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*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Drug-induced liver injury (DILI) is a leading cause of acute liver failure in developed countries. Hepatotoxicity is a well- ... It was concluded that the encapsulation of paraquat in nanoparticles can provide a useful means of reducing adverse impacts on ... was identical to that in the liver, and the tumor appeared to be contiguous with the liver. Thus, we suspected liver herniation ... Core needle biopsy revealed liver cells without neoplastic tissue. Upon surgical exploration, herniation of the liver was found ...
  https://www.jove.com/visualize?author=M%20Nishisaka%20
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Drug-induced liver injury (DILI) is a leading cause of acute liver failure in developed countries. Hepatotoxicity is a well- ... This hypoglycemia might be induced by two causes, both adrenal insufficiency as an adverse effect of sorafenib and activation ... DILI that fulfils the criteria for AIH is referred to as drug-induced autoimmune hepatitis (DIAIH). MS is a potentially severe ... However, emerging drugs that directly inhibit the IGF signal can be expected to be highly effective in the treatment of HCC ...
  https://www.jove.com/visualize?author=H%20Okushin%20
*  Anti-tuberculosis Drug-induced Liver Injury (ATLI) Effects
Pyrazinamide contributes significantly to acute liver failure [ Durand 1995].The most important adverse effects of isoniazid ... These drugs effectively kills the bacteria but it induced hepatotoxicity known as anti-tuberculosis drug-induced liver injury ( ... rifampicin and pyrazinamide have the potential to induce liver damage.This anti-tuberculosis drug-induced liver injury (ATLI) ... Anti-tuberculosis Drug-induced Liver Injury (ATLI) Effects. Print Reference this Disclaimer: This work has been submitted by a ...
  https://www.ukessays.com/essays/sciences/antituberculosis-druginduced-liver-injury-atli-6034.php
*  DailyMed - ISONIAZID- isoniazid solution
... severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology. ... including drug-induced hepatitis; previous isoniazid-associated hepatic injury; ... Usually, enzyme levels return to normal despite continuance of drug, but in some cases progressive liver dysfunction occurs. ... Patients should be instructed to immediately report signs or symptoms consistent with liver damage or other adverse effects. ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fada0e39-68f7-434d-91fc-84a67fc940f9
*  Drug-Induced Liver Injury: An Overview
Use of Hy's Law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. ... Causality assessment of adverse reactions to drugs-II. An original model for validation of drug causality assessment methods: ... Drug-induced liver injury. UptoDate. www.uptodate.com/contents/drug-induced-liver-injury. Accessed July 8, 2016.. 6. Pandit A, ... Drug-induced liver injury in obesity. J Hepatol. 2013;58:824-826.. 25. Corsini A, Bortolini M. Drug-induced liver injury: the ...
  https://www.uspharmacist.com/article/druginduced-liver-injury-an-overview
*  Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study | CMAJ
Whether chronic liver disease increases a patient's risk for drug-induced liver injury is unknown. However, preexisting liver ... Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia (PA): Lippincott Williams ... Are patients with elevated liver tests at increased risk of drug-induced liver injury? Gastroenterology 2004;126:1477-80. ... Ciprofloxacin-induced acute liver injury: case report and review of literature. Virchows Arch 2004;444:87-9. ...
  http://www.cmaj.ca/content/184/14/1565
*  Hepatic disease | Veterinary Medicine
Most adverse hepatic drug reactions are associated with acute hepatic injury.. Copper-associated liver disease (Proceedings) ... Drug-induced injury is an important cause of hepatic disease in dogs and cats. The incidence of drug-induced hepatic disease is ... Many drugs have been suspected of causing hepatic injury in dogs and cats. ... These products include both prescription drugs and dietary supplements (vitamins, minerals, herbs, nutraceuticals). A drug is ...
  http://veterinarymedicine.dvm360.com/hepatic-disease?page=1
*  Darunavir and Cobicistat (Professional Patient Advice) - Drugs.com
Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... Infrequent cases of drug-induced hepatitis (including acute and cytolytic) have been reported with darunavir. Liver injury has ... Concerns related to adverse effects:. • Fat redistribution: May cause redistribution of fat (eg, buffalo hump, peripheral ... Concurrent drug therapy issues:. • Drug-drug interactions: Potentially significant interactions may exist, requiring dose or ...
  https://www.drugs.com/ppa/darunavir-and-cobicistat.html
*  Hepatotoxicity - Wikipedia
Drug-induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures. Adverse drug ... Drug-induced liver injury is a cause of acute and chronic liver disease. The liver plays a central role in transforming and ... but overdose is the most common cause of drug-induced liver disease and acute liver failure worldwide. Damage to the liver is ... 2006). "Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry". Hepatology ...
