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*  The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells.
Patients with adrenocortical carcinoma (ACC) need new treatment options. The aim of this study was to evaluate the effects of the mTOR-inhibitors sirolimus and temsirolimus on human-ACC cell growth and cortisol production. In H295, HAC15 and SW13 cel
  http://www.biomedsearch.com/nih/role-mTOR-inhibitors-in-inhibition/22420007.html
*  11C-metomidate PET imaging of adrenocortical cancer
Adrenocortical cancer (ACC) is a rare disease that is often difficult to diagnose, and therefore often presents at an advanced stage. Various cytotoxic treatments have been tried with little success. Evaluation of new diagnostic methods and improvement of medical therapies are therefore crucial.. The diagnostic potential of 11C-metomidate positron emission tomography (PET) was evaluated in eleven ACC patients. PET visualized all viable tumors with high tracer uptake, including two lesions that CT failed to detect. Necrotic or fibrotic tumors were PET negative. Medication with adrenal steroid inhibitors and chemotherapy may decrease the tracer uptake.. We performed a phase-II study with streptozocin and o,p'-DDD (SO) combination therapy in 40 ACC patients. The SO therapy was found to have impact on the disease-free interval (P = 0.02) as well as on survival (P = 0.01) in patients who received adjuvant therapy after curative resection. Complete or partial response was obtained ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:164511
*  Adrenal Cortical Carcinoma
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  http://www.psychiatryadvisor.com/endocrinology-metabolism/adrenal-cortical-carcinoma/article/595716/
*  Adrenocortical Carcinoma, Adrenal Cancer Facts - Dana-Farber Cancer Institute | Boston, MA
Adrenocortical carcinoma is a rare cancer that forms in the adrenal gland. Learn about adrenocortical carcinoma and learn how we care for adult patients with adrenocortical carcinoma before, during, and after treatment.
  http://www.dana-farber.org/adrenocortical-carcinoma/
*  Adrenocortical Carcinoma - Pipeline Review, H1 2017
... Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Adrenocortical Carcinoma - Market research report and industry analysis - 10909461
  https://www.marketresearch.com/Global-Markets-Direct-v3480/Adrenocortical-Carcinoma-Pipeline-Review-H1-10909461/
*  Adrenocortical hyperplasia | definition of adrenocortical hyperplasia by Medical dictionary
Looking for online definition of adrenocortical hyperplasia in the Medical Dictionary? adrenocortical hyperplasia explanation free. What is adrenocortical hyperplasia? Meaning of adrenocortical hyperplasia medical term. What does adrenocortical hyperplasia mean?
  http://medical-dictionary.thefreedictionary.com/adrenocortical+hyperplasia
*  Adrenocortical Cancer | Harrison's Manual of Oncology, 2e | AccessHemOnc | McGraw-Hill Medical
At the time of disease discovery there may be no symptoms (the tumor may be found incidentally on imaging). In other patients there may be symptoms of hormone excess or complaints referable to an abdominal mass. Hormone excess presents clinically as Cushing's syndrome, virilization, feminization, or, less frequently, hypertension with hypokalemia. Hormone hypersecretion can be found in as many as 73%-79% of ACC patients, although not all patients have symptoms (2). In one study, amongst 45 ACC patients, routine biochemistry documented hormone excess in 33 (73%) with excess glucocorticoid and adrenal androgen in 12, isolated glucocorticoid in 11, isolated adrenal androgen in 7, and 17β-estradiol excess in combination with glucocorticoid and adrenal androgen excess in two and one, respectively. Steroid profiling revealed predominantly immature, early-stage steroid precursors, and their production most likely a ...
  http://hemonc.mhmedical.com/content.aspx?bookid=1799§ionid=124754633
*  Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor - Full Text View -...
