Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells | Garvan Institute of Medical Research
Cdk4, although MDA-MB-134 cells displayed the highest level of both cyclin D1 expression and Cdk4 activity. Similarly, there ... Cdk4, although MDA-MB-134 cells displayed the highest level of both cyclin D1 expression and Cdk4 activity. Similarly, there ... These data suggest that properties of cyclins D1 and E in addition to their ability to activate Cdk4 and Cdk2 may contribute to ... These data suggest that properties of cyclins D1 and E in addition to their ability to activate Cdk4 and Cdk2 may contribute to ...https://www.garvan.org.au/research/publications/1235
WikiGenes - Cdk4 - cyclin-dependent kinase 4
A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK ... The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. ... Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal ... However, cyclin D/CDK4 has been postulated to act in a noncatalytic manner to regulate the cyclin E/CDK2-inhibitory activity of ...http://www.wikigenes.org/e/gene/e/12567.html
CDK4 - Cyclin dependent kinase 4 - Mus musculus (Mouse) - CDK4 gene & protein
tr,Q9JKW8,Q9JKW8_MOUSE Cyclin dependent kinase 4 (Fragment) OS=Mus musculus GN=CDK4 PE=4 SV=1 ... Name:CDK4Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/ ... CyclinImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/ ... Cyclin dependent kinase 4Imported. ,p>Information which has been imported from another database using automatic procedures.,/p ...http://www.uniprot.org/uniprot/Q9JKW8
CDK4 - Cyclin-dependent kinase 4 - Sus scrofa (Pig) - CDK4 gene & protein
Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 ... Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a ... Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) ... Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 ...http://www.uniprot.org/uniprot/P79432
Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity - Chemical Communications (RSC Publishing)
... complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosph Biological optical ... We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and ... Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity J. A. González-Vera, D. Bouzada, C. Bouclier, M. ... We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and ...http://pubs.rsc.org/en/content/articlelanding/2017/cc/c6cc09948c
The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis. | Sigma...
Overexpression of cyclin D1 and its catalytic partner, CDK4, is frequently seen in human cancers. We constructed cyclin D1 and ... The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis.. [Siwanon ... One of the novel partners of CDK4 is FKBP5, which we found to be required to maintain CDK4 levels in cancer cells. An ... and identified novel CDK4 protein partners. Among CDK4 interactors we observed several proteins functioning in protein folding ...https://www.sigmaaldrich.com/catalog/papers/25486477
Cyclin D/Cdk4 - Wikipedia
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or ... Once Cdk4 is activated and is bound with Cyclin D, the Cyclin D/Cdk4 complex phosphorylates Retinoblastoma protein (pRb). Once ... The phosphorylation of p27 inhibits p27's ability to bind Cdk4, thus freeing Cdk4 to associate with Cyclin D and form an active ... First and foremost, under non-dividing conditions multiple proteins can inhibit the Cyclin D/Cdk4 complex by binding Cdk4 and ...https://en.wikipedia.org/wiki/Cyclin_D/Cdk4
RCSB PDB - 1GIH: HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR Methods Report Page
CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein. ... HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 ... Crystallographic approach to identification of cyclin-dependent kinase 4 ( ...http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1GIH
The ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1...
... interrupted the cell cycle in S-phase and down-regulated the cyclin D1/cyclin-dependent kinase (CDK)-4 complex, whereas the 8,9 ... Cyclin D1 down-regulation by 17,18-epoxy-EPA was mediated by activation of the growth-suppressing p38 MAP kinase, but the ... ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 ... ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 ...http://researchrepository.murdoch.edu.au/id/eprint/4019/
Control of intestinal epithelial homeostasis by Drosophila cyclin D/Cdk4 regulates organismal energy storage - Research...
