*  SLC22A3 - Wikipedia
The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. OCT3 is widely ... Known substrates for transport include: histamine, serotonin, norepinephrine, dopamine and MPP+. Capacity for transport and ... Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine ... 2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show ...
  https://en.wikipedia.org/wiki/SLC22A3
*  Norepinephrine and Serotonin Transporters: Molecular Targets of Antidepressant Drugs
... by transporter proteins localized in the plasma membranes of presynaptic terminals (. ). Transmitter reuptake is believed to ... suggests that both carriers move net charge per transport cycle in a voltage-sensitive manner. ... been found for other membrane proteins such as ion channels and receptors? Virtually identical transport activities can arise ... domain motif is common to membrane-associated proteins, particularly those responsible for ion and solute transport. Comparison ...
  http://www.acnp.org/g4/GN401000029/CH029.html
*  Membrane transport protein - Wikipedia
Often these redox proteins are not considered transport proteins. Each carrier protein, even within the same cell membrane, is ... and cause an internal translocation so that the opening in the protein now faces the other side of the plasma membrane. The ... "A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters". ... Unlike channel proteins which only transport substances through membranes passively, carrier proteins can transport ions and ...
  https://en.wikipedia.org/wiki/Membrane_transport_protein
*  MCAT - Biology Flashcards by Caitlin Rodeghier | Brainscape
Osmoregulatory protein in the blood plasma. A fat carrier (like lipoproteins) that free fatty acids combine with in the blood ... Effects on proteins is accomplished by increasing amino acid transport across the cell membrane, increasing translation and ... Catecholamines - epinephrine and norepinephrine.. -> Stress hormones, contribute to 'fight or flight' response with sympathetic ... A cell wall on the exterior of the plasma membrane which prevents the protoplast (the bacterial plasma membrane and everything ...
  https://www.brainscape.com/flashcards/mcat-biology-422004/packs/486133
*  Norepinephrine transporter - Wikipedia
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is ... They are found closer to the plasma membrane of the cell. This requires norepinephrine to diffuse from the site it is released ... can transport norepinephrine and dopamine. The reuptake of norepinephrine and dopamine is essential in regulating the ... The transport of norepinephrine back into presynaptic cell is made possible by the cotransport with Na+ and Cl−. The sequential ...
  https://en.wikipedia.org/wiki/Norepinephrine_transporter
*  Dopamine transporter - Wikipedia
"Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". ... transport, and degradation. The gene for DAT, known as DAT1, is located on chromosome 5p15. The protein encoding region of the ... In contrast, the human serotonin transporter (hSERT) and human norepinephrine transporter (hNET) do not contain zinc binding ... "Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that ...
  https://en.wikipedia.org/wiki/Dopamine_transporter
*  Dopamine Transporter Tryptophan Mutants Highlight Candidate Dopamine- and Cocaine-Selective Domains | Molecular Pharmacology
... in the plasma membranes (Fig. 1C). W310A displayed only small amounts of DAT plasma membrane immunostaining, about 10% of wild- ... 2000) Three-dimensional structure of the ion-coupled transport protein NhaA. Nature (Lond) 403:112-115. ... norepinephrine transporter. SERT. serotonin transporter. rDAT. rat dopamine transporter. WT. wild-type. CFT. (−)-2-β- ... and return of the unloaded carrier to its extracellular-facing state (Povlock and Schenk, 1997). DAT's turnover rate for ...
  http://molpharm.aspetjournals.org/content/58/6/1581.long
*  Vesicular monoamine transporter 2 - Wikipedia
... synaptic cleft by simultaneously reversing the direction of transport through the primary plasma membrane transport proteins ... Play media The vesicular monoamine transporter 2 (VMAT2) also known as solute carrier family 18 member 2 (SLC18A2) is a protein ... norepinephrine, serotonin, and histamine-from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic ... VMAT2 is an integral membrane protein that transports monoamines-particularly neurotransmitters such as dopamine, ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_2
*  Sodium-dependent noradrenaline transporter - DrugBank
membrane / plasma membrane / integral component of plasma membrane / neuron projection. General Function. Norepinephrine:sodium ... transport / norepinephrine transport / synaptic transmission / transmembrane transport / monoamine transport / response to pain ... Solute carrier family 6 member 2. Gene Name. SLC6A2. Organism. Human. Amino acid sequence. ,lcl,BSEQ0000970,Sodium-dependent ... GenBank Protein ID. 189258. GenBank Gene ID. M65105. GenAtlas ID. SLC6A2. HGNC ID. HGNC:11048. ...