This phase III clinical trial is studying how well cisplatin-based chemotherapy and/or surgery works in treating young patients with stage I, stage II, stage III or stage IV adrenocortical cancer. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving it after surgery may kill any tumor cells that remain after surgery ...
  https://clinicaltrials.gov/ct2/show/NCT00304070?term=COG+ARAR0332&rank=1
*  Plus it
Li-Fraumeni Syndrome (LFS) is a rare autosomal hereditary disorder that is commonly associated with germline mutations in the TP53 gene. People with LFS are at high risk to develop a wide range of malignancies including breast cancer, brain tumors, acute leukemias, soft tissue sarcomas, bone sarcomas, and adrenal cortical carcinomas. Although no therapies are approved to treat or prevent LFS, preclinical studies have shown that the anti-diabetic drug metformin is preferentially cytotoxic to p53 null cells in the absence of glucose. This led us to hypothesize that metformin has therapeutic potential in LFS. To confirm the p53 dependence of metformin in vitro, isogenic human and murine cancer cell lines were treated with metformin in the absence or presence of glucose. Metformin induced greater toxicity in p53-deficient cells in a dose-dependent manner. Metformin was then tested in two mouse models that recapitulate the increased tumorigenesis and cancer-related mortality in ...
  http://cancerres.aacrjournals.org/content/71/8_Supplement/614
*  Study of Adrenal Gland Tumors - Full Text View - ClinicalTrials.gov
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone ...
  https://clinicaltrials.gov/ct2/show/NCT00005927?cond=%22Adenoma+of+the+adrenal+gland%22&rank=5
*  Study of Adrenal Gland Tumors - Full Text View - ClinicalTrials.gov
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone ...
  https://clinicaltrials.gov/ct2/show/NCT00005927?term=cushing%27s&recr=Open&rank=24
*  Study of Adrenal Gland Tumors - Full Text View - ClinicalTrials.gov
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone ...
  https://clinicaltrials.gov/ct2/show/NCT00005927?term=nichd+Cushing
*  Adrenocortical Carcinoma | CTD
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM ...
  http://ctdbase.org/detail.go?type=disease&acc=MESH%3AD018268
*  Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome Profiling | Clinical Cancer Research
ACC, compared with most other carcinomas, is an extremely rare disease and accordingly challenging to study. The unavailability of large series of cases precludes many types of analyses, especially those designed to identify clinicopathologic variables related to treatment and survival, although progress related to the efficacy of mitotane therapy has been recently reported (40). The need for such studies is great and will continue to grow as novel targeted therapies are used to treat patients with ACC.. Our DNA microarray analysis clearly shows the power of molecular profiling as a tool for the diagnosis of adrenocortical tumors. Microarray-based assessment can accurately separate ACAs from ACCs and may actually do so with slightly higher accuracy than morphology, given that one tumor diagnosed as an ACC may be a large ACA. Use of DNA microarrays as an adjunctive diagnostic tool may be useful, especially at centers with limited experience with these rare tumors. Additionally, we provide a rich ...
  http://clincancerres.aacrjournals.org/content/15/2/668.long
*  Adrenal carcinoma - Radiology Imaging
An interesting phenomenon consists of adrenal collision tumors. Thus a contiguous adrenal adenoma and metastasis results in the adenoma component displaying a signal loss on opposed-phase MR images and the metastatic component increasing in signal intensity. At times neither a biopsy nor a resected specimen allows adequate evaluation of an adrenocortical tumor if only histologic criteria are employed; immunohistologic staining is often helpful. Nevertheless, even then the true nature of a tumor may not be apparent. For example, CT and US discovered an incidental homogeneous adrenal tumor in a 43-year-old woman; endocrine tests revealed preclinical Cushing's syndrome. An adrenalectomy was performed, and histology revealed an adrenocorticaltumor of undetermined nature, 4 months later the patient presented with a metastatic cortisol and androgen-producing adrenocortical ...
