Loading...


*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis has been identified as the causative agent of the Black Death pandemic in the 14(th) century. However, ... Yersinia pestis and the plague of Justinian 541-543 AD: a genomic analysis. ... pestis strains and 30 previously confirmed clinical human plague samples. The optimized LOD was down to 4 gene copies. 29 ... Yersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include ...
  https://www.jove.com/visualize?author=Ingrid+Wiechmann
*  Frontiers | TyrR, the regulator of aromatic amino acid metabolism, is required for mice infection of Yersinia pestis |...
... the causative agent of plague, poses a serious health threat to rodents and human beings. TyrR is a transcriptional regulator ... Transcriptome analysis revealed that TyrR, directly or indirectly, regulated 29 genes encoded on Y. pestis chromosome or ... Transcriptome analysis revealed that TyrR, directly or indirectly, regulated 29 genes encoded on Y. pestis chromosome or ... the causative agent of plague, poses a serious health threat to rodents and human beings. TyrR is a transcriptional regulator ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2015.00110/full
*  Protocols and Video Articles Authored by Thomas O. Metz
The MPLEx Protocol for Multi-omic Analyses of Soil Samples' ... the genomes of Yersinia pestis (YP) the causative agent of ... Phylogenetic analysis of the 16S rRNA gene placed the strain in the order Rhizobiales and it shared 94 % identity with the type ... plague with a high mortality rate and Yersinia pseudotuberculosis (YPT) an enteric pathogen with a modest mortality rate are ... including Yersinia pestis, Salmonella Typhimurium, and Campylobacter jejuni in pure culture, and Yersinia pestis, Campylobacter ...
  https://www.jove.com/author/Thomas+O._Metz
*  List of sequenced bacterial genomes - Wikipedia
2001). "Genome sequence of Yersinia pestis, the causative agent of plague". Nature. 413 (6855): 523-7. Bibcode:2001Natur.413.. ... 2006). "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging ... 2004). "Comparative analysis of the Borrelia garinii genome". Nucleic Acids Res. 32 (20): 6038-46. doi:10.1093/nar/gkh953. PMC ... 2004). "Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis". Proc ...
  https://en.wikipedia.org/wiki/List_of_sequenced_bacterial_genomes
*  Structural gene - Wikipedia
Yersinia pestis (the bubonic plague) was found to carry several virulence and inflammation-related structural genes on plasmids ... The identification of the genetic basis for the causative agent of a disease can be an important component of understanding its ... Original analyses enriched samples for structural genes via hybridization to mRNA. More recent phylogenetic approaches focused ... Brubaker, Robert R. (2007-08-01). "How the structural gene products of Yersinia pestis relate to virulence". Future ...
  https://en.wikipedia.org/wiki/Structural_gene
*  IDEALS @ Illinois: Cellular and Genetic Basis for the Resistance of BALB /Cj and 129S1 /Svimj Mice to Yersinia Pestis
Yersinia pestis, the causative agent of plague, has been well studied at the molecular and genetic level, but little is known ... Surprisingly, heterozygous IL-10+/- mice also survive high dose infection with Y. pestis KIM5. Analysis of commercial IL-10-/- ... gene. Interestingly, two substrains of 129 mice were resistant to high dose Y. pestis KIM5. Resistance does not appear to be ... Cellular and Genetic Basis for the Resistance of BALB /Cj and 129S1 /Svimj Mice to Yersinia Pestis. Welcome to the IDEALS ...
  https://www.ideals.illinois.edu/handle/2142/86706
*  ASMscience | Role of Cyclic Di-GMP in
... is the causative agent of bubonic, septicemic, and pneumonic plague. In general, increased levels of cyclic di-GMP (c-di-GMP) ... analysis suggests that HmsT and Y3730 are the only two functional DGCs and that HmsP is the only functional PDE in Y. pestis. ... Mutations in speC (encoding ornithine decarboxylase), speA (encoding arginine decarboxylase), or both genes cause progressively ... A Y. pestis hmsP mutant overproduces biofilm but shows no increase in the levels of HmsHFRS proteins. All other potential DGCs ...
  http://www.asmscience.org/content/book/10.1128/9781555816667.ch18
*  ASMscience | Evolution of Enteric Pat
The Shigella clones of E. coli, the Pestis clone of Yersinia pseudotuberculosis, and serovar Typhi of S. enterica all have many ... and the EAF plasmid with genes for adherence. The EHEC O157:H7 clone was discovered in the early 1980s when several outbreaks ... and Yersinia spp. S. enterica has been assigned to serovars based on the combination of antigenic properties of the ... Genome sequence of Yersinia pestis, the causative agent of plague. Nature 413:523-527.. ...