  https://www.drugbank.ca/biodb/polypeptides/P23975
*  TAAR1 - Wikipedia
... must enter the presynaptic neuron through a membrane transport protein or be able to diffuse across the presynaptic membrane in ... indicating that trace amine induced LLA does not act on receptors found on the plasma membrane but requires their transport to ... norepinephrine, and serotonin neurons, the primary membrane transporters are DAT, NET, and SERT respectively. TAAR1-D2sh is a ... Monoamine transporters and SLC22A carrier subfamily transport TAAR1 ligand: Studies using the rhesus monkey TAAR1 have shown ...
  https://en.wikipedia.org/wiki/TAAR1
*  The Placental Barrier: the Gate and the Fate in Drug Distribution | SpringerLink
Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of ... Prasad PD, Hoffmans BJ, Moe AJ, Smith CH, Leibach FH, Ganapathy V. Functional expression of the plasma membrane serotonin ... Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line. Int J Pharm. 2000;195:115-24.PubMed ... Human placental norepinephrine transporter mRNA: expression and correlation with fetal condition at birth. Placenta. 1997;18: ...
  https://link.springer.com/article/10.1007/s11095-017-2286-0
*  Dopamine - Wikipedia
After synthesis, dopamine is transported from the cytosol into synaptic vesicles by a solute carrier-a vesicular monoamine ... Torres GE, Gainetdinov RR, Caron MG (2003). "Plasma membrane monoamine transporters: structure, regulation and function". ... is separating the high level of plasma homovanillic acid contributed by the metabolism of norepinephrine. Although dopamine is ... These amino acids are found in nearly every protein and so are readily available in food, with tyrosine being the most common. ...
  https://en.wikipedia.org/wiki/Dopamine
*  Publications | Sling
Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.. Lees JA, Messa M, Sun EW, ... Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.. Chatterjee P, Lim WL, Shui G ... Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.. Thong ... Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake ...
  https://sling.sg/publications/
*  Research Interests for Edward D. Levin
Norepinephrine, Norepinephrine Plasma Membrane Transport Proteins, North Carolina, Nucleus Accumbens, Obesity, Oligonucleotide ... Carrier Proteins, Catecholamines, Catheterization, Catheters, Indwelling, Caudate Nucleus, Cebus, Cell Death, Cell ... Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Membranes, Memory, Memory Disorders, Memory, Short-Term ... Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Sertraline, Severity of Illness Index, Sex ...
  http://fds.duke.edu/db/aas/pn/faculty/edlevin/research.html
*  Patent US8268887 - Drug conjugates and methods of use thereof - Google Patenten
Such carriers are compatible with skin, nails, mucous membranes, tissues and/or hair, and can include any conventionally used ... It acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- ... GABAA and GABAC are ionotropic receptors, whereas GABAB is a G protein coupled metabotropic receptor. Low levels of GABA have ... Unlike GABA itself, these GABA derivatives not only can pass through the blood-brain barrier likely by active transport ...
  http://www.google.nl/patents/US8268887
*  TCDB » SEARCH
... tubulin polymerization-promoting protein, TPPP; 094811) increases dopamine transporter localization to the plasma membrane ( ... Protein(s). *2.A.22.1.1. Serotonin (5-hydroxytryptamine; 5 HT):Na+:Cl- symporter, SERT.A Also transports amphetamines; blocked ... interacts directly with the secretory carrier-associated membrane protein-2 (SCAMP2; O15127) to regulate the subcellular ... and norepinephrine through their cognate transporters as well as blocking the reuptake of neurotransmitter by the same ...
  http://tcdb.org/search/result.php?tc=2.A.22.3
*  Human Metabolome Database: Showing metabocard for Progesterone (HMDB0001830)
Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. ... 7. Solute carrier family 22 member 3. General function:. Involved in transmembrane transport. Specific function:. Mediates ... Only showing the first 10 proteins. There are 37 proteins in total. ... Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin ...
