Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types.
... macrophage like cells, and the non-macrophage cell lines HFL-1... (More). BACKGROUND: Galectin-3 (the Mac-2 antigen) is ... macrophage like cells, and the non-macrophage cell lines HFL-1 fibroblasts and SKBR3 breast carcinoma. RESULTS: Galectin-3 ... and compared it between variants of a macrophage like cell line, and non-macrophage cells. METHODS: Endocytosis of galectin-3 ... and compared it between variants of a macrophage like cell line, and non-macrophage cells. METHODS: Endocytosis of galectin-3 ...https://lup.lub.lu.se/search/publication/2431447
Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of...
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... "Mesenchymal stem cell-mediated T cell suppression occurs through secreted galectins," International Journal of Oncology, vol. ... "The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells," Cell and Tissue ...https://www.hindawi.com/journals/sci/2017/3282656/ref/
Galectin-3 translocates to the immunological synapse and inhibits cytokine production in CD4+ T cells activated by engagement...
Injury- and antigen-specific control of CD4 T cell reactivity by CD4+CD25+ regulatory T cells (88.42) ... CD4+ T cells secreted more IFNγ and IL-4 compared to gal3+/+ cells. We also found that serum levels of IFNγ were significantly ... Galectin-3 is induced in CD4+ T cells upon activation by mitogens or TCR engagement, but its function in this cell type has not ... We conclude that galectin-3 is an inhibitory regulator of T cell activation that down-regulates signal transduction, and ...http://www.jimmunol.org/content/178/1_Supplement/S140.3
Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model...
TMEV also reduced neuroblast and proliferative SVZ cell numbers in WT mice but this was restored in Gal-3(-/-) mice and was ... Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3 ... Though numerous CD45+ immune cells entered the SVZ of WT mice after TMEV infection, their numbers were significantly diminished ... reduced immune cell migration into the SVZ, reestablished SVZ proliferation and increased the number of progenitors in the ...https://www.ndcn.ox.ac.uk/publications/546924
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid...
... which are superior to conventional dendritic cells in activating CD8+ T cells. Thus, inhibiting galectin-3 in conjunction with ... T cells only in the tumor microenvironment. Galectin-3-deficient mice exhibit improved CD8+ T-cell effector function and ... T cells in vitro. Lastly, galectin-3-deficient mice have elevated levels of circulating plasmacytoid dendritic cells, ... Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid ...http://cancerimmunolres.aacrjournals.org/content/early/2015/03/03/2326-6066.CIR-14-0150
Galectin-3 - Wikipedia
... cell activation and chemoattraction, cell growth and differentiation, cell cycle, and apoptosis. Given galectin-3's broad ... Companies have developed galectin modulators that block the binding of galectins to carbohydrate structures. The galectin-3 ... "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". International Journal of ... is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix ...https://en.wikipedia.org/wiki/Galectin-3
Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1...
... galectin-1 and galectin-3. Autor Gil, C. D. La, M. Perretti, M. Oliani, S. M. ... Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 ... Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as important mediators that promote ... Cell Biology International. London: Academic Press Ltd Elsevier B.V., v. 30, n. 4, p. 338-344, 2006.. ...http://repositorio.unifesp.br/handle/11600/28811
Galectin 3 293T transfected lysate (ab94225) | Abcam
Buy our Galectin 3 293T transfected lysate (positive control). ab94225 has been validated in western blot. Abcam now offers a ... ab94225 is a 293T cell transfected lysate in which Human Galectin 3 has been transiently over-expressed using a pCMV-Galectin 3 ... Cell Biology. Epigenetics. Metabolism. Developmental Biology. By research area. Immunology. Microbiology. Neuroscience. Signal ... Cell and tissue imaging tools. Cellular and biochemical assays. By product type. Proteins and Peptides. Proteomics tools. ...http://www.abcam.com/galectin-3-overexpression-293t-lysate-whole-cell-ab94225.html
Galectin-3 Deficiency Accelerates High-Fat Diet-Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic...
Type 1 T/NKT cells are increased in VAT in obese LGALS3−/− mice.. Significantly increased CD3+ T cells and CD3+NK1.1+ NKT cells ... Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. Biochem Biophys Res Commun 2006;344: ... 2A) with markedly increased CD3+NK1.1+ IFN-γ+ type 1 NKT cells, and CD3+IFN-γ+ type 1 T cells were significantly higher ... Increased type 1 T and NKT cells and reduced Tregs in VAT of HFD-fed LGALS3−/− mice. A: Increased percentages of CD3+ T cells ...http://diabetes.diabetesjournals.org/content/62/6/1932.long
Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice. - Semantic Scholar
... located on cell surface and in extracellular matrix. The products of Golgi UDP-GlcNAc:N-acetylglucosaminyltransferases (encoded ... Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. *Nancy L. Perillo, Madeline E. Marcus, ... Galectin-3 promotes neural cell adhesion and neurite growth.. *Penka Pesheva, Stephan Kuklinski, Brigitte Schmitz, Rainer ... Metabolism, Cell Surface Organization, and Disease. *J. W. Dennis, Ivan Robert Nabi, Michael Demetriou ...https://www.semanticscholar.org/paper/Beta-N-acetylglucosaminyltransferase-V-%28Mgat5%29-the-Soleimani-Roder/6e3b5f605693917354c83de89032e306a6349f1f
Poly N-acetyllactosamine substitutions on N- and not O-oligosaccharides or Thomsen-Friedenreich antigen facilitate lung...