Control of intestinal epithelial homeostasis by Drosophila cyclin D/Cdk4 regulates organismal energy storage. * Mendeley ...https://www.research-collection.ethz.ch/handle/20.500.11850/153101
siRNA targeting cyclin-dependent kinase 4 (CDK4) - Patent application
siRNAs that Target Cyclin-Dependent Kinase 4  siRNAs that target nucleotide sequences for CDK4 (NCBI accession numbers NM ... Patent application title: siRNA targeting cyclin-dependent kinase 4 (CDK4). Inventors: Anastasia Khvorova (Boulder, CO, US) ... 0072] In various embodiments, siRNAs that target cyclin-dependent kinase 4 (CDK4) are provided. In various embodiments, the ... 0073] In various embodiments, an siRNA that targets CDK4 is provided, wherein the siRNA is selected from the group consisting ...http://www.patentsencyclopedia.com/app/20110319474
Gene Expression Literature Summary - MGI
Cdk4 cyclin-dependent kinase 4. MGI:88357 88 matching records from 88 references.. Summary by Age and Assay: Numbers in the ... J:131845 Ciemerych MA, Yu Q, Szczepanska K, Sicinski P, CDK4 activity in mouse embryos expressing a single D-type cyclin. Int J ... J:31366 Fromm L, Overbeek PA, Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation ... GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior ...http://www.informatics.jax.org/gxdlit/marker/MGI:88357
Cell Division Cycle | www.antibodies-online.com
CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4)): CDKN2C antibodies CDKN2C ELISA Kits CDKN2C Proteins ... Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with ... CCNA1 - Cyclin A1: CCNA1 antibodies CCNA1 ELISA Kits CCNA1 Proteins CCNA2 - Cyclin A: CCNA2 antibodies CCNA2 ELISA Kits CCNA2 ... CCNB3 - Cyclin B3: CCNB3 antibodies CCNB3 ELISA Kits CCNB3 Proteins CCNC - Cyclin C: CCNC antibodies CCNC ELISA Kits CCNC ...https://www.antibodies-online.com/cell-division-cycle-pathway-13/
Prostate Cancer | Smore Newsletters
CDK4 (cyclin-dependent Kinase 4).' CDK4 (cyclin-dependent Kinase 4). N.p., n.d. Web. 29 Oct. 2015. ... CDK4 Gene.' Genetics Home Reference. Genetics Home Reference, 26 Oct. 2015. Web. 29 Oct. 2015. ,http://ghr.nlm.nih.gov/gene/ ... CDK4,.. 'CDKN2A Gene.' Genetics Home Reference. Genetics Home Reference, 26 Oct. 2015. Web. 29 Oct. 2015. ,http://ghr.nlm.nih. ...https://www.smore.com/7jh9h
Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin...
Cdk4, cyclin D1, c-Myc and MDM2. Increase in Cdk4 expression is seen in HCC sample from elf+/− mouse (d) as compared with ... Increased cyclin D1 expression in human HCC tissue and cell lines and the effect of ectopic ELF expression. Cyclin D1 is ... Restoration of ELF and TBRII suppresses cyclin D1 with TGF-β stimulation in SNU-398 cells (a). No significant change in cyclin ... cyclin-dependent kinase 4 (Cdk4), c-Myc and MDM2 expression. Reduced ELF but not TBRII, or Smad4 was observed in 8 of 9 human ...https://www.ncbi.nlm.nih.gov/pubmed/17546056
CDK4 Gene - GeneCards | CDK4 Protein | CDK4 Antibody
Cyclin Dependent Kinase 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. *CDK4_HUMAN,P11802 ... GeneCards Summary for CDK4 Gene CDK4 (Cyclin Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 ... Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDK4
US5677428A - RNA editing enzyme and methods of use thereof - Google Patents
Cdk4 (cyclin dependent kinase 4) binding proteins US6544768B1 (en) 2003-04-08. Mammalian soluble adenylyl cyclase ...https://patents.google.com/patent/US5677428
Cyclin-dependent kinase 4 - Wikipedia
Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 ... Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". ... Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1". J. Biol. Chem. 273 (50): 33279-86. doi:10.1074/jbc.273.50 ... CDK4 is a member of the cyclin-dependent kinase family. The protein encoded by this gene is a member of the Ser/Thr protein ...https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_4
Professor Ravinay Bhindi - The University of Sydney
Vascular Smooth Muscle Cell Growth and Intimal Thickening by Repressing p21WAF1/Cip1 Transcription and p21WAF1/Cip1-Cdk4-Cyclin ... Vascular Smooth Muscle Cell Growth and Intimal Thickening by Repressing p21WAF1/Cip1 Transcription and p21WAF1/Cip1-Cdk4-Cyclin ...http://sydney.edu.au/medicine/people/academics/profiles/ravinay.bhindi.php
The Dual Role of Zonula Occludens (ZO) Proteins
ZONAB: ZO-1 associated nucleic acid binding protein; Cdk-4: Cyclin-dependent kinase-4; ARVCF: Armadillo repeat gene deleted in ... Cdk4) which interacts and colocalizes with ZONAB at TJs. In this way, Cdk4 is prevented from entering the nucleus and ... M. Huerta, R. Munoz, R. Tapia et al., "Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription ... R. Tapia, M. Huerta, S. Islas et al., "Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits ...https://www.hindawi.com/journals/bmri/2010/402593/
... cyclin-dependent kinases (e.g., CDK2/CDK4), cyclin-dependent kinase inhibitors (e.g., CDKN1A/CDKN2A/B), and other cell-cycle ... dysregulated by IGF1R inhibition in a time-dependent manner relative to vehicle-treated control included numerous cyclins (e.g ...http://mct.aacrjournals.org/content/10/8/1407
Immunohistochemistry in Gynecologic Pathology - Redorbit
p16 (cyclin-dependent kinase inhibitor 4) is a tumor suppressor protein that binds to cyclin-cdk4/6 complexes. It blocks their ...http://www.redorbit.com/news/health/1252622/immunohistochemistry_in_gynecologic_pathology/
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts |...
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J ... including Cdk4/cyclin D1, Cdk2/cyclin A, fibroblast growth factor receptor, and platelet-derived growth factor receptor. ... which also complexes with cyclin D subunits and is highly homologous to Cdk4, can perform identical functions to Cdk4 by ... Furthermore, cyclin D1 is a true oncogene capable of transforming cells itself, and p16, a natural inhibitor of Cdk4 that is ...http://mct.aacrjournals.org/content/3/11/1427.long
Antitumor Research on Artemisinin and Its Bioactive Derivatives | Springer for Research & Development
Down-regulated the transcript and protein levels of the CDK2 and CDK4 cyclin-dependent kinases, cyclin E, cyclin D1, and the ... Suppressed the transcription and protein expressions of the CDK2 and CDK4 cyclin-dependent kinases, cyclin E, cyclin D1, and ... DHA exposure resulted in downregulation of cell cycle-related proteins, such as cyclin E, CDK2 and CDK4. Cyclin E, CDK2, and ... Reduced the transcription activity of CDK2, CDK4, cyclin E ; increased the expression of CD71 ; up-regulated the ...https://rd.springer.com/article/10.1007/s13659-018-0162-1
Frontiers | "Till Death Do Us Part": A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in...
CCE (G1/S phase checkpoint) requires phosphorylation of Rb by Cdk4/Cyclin D1 among others mitogenic events. CCE primarily ... cyclins, cyclin-dependent kinases (Cdk) and cyclin-dependent kinase inhibitors (Cdki), is the master regulator of the ... Cdk4 and, all D cyclins. In addition, the expressions of specific Cdkis including p27Kip1, p19Ink4d, p18Ink4c, and p21Cip1 ... genetic deletion of cyclin D2 but not cyclin D1 completely eliminates proliferation of all neuronal precursors (hence ...https://www.frontiersin.org/articles/10.3389/fnins.2018.00144/full