  http://www.asmscience.org/content/book/10.1128/9781555815622.ch15
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis and Bacillus anthracis are Category A bacterial pathogens that are the causative agents of the plague and ... Controlled gene deletion allows the investigation of gene function in specific tissues and at distinct time points. Analysis of ... Gene Targeting, Eukaryota, Toxoplasma gondii, genetic manipulation, gene targeting, gene deletion, gene replacement, gene ... We outline efficient methods for generating gene deletions, gene replacements, and tagged genes by targeted insertion or ...
  https://www.jove.com/visualize/abstract/24466294/isolation-characterization-numerous-novel-phages-targeting-diverse
*  ASMscience | Genomics of the Enteropa
Perhaps the most striking aspect of the evolution of Yersinia is the extremely rapid emergence of Y. pestis from Y. ... With respect to the enteropathogenic yersiniae, the natural deselection highlights many known genes required for the ... pseudotuberculosis, and genome analysis shows how this has happened. ... The enteropathogenic yersiniae are ubiquitous in the environment, and are a common cause of animal infections, and they have ...
  http://www.asmscience.org/content/book/10.1128/9781555816902.ch08
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis and Bacillus anthracis are Category A bacterial pathogens that are the causative agents of the plague and ... reporter phage were genetically engineered by integrating the Vibrio harveyi luxAB genes into the genome of Y. pestis and B. ... Utilizing an acute lung inflammation model in mice, it is possible to conduct a high resolution analysis of the host innate ... Plague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly ...
  https://www.jove.com/visualize/abstract/24358292/yopp-expressing-variant-ofy-pestis-activates-potent-innate-immune
*  The genome sequence of Mycoplasma mycoides subsp mycoides SC type strain PG1(T), the causative agent of contagious bovine...
Genome sequence of Yersinia pestis, the causative agent of plague.. Parkhill J, Wren BW, Thomson NR, Titball RW, Holden MT, ... Phylogeny of the Mycoplasma mycoides cluster as determined by sequence analysis of the 16S rRNA genes from the two rRNA operons ... J. Westberg, et al., "The genome sequence of Mycoplasma mycoides subsp mycoides SC type strain PG1(T), the causative agent of ... The genome sequence of Mycoplasma mycoides subsp mycoides SC type strain PG1(T), the causative agent of contagious bovine ...
  https://pub.uni-bielefeld.de/publication/1608756
*  NF-κB - Wikipedia
YopP is a factor secreted by Yersinia pestis, the causative agent of plague, that prevents the ubiquitination of IκB. This ... the expression of specific genes that have DNA-binding sites for NF-κB nearby. The activation of these genes by NF-κB then ... In the final analysis, the role of NF-κB in neurons remains opaque due to the difficulty of measuring transcription in cells ... either due to mutations in genes encoding the NF-κB transcription factors themselves or in genes that control NF-κB activity ( ...
  https://en.wikipedia.org/wiki/NF-%CE%BAB
*  Microbiology Society Journals | A putative DNA adenine methyltransferase is involved in Yersinia pseudotuberculosis...
YamA might thus be dispensable for Y. pestis growth and virulence because this species has acquired another gene fulfilling the ... The in silico analysis indicated that the chromosomal region carrying the Y. pseudotuberculosis yrmI locus has been replaced in ... pestis and Y. pseudotuberculosis indicated that the yrmI system has been lost by Y. pestis and that yamA (but not yrsA or yreA ... This system is composed of three adjacent genes which could potentially encode an N 6-adenine DNA methylase (YamA), an enzyme ...
  http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.2007/005736-0
*  The Role of the Black Death in Human Evolution
TLRs are known to recognize bacteria like Yersinia pestis, which is the causative agent of the Black Death, the devastating ... a gene that did not show selection in the initial analysis, did not change the PBMCs response to Y. pestis. ... The plague exacted a heavy toll, killing an estimated 30-50% of the global population and acting as a potential selective force ... pestis and Y. pseudotuberculosis (the parent to Y. pestis). TLR2 alone induced a large cytokine response to both Yersinia ...
  http://www.promegaconnections.com/the-role-of-the-black-death-in-human-evolution/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis and Bacillus anthracis are Category A bacterial pathogens that are the causative agents of the plague and ... The described gene targeting protocol can be used in a variety of ways in Δku80 strains to advance functional analysis of the ... Gene Targeting, Eukaryota, Toxoplasma gondii, genetic manipulation, gene targeting, gene deletion, gene replacement, gene ... In the fully virulent CO92 strain of Yersinia pestis, the tatA gene was deleted. The mutant was assayed for loss of virulence ...
  https://www.jove.com/visualize/abstract/25101850/a-yersinia-pestis-tat-mutant-is-attenuated-bubonic-small-aerosol
*  Microbiology Society Journals | CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage...
