Each cell population has its own distinct developmental features and generates unique cell types. However, it is essential that ... However, it is essential that neural crest and placodes associate together throughout embryonic development to coordinate the ... Each cell population has its own distinct developmental features and generates unique cell types. ... These cells arise within the dorsal ectoderm of all vertebrate embryos and have the developmental potential to form many of the ...

Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular ... Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non- ... Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain ... Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. Cell Reports 8,1018- ...

... and FKBP8 plays a more important role in ventral cells. These results suggest that the requirement for each of these factors in ... In Drosophila, the transcription factor Cubitus interruptus (Ci, the ortholog of vertebrate GLI) mediates Hedgehog(Hh)-induced ... Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse. Mech. Dev. ... B) PAX2 (red) and PAX6 (green) immunofluorescence staining of optic vesicles at E10.5. PAX2 is ectopically expressed in the ...

... cells is increased, but these cells still cross the midline. Pax2-expressing cells are expanded into more ventral parts within ... Based on their mode of regulation these transcription factors can be subdivided into two classes: Class I genes such as Pax6 ... Cell culture. Mouse embryonic fibroblasts (MEFs) were generated from single embryos,stage E12.5 (Ftm littermates), and ... The quantification of Ptc1 induction reveals that G0-phase wild-type MLCs show an increase of Ptc1transcripts by a factor of ...

Previous studies have demonstrated that transcription factors such as Pax genes play important roles during their development. ... Pax2/5/8-expressing cells are present in regions where the future sensory cells such as the polyplacophoran esthetes are ... and a Pax2/5/8 expression domain separating the Otx-domain from a Hox-gene-expressing posterior brain region. Thus, Pax2/5/8 ... Pax2/5/8 is expressed in regions where sensory cells develop subsequently during ontogenesis. Expression domains include ...

... and reduced expression of some of the ventral retinal fate genes due to deregulated protein signaling. Using zebrafish and cell ... KO embryos exhibit altered mRNA levels and expression patterns of several key transcription factors involved in eye development ... Functional study has illustrated that the PAX2-P130R, PAX2-R140G and PAX2-R140W variants all had a significant inhibitory ... To reveal potential candidate genes, we utilised transcriptomes experimentally generated from embryonic eye tissues derived ...

Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor. Experimental Cell Research 312(18): ... Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Developmental Cell 11(5): 711- ... Lund, C.V.; Popkov, M.; Magnenat, L.; Barbas, C.F. 2005: Zinc finger transcription factors designed for bispecific coregulation ... Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic ...

We identified several genes acting downstream of fgfAin these processes, including the transcription factors pea3 and pax2/5/8 ... Functions and regulations of fibroblast growth factor signaling during embryonic development. Dev. Biol ... 1F,G). Double in situ hybridization with probes for fgfAand nodal, which is expressed on the presumptive ventral side, showed ... Fibroblast growth factors 2 and 4 stimulate migration of mouse embryonic limb myogenic cells. Dev. Dyn ...

The transcription factor LIN-29 has been proposed to regulate vulval cell-type genes in a temporal window (Newman et al., 2000 ... A network of transcription factors controls the seven mature adult cell types; these include the LIM domain protein LIN-11, the ... D. In a lin-12(lf) mutant in which all ventral uterine cells but one anchor cell have been ablated, and in which P7.p has been ... Sulston, J.E., and Horvitz, H.R. (1977). Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, ... It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), ... RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In ... Negative Regulation Of Cell Proliferation. *Response To Glucose. *Post-embryonic Development. *Anterior/posterior Pattern ...

Volcano plot of differentially regulated genes showing changes in several key transcription factor, melanin pigmentation, and ... PAX2 expression in Zfp503−/− eyes extended dorsally and distally into the ventral pRPE (compare J, M, P with A, D, G, arrow). ... Patel A, Sowden JC.. Genes and pathways in optic fissure closure. Semin Cell Dev Biol. 2019; 91: 55-65. - PubMed ... Loss of Zfp503 expression is associated with an abnormal expression pattern of transcription factors important for RPE ...

Cell fate decisions, transcription factors and signaling during early retinal development. Diacou R, Nandigrami P, Fiser A, Liu ... Volcano plot of differentially regulated genes showing changes in several key transcription factor, melanin pigmentation, and ... PAX2 expression in Zfp503−/− eyes extended dorsally and distally into the ventral pRPE (compare J, M, P with A, D, G, arrow). ... Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye. Sun WR, ...

These cells are LHX1 positive and specified by an FGF/LHX1 axis, which, in turn, is regulated by a BMP/PAX2 axis (Atsuta and ... E, embryonic day in mouse; D, dorsal; MD: Müllerian duct; P, posterior (caudal); V, ventral; WD, Wolffian duct. Adapt- ed from ... 2011) FOXO transcription factors and their role in disorders of the female reproductive tract. Curr Drug Targets. 12(9):1291- ... 2006) Evidence for activation of the Amh gene expression by steoidogenic factor 1. Mech Dev. 123(6):472-480. Suarez SS and AA ...

4A). These cells express pax2, lhx1 and lhx5 (Fig. 4D,F; Fig. S6; Table S2.3), which may constitute a transcription factor code ... However, r7 cells (C2 ventral and C5 dorsal) do not cluster adjacent to r6 cells, reflecting that, although some genes are ... This is achieved through a network of cell-cell signalling and transcription factors that inhibit or promote cell ... Three 10X libraries representing the 16 hpf, 24 hpf and 44 hpf stages of embryonic development were aggregated using the 10X ...

