*  Live cell imaging of mechanotransduction | Journal of The Royal Society Interface
Rho, Rac and Cdc42. Rho, Rac and Cdc42 are closely related small GTP-binding proteins that play important roles in ... Matsuda's group developed FRET-based Rac and Cdc42 biosensors, namely Raichu-Rac and Raichu-Cdc42, respectively (Itoh et al. ... a CaM-binding peptide and two FPs serving as a FRET pair. When Ca2+ binds to the docking sites in CaM, the bound CaM can wrap ... pRaichu-RhoA and pRaichu-Cdc42 biosensors. The results revealed that only the activity of RhoA, but not Rac or Cdc42, was ...
  http://rsif.royalsocietypublishing.org/content/early/2010/03/29/rsif.2010.0042.focus
*  Phospho-PAK1 (Thr212) Antibody
These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ... receptor signaling protein serine/threonine kinase activity. protein binding. collagen binding. ATP binding. protein kinase ... Protein Aliases: Alpha-PAK; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase ... PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a ...
  https://www.thermofisher.com/antibody/product/Phospho-PAK1-pThr212-Antibody-Polyclonal/PA5-12761
*  Plus it
... rac, and cdc42 (for review, see Denhardt, 1996). Activation of the small GTP binding proteins leads to modulation of serine/ ... Growth factors may mediate neuronal survival by regulating signaling cascades downstream of the small GTP binding proteins ras ... 1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell ... 1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-jun activation domain ...
  http://www.jneurosci.org/content/18/1/104
*  Plus it
Cdc42 belongs to the Rho family of small GTP binding proteins along with Rac and Rho ( 30). It is involved in regulating a ... Protein samples from normal B cells labeled with Cy5 were mixed with protein samples from WM B cells labeled with Cy3 protein ... Proteins up-regulated by ,2-fold included Ras family proteins, such as Rab-4 and p62DOK, and Rho family proteins, such as ... These included the heat shock protein HSP90, the Ras family protein CDC25C, and the chemotaxis protein p43/EMAPII. ...
  http://cancerres.aacrjournals.org/content/67/8/3777
*  P21 (CDKN1A)-activated kinase 2 | definition of p21 (CDKN1A)-activated kinase 2 by Medical dictionary
... which serve as targets for the small GTP-binding proteins Cdc42 and RAC and have been implicated in a wide range of biological ... A gene on chromosome 3q29 that encodes a PAK protein of the serine/threonine p21-activating kinase family, ... p21 protein (Cdc42/Rac)-activated kinase 1. *p21 protein (Cdc42/Rac)-activated kinase 2 ... p21 protein (Cdc42/Rac)-activated kinase 3. *p21 protein (Cdc42/Rac)-activated kinase 4 ...
  https://medical-dictionary.thefreedictionary.com/p21+
*  Protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs | definition of protein kinase related to S. cerevisiae...
What is protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs? Meaning of protein kinase related to S. cerevisiae ... What does protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs mean? ... protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs explanation free. ... Looking for online definition of protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs in the Medical Dictionary ...
  http://medical-dictionary.thefreedictionary.com/protein+kinase+related+to+S.+cerevisiae+STE20%2C+effector+for+Cdc42Hs
*  Angiotensin II Signal Transduction Through Small GTP-Binding Proteins | Hypertension
Rac, and Cdc42, also has various effectors. One of the Rho effectors, Rho-kinase (ROCK), plays an important role in actin ... Small GTP-binding proteins (G proteins) are monomeric G proteins with a low molecular weight of 20 to 40 kDa. A small G protein ... Also, eIF4E is released from eIF4E binding protein/PHAS-I on phosphorylation of eIF4E binding protein/PHAS-I regulated through ... Angiotensin II Signal Transduction Through Small GTP-Binding Proteins. Haruhiko Ohtsu, Hiroyuki Suzuki, Hidekatsu Nakashima, ...
  http://hyper.ahajournals.org/content/48/4/534
*  PAK4 - Wikipedia
They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological ... PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a ... PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical ... Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. PAK4 is one of six members of ...
  https://en.wikipedia.org/wiki/PAK4
*  P21-activated kinases - Wikipedia
They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological ... PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)". "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". "Entrez ...