  https://en.wikipedia.org/wiki/Hepatotoxicity
*  stem cell institute Archives - Stem Cell Institute
It occurs as a result of a number of acute and chronic clinical inciting factors, including drug-/alcohol-induced ... The only available cure, liver transplantation, is severely limited by a lack of donors and further complicated by the adverse ... spinal cord injury, Spinal Cord Injury, Sports Injuries, Stem Cell Institute Panama, Stem Cell Therapy, Texas, Umbilical cord ... jaytest 2016-11-08T18:53:52+00:00 November 8th, 2016,Adipose Stem Cells, Adult Stem Cells, Bone Marrow Stem Cells, Liver, Liver ...
  https://www.cellmedicine.com/tag/stem-cell-institute/
*  stem cells
It occurs as a result of a number of acute and chronic clinical inciting factors, including drug-/alcohol-induced ... The only available cure, liver transplantation, is severely limited by a lack of donors and further complicated by the adverse ... Common conditions treated include meniscal tears, ACL injuries, rotator cuff injuries, runner's knee, tennis elbow, and joint ... jaytest 2016-11-08T18:53:52+00:00 November 8th, 2016,Adipose Stem Cells, Adult Stem Cells, Bone Marrow Stem Cells, Liver, Liver ...
  https://www.cellmedicine.com/tag/stem-cells/
*  SAFE-T | IMI - Innovative Medicines Initiative
... and monitoring of drug-induced injuries to the kidney, liver, and vascular system, using markers in patients' blood and/or ... and improve diagnosis and management of acute and chronic diseases relevant to public health not only in Europe, but globally. ... Application of SAFE-T biomarkers will make drugs safer, reduce the number of drugs that have to be abandoned in late stages of ... many drug side effects are not adequately predictable and are detected too late, when the risk for serious outcomes is high. ...
  http://www.imi.europa.eu/projects-results/project-factsheets/safe-t
*  ViiV Healthcare launches eighth phase III study in two-drug regimen programme for HIV-1 treatment | GSK
... based regimen of at least three drugs are able to maintain viral suppression upon switching to a two-drug regimen (2DR) of ... Drug-induced liver injury leading to liver transplant has been reported with TRIUMEQ (abacavir, dolutegravir, and lamivudine) ... Cases of hepatic toxicity, including elevated serum liver biochemistries, hepatitis, and acute liver failure, have also been ... Risk of Adverse Reactions or Loss of Virologic Response Due to Drug Interactions:. The concomitant use of TIVICAY and other ...
  https://www.gsk.com/en-gb/media/press-releases/viiv-healthcare-launches-eighth-phase-iii-study-in-two-drug-regimen-programme-for-hiv-1-treatment/
*  Antituberculous drug-induced liver injury: current perspective
Antituberculosis drug-induced liver injury (TB DILI) is a leading cause of DILI and drug-induced acute liver failure (DIALF) in ... Drug-induced liver disease. In: Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd ed. ... Indeed, it is a leading cause of drug-induced liver injury in India and of drug-induced acute liver failure leading to death ( ... Antituberculous drug-induced liver injury: current perspective. Keywords : antituberculosis drugs, DILI, liver injury, ...
  http://www.tropicalgastro.com/articles/32/3/antituberculous-drug-induced.html
*  Thrombopoietin Receptor Agonists: Characteristics, Adverse Effects, and Indications | SpringerLink
... parameters and corresponding dose titration or discontinuation actions are recommended to prevent drug-induced liver injury. ... including myelodysplastic syndrome and acute myelogenous leukemia, chemotherapy-induced thrombocytopenia, congenital ... TPO-RAs have not yet been extensively studied in the setting of chemotherapy-induced or radiation-induced thrombocytopenia and/ ... including myelodysplastic syndrome and acute myelogenous leukemia, chemotherapy-induced thrombocytopenia, congenital ...
  https://link.springer.com/chapter/10.1007/978-3-319-68038-5_18
*  Drug-induced liver injury | Article about drug-induced liver injury by The Free Dictionary
Find out information about drug-induced liver injury. Law a violation or infringement of another person's rights that causes ... him harm and is actionable at law A structural or functional stress or trauma that... Explanation of drug-induced liver injury ... Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.. Hepatitis E virus infection among ... are critical to understanding this serious adverse drug event," said Dr.. The Hamner Institutes for Health Sciences Announces ...