... in association with genes involved in DNA recombination and repair. In the Yersinia pestis genome, three such elements are ... In nine strains of Yersinia pseudotuberculosis, 132 spacers were found, of which only three are common to Y. pestis isolates. ... In Y. pestis of the Orientalis biovar investigated in detail here, deletion of motifs is observed but it appears that addition ... The authors have sequenced a total of 109 alleles of the three Y. pestis CRISPRs and they describe 29 new spacers, most being ...
  http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.27437-0
*  Yersinia pestis bacteria clearly identified as the cause of the big plague epidemic of the Middle Ages
... have proven that the bacteria Yersinia pestis was indeed the causative agent behind the 'Black Death' that raged across Europe ... Once the infection with Yersinia pestis had been conclusively proven, Stephanie Hänsch and Barbara Bramanti used an analysis of ... and the Netherlands showed a Yersinia pestis-specific gene. Because the samples from Parma, Italy and Augsburg, Germany gave no ... Yersinia pestis bacteria clearly identified as the cause of the big plague epidemic of the Middle Ages The 'Black Death' was ...
  http://www.uni-mainz.de/presse/13883_ENG_HTML.php
*  LSHTM Research Online
Genome sequence of Yersinia pestis, the causative agent of plague. Nature, 413 (6855). pp. 523-527. ISSN 0028-0836 DOI: https ... Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene. Molecular and ... Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar typhi ... Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. ...
  http://researchonline.lshtm.ac.uk/view/divisions/ITPM/2001.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis and Bacillus anthracis are Category A bacterial pathogens that are the causative agents of the plague and ... reporter phage were genetically engineered by integrating the Vibrio harveyi luxAB genes into the genome of Y. pestis and B. ... by use of different DTI analyses in comparison with matched controls. DTI data analysis is performed in a variate fashion, i.e. ... pestis isolate using a luxAB reporter phage constructed from the CDC plague diagnostic phage ΦA1122 6,7 (Figure 1). A similar ...
  https://www.jove.com/visualize/abstract/22536419/evidence-that-prefibrotic-myelofibrosis-is-aligned-along-clinical
*  The COG database: an updated version includes eukaryotes | BMC Bioinformatics | Full Text
Genome sequence of Yersinia pestis, the causative agent of plague. Nature 2001, 413: 523-527. 10.1038/35097083View Article ... Huynen MJ, Snel B: Gene and context: integrative approaches to genome analysis. Adv Prot Chem 2000, 54: 345-379.View Article ... which are represented in the causative agent of plague, Yersinia pestis [52], but not in other Proteobacteria (the taxon to ... 5b). These genes probably have been acquired by Y. pestis via horizontal gene transfer. On a more practical note, some of these ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-4-41
*  The American Journal of Tropical Medicine and Hygiene | Chromosomal Rearrangement Features of Yersinia pestis Strains from...
To identify the chromosomal rearrangement features of Y. pestis strains from five typical plague foci in China and study ... pestis isolates; furthermore, most of the rearrangement events are stable in certain lineages of Y. pestis genomes. ... We conclude Y. pestis chromosome rearrangement patterns may reflect the genetic features of specific geographical areas and can ... pestis strains by a polymerase chain reaction-based method. Our results suggest most strains have relatively stable chromosomal ...
  http://www.ajtmh.org/content/journals/10.4269/ajtmh.13-0491
*  Yersinia pestis - Wikipedia
"Genome sequence of Yersinia pestis, the causative agent of plague". Nature. 413 (6855): 523-527. doi:10.1038/35097083. PMID ... 2006). "Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal 516: Evidence of Gene Reduction in an Emerging ... A comprehensive and comparative proteomics analysis of Y. pestis strain KIM was performed in 2006. The analysis focused on the ... Yersinia Pestis) Wyndham Lathem speaking on "From Mild to Murderous: How Yersinia pestis Evolved to Cause Pneumonic Plague.". ...
  https://en.wikipedia.org/wiki/Yersinia_pestis
*  Yersinia pestis - Wikipedia
"Genome sequence of Yersinia pestis, the causative agent of plague". Nature. 413 (6855): 523-527. doi:10.1038/35097083. PMID ... "Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague". Nature Communications. 9 (1 ... "Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal 516: Evidence of Gene Reduction in an Emerging Pathogen" ... Plague (Yersinia Pestis). *Wyndham Lathem speaking on "From Mild to Murderous: How Yersinia pestis Evolved to Cause Pneumonic ...
  https://en.m.wikipedia.org/wiki/Yersinia_pestis
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Yersinia pestis and Bacillus anthracis are Category A bacterial pathogens that are the causative agents of the plague and ... reporter phage were genetically engineered by integrating the Vibrio harveyi luxAB genes into the genome of Y. pestis and B. ... In this report, we describe a live cell imaging based method for qualitative and quantitative analysis of the dynamic process ... Legionella pneumophila, the causative agent of a severe pneumonia named Legionnaires' disease, is an important human pathogen ...
  https://www.jove.com/visualize/abstract/19956758/anthrax-toxin-uptake-primary-immune-cells-as-determined-with-lethal