Galectin-3 on vascular endothelium has been shown to facilitate lung specific metastasis. Metastatic variants of B16 melanoma ... Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion. Glycoconj. J. 11, 462- ... Versatile roles in cell-cell interaction. J. Cell Biol. 147, 467-470 (1999). doi: 10.1083/jcb.147.3.467 PubMedCrossRefGoogle ... Cell 127, 679-695 (2006). doi: 10.1016/j.cell.2006.11.001 PubMedCrossRefGoogle Scholar ...https://rd.springer.com/article/10.1007/s10719-008-9194-9
In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices | Protocol
We rarely see cells stopping for more than 6 min, and find that, over a 3-hr period, they generally spend an average of 30 min ... Comte, I., et al. Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb. J. Cell Sci. 124, 2438 ... In a cell culture hood, cut away the most caudal third of the brain slice and remove any glue traces using fine straight ... Moreover, these cells are able to target sites of the brain affected by injury and neurodegeneration4,28. Being able to monitor ...https://www.jove.com/video/50905/in-vivo-postnatal-electroporation-time-lapse-imaging-neuroblast
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα ...
We first document that myelin, oligodendrocytes and Schwann cells express CD47 without SIRPα and further confirm that microglia ... Activation follows myelin binding to receptors that mediate its phagocytosis (e.g. complement receptor-3), which has been ... Non-adherent cells were washed away. The remaining adhered cells are macrophages that express Galectin-3 (formally known as MAC ... CD47 is expressed on myeloid cells, RBCs (red blood cells), platelets, neurons, fibroblasts and endothelial cells [19, 20]. ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-24
Circulating galectin-3 promotes m... preview & related info | Mendeley
Adhesion of circulating tumor cells to the blood vessel endothelium is a critical step in cancer metastasis. We show in this ... study that galectin-3, the concentration of which is greatly increased i... ... of the cell-surface MUC1 by causing MUC1 polarization, leading to exposure of smaller cell-surface adhesion molecules/ligands ... increases cancer cell adhesion to macrovascular and microvascular endothelial cells under static and flow conditions, increases ...https://www.mendeley.com/research-papers/circulating-galectin3-promotes-metastasis-modifying-muc1-localization-cancer-cell-surface/
PubMed Journals Articles About 'Neuropsychiatric Disorder Cluster Drug Development Pipeline Review 2017'
... where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in ... To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells ... Role of Galectin-3 in Bone Cell Differentiation, Bone Pathophysiology and Vascular Osteogenesis. ... Galectin-3 is expressed in various tissues, including the bone, ...https://www.bioportfolio.com/resources/pubmed/?keyword=Neuropsychiatric+Disorder+Cluster+Drug+Development+Pipeline+Review+2017&
Frontiers | Extracellular Galectin-3 in Tumor Progression and Metastasis | Oncology
... such as cell adhesion, cell activation and chemoattraction, cell cycle, apoptosis and cell growth and differentiation. However ... such as cell adhesion, cell activation and chemoattraction, cell cycle, apoptosis and cell growth and differentiation. However ... the only chimera galectin found in vertebrates, is one of the best-studied galectins. It is expressed in several cell types and ... the only chimera galectin found in vertebrates, is one of the best-studied galectins. It is expressed in several cell types and ...https://www.frontiersin.org/articles/10.3389/fonc.2014.00138/full
Jurkat, Clone E6-1 ATCC ® TIB-152™ Homo sapiens peripheral b
This is a clone of the Jurkat-FHCRC cell line, a derivative of the Jurkat cell line. ... The line was cloned from cells obtained from Dr. Kendall Smith and are mycoplasma free. ... The Jurkat cell line was established from the peripheral blood of a 14 year old boy by Schneider et al., and was originally ... Expression of galectin-3 modulates T-cell growth and apoptosis. Proc. Natl. Acad. Sci. USA 93: 6737-6742, 1996. PubMed: 8692888 ...https://atcc.org/products/all/TIB-152.aspx
Proteomic analysis of human osteoprogenitor response to disordered nanotopography | Journal of The Royal Society Interface
On the flat surface (e-h) cells were fully spread and proliferated to form a confluent tissue layer (e,f). Also, (g,h) cells ... Upregulation of beta-galactoside-binding lectin precursor (galectin precursor) and galectin-1 was found. These results may ... Confluent cell sheets were trypsinized and 1×105 cells were seeded onto NSQ50 and control flat PCL sheets. The tissue culture ... 2003 Tensegrity I. Cell structure and hierarchical systems biology. J. Cell Sci. 116, 1157-1173. doi:10.1242/jcs.00359. ...http://rsif.royalsocietypublishing.org/content/6/40/1075
Detection of galectin-3 in tear fluid at disease states and immunohistochemical and lectin histochemical analysis in human...