Genes, Homeobox. Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY ... DevelopmentalMorphogenesisEmbryonic InductionSignal TransductionGenes, HomeoboxMutationPhenotypeGenes, InsectEmbryonic ... Transcription FactorsXenopus ProteinsFibroblast Growth Factor 8Wnt ProteinsInsect ProteinsWnt1 ProteinFibroblast Growth Factors ... by organizer properties and by being the early site of action of Wnt1 and engrailed genes, and of genes of the Pax2/5/8 ...

Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases ... Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila ... Cell Signalling); cJun (Santa Cruz); calbindin (Swant); Pax6 (Covance); Par3 (Upstate); Pax2 (Invitrogen); Chx10 (a kind gift ... Secreted frizzled-related proteins (Sfrps) are a family of secreted factors involved in embryonic development and tissue ...

Notably, hemichordates possess a deuterostome-specific genomic cluster of four ordered transcription factor genes, the ... Comparative analysis reveals numerous deuterostome-specific gene novelties, including genes found in deuterostomes and marine ... The authors identify a cassette of genes specifically associated with the development of pharyngeal slits, which are serial ... The putative functions of these genes can be linked to physiological, metabolic and developmental specializations of the filter ...

The expression of ventral genes such as chordin, foxA, brachyury, onecut/hnf6 and of ciliary band genes such as pax2/5/8 and ... The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice. 2010, Pubmed ... a gene involved in ulnar-mammary syndrome. 1999, Pubmed Howard-Ashby, Gene families encoding transcription factors expressed in ... Gene regulatory network controlling embryonic specification in the sea urchin. 2005, Pubmed , Echinobase Oliveri, Gene ...

POU genes are a family of evolutionarily conserved transcription factors with key functions in cell type specification and ... These and previous findings suggest that the embryonic dorso-ventral patterning lack scaling in the ventral and dorsal sides ... In the past few decades, genetic studies have identified the LEAFY transcription factor and the UNUSUAL FLORAL ORGANS (UFO) F- ... We report that the anterior expression boundary of early pronephric markers (Pax2 and Lim1), positioned at the level of somite ...

Single factors direct the differentiation of stem cells from the fetal and adult nervous system. Genes Dev 10: 3129-3140. ... Embryonic stem (ES) cells provide a potentially unlimited source of specialized cells for regenerative medicine. The ease of ... The Abercrombie correction factor [N = n × T/(T + D)], where N is the actual number of cells, n is the number of nuclear ... Bcl-XL overexpression led to an increase in the expression of midbrain-hindbrain genes Pax2, Pax5, Wnt1, and En1. Pax2, Wnt1, ...

Paired Box Transcription Factors. A family of transcription factors that control EMBRYONIC DEVELOPMENT within a variety of cell ... Growth FactorPAX2 Transcription FactorSOXF Transcription FactorsInsect ProteinsDNA PrimersIntercellular Signaling Peptides and ... Genes, Homeobox. Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY ... the left-right axis is established by a series of molecular signals that are produced by cells in the embryos ventral (bottom ...

The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog ... Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors ... E) Loss of ZC4H2+ cells in the Rnf220−/− spinal cord at E10.5 (thoracic level). Loss of Chx10+ cells and ZC4H2+ cells in the ... PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their ...

... suggesting that the transcription of these genes directly depends on metals. Cell-free extract from C. robusta tissues show the ... Complement components can be subdivided in 5 gene families: C3/C4/C5, Bf/C2, MASP/C1r-s, C6/C7/C8A/C8B/C9 and Factor I. Until ... The set of transcription factors that regulate proliferation and differentiation of the cellular immune system are conserved ... They offer the opportunity to investigate and compare the behaviour of both embryonic and adult stem cells. Morphological data ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

PAX2 Transcription Factor D12.776.930.626.750 PAX7 Transcription Factor D12.776.930.626.875 D12.776.930.700.875 PAX9 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Octamer Transcription Factor-6 D12.776.930.632.500.600 D12.776.930.710.500.600 Octamer Transcription Factors D12.776.930.632. ... Gene Ontology L1.224.65.480.500.500 L1.224.50.375.480.500.500 L1.700.508.300.550.500.500 L1.313.500.750.300.550.500.500 Genetic ...

Differential expression of Pax genes determines which cells become optic cup (future retina), and which cells become optic ... Initially, the transcription factor Mitf is expressed throughout the optic vesicle, but the subsequent expression of Vsx-2 in ... mutations of Pax-2 genes are seen. In Pax-2-mutant mice, retinal axons do not cross the midline through the optic chiasm, but ... During embryonic life, mitotic activity is spread throughout the outer lens epithelial cells. Around the time of birth, mitotic ...

cytoplasm, nucleus, transcription factor complex. Links to other databases. Entrez Gene. 373988. ... cardiac muscle cell differentiation, cell-cell signaling, embryonic forelimb morphogenesis, embryonic limb morphogenesis, ... Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev Biol. 2004 ... Peters MA, Cepko CL (2002). The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene ...

The molecular response by the intermediate mesoderm is the expression of the transcription factors Pax-2 and Pax-8, which then ... FGF, fibroblast growth factor; GDNF, glial cell line-derived neurotrophic factor; LIF, leukemia inhibitory factor.. ... 16.17). The most common form, autosomal dominant, is the result of mutations of the genes PKD1 and PKD2, which produce the ... During the late embryonic and early fetal period, they undergo a pronounced shift in position that moves them into the ...