  https://en.wikipedia.org/wiki/P21-activated_kinases
*  PAK1 - Wikipedia
These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... "Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16". The Journal ... Seoh ML, Ng CH, Yong J, Lim L, Leung T (March 2003). "ArhGAP15, a novel human RacGAP protein with GTPase binding property". ...
  https://en.wikipedia.org/wiki/PAK1
*  Diffuse glioma growth: a guerilla war | SpringerLink
Rac and cell division cycle protein Cdc42, are pivotal regulators of these processes. When bound to GTP, these proteins can ... binds with high affinity with IGF-Binding Protein 2 (IGFBP2), a soluble protein that is frequently overexpressed in high-grade ... an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell ... Engagement of CD44 with its ligand activates the small GTP binding protein Rac1, leading to actin cytoskeleton rearrangements ...
  https://link.springer.com/article/10.1007%2Fs00401-007-0293-7
*  Plus it
... have indicated that shrinkage activation of p38 involves Cdc42 and/or Rac, small GTP-binding proteins (G proteins of the Rho ... A 5-μl aliquot was removed for protein determination using the DC Protein Assay from Bio-Rad. Aliquots of ∼20 μg protein (equal ... Lewis A, Di Ciano C, Rotstein OD, Kapus A. Osmotic stress activates Rac and Cdc42 in neutrophils: role in hypertonicity-induced ... Equal amounts of protein were loaded in each well as calculated by protein content determination and verified by Ponceau S red ...
  http://ajpcell.physiology.org/content/294/4/C1046
*  Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase | The EMBO Journal
Members of this protein kinase family bind the Rho‐like small GTP binding proteins Cdc42 or Rac at a conserved binding site ... 335-352 corresponds to a sequence motif known to be sufficient to bind Cdc42 or Rac in a variety of Cdc42/Rac binding proteins ... proteins. Interestingly, some members of the Ste20p/p65PAK family are lacking a Cdc42/Rac binding site, including GC kinase ... A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem, 270, 29071- ...
  http://emboj.embopress.org/content/16/1/83
*  Interactive Fly, Drosophila
They become activated by interaction with Rho-type small GTP-binding proteins Rac and Cdc42 in the GTP-bound conformation, ... PAK1 protein forms a homodimer. The binding of GTP bound Cdc42 or Rac dissociates the PAK dimer, leading to PAK activation. In ... Three additional candidate proteins, DPR2, MSE55, and MLK3 show binding to the GTP form of Cdc42 and weaker binding with Rac, ... These results indicate that proteins containing the CRIB motif bind to Cdc42 and/or Rac in a GTP-dependent manner, and they may ...
  http://www.sdbonline.org/sites/fly/cytoskel/pak-kn2.htm
*  Myosin phosphatase releases moesin-mediated inhibition. | Open-i
cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ... cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4322047_JEM_20140508_Fig8&req=4
*  Rho Kinase Regulates Schwann Cell Myelination and Formation of Associated Axonal Domains | Journal of Neuroscience
Rho GTPases, a family of small GTP-binding proteins, are important candidates to coordinate remodeling of the actin ... Rho, Rac, and Cdc42 have been the most extensively characterized family members and were originally implicated in the signal ... GDP-bound) and an active (GTP-bound) state. In their active state, these molecules bind to a variety of effectors that regulate ... and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J ...
  http://www.jneurosci.org/content/24/16/3953.long
*  A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation | The Journal of Immunology
Binding of GTP-loaded Cdc42 or Rac to PAK family members through the Cdc42/Rac interactive binding region (CRIB) domain results ... These GTP-binding proteins are molecular switches, which cycle between the active GTP-bound form and the inactive GDP-bound ... PAKs are known to be critical effectors of Cdc42/Rac (4). Although Cdc42/Rac binding results in PAK activation, there is a ... A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:29071. ...
  http://www.jimmunol.org/content/172/12/7324.long
*  T-Type Calcium Channels | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors
... as well as the GTP binding protein Cdc42/Rac (12-15). These connections are necessary for Par6 legislation TAK-441 of cell ... The Polarity protein complex Par6/aPKC/Cdc42 regulates polarization processes during epithelial morphogenesis. The Polarity ... Par6 is normally a scaffolding molecule that's involved with multiple protein-protein connections (10 11 One of the most ... Therefore the polarity proteins Par6 promotes change of epithelial cells not merely by regulating cell polarity pathways but ...