... thus contributing to cell-cell and cell-matrix interaction,6-8 regulation of cell growth,9 10 and programmed cell death.11 In ... mast cells, and epithelial cells including corneal epithelium.2 6 14 15 It is a mitogen capable of stimulating fibroblast cell ... The inflammatory cells infiltrating the cornea express the galectin-3 in cytoplasm in contrast with absence of galectin-3 in ... Inflammatory cells (granulocytes and macrophages) that express galectin-3 were found in tear fluid samples which were positive ...http://bjo.bmj.com/content/85/11/1336
Frontiers | Drugs and Targets in Fibrosis | Pharmacology
In liver and pancreas, precursor cells like hepatic stellate cells (HSC) (Moreira, 2007) and pancreatic stellate cells (Apte et ... Li, L. C., Li, J., and Gao, J. (2014). Functions of galectin-3 and its role in fibrotic diseases. J. Pharmacol. Exp. Ther. 351 ... These recruited immune cells function as the scavenger to remove tissue debris and dead cells, resulting in acute inflammation ... Finally, immune cells undergo apoptosis and epithelial/endothelial cells proliferate to regenerate injury sites, leading to ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00855/full?utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Pharmacology&id=306391
CA-125 - Wikipedia
"The cancer antigen CA125 represents a novel counter receptor for galectin-1". Journal of Cell Science. 116 (Pt 7): 1305-18. doi ... MUC16 is also thought to participate in cell-to-cell interactions that enable the metastasis of tumor cells. This is supported ... Evidence suggests that expression of the cytoplasmic tail of MUC16 enables tumor cells to grow, promotes cell motility and may ... "Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier". The Journal of ...https://en.wikipedia.org/wiki/CA-125
Lime Flavor PectaSol-C Stick Packs
Ongoing scientific research demonstrates PectaSol-C®'s natural ability to support healthy cell growth and behavior by binding ... Supports Healthy Cells & Blocks Galectin-3*. Ongoing scientific research demonstrates PectaSol-C®'s natural ability to support ... healthy cell growth and behavior by binding Galectin-3. MCP is a natural ligand for Galectin-3, a molecule present in large ... Due to its unique molecular structure, PectaSol-C® easily enters the blood stream to bind and block excess Galectin-3 ...https://www.econugenics.com/lime-infusion-pectasol-cr-stick-packs/
子宫内膜 在 妇产科学 分类中 的翻译结果--cnki翻
Results The expression of MMP-9 in gland cells, and that of MMP-3 in stroma cells in the ectipic endometriotic tissues were ... Effects of galectin-3 inhibition on endometrial cell cycle and adhesion In order to investigate the role of gal-3 in the ... Bovine epithelial cells were obtained for culture from the uterine endometrium of adult, cyclic cattle. ... Endocrine Cells of Human Normal Endometrium and Endometrioid Adenocarcinoma--Morphological and Immunohistochemical Study ...http://dict.cnki.net/h_4951068.html
Monoclonal antibodies against human erythrocyte band 3 protein. Localization of proteolytic cleavage sites and...
The cleavage site, in human band 3, corresponds to Lys-761 in mouse band 3; the site is 168 residues from the C terminus of the ... With previous data on the remainder of the membrane domain, there is now direct evidence that the band 3 polypeptide crosses ... Monoclonal antibodies against the membrane domain of human red blood cell band 3 protein have been prepared and used in ... of the H2DIDS reacts covalently with a lysine residue that is between about 70 and 168 residues from the C terminus of band 3. ...https://www.semanticscholar.org/paper/Monoclonal-antibodies-against-human-erythrocyte-3-Jennings-Anderson/8b9011fed97254e5d1dcaa6531e8c03d14e0c7e9
Frontiers | Granulocytes: New Members of the Antigen-Presenting Cell Family | Immunology
In addition, they can acquire surface expression of MHC class II and co-stimulatory molecules as well as T cell stimulatory ... In addition, they can acquire surface expression of MHC class II and co-stimulatory molecules as well as T cell stimulatory ... A substantial body of recent evidence demonstrates that granulocytes can acquire the function as antigen-presenting cells (APC ... is therefore changing to phenotypically and functionally heterogeneous cells that are engaged in cross-talk with other ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01781/full