiki/PLA2G5
S100A10 - Wikipedia
"Transforming growth factor-alpha stimulates prostaglandin generation through cytosolic phospholipase A(2) under the control of ... P11's involvement with the cytoskeleton may aid the transport of other proteins throughout the cell and to the cell membrane. ... "Transforming growth factor-alpha stimulates prostaglandin generation through cytosolic phospholipase A(2) under the control of ... It is found in cell types throughout the body though it is located predominantly in the lungs and kidneys. It is involved in ...https://en.wikipedia.org/wiki/S100A10
Phospholipase C in Living Cells | JGP
Inhibition of phospholipase C dependent processes by U-73,122. Adv. Prostaglandin Thromboxane Leukot. Res. 19:590-593. ... Phospholipase C in Living Cells. Lisa F. Horowitz, Wiebke Hirdes, Byung-Chang Suh, Donald W. Hilgemann, Ken Mackie, Bertil ... Phospholipase C in Living Cells. Lisa F. Horowitz, Wiebke Hirdes, Byung-Chang Suh, Donald W. Hilgemann, Ken Mackie, Bertil ... A-C) Cells treated with oxo-M and then with 50 μM m-3M3FBS. (D-F) Cells treated with oxo-M and then with 50 μM o-3M3FBS. (G-I) ...http://jgp.rupress.org/content/126/3/243
Phospholipases | definition of Phospholipases by Medical dictionary
Phospholipases explanation free. What is Phospholipases? Meaning of Phospholipases medical term. What does Phospholipases mean? ... Looking for online definition of Phospholipases in the Medical Dictionary? ... Various phospholipases digest cell membranes, aid in the synthesis of prostaglandins, and help produce arachidonic acid, one of ... Related to Phospholipases: Phospholipase B phospholipase. [fos″fo-lip´ās] any of four enzymes (phospholipase A to D) that ...https://medical-dictionary.thefreedictionary.com/Phospholipases
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early...
Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: ... B cells, various T-cell classes, and even eosinophils and mast cells (4-6). In contrast, much less is known about adipose ... Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver. Prostaglandins Other Lipid ... Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity ...http://diabetes.diabetesjournals.org/content/62/9/3053?with-ds=yes
Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating...
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J. Immunol. 175: 1483-1490 ... 105 cells/well (Foxp3−CD4+ T only) or 1.8 × 105 cells/well (Foxp3−CD4+ T cells) with 0.2 × 105 cells/well of other cells (+/+, ... 1D, 1E). However, there was no significant change in the ratio of CD4+ T cells, CD8+ T cells, and CD19+ B cells (Fig. 1F). The ... cells with DCs or macrophages were treated with bvPLA2 (gated on CD4+ T cells). (E) Isolated Foxp3−CD4+ T cells were plated at ...http://www.jimmunol.org/content/195/10/4853
test #39 4.29 Flashcards by Nashid Chaudhury | Brainscape
inhibit production of leukotrienes and prostaglandins (block phospholipase A2 cleavage). - inhibit leukocyte adhesion ( ... Leydig cell tumor, nongerm cell.. androgen producing, gynecomastia in men, precocious puberty in kids. golden brown colour ... 1. Th1 CD4+ cells secrete IFN-y. 2. activates CD8+ cytotoxic T cells and macrophages. 3. macrophages secrete TNF-alpha, ... most potent: increase histamine synthesis & release by ECL cells. also: stimulates Ca2+ and acid release from parietal cells ...https://www.brainscape.com/flashcards/test-39-429-2275565/packs/3729903
Plaa - Phospholipase A-2-activating protein - Mus musculus (Mouse) - Plaa gene & protein
Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Plays also a role in prostaglandin E2 secretion during ... In smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid ... Expressed in the brain, with highest levels in hippocampal neurons, cerebellar granular cell layer and Purkinje cells (PubMed: ... Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Plays also a role in prostaglandin E2 secretion during ...http://www.uniprot.org/uniprot/P27612
Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells : Carcinogenesis - oi
... prostaglandins; PLA2, phospholipase A2; PPARs, peroxisome proliferator-activated receptors; PPRE, peroxisome proliferator ... While exogenous LDL caused a significant stimulation of cell growth and PGE2 synthesis, no change was seen in regulation of the ... Analysis of ldlr mRNA expression and LDLr function demonstrated that human PC-3 prostate cancer cells lack normal feedback ... These data suggest that unregulated over-expression of LDLr in tumor cells would permit increased availability of AA, which ...http://oxfordindex.oup.com/view/10.1093/carcin/22.5.701
Frontiers | TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary...
... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). We found that TNF- ... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). We found that TNF- ...https://www.frontiersin.org/articles/10.3389/fphar.2016.00447/full
Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells | SpringerLink
... which accounted for this degradation of PIP2 further leads to an increased synthesis of prostaglandins (PG). The present study ... Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells. ... Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells. In: Heilmeyer L.M ... Mesangial Cell Pertussis Toxin Inositol Phosphate PGE2 Synthesis Rapid Hydrolysis These keywords were added by machine and not ...https://link.springer.com/chapter/10.1007/978-1-4757-0166-1_39
Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research | SpringerLink
The International Symposium on Prostaglandins and Related Compounds, first held in Vienna 1972, revisited the city after 24 ... Reactive Oxygen Species Generation and Phospholipase A2 Stimulation in a Human Keratinocyte Cell Line ... Prostaglandin Receptors of the EP2 and EP4 Subtypes Regulate B Lymphocyte Activation and Differentiation to IGE-Secreting Cells ... Regulation of MAP-Kinase Activation by 8-Iso-Prostaglandin F2a in Cultured Rat Aortic Smooth Muscle Cells ...https://link.springer.com/book/10.1007/978-1-4899-1810-9
Involvement of Plasmalogens in Neurological Disorders | Springer for Research & Development
Farooqui A. A. and Horrocks L. A. (2005). Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei ... Daniel L. W., Sciorra V. A., and Ghosh S. (1999). Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. ... Cummings B. S., McHowat J., and Schnellmann R. G. (2000). Phospholipase A2s in cell injury and death. J. Pharmacol. Exp. Ther. ... of various cell types of neural cells in normal brain and brains from patients with neural trauma and neurodegenerative ...https://rd.springer.com/chapter/10.1007/978-0-387-77401-5_6
Casein glycomacropeptide hydrolysates inhibit PGE2 production and COX2 expression in LPS-stimulated RAW 264.7 macrophage cells...
GMPH reduced the production of prostaglandin E2 (PEG2) and the expression of cyclooxygenase-2 (COX-2) and cytosolic ... phospholipase A2 (cPLA2) in LPS-stimulated macrophages. GMPH also attenuated LPS-induced phosphorylation of MAPK (c-Jun NH2- ... Casein glycomacropeptide hydrolysates inhibit PGE2 production and COX2 expression in LPS-stimulated RAW 264.7 macrophage cells ... Casein glycomacropeptide hydrolysates inhibit PGE2 production and COX2 expression in LPS-stimulated RAW 264.7 macrophage cells ...http://pubs.rsc.org/en/content/articlelanding/2018/fo/c7fo01989k
Diverse Functions of Secretory Phospholipases A2
II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells," ... "Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after ... I. Kudo and M. Murakami, "Phospholipase A2 enzymes," Prostaglandins and Other Lipid Mediators, vol. 68-69, pp. 3-58, 2002. View ... N. M. Muñoz, Y. J. Kim, A. Y. Meliton et al., "Human group V phospholipase A2 induces group IVA phospholipase A2-independent ...https://www.hindawi.com/journals/avm/2014/689815/ref/
Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells |...
II acutely stimulates prostaglandin synthesis in endothelial cells by promoting phospholipase-catalyzed deacylation of ... This effect of Ang II on prostaglandin production by endothelial cells was attenuated in cells treated with SnCl2 (10 μmol/L), ... the heme-HO system and prostaglandin synthesis in human endothelial cells. We found that the stimulation of prostaglandin ... Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells. Am J Physiol. 1987; 253: C113-C120. ...http://hyper.ahajournals.org/content/41/3/715