  http://www.hmdb.ca/metabolites/HMDB01830?pathways=2
*  Kidneys sans glomeruli | Renal Physiology
... voltage-dependent organic anion transport that is mediated by the transport protein OATv1 located in the apical membrane of the ... Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization ... Norepinephrine (norepi) stimulates (+) transepithelial organic anion transport by stimulating the Na/K pump. PKC inhibits (-) ... Measures of the PAH/inulin clearance ratio assign a single number to the relationship between renal plasma flow and the ...
  http://ajprenal.physiology.org/content/286/5/F811.full
*  PortaCellTec
... and C-termini located at the cytosolic side of the plasma membrane. Immunohistological studies revealed the expression of OAT1 ... Organic anion transporting. polypeptide. Bile acid transporters Peptide transporters Drug efflux transporter References ... The secondary structure analysis of the hOAT1 protein predicted 12 transmembrane helices with the N- ... hypoxanthine and several acidic metabolites of neurotransmitters norepinephrine and dopamine, such as vanillinemandelate and 3, ...
  http://portacelltec.de/oat1.php
*  Quantitative Analysis of Inward and Outward Transport Rates in Cells Stably Expressing the Cloned Human Serotonin Transporter:...
1977) Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets. J Biol Chem 252: ... 1999) Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the ... 1998) Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J Pharmacol Exp Ther 284: ... 1989) The transport of amines across the axonal membranes of noradrenergic and dopaminergic neurones. in Handbook of ...
  http://molpharm.aspetjournals.org/content/59/5/1129
*  Plus it
Salaün C, James DJ, Greaves J, and Chamberlain LH (2004) Plasma membrane targeting of exocytic SNARE proteins. Biochim Biophys ... These results suggest that SYN1A binding to membrane carriers regulates their functional conformations in a voltage-dependent ... Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface ... Deken SL, Beckman ML, Boos L, and Quick MW (2000) Transport rates of GABA transporters: regulation by the N-terminal domain and ...
  http://molpharm.aspetjournals.org/content/74/4/1101
*  Cocaine Acts as an Apparent Competitive Inhibitor at the Outward-Facing Conformation of the Human Norepinephrine Transporter:...
Catecholamine transporters are integral membrane proteins spanning the membrane and exposed on both sides of membrane. They are ... The norepinephrine transporter (NET) mediates uptake of synaptic norepinephrine (NE) into NE neurons. It also transports ... 1994) The noradrenaline transporter of the neuronal plasma membrane. Ann NY Acad Sci 733:193-202. ... 1988) Kinetic evidence for a common binding site for substrates and inhibitors of the neuronal noradrenaline carrier. Naunyn ...
  http://www.jneurosci.org/content/18/24/10257
*  Index of biophysics articles - Wikipedia
Membrane fluidity Membrane lipids Membrane nanotube Membrane potential Membrane protein Membrane topology Membrane transport ... Calcium 2-aminoethylphosphate Calcium channel Canadian Society for Biomechanics Cardiolipin Carlos Chagas Filho Carrier protein ... Phosphatidylglycerol Phosphatidylinositol Phosphatidylserine Physics of skiing Pink algae Plasma membrane monoamine transporter ... Nav1.1 Nav1.2 Nav1.4 Nav1.5 Nectin Neurophysins Nicolas Rashevsky Nicotinic acetylcholine receptor Niosome Norepinephrine ...
  https://en.wikipedia.org/wiki/Index_of_biophysics_articles
*  Free Pharmacology Flashcards about Drug Law Review
Most common mechanism of drug carrier-mediated transport. ATP transportation. Most common mechanism of drug active-transport. ... Binding of drugs to plasma proteins (PP), usually ALBUMIN fraction, leads to high concentrations of drug in the plasma.. ... norepinephrine, noradrenaline. The action of sympathomimetic drugs on the liver causes an increase in blood glucose levels by a ... Medication administered through the mucous membrane. sublingual. Medication administered via the respiratory tract. inhalation ...
  https://www.studystack.com/flashcard-14270
*  Frontiers | Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake | Neuroscience
... and agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons. Hypothalamic ROS release is under the influence of different ... and agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons. Hypothalamic ROS release is under the influence of different ... which are mitochondrial inner membrane proteins promoting proton leak (Aquila et al., 1985). These proteins control mROS ... Strehler, E. E., Caride, A. J., Filoteo, A. G., Xiong, Y., Penniston, J. T., and Enyedi, A. (2007). Plasma membrane Ca2+ ...
  https://www.frontiersin.org/articles/10.3389/fnins.2015.00056/full