  http://radiology-information.blogspot.com/2014/04/adrenal-carcinoma.html
*  Plus it
The differentiation between malignant and benign adrenocortical tumors is often difficult, and better markers are required. Because the genetic background of adrenocortical tumors is poorly characterized, we used comparative genomic hybridization (CGH) to screen for DNA sequence copy number changes in 8 sporadic primary adrenocrotical cancers and 14 adenomas. There was a strong relationship between the number of genetic aberrations detected using CGH and both tumor size and malignancy. No alterations were seen in the smaller adenomas (,5 cm), whereas the two largest adenomas (5 cm each) and seven of the eight cancers (7-20 cm) showed an increased number of genetic alterations. The presence of genetic aberrations detected using CGH was associated with an aneuploid DNA pattern. In the cancers, losses most often involved the chromosomal regions 2, 11q, and 17p (four of eight tumors), whereas gains took place at chromosomes 4 and 5 (four of eight tumors). In conclusion, our data indicate that ...
  http://cancerres.aacrjournals.org/content/56/18/4219
*  Rare Cancer News & Clinical Trials » Google - Adrenocortical Carcinoma
Infinity also announced today that it is adding two additional cohorts to the combination expansion component of the study, one in mesothelioma and one in adrenocortical carcinoma (cancer of the adrenal gland). These two new cohorts are based in part ... ...
  http://news.rare-cancer.org/Google_-_Adrenocortical_Carcinoma/
*  Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review | Journal of Clinical...
Aims: Structured multicentre efforts are needed if the prognosis of adrenocortical carcinoma (ACC) is to be improved. Data collection may be enhanced through standardised histopathological reporting using criteria such as the recently published Royal College of Pathologists' (UK) minimum dataset (MDS). This study aimed to perform a clinicopathological review of the adult patients treated at the Royal Victoria Infirmary, Newcastle upon Tyne, in the 10 years preceding the MDS.. Methods: Case records were examined for all patients diagnosed with ACC between 1996 and 2006. Pathology was reviewed and compared with the Royal College of Pathologists' MDS along with the original reports. A systematic evaluation of Ki-67 immunolabelling was also performed.. Results: Eleven patients with ACC were diagnosed and treated. Histopathological reporting according to the MDS identified more features of malignancy than in the original reports (8.5±1.2 versus 5.1±0.8, p,0.02). The median number of microscopic ...
  http://jcp.bmj.com/content/61/8/939
*  Contemporary management of adrenocortical carcinoma.
Abstract CONTEXT: Adrenocortical carcinoma (ACC) is a rare and typically aggressive malignancy. Available recommendations are based primarily on retrospective series or expert opin..
  https://www.omicsonline.org/references/contemporary-management-of-adrenocortical-carcinoma-1436085.html
*  Adrenocortical Carcinoma | Portsmouth Regional Hospital
Learn more about Adrenocortical Carcinoma at Portsmouth Regional Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  https://portsmouthhospital.com/hl/?/179661/Adrenal-cancer&com.dotmarketing.htmlpage.language=1
*  Adrenocortical Carcinoma | Memorial Hospital
Learn more about Adrenocortical Carcinoma at Memorial Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  http://memorialhospitaljax.com/hl/?/179661/Adrenocortical-carcinoma&com.dotmarketing.htmlpage.language=1
*  Adrenocortical Carcinoma | Largo Medical Center | Largo, FL
Learn more about Adrenocortical Carcinoma at Largo Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  http://largomedical.com/hl/?/179661/Cancer-of-the-adrenal-cortex
*  The Division of Biology & Biomedical Sciences
Another area of interest is the role of GATA factors in the regulation of steroidogenic cell differentiation. Our experimental system takes advantage of the observation that GATA-4 normally is expressed in gonadal but not adrenocortical steroidogenic cells of the adult mouse. Interestingly, certain inbred strains of mice develop sex steroid-producing adrenocortical neoplasms in response to prepubertal gonadectomy. This phenomenon is thought to reflect metaplasia of competent cells in the adrenal gland, which transform into gonadal-like stroma in response to changes in the hormonal milieu, and increased expression of GATA4 is a hallmark of this transformation. To examine the signaling pathways involved in this form of tissue-type switching, we have created new inbred and transgenic models of adrenocortical neoplasia .. ...
  http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=1644
*  MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy - Patterson - 2010 - Cancer - Wiley...
Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004; 64: 5245-5250 ...
  http://onlinelibrary.wiley.com/doi/10.1002/cncr.25724/references