Cempra Doses Initial Patient in Phase 2 Clinical Trial of Solithromycin in NASH
... which has potent activity against most macrolide-resistant bacterial strains. In vitro and in vivo studies have shown potent ... These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results ... Cempra has also synthesized novel macrolides for non-antibiotic uses such as the treatment of chronic inflammatory diseases, ... It is also active against atypical bacteria, such as legionella, chlamydia, mycoplasma and ureaplasma, and against gonococci ...https://www.cnbc.com/2016/01/05/globe-newswire-cempra-doses-initial-patient-in-phase-2-clinical-trial-of-solithromycin-in-nash.html
Cempra Announces FDA Acceptance of Solithera™ New Drug Applications in the Treatment of Community-Acquired Bacterial Pneumonia
... which has potent activity against most macrolide-resistant strains. In vitro and in vivo studies have shown potent activity ... Although many strains of the primary CABP pathogen, Streptococcus pneumoniae, are resistant to currently-approved macrolides, ... It is 8-16 times more potent than azithromycin against many bacteria and is active against azithromycin-resistant strains. ... These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results ...https://www.cnbc.com/2016/07/05/globe-newswire-cempra-announces-fda-acceptance-of-solitheraa-new-drug-applications-in-the-treatment-of-community-acquired-bacterial.html
Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
... activity of macrolides and their effects on the virulence of and tissue damage caused by the chronic colonising bacteria [234- ... macrolide-resistant strain of S. pneumoniae to a range of macrolides and macrolide-like agents resulted in significant ... This includes a number of in vitro studies which have demonstrated the inhibitory effects of macrolides and macrolide-like ... Macrolide antibiotics are generally used to treat respiratory and soft tissue infections caused by Gram-positive bacteria. They ...https://www.hindawi.com/journals/mi/2012/584262/
Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced - Full Text View -...
A secondary aim is to detect macrolide resistant Mg-strains and study whether there are any emerging macrolide resistant Mg- ... due to infection caused by the sexually transmitted bacteria Chlamydia trachomatis (CT) and Mycoplasma genitalium(Mg)) it takes ... In contrast to Chlamydia trachomatis antibiotic resistance is common against tetracyclines and is emerging against macrolides ... The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study ...https://clinicaltrials.gov/ct2/show/NCT01661985?recr=Open&cond=%22Chlamydia+Infections%22&rank=6
Alterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area | British...
Most colonising bacteria (resistant or sensitive) will not go on to cause a productive infection. Productive infections are ... In a large Finnish study,20 higher rates of macrolide resistant S pyogenes occurred in parallel with the increased prescription ... While Chlamydiahas remained sensitive to macrolides and azalides including azithromycin, other bacteria may develop resistance ... The most frequent pathogenic bacteria isolated in this study wereS pneumoniae and H influenzae, and Moraxella. The prevalence ...http://bjo.bmj.com/content/83/12/1332
Clinical and economic burden of community-acquired pneumonia among adults in Europe | Thorax
... thromboembolic events and infection with resistant nosocomial bacteria.108. Discussion. The studies reviewed here highlight the ... Although macrolides are generally a good alternative to β-lactams, treatment failures with macrolides are increasing.56 ... 54 These studies confirmed that numerous microbial pathogens cause CAP, and the most frequently isolated pathogen in most ... Evolving resistance patterns of Streptococcus pneumoniae: a link with long-acting macrolide consumption? J Chemother 1999;11:35 ...http://thorax.bmj.com/content/early/2010/09/22/thx.2009.129502
National surveillance programme on susceptibility patterns of respiratory pathogens in South Africa: moxifloxacin compared with...
... were macrolide resistant.8 In our present study, 61% of the pneumococci tested were resistant to both clarithromycin and ... Surveillance of resistance in bacteria causing community-acquired respiratory tract infections. Clin Microbiol Infect2002;8( ... Resistance to macrolides was less evident, with 86% of strains susceptible to both clarithromycin and azithromycin. ... The levels of macrolide resistant S pyogenes in Europe as reported in the PROTEKT study varied between 0% in Austria, Belgium, ...http://jcp.bmj.com/content/56/5/344
Azithromycin Failure in Mycoplasma genitalium Urethritis - Volume 12, Number 7-July 2006 - Emerging Infectious Disease journal ...
In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in ... In vitro studies also suggest that macrolide-resistant mutants can be selected by serial passage of mycoplasmas in ... In vitro studies suggest it is susceptible to tetracyclines, macrolides, and fluoroquinolones (2-4), although reduced ... which may be suboptimal for eradication of a slow-growing bacterium such as M. genitalium. Studies are ongoing to establish ...https://wwwnc.cdc.gov/eid/article/12/7/05-1558_article
Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048 - Full Text...
The purpose of this study is to see if people who take azithromycin carry more antibiotic-resistant bacteria than people who ... Antibiotics, Macrolide. Azithromycin. Drug Administration Schedule. Drug Resistance, Microbial. Carrier State. Streptococcus ... These isolates are tested for susceptibility to macrolides, penicillin, cephalosporins, quinolones, and TMP-SMX. The rates of ... Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048. This study has ...https://clinicaltrials.gov/show/NCT00000933?order=535
Antimicrobial Resistance and Plasmid Profiles of Campylobacter Species from Infants Presenting with Diarrhoea in Osun State,...
1996) Ciprofloxacin- and azithromycin-resistant Campylobacter causing traveler's diarrhea in U.S. troops deployed to Thailand ... A collective name for infectious disease caused by members of these bacteria is called Campylobacteriosis . Campylobacter ... Studies in Europe have shown C. jejuni to be sensitive in-vitro to antibiotics such as tetracycline, erythromycin and ... Engberg J, Aarestrup FM, Taylor DE, Gerner-Smidt P, Nachamkin I (2001) Quinolone and macrolide resistance in Campylobacter ...https://www.omicsonline.org/open-access/antimicrobial-resistance-and-plasmid-profiles-of-campylobacter-species-from-infants-presenting-with-diarrhoea-2161-0703.1000172.php?aid=39017
Repetitive use of antibiotic macrolide increases long-lasting obesity and asthma - Healthcanal.com : Healthcanal.com
New compound family to treat multi-resistant bacteria 09/16/2018 Infections ... The team studied a well-controlled cohort of pre-school children (142 children, 2-7 years old) who for instance received the ... Finally, the researchers found that the use of macrolides was associated with a decreased level of bile salt hydrolase, en ... Antidepressants may cause antibiotic resistance 09/05/2018 Infections New breakthrough in the war against antibiotic resistance ...https://www.healthcanal.com/infections/70031-repetitive-use-of-antibiotic-macrolide-increases-long-lasting-obesity-and-asthma.html
Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance. (Perspectives). - Free Online Library
Pathogenic Prevention Drug resistance in microorganisms Microbial drug resistance Pathogenic bacteria Respiratory tract ... Perspectives).(Editorial) by 'Emerging Infectious Diseases'; Health, general Antibacterial agents Usage Antibiotics Bacteria, ... Moreover, clinical data on quinupristin/dalfopristin therapy of pneumococcal pneumonia caused by macrolide resistant strains of ... Whereas 10.4% of all S. pneumoniae isolates were resistant to penicillin and 16.5% resistant to macrolides in 1996, these ...https://www.thefreelibrary.com/Dead+bugs+don%27t+mutate%3A+susceptibility+issues+in+the+emergence+of+...-a097116553
ASMscience | Other Pathogens
Most early studies on growth and susceptibility testing of Leptospira were performed using different media supplemented with ... Numerous bacterial species can cause infections in animals and humans or function as reservoirs for antimicrobial resistance ... Actinobaculum suis seems to be susceptible to penicillin, ampicillin, ceftiofur, tetracyclines, macrolides, lincosamides, ... pleuromutilins, chloramphenicol, florfenicol, and spectinomycin but intrinsically resistant to the fluoroquinolones, ...http://www.asmscience.org/content/book/10.1128/9781555817534.chap15
Advanced Life Sciences to Participate in Key Infectious Disease ... ( CHICAGO Aug. 17 /- Advanced Life Sci...)
... macrolide- and fluoroquinolone-resistant bacteria. Restanza's demonstrated potency and ability to overcome bacterial resistance ... This bacterium can be found in contaminated water, soil and on market produce. It causes deadly infectious diseases endemic to ... It has shown higher in vitro potency and a broader range of activity than macrolides against Gram-positive bacteria including ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their ...http://www.bio-medicine.org/medicine-technology-1/Advanced-Life-Sciences-to-Participate-in-Key-Infectious-Disease-Conference-10210-1/
Macrolide antibiotics | definition of Macrolide antibiotics by Medical dictionary
What is Macrolide antibiotics? Meaning of Macrolide antibiotics medical term. What does Macrolide antibiotics mean? ... Looking for online definition of Macrolide antibiotics in the Medical Dictionary? Macrolide antibiotics explanation free. ... Comparative study of anti-inflammatory activity of newer macrolides with etoricoxib. For example, the macrolide antibiotic ... improvement in acne rosacea patients without causing the gastrointestinal side effects typical of other macrolide antibiotics, ...http://medical-dictionary.thefreedictionary.com/Macrolide+antibiotics
Rib-X Pharmaceuticals to Present at Cambridge Healthtech Institute's 2nd Annual Challenge of Antibacterial Development ... ( ...
... active against a broad spectrum of bacteria, including methicillin-resistant Staphylococcus aureus. Additionally, the Company ... The first of these programs is focused on design and development of an orally active macrolide for community use for treatment ... Three distinct compound families with drug-like properties are being advanced for Phase 1 studies to commence late in 2008. In ... Rib-X's most advanced discovery program is focused on engineering novel macrolides that overcome multiple forms of bacterial ...http://www.bio-medicine.org/biology-technology-1/Rib-X-Pharmaceuticals-to-Present-at-Cambridge-Healthtech-Institutes-2nd-Annual-Challenge-of-Antibacterial-Development-Conference-4766-1/
Quinolone antibiotic - Wikipedia
Fluoroquinolines use in children may be appropriate when the infection is caused by multidrug-resistant bacteria, or when ... instead recommending macrolide or doxycycline as first-line agents. The Drug-Resistant Streptococcus pneumoniae Working Group ... In a study comparing the safety and efficacy of levofloxacin to that of azithromycin or ceftriaxone in 712 children with ... Skalsky K, Yahav D, Lador A, Eliakim-Raz N, Leibovici L, Paul M (April 2013). "Macrolides vs. quinolones for community-acquired ...https://en.wikipedia.org/wiki/Quinolone_antibiotic
Clindamycin - Wikipedia
... to determine if there is a macrolide-resistant subpopulation of bacteria present. This test is necessary because some bacteria ... The rationale for this approach is a presumed synergy between vancomycin, which causes the death of the bacteria by breakdown ... 1999). "Macrolides and clindamycin". In Root, Richard E.; Francis Waldvogel; Lawrence Corey; Walter E. Stamm. Clinical ... Both in vitro and in vivo studies have shown clindamycin reduces the production of exotoxins by staphylococci; it may also ...https://en.wikipedia.org/wiki/Clindamycin
Macrolide - Wikipedia
They are used to treat respiratory tract infections caused by macrolide-resistant bacteria. Ketolides are especially effective ... Antibiotic macrolides are used to treat infections caused by Gram-positive bacteria (e.g., Streptococcus pneumoniae) and ... Kinetic studies". European Journal of Biochemistry / FEBS. 164 (1): 53-8. doi:10.1111/j.1432-1033.1987.tb10991.x. PMID 3549307 ... and in DPB cases with the occurrence of the macrolide-resistant bacterium Pseudomonas aeruginosa, macrolide therapy still ...https://en.wikipedia.org/wiki/Macrolide
Pneumococcal infection - Wikipedia
Pneumococcal infection is an infection caused by the bacterium Streptococcus pneumoniae. S. pneumoniae is a common member of ... A varying proportion of strains may also be resistant to cephalosporins, macrolides (such as erythromycin), tetracycline, ... 2003). "Addition of a Macrolide to a β-Lactam based empirical antibiotic regimen is associated with lower in-hospital mortality ... Avery OT, Macleod CM, McCarty M (1944). "STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF ...https://en.wikipedia.org/wiki/Pneumococcal_infection
Mycoplasma pneumoniae - Wikipedia
Studies that followed until 1963 determined that Eaton's agent was a bacterium that caused human lower respiratory tract ... "Macrolide-resistant Mycoplasma pneumoniae in humans, Ontario, Canada, 2010-2011". Emerg Infect Dis. 19. doi:10.3201/ ... and are not able to cause bacterial cell death. The most common macrolides used in the treatment of infected children in Japan ... Mycoplasma pneumoniae is a very small bacterium in the class Mollicutes. It is a human pathogen that causes the disease ...https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae
Diffuse panbronchiolitis - Wikipedia
... to DPB-causing bacteria or viruses, caused by several genes that are found predominantly in individuals of East Asian descent. ... Schultz, M. J. (Jul 2004). "Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and ... particularly if macrolide-resistant P. aeruginosa is present or previously untreated DPB has progressed to the point where ... After further study, it was concluded that a DPB susceptibility gene is located near the HLA-B locus at chromosome 6p21.3. ...https://en.wikipedia.org/wiki/Diffuse_panbronchiolitis
Burkholderia pseudomallei - Wikipedia
From the point of view of the bacterium, human infection is a developmental "dead end". Strains which cause disease in humans ... the organism appears highly resistant (it is innately resistant to a large number of antibiotics including colistin and ... Unfortunately, the majority of strains in Sarawak, Borneo, are susceptible to aminoglycosides and macrolides, which means the ... Moore RA, DeShazer D, Reckseidler S, Weissman A, Woods DE (March 1999). "Efflux-mediated aminoglycoside and macrolide ...https://en.wikipedia.org/wiki/Burkholderia_pseudomallei
Sepsis - Wikipedia
... gram negative bacteria became the predominant cause of sepsis from the 1960s to the 1980s. After 1980s, gram-positive bacteria ... and more careful design of preclinical studies. One approach is to rely more on studying biopsies and clinical data from people ... The defect in the TLR4 gene that led to the endotoxin resistant phenotype was discovered to be due to a mutation in the ... For Legionella infection, addition of macrolide or fluoroquinolone is chosen. If fungal infection is suspected, an echinocandin ...https://en.wikipedia.org/wiki/Sepsis
Thus pneumonia caused by intermediately resistant strains (MIC = 2 ìg/mL) still responds well to usual doses of these drugs, ... In Europe, most macrolide resistance is due to a mutation in ermB, which confers highlevel resistance not only to macrolides ... If the organism is resistant, treatment with both drugs should be continued. A very few studies of experimental animals suggest ... Bacteria are trapped in a normally sterile site when drainage is impaired, often as a result of viral infection, allergies, or ...http://www.gkhub.info/pneumococcal-infections.html