  http://researchreport-digital.com/category/t-type-calcium-channels/
*  Dbl homology (DH) domain (IPR000219) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins ... The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras ...
  http://www.ebi.ac.uk/interpro/entry/IPR000219
*  Figure 1, [Activation of Rho, Rac and...]. - Madame Curie Bioscience Database - NCBI Bookshelf
Phagocytosis generally involves the receptor-mediated, GEF-dependent activation of one or more Rho GTP-binding proteins, which ... Type I phagocytosis is characterized by the independent activation of Rac and Cdc42, whereas only Rho activity is required ... Yersinia outer protein; FcγR, Fcγ receptor; AC, apoptotic cell; CR3, complement receptor type 3; WASp, Wiskott-Aldrich Syndrome ... that activate or inhibit the function or one or more Rho proteins, thereby modulating actin polymerization and phagocytosis. ...
  https://www.ncbi.nlm.nih.gov/books/NBK6206/figure/A32130/?report=objectonly
*  Targeting Rho in Cardiovascular Disease | Circulation Research
Rho proteins cycle between the active GTP-bound and the inactive GDP-bound states. Activators of Rho include growth factors, ... activation of Rac leads to the formation of lamellipodia and membrane ruffles, whereas activation of Cdc42 induces actin-rich ... The Rho GTPases are members of the Ras superfamily of small GTP-binding proteins.1 They consist of at least 14 distinct ... proteins ranging from 20 to 24 kDa, which can be additionally subdivided into Rho, Rac, and Cdc42.1 Rho GTPases are major ...
  http://circres.ahajournals.org/content/87/7/526
*  Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. - PubMed -...
cdc42 GTP-Binding Protein/genetics. *cdc42 GTP-Binding Protein/metabolism*. *rac GTP-Binding Proteins/metabolism* ... Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related ... Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.. Nishikimi ... cdc42 GTP-Binding Protein/chemistry. * ... rac GTP-Binding Proteins. Secondary source ID. *GENBANK/ ...
  https://www.ncbi.nlm.nih.gov/pubmed/15710388
*  A Rac switch regulates random versus directionally persistent cell migration | JCB
Cdc42, and Rho. Densitometry for each GTP-bound protein was normalized to the amount of the total protein, and results are ... Cdc42 siRNA led to a substantial decrease of both Cdc42 protein levels (total-Cdc42) and Cdc42 activity (Cdc42-GTP) by pull- ... Activities in pull-down assays for Rac-GTP, Cdc42-GTP, and Rho-GTP and total amounts of each protein in lysates of cells ... The amount of active Rac (Rac-GTP) was reduced to 67% of original levels and the total amount of Rac protein (total-Rac) was ...
  http://jcb.rupress.org/content/170/5/793
*  Fgd4 - FYVE, RhoGEF and PH domain-containing protein 4 - Mus musculus (Mouse) - Fgd4 gene & protein
... and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin ... Activates CDC42, a member of the Ras-like family of Rho- ... direct activation of Cdc42 and indirect activation of Rac.". ... Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates ... Protein-protein interaction databases. Protein interaction database and analysis system. More...IntActi. Q91ZT5. 2 interactors. ...
  http://www.uniprot.org/uniprot/Q91ZT5
*  The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42 | The Journal of Immunology
Significantly higher levels of GTP-bound Cdc42 (Fig. 7⇓A, right panel) but not Rac (Fig. 7⇓B, right panel) or Rho (Fig. 7⇓C, ... Secondly, AND-34 could activate Cdc42 by acting as an adapter protein rather than a GEF. AND-34 binds to p130Cas by its "GEF" ... GTP-bound Cdc42 was detected by immunoblotting with anti-Cdc42 mAb. Equal expression of Cdc42 was confirmed by immunoblotting ... Consistent with these results, AND-34 overexpression augmented levels of GTP-bound Cdc42 but not Rac (Fig. 7⇓F, right panel, ...
  http://www.jimmunol.org/content/170/2/969?ijkey=5e163188919689daab370c4d49dd15de6a53e605&keytype2=tf_ipsecsha