  http://encyclopedia2.thefreedictionary.com/drug-induced+liver+injury
*  Causality Assessment Methods in Drug-Induced Liver Injury | SpringerLink
... and herb-induced liver injury (HILI) but is also critical for the... ... is not only indispensable for the diagnosis of suspected drug-induced liver injury (DILI) ... Reuben A, Koch DG, Lee WM, the Acute Liver Failure Study Group (2010) Drug-induced acute liver failure: results of a U.S. ... Evaluation of Naranjo Adverse Drug Reactions Probability Scale in causality assessment of drug-induced liver injury. Aliment ...
  https://link.springer.com/protocol/10.1007/978-1-4939-7677-5_27
*  Human Metabolome Database: Showing metabocard for Acetaminophen (HMDB0001859)
Because of its importance, the mechanisms of AAP-induced liver cell injury have been extensively investigated and ... Single doses of paracetamol are effective analgesics for acute postoperative pain and give rise to few adverse effects (PMID: ... hepatotoxin to study mechanisms of chemical-induced cell injury and to test the hepatoprotective potential of new drugs and ... Jaeschke H: Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2005 ...
  http://www.hmdb.ca/metabolites/HMDB01859
*  TRIMETHOBENZAMIDE
Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, ... Drug-induced hepatic injury in children: a case/non-case study of suspected adverse drug reactions in VigiBase. Br J Clin ... Trimethobenzamide is also not listed in large case series on drug induced liver injury. Thus, clinically apparent liver injury ... Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced ...
  https://livertox.nlm.nih.gov/Trimethobenzamide.htm
*  The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model
... a systematic review and meta-analysis from the Research on Adverse Drug events And Reports (RADAR) project," Drug Safety, vol. ... illustrating further that LPS attenuates the NVP-induced subclinical liver injury, as it was in the acute phase (Figures 3(d)-3 ... M. P. Holt and C. Ju, "Mechanisms of drug-induced liver injury," AAPS Journal, vol. 8, no. 1, pp. E48-E54, 2006. View at ... and therefore little or no liver injury occurred. In effect, LPS attenuated NVP-induced liver injury by inhibiting the ...
  https://www.hindawi.com/journals/isrn/2012/932542/
*  Laboratory-based Surveillance for Hepatitis E Virus Infection, United States, 2005-2012 - Volume 19, Number 2-February 2013 -...
... we tested samples from persons seronegative for acute hepatitis A and B whose clinical specimens were referred to the Centers ... Drug-Induced Liver Injury Network (DILIN). Acute hepatitis E infection accounts for some cases of suspected drug-induced liver ... The nonimported form was observed to affect SOTRs, be able to lead to adverse outcomes, and be associated with infection by HEV ... a trend consistent with the finding recently reported by the Drug-Induced Liver Injury Network of 9 patients seropositive for ...
  https://wwwnc.cdc.gov/eid/article/19/2/12-0961_article
*  Rilutek Side Effects in Detail - Drugs.com
Frequency not reported: Drug-induced hepatic injury. Postmarketing reports: Acute hepatitis and icteric toxic hepatitis[Ref] ... Study data indicate that Asian patients may be more susceptible to liver function test abnormalities; 3.2% (194/5995) of Asian ... The most commonly reported adverse reactions have included asthenia, nausea, dizziness, decreased lung function, and abdominal ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ...
  https://www.drugs.com/sfx/rilutek-side-effects.html
*  Inpatient Admissions for Drug-induced Liver Injury: Results from a Single Center | SpringerLink
Objective To review all cases of drug-induced liver injury (DILI) requiring hospitalization at a single tertiary care center. ... Liver transplantation for acute liver failure from drug-induced liver injury in the United States. Liver Transpl 10:1018-1023 ... Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish committee on adverse drug reactions between 1978 ... Hepatotoxicity Drug-induced liver injury Fulminant hepatic failure Abbreviations. A-DILI. Acetaminophen drug-induced liver ...
  https://link.springer.com/article/10.1007%2Fs10620-008-0250-x
*  Herbal Hepatotoxicity | Springer for Research & Development
The liver is probably the most important organ responsible for protecting humans from exposure to foreign compounds. With its ... Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl 10(8):1018- ... Zimmerman H (1999) Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Lippincott, Philadelphia ... Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology 60(4):1399-1408 ...
  https://rd.springer.com/chapter/10.1007/978-3-319-43806-1_12
*  Hydrocodone and Acetaminophen (Professional Patient Advice) - Drugs.com
Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of ... Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of ... Isoniazid: May enhance the adverse/toxic effect of Acetaminophen. Monitor therapy. Kava Kava: May enhance the adverse/toxic ...
  https://www.drugs.com/ppa/hydrocodone-and-acetaminophen.html