Patent US6242570 - Production and use of recombinant protein multimers with increased ... - Google Patents
The fusion proteins can be linked by a peptide linker. The fusion proteins can be used, for example, to treat or prevent anemia ... are nucleotide sequences encoding the fusion proteins vectors comprising the nucleic acid sequences of the fusion proteins and ... The invention relates to novel recombinant fusion proteins comprising two or more erythropoietin molecules. ... A pharmaceutical composition comprising said recombinant fusion protein of claim 1 and a pharmaceutically acceptable carrier. ...http://www.google.com/patents/US6242570
Control:Fc fusion protein (human), (recombinant), Enzo Life Sciences | VWR
Proteins and Peptides. , Control:Fc fusion protein (human), (recombinant), Enzo Life Sciences ... Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.. ... Control:Fc fusion protein (human), (recombinant), Enzo Life Sciences. Supplier: Enzo Life Sciences. ... Protein Type. Recombinant. Sensitivity. Reconstitute with 50µl sterile distilled water. ...https://us.vwr.com/store/product/10915444/control-fc-fusion-protein-human-recombinant-enzo-life-sciences
Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP | JCB
... and 2 μg of nonphosphorylated recombinant fusion protein, GST-Cx43CT (carrier peptide), in 50 mM ammonium bicarbonate, pH 8.0, ... The GJ protein Cx43 is one of the more ubiquitous of the GJ proteins. Its importance is underscored by the abnormal heart ... CT fusion protein was used to first test for phosphorylation by PKA in vitro. As can be seen in Fig. 4 B, the Cx43 fusion ... connexin43; cAMP; protein kinase A; gap junction; site-directed mutagenesis. Introduction. Gap junction (GJ)*proteins (termed ...http://jcb.rupress.org/content/155/7/1307
Patent US6303749 - Agouti and agouti-related peptide analogs - Google Patents
The present invention provides peptides related to agouti signaling protein and agouti related protein which are useful in ... Conjugates of AGRP/ASP peptide and a suitable carrier protein also can be made in recombinant cell culture as fusion proteins. ... The subsequent Fc-fusion peptide can be purified by use of a Protein A affinity column. Fc is known to exhibit a long ... It may be useful to conjugate AGRP/ASP peptide or a peptide fragment thereof to a carrier protein that is immunogenic in the ...http://www.google.com/patents/US6303749?dq=5787449
BMPR1A Recombinant Human Protein - Thermo Fisher Scientific
BMPR1A is one of the bone morphogenetic protein (BMP) receptors which are a family of transmembrane serine/threonine kinases ... Fc Chimera is a bioactive protein intended for use in cell culture applications. ... Protein Subtype:. BMPs (Bone Morphogenetic Proteins) & Related Factors. Protein Tag or Fusion:. Untagged. ... Bone Morphogenetic Protein Receptor 1A Fc Chimera is one of our more than 250 available Gibco® recombinant proteins. To help ...https://www.thermofisher.com/order/catalog/product/PHC9241
CiNii 論文 - The Use of rhBMP-2 in Interbody Fusion Cages : Definitive Evidence of...
Effect of Recombinant Human Bone Morphogenetic Protein-2 in an Experimental Model of Spinal Fusion in a Radiated Area AMES ... The use of an osteoinductive growth factor for lumbar spinal fusion : Part II. Study of dose, carrier, and species BODEN S ... Bone morphogenetic proteins and their gene expression WOZNEY JM. Cellular and Molecular Biology of Bone, 1993 ... Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements SANDHU ...http://ci.nii.ac.jp/naid/10018092847
Recombinant human Sonic Hedgehog protein (ab174054)
Ab174054 is an active protein fragment produced in HEK 293 cells and has been validated in FuncS, SDS-PAGE… ... Recombinant human Sonic Hedgehog protein. See all Sonic Hedgehog proteins and peptides. ... Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage. ... Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of ...http://www.abcam.com/recombinant-human-sonic-hedgehog-protein-ab174054.html
Plant Production and Delivery System for Recombinant Proteins as Protein-Flour or Protein-Oil Compositions - University of...
... wherein the plant material contains a recombinant protein comprises a bactericidal or an insecticidal ... The oleosins are efficient carriers for delivering foreign fusion proteins to lipid bodies in B. napus (van Rooijen and Moloney ... An oil body protein (OBP) fusion, comprising an oil body protein fused to a recombinant protein comprising a bactericidal or an ... The oil body protein fusion of claim 18, wherein operably positioned between the oil body protein and the recombinant protein ...http://www.freepatentsonline.com/y2011/0263487.html
US8119117B2 - Adenoviral expression vector comprising a CD40L fusion protein adapted to elicit cellular immunity -...
... by administering an effective amount of the invention vector which enocodes the E6 or E7 protein of HPV. The immunity generated ... 3. Western Blot Analysis of the Proteins in Cells 293 Infected by the Recombinant Adenovirus ... Liquid carriers include syrup, peanut oil, olive oil, saline and water. The carrier may also include a sustained release ... C07K2319/70-Fusion polypeptide containing domain for protein-protein interaction * C07K2319/74-Fusion polypeptide containing ...https://patents.google.com/patent/US8119117?oq=6004266
Patent US20040009185 - Enhancing the immune response to an antigen by presensitzing with an ... - Google Patents
In one embodiment, the vaccine composition comprises a recombinant fusion protein comprising an inducing agent linked to an ... For example, carrier proteins (e.g. tetanus toxoid (TT), diphtheria toxoid (DT)), when coupled to T-independent antigens, ... the inducing agent and the antigen will be expressed in vivo as a recombinant fusion protein. In another example, the inducing ... the inducing agent and antigen may be covalently linked for example they may be prepared as a recombinant fusion protein in ...http://www.google.com/patents/US20040009185
Bone morphogenetic protein 2 - Wikipedia
The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen ... lesser protein delivery, [and] inactivation of the protein" reveal a further need "to modify the available carrier systems as ... Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic ... Bone morphogenetic protein 2 is shown to stimulate the production of bone. Recombinant human protein (rhBMP-2) is currently ...https://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2
IDELVION 2000 IU powder and solvent for solution for injection - Summary of Product Characteristics (SmPC) - (eMC)
Albumin is a natural, inert carrier protein in plasma with a half-life of approximately 20 days. Genetic fusion of recombinant ... The product contains traces of hamster proteins. If symptoms of hypersensitivity occur, patients should be advised to ... generated by the genetic fusion of recombinant albumin to recombinant coagulation factor IX. The genetic fusion of the cDNA of ... One vial contains nominally 250 IU of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP), (INN = ...https://www.medicines.org.uk/emc/product/7847
Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells - Dana-Farber Cancer Institute, Inc.
... conjugated to a second protein or protein portion or in a recombinant form (e.g., chimeric or bispecific HB22). The ... Similarly, polypeptides of the invention may also be joined to carrier proteins. In addition, a chimeric HB22 antibody may be ... For example, a fusion protein comprising at least the antigen-binding region of an HB22 antibody may be joined to a portion of ... Alternatively, recombinant CD22 protein may be bound to an insoluble matrix or surface as the testing agent. As the mAb of the ...http://www.freepatentsonline.com/5484892.html
Patent US7601814 - Reducing the immunogenicity of fusion proteins - Google Patents
... or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and ... Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional ... Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. ... Recombinant antibody cytokine fusion proteins. US5650492. 18 Apr 1995. 22 Jul 1997. Hoffmann-La Roche Inc.. P-40 homodimer of ...http://www.google.ca/patents/US7601814
Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various...
Structure (a) and theoretical modelling of 3D-structures (b) of monomeric recombinant fusion proteins Flg-HA2-2-4M2ehs and ... of recombinant proteins have shown that the immunogenicity of an antigen depends on its location within its protein-carrier. ... Design and characterization of fusion proteins. Fusion protein Flg-HА2-2-4M2ehs was designed containing full-length flagellin ... Expression and purification of recombinant proteins. For recombinant proteins expression, the corresponding vectors were ...https://link.springer.com/article/10.1186/s12929-018-0433-5
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : [Mechanisms of recombinant adenovirus-mediated SD-HA fusion...
Mechanisms of recombinant adenovirus-mediated SD-HA fusion protein proliferation inhibition and induced apoptosis of K562 cells ... Proteins: pRBHis Retinoblastoma Protein, Tumor Suppressor Protein, Transcription Factor and Proliferation Factorhuman, ... Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional ... Recombinant (HEK cells) human CD20_MS4A1 (141-184 aa) hFc- fusion Protein Species Reactivity: 10 ug Product tipe: Recombinant ...http://www.antibody-antibodies.com/pubmed-29779329-Mechanisms_of_recombinant_adenovirusmediated_SDHA_fusion_protein_proliferation_inhibition_and_induced_apoptosis_of_K562_cells.html
Albinterferon Alfa-2b Was Not Inferior to Pegylated Interferon-α in a Randomized Trial of Patients With Chronic Hepatitis C...
A phase I/II study evaluating escalating doses of recombinant human albumin-interferon-alpha fusion protein in chronic ... 10 Human serum albumin is a natural carrier protein with a long half-life, and the genetic fusion of albumin to IFNalfa-2b ... Albumin-fusion technology represents a novel and flexible alternative platform for the production of proteins with extended ... and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients. J ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3175757/?lang=en-ca
Recombinant Picornain 3C protein (ab157275) | Abcam
Ab157275 is an active full length protein produced in Escherichia coli and has been validated in FuncS, SDS-PAGE… ... The high specificity of ab157275 makes it an ideal tool for cleaving fusion proteins at definite cleavage sites. The enzyme ... Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage. ... One unit will cleave ,95% of 100 µg control fusion protein in 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 at 4°C for 16 h. ...http://www.abcam.com/recombinant-picornain-3c-protein-ab157275.html
Breaking the Non-Responsiveness of C57BL/6 Mice to the Malarial Antigen EB200 - The Role of Carrier and Adjuvant Molecules
This was evident as the subsequent boosting with the corresponding recombinant fusion proteins Pf70C-EB200 elicited strong ... Mycobacterium vaccae or Chlamydia pneumoniae and boosted with a recombinant fusion protein Pf70C-EB200 or with a panel of HSPs ... The potential of heat shock proteins (HSPs) to function as adjuvants when fused to or co-delivered with protein antigens, make ... The use of novel vaccine adjuvants or carrier proteins, which are known to enhance the immunogenicity of the subunit antigens ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:193906
Patent US20070250139 - Enhanced systems and methods for RF-induced hyperthermia II - Google Patentsuche
... fusion proteins and organometallics, fusion proteins and radioisotopes, bispecifics and metals or organometallics, bispecifics ... and/or liposomes and/or another carrier) carry a gene (or other biomolecule) for production of a protein