KAKEN - Research Projects | Leukotriene receptors and new lipid ligands (KAKENHI-PLANNED-22116002)
Journal Article] Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. ... BLT1 defines dendritic cell subsets with different characteristics in differentiation and proliferation of T cells.2015. *. ... Presentation] Distinct roles of BLT1hi DCs and BLT1lo DCs in activating T cells.2015. *. Author(s). Koga T, Sasaki F, Saeki K, ... Presentation] BLT1 as a potential marker of mouse dendritic cell subsets2011. *. Author(s). Koga T., Sasaki F., Saeki K., Okuno ...https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22116002/
The sPLA2 Inhibition to Decrease Enzyme Release After Percutaneous Coronary Intervention (SPIDER-PCI) TrialClinical Perspective...
Prostaglandin production in human coronary artery endothelial cells is modulated differentially by selective phospholipase A(2 ... Type II secretory phospholipase A2 binds to ischemic flip-flopped cardiomyocytes and subsequently induces cell death. Am J ... Secretory phospholipase A2 (sPLA2) may play a key role in the promotion of myocardial injury associated with PCI, its activity ... Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans. Cardiovasc Res. 2002; ...http://circ.ahajournals.org/content/122/23/2411
Phospholipases | definition of Phospholipases by Medical dictionary
Phospholipases explanation free. What is Phospholipases? Meaning of Phospholipases medical term. What does Phospholipases mean? ... Looking for online definition of Phospholipases in the Medical Dictionary? ... Various phospholipases digest cell membranes, aid in the synthesis of prostaglandins, and help produce arachidonic acid, one of ... Related to Phospholipases: Phospholipase B phospholipase. [fos″fo-lip´ās] any of four enzymes (phospholipase A to D) that ...https://medical-dictionary.thefreedictionary.com/Phospholipases
Phospholipase C in Living Cells | JGP
Inhibition of phospholipase C dependent processes by U-73,122. Adv. Prostaglandin Thromboxane Leukot. Res. 19:590-593. ... Phospholipase C in Living Cells. Lisa F. Horowitz, Wiebke Hirdes, Byung-Chang Suh, Donald W. Hilgemann, Ken Mackie, Bertil ... Phospholipase C in Living Cells. Lisa F. Horowitz, Wiebke Hirdes, Byung-Chang Suh, Donald W. Hilgemann, Ken Mackie, Bertil ... A-C) Cells treated with oxo-M and then with 50 μM m-3M3FBS. (D-F) Cells treated with oxo-M and then with 50 μM o-3M3FBS. (G-I) ...http://jgp.rupress.org/content/126/3/243
The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under...
... which is liberated from cell membranes by phospholipase A2, into prostaglandin H2 (PGH2). PGH2 then acts as a substrate for a ... LMWF-5A affects prostaglandin release by cytokine-stimulated OA synovial fibroblasts. Cell culture media was collected from OA ... Levels of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) in the media were quantified by competitive ELISA. ... Prostaglandin enzyme-linked immunosorbent assays (ELISAs). Conditioned media for the two prostaglandin assays used in this ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5613771/
Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating...
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J. Immunol. 175: 1483-1490 ... 105 cells/well (Foxp3−CD4+ T only) or 1.8 × 105 cells/well (Foxp3−CD4+ T cells) with 0.2 × 105 cells/well of other cells (+/+, ... 1D, 1E). However, there was no significant change in the ratio of CD4+ T cells, CD8+ T cells, and CD19+ B cells (Fig. 1F). The ... cells with DCs or macrophages were treated with bvPLA2 (gated on CD4+ T cells). (E) Isolated Foxp3−CD4+ T cells were plated at ...http://www.jimmunol.org/content/195/10/4853
Plaa - Phospholipase A-2-activating protein - Mus musculus (Mouse) - Plaa gene & protein
Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Plays also a role in prostaglandin E2 secretion during ... In smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid ... Expressed in the brain, with highest levels in hippocampal neurons, cerebellar granular cell layer and Purkinje cells (PubMed: ... Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Plays also a role in prostaglandin E2 secretion during ...http://www.uniprot.org/uniprot/P27612
The elmiric acids: biologically active anandamide analogs
Prostaglandins and cannabis--VIII. Elevation of phospholipase A2 activity by cannabinoids in whole cells and subcellular ... Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? Cell Signal. 2002;14:573-583. [PubMed ... Prostaglandins and cannabis--VI. Release of arachidonic acid from HeLa cells by delta1-tetrahydrocannabinol and other ... 2. Cell proliferation effects. In view of the reported inhibition of cell proliferation by anandamide (vide supra), it was ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2621443/?lang=en-ca
Patent US5187263 - Expression of biologically active PDGE analogs in eucaryotic cells - Google Patents
Eucaryotic cells transformed with these DNA constructs are also disclosed. Methods of promoting the growth of mammalian cells, ... comprising incubating the cells with a biologically active PDGF analog expressed by a eucaryotic host cell transformed with ... The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and ... secretion of biologically active PDGF analogs in eucaryotic cells. The DNA construct contains a transcriptional promoter ...http://www.google.com.au/patents/US5187263
β-Cell Calcium-Independent Group VIA Phospholipase A2 (iPLA2β) | Diabetes
Morita I, Schindler M, Regier MK, Otto JC, Hori T, DeWitt DL, Smith WL: Different intracellular locations for prostaglandin ... β-Cell Calcium-Independent Group VIA Phospholipase A2 (iPLA2β) Message Subject (Your Name) has forwarded a page to you from ... Stably transfected cells obtained with EGFP-N2 control vector and FPN2 construct are designed as N2 cells and FPN2 cells, ... β-Cell Calcium-Independent Group VIA Phospholipase A2 (iPLA2β). Tracking iPLA2β Movements in Response to Stimulation With ...http://diabetes.diabetesjournals.org/content/53/suppl_1/S186
Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells |...
II acutely stimulates prostaglandin synthesis in endothelial cells by promoting phospholipase-catalyzed deacylation of ... This effect of Ang II on prostaglandin production by endothelial cells was attenuated in cells treated with SnCl2 (10 μmol/L), ... the heme-HO system and prostaglandin synthesis in human endothelial cells. We found that the stimulation of prostaglandin ... Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells. Am J Physiol. 1987; 253: C113-C120. ...http://hyper.ahajournals.org/content/41/3/715
Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo...
3The enzyme activity of the cyclo-oxygenase/prostaglandin E (PGE) isomerase was measured in cell membranes from control cells ... in dexamethasone-treated cells as compared to control cells. Thus, glucocorticoids inhibit not only phospholipase A2 in these ... Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo- ... When the cells were preincubated with dexamethasone (10−7 and 10−6m) overnight, prostaglandin synthesis was inhibited by 66.5 ...http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1989.tb12676.x/abstract
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat. Med. ... prostaglandin D2. PGE2. prostaglandin E2. PLA2. phospholipase A2. PLA2G2D. group IID sPLA2. PUFA. polyunsaturated fatty acid. ... cells and CD4+CD25+ T reg cells in mouse spleen. Among T cells, Pla2g2d was enriched in CD4+CD25+ T reg cells relative to total ... Culture of LN cells.. LN cells (106 cells/ml) were isolated from mice that had been sensitized with DNFB for 5 d and cultured ...http://jem.rupress.org/content/early/2013/05/14/jem.20121887
IJMS | Free Full-Text | Lipid Based Therapy for Ulcerative Colitis-Modulation of Intestinal Mucus Membrane Phospholipids as a...
Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: Role of cytosolic ... The cytosolic phospholipase cPLA2α is activated by calcium binding which triggers its translocation to PC enriched membranes. ... Synthesis of arachidonic acid is the rate limiting step in prostaglandin production  via the COX pathway. Prostaglandins, ... p38 and JNK in a cell culture model revealed that MAP kinases contribute to prostaglandin signaling by regulating the release ...http://www.mdpi.com/1422-0067/11/10/4149/htm
Diverse Functions of Secretory Phospholipases A2
II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells," ... "Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after ... I. Kudo and M. Murakami, "Phospholipase A2 enzymes," Prostaglandins and Other Lipid Mediators, vol. 68-69, pp. 3-58, 2002. View ... N. M. Muñoz, Y. J. Kim, A. Y. Meliton et al., "Human group V phospholipase A2 induces group IVA phospholipase A2-independent ...https://www.hindawi.com/journals/avm/2014/689815/ref/
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early...
Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: ... B cells, various T-cell classes, and even eosinophils and mast cells (4-6). In contrast, much less is known about adipose ... Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver. Prostaglandins Other Lipid ... Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity ...http://diabetes.diabetesjournals.org/content/62/9/3053?with-ds=yes
Abstract 143: Group X Secretory Phospholipase A2 Regulates Insulin Secretion by Mouse Pancreatic Beta Cells | Arteriosclerosis,...
AA is a precursor of bioactive prostaglandins that are known to modulate insulin secretion by β-islet cells. C57BL/6 mice ... Abstract 143: Group X Secretory Phospholipase A2 Regulates Insulin Secretion by Mouse Pancreatic Beta Cells. Preetha Shridas, ... Treatment of these cells with NS398- an inhibitor of COX2 enzyme, abolished the decrease in GSIS shown by these cells. ... Abstract 143: Group X Secretory Phospholipase A2 Regulates Insulin Secretion by Mouse Pancreatic Beta Cells ...http://atvb.ahajournals.org/content/32/Suppl_1/A143
Frontiers | TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary...
... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). We found that TNF- ... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). We found that TNF- ...https://www.frontiersin.org/articles/10.3389/fphar.2016.00447/full
Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells : Carcinogenesis - oi
... prostaglandins; PLA2, phospholipase A2; PPARs, peroxisome proliferator-activated receptors; PPRE, peroxisome proliferator ... While exogenous LDL caused a significant stimulation of cell growth and PGE2 synthesis, no change was seen in regulation of the ... Analysis of ldlr mRNA expression and LDLr function demonstrated that human PC-3 prostate cancer cells lack normal feedback ... These data suggest that unregulated over-expression of LDLr in tumor cells would permit increased availability of AA, which ...http://oxfordindex.oup.com/view/10.1093/carcin/22.5.701
Quinacrine - DrugBank
It is used in cell biological experiments as an inhibitor of phospholipase A2. ... Formyl-methionyl-leucyl-phenylalanine induces prostaglandin E2 release from human amnion-derived WISH cells by phospholipase C- ... It is used in cell biological experiments as an inhibitor of phospholipase A2. ... Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)(2)D(3) through regulation of phospholipase ...https://www.drugbank.ca/drugs/DB01103
S100A10 - Wikipedia
"Transforming growth factor-alpha stimulates prostaglandin generation through cytosolic phospholipase A(2) under the control of ... P11's involvement with the cytoskeleton may aid the transport of other proteins throughout the cell and to the cell membrane. ... "Transforming growth factor-alpha stimulates prostaglandin generation through cytosolic phospholipase A(2) under the control of ... It is found in cell types throughout the body though it is located predominantly in the lungs and kidneys. It is involved in ...https://en.wikipedia.org/wiki/S100A10
Involvement of Plasmalogens in Neurological Disorders | Springer for Research & Development
Farooqui A. A. and Horrocks L. A. (2005). Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei ... Daniel L. W., Sciorra V. A., and Ghosh S. (1999). Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. ... Cummings B. S., McHowat J., and Schnellmann R. G. (2000). Phospholipase A2s in cell injury and death. J. Pharmacol. Exp. Ther. ... of various cell types of neural cells in normal brain and brains from patients with neural trauma and neurodegenerative ...https://rd.springer.com/chapter/10.1007/978-0-387-77401-5_6
Intracellular- and extracellular-derived Ca2+ influence phospholipase A2-mediated fatty acid release from brain phospholipids
... prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell ... cytosolic phospholipase A2. iPLA2. Ca2+-independent phospholipase A2. sPLA2. secretory phospholipase A2. PUFA. polyunsaturated ... Cell. 1995;80:259-268. [PubMed]. 28. Nardicchi V, Macchioni L, Ferrini M, Goracci G. The presence of a secretory phospholipase ... Brain phospholipases A2: a perspective on the history. Prostaglandins Leukot Essent Fatty Acids. 2004;71:161-169. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2735787/
Peroxisome Proliferator-Activated Receptor-γ Is a Target of Nonsteroidal Anti-Inflammatory Drugs Mediating Cyclooxygenase...
High levels of prostaglandin production by NSCLC cells are correlated with increased expression of both cytosolic phospholipase ... Cell Culture and Transfection.. Non-small-cell lung cancer cell lines (H2122, A549, H460) and small-cell lung cancer cell lines ... 1991) Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell ... small-cell lung cancer. NSCLC. non-small-cell lung cancer. cPLA2. cytosolic phospholipase A2. PPAR-RE. peroxisome proliferator- ...http://molpharm.aspetjournals.org/content/62/5/1207
The Pathophysiology of Moyamoya Disease: An Update
... confluence-dependent interaction of cytosolic phospholipase a2-alpha with annexin a1 regulates endothelial cell prostaglandin ... Smooth-muscle progenitor cells isolated from patients with moyamoya disease: Novel experimental cell model. J Neurosurg 2014; ... RNF213, Ring finger 213; EPCs, endothelial progenitor cells; SPCs, smooth muscle progenitor cells; miRNAs, microRNAs; CRABP-1, ... RNF213, Ring finger 213; EPCs, endothelial progenitor cells; SPCs, smooth muscle progenitor cells; miRNAs, microRNAs; CRABP-1, ...http://j-stroke.org/journal/view.php?number=114&viewtype=pubreader
Download our free solidary book to support research on VHL disease