Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant - Tabular...
Primary graft dysfunction (PGD) is the most common cause of early morbidity and mortality following lung transplant and is characterized by acute lung injury and capillary leak leading to an increase in extravascular lung water index (ELWI) and impaired graft function. PGD has many features in common with acute respiratory distress syndrome (ARDS). PGD may be life-threatening and can also lead to impaired long term lung function. In ARDS, a restrictive fluid strategy has been associated with an improvement in lung function and outcomes. Accurate methods of evaluating, quantifying and guiding the hemodynamic / fluid management and limiting the extent of ELWI that accumulates in the setting of PGD are lacking. Using transpulmonary thermodilution to estimate ELWI and the pulmonary permeability index (PPI) represents a novel approach to fluid management, which has been used in patients with ARDS, but to date not ...https://clinicaltrials.gov/ct2/show/record/NCT01605214
Primary graft dysfunction in lung transplantation: the role of CD26/dipeptidylpeptidase IV and vasoactive intestinal peptide -...
Background. Enzymatic activity inhibition of CD26/dipeptidylpeptidase IV (CD26/DPP IV) attenuated short-term post-Tx (transplantation) ischemia-reperfusion injury after 18-hr-ischemia. Here, we investigated the effect of intragraft CD26/DPP IV catalytic inhibition on primary graft dysfunction during 7 day post-Tx, following extended ischemia. Methods. A syngeneic rat (LEW [Lewis abstract]) orthotopic lung Tx model was used, grafts exposed to 18 hr cold ischemia before Tx. Controls were flushed and preserved in Perfadex, and harvested after 1 day (CON1) or 7 day (CON7) post-Tx. Investigational groups IN1, IN3, and IN7 grafts were perfused with and stored in Perfadex + inhibitor (AB192) and harvested at 1, 3, and 7 days post-Tx, respectively. Blood gas analysis, peak airway pressure (PAwP), wet/dry weight ratio, myeloperoxidase thiobarbituric ...https://repository.uantwerpen.be/link/irua/77275
METHODS AND COMPOSITIONS FOR DIAGNOSING PULMONARY FIBROSIS SUBTYPES AND ASSESSING THE RISK OF PRIMARY GRAFT DYSFUNCTION...
METHODS AND COMPOSITIONS FOR DIAGNOSING PULMONARY FIBROSIS SUBTYPES AND ASSESSING THE RISK OF PRIMARY GRAFT DYSFUNCTION AFTER LUNG TRANSPLANTATION - diagram, schematic, and image 07 ...http://www.patentsencyclopedia.com/imgfull/20130029873_07
Vivek N. Ahya, MD || Perelman School of Medicine at the University of Pennsylvania
Diamond JM, Kawut SM, Lederer DJ, Ahya VN, Kohl B, Sonett J, Palmer SM, Crespo M, Wille KM, Lama V, Shah PD, Orens J, Bhorade S, Weinacker A, Demissie E, Bellamy S, Christie JD, and Ware LB for the Lung Transplant Outcomes Group: Elevated Plasma Clara Cell Secretory Protein Concentration is Associated with High-Grade Primary Graft Dysfunction. American Journal of Transplantation. (eds.). 11(2): 561-567, March 2011 ...http://www.med.upenn.edu/apps/faculty/index.php/g275/p7181
Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia - Zurich...
RESULTS: During the observation period, the mean pulmonary artery pressure, oxygenation, airway pressure, and static lung compliance were significantly better in NAC animals compared with controls (p , 0.05). Extravascular lung water index was higher at points during the reperfusion in the control group. BAL protein, nitrite, NE, and IL-8 cytokine levels at the end of the experiment were significantly higher in the controls than in the NAC group (p , 0.05). Lung tissue reduced GSH levels were significantly higher in the NAC group than in the control group. Red blood cell GSH levels were always higher in the NAC group during the reperfusion period. Reverse transcription polymerase chain reaction for IL-8 messenger RNA was significantly higher in controls during the reperfusion period than in the NAC group (p = 0.001). The amount of lung tissue nuclear NF-κB (p50 sub-unit) was significantly higher in controls than in NAC pigs (p = 0.03 ...http://www.zora.uzh.ch/id/eprint/44466/
Morphofunctional Lung Analysis by PET and CT After Lung Transplantation - Full Text View - ClinicalTrials.gov
Pulmonary transplantation is considered as a lifesaving procedure in end-stage pulmonary disease. However morbidity and mortality after lung transplantation are still significant.. Primary graft dysfunction (PGD) is the main cause of early death. PGD is similar to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS): oxygenation is compromised, pulmonary compliance is decreased, chest Rx shows several infiltrates, and alveolar damage is present.. 25% of patients develops PGD within 72 hours from transplantation and 30 days mortality is eight times higher in patients who develop PGD.. 72 hours after lung transplantation, patients, whose clinical condition allow to bring them to nuclear medicine department, will undergo pulmonary computed tomography (CT) to study lung morphology and measure lung recruitability and positron emission tomography (PET) to study lung functionality and estimate lung inflammation.. Aim of this study is ...https://clinicaltrials.gov/show/NCT01746914
Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation - Full Text View - ClinicalTrials.gov
The purpose of this study is to take a population of lung transplant recipients who meet UCLA criteria for induction chemotherapy with thymoglobulin and prospectively study weather giving the first dose intraoperatively versus postoperatively makes a difference with how patients do during and after lung transplantation. In addition, these cohorts will be compared to patients who do not qualify for thymoglobulin and receive either an alternative agent or no agent. The primary endpoint is primary graft dysfunction. We will also evaluate several other early and late end points such as ventilator days, ICU/hospital days, acute/chronic rejection, infection, CT chest abnormalities, and survival.. We will also collect donor lung tissue and lavage fluid for measurement of various proteins and receptor expression at two time points: (1) prior to implementation and dosing of induction chemotherapy and (2) after transplantation ...https://clinicaltrials.gov/ct2/show/NCT00592306?recr=Open&intr=%22lung+transplantation%22&rank=6
Toronto XVIV0 Lung Perfusion System allows high-risk lungs to be safely transplanted
Results at 72 hours showed that 15% of the lungs treated with the Toronto XVIVO System had primary graft dysfunction, in comparison to 30% in the control group. Both groups of lung transplant patients had similar results in their secondary endpoints, i.e. 30-day mortality, bronchial complications, length of hospital and ICU stay and mechanical ventilation.. The Toronto XVIVO System was associated with gradual improvement in function in most lungs and, importantly, it was also helpful in determining a small subset of donor lungs (three) that were not suitable for transplantation. "For the first time, we can assess more precisely the function of an organ before using it. The most important finding of this study was that even donor lungs previously thought to be unusable can now be used for transplantation with excellent outcomes, if they perform with acceptable function on the XVIVO system. This will give us more lungs with ...http://www.innovations-report.com/html/reports/medicine-health/toronto-xviv0-lung-perfusion-system-high-risk-lungs-173747.html
Kidney Transplantation: Diagnosis and Management of Early Graft Dysfunction - Post-Renal Causes and Treatments - The Clinical...
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice.http://www.clinicaladvisor.com/nephrology-hypertension/kidney-transplantation-diagnosis-and-management-of-early-graft-dysfunction--post-renal-causes-and-treatments/article/616546/
Modern Homoeopathy | Treatments for IPF (Idiopathic Pulmonary Fibrosis) - 2
Lung Transplantation may be suitable for those patients, physically eligible to undergo a major transplant operation.. In IPF patients, lung transplantation reduces the risk of death by 75% as compared with patients who remain on the waiting list.. Since the introduction of the lung allocation score (LAS), which prioritizes transplant candidates based on survival for lung transplantation in the USA.. Symptomatic patients with IPF younger than 65 years of age and with a body mass index (BMI) ≤ 26kg/m² should be referred for lung transplantation, but there are no clear data to guide the precise timing for LT.. Bilateral lung transplantation is superior to single lung transplantation in patients with IPF ...http://www.modernhomeopathy.co.in/blog/p2-2/
PubMed Kidney Transplant | Transplant Professional Portal
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive. All kidney transplant recipients received same immunosuppressive drugs. Primary disease of the renal allograft recipients demonstrates that majority 88.58% had glomerulonephritis, 5.72% had polycystic ...http://tpp.uah.edu/aggregator/sources/15?page=8
British Library EThOS: Pancreas transplantation : associations with graft failure and measures of function
Pancreas transplantation, either as a simultaneous pancreas kidney (SPK) or an isolated pancreas (IP), is a successful treatment option for some people with diabetes; however, grafts at the highest risk of failing are difficult to identify, and a means of monitoring graft function effectively post-transplant is lacking. The work in this thesis aimed to identify factors associated with pancreas graft failure and explore metabolic features of early graft dysfunction. First, the published Pancreas Donor Risk Index tool was predictive using UK National data in SPK but not IP transplantation, suggesting greater influence of recipient and post-transplant factors in determining IP graft survival. HLA antibody monitoring showed that the development of de novo DSA post-transplant was associated with poorer ...http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712490
CD8+ T-cell maturation following lung transplantation: the dif...
CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.: Studies on persistent viral infections demonstrate thttps://www.mysciencework.com/publication/show/cd8+-t-cell-maturation-following-lung-transplantation-differential-impact-cmv-acute-rejection-95633a52
Combined Heart-Lung Transplantation: A Perspective on the Past and the Future | SpringerLink
During the last 20 years, there has been a shift away from combined heart-lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be thttps://link.springer.com/article/10.1007%2Fs00246-012-0397-2
Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) - Full Text View -...
The study population characteristics raise the need to establish a treatment regime that assures suitable intensity immunosuppression to avoid the appearance of rejection episodes, but minimizes the doses to prevent over-immunosuppression in a population with a theoretic minor immune response.. On the other hand, the delay in the introduction of calcineurin inhibitors will prevent increasing the risk of early graft dysfunction allowing the highest post-transplant renal recovery in organs with less operative mass and greater sensibility to the nephrotoxic effect of these drugs.. The results of several studies confirm the goodness of regimes that include low doses of calcineurin inhibitors, delay their introduction or avoid them.. Nevertheless, although it is standard practice to evaluate the effectiveness of the regimes for a time to assure, with certainty, the response to the treatments, these follow-ups are still relatively short to assure ...https://clinicaltrials.gov/ct2/show/NCT00290069
Unexplained Graft Dysfunction after Heart Transplantation-Role of Novel Molecular Expression Test Score and QTc-Interval: A...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.http://pubmedcentralcanada.ca/pmcc/articles/PMC2905689/
Induction immunosuppression following lung transplantation
One of the major accomplishments of the first successful lung transplantation in 1963 was the prevention of allograft rejection by using,, and Cobalt-60 irradiation to suppress the recipient immune system. Since then, great progress has been made inhttp://www.uptodate.com/contents/induction-immunosuppression-following-lung-transplantation
Surveillance Study of Viral Infections Following Lung Transplantation
The present study was conducted to study the impact community acquired respiratory virus (CARV) infections in an outpatient setting on graft function ofhttp://www.knowcancer.com/cancer-trials/NCT00701922/
The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study - AdisInsight
This study is evaluating the effect of exogenous calf surfactant (calfactant) on the prevention of primary graft failure due to ischemic-reperfusion lung injuryhttp://adisinsight.springer.com/trials/700261949
Department of Surgery - Peggy Knudson Gives 42nd AAST Fitts Oration%3a %22When Peace Breaks Out%22
Cytomegalovirus (CMV), a member of the Herpes virus family, has evolved alongside humans for thousands of years with a complex balance of latency, immune evasion, and transmission. While up to 70% of humans worldwide have evidence of CMV infection and seroprevalence approaches 100% in certain areas, healthy people show little to no clinical symptoms of primary infection. CMV disease is rarely observed in immune competent hosts because of innate immune responses and constant surveillance by natural killer (NK) and T cells that cooperatively control CMV. However, CMV is one of the most problematic pathogens in the immunocompromised host, after solid organ and stem cell transplantation causing increased risk of graft dysfunction, mortality and graft loss.. We propose to study the innate and adaptive immune responses to CMV in immunocompromised solid organ transplant recipients ...https://surgery.ucsf.edu/news--events/ucsf-news.aspx?id=74168
Human Herpesvirus 6 Publications and Abstracts | PubFacts.com
Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathological effects of HHV-6 remains the gold standard for diagnosis of end-organ disease. HHV-6 reactivation may be restricted to the infected organ with no evidence of active infection in the blood. Read More ...https://www.pubfacts.com/search/Human+Herpesvirus+6
Towards Evidence Based Donor Lung Evaluation: The Potential Role For Microbiomics In Lung Transplantation
Lung transplantation remains the only meaningful therapeutic option for patients with end-stage lung diseases. Waiting list mortality for lung transplantation,...https://www.omicsonline.org/proceedings/towards-evidence-based-donor-lung-evaluation-the-potential-role-for-microbiomics-in-lung-transplantation-22865.html
Information about lung transplantation, its indications, types of lung transplantation and hospitals offering this transplantation in India.http://www.mohanfoundation.org/lung-transplantation.asp
Articles about Lung Transplant - tribunedigital-orlandosentinel
Lung Transplant News. Find breaking news, commentary, and archival information about Lung Transplant From The tribunedigital-orlandosentinelhttp://articles.orlandosentinel.com/keyword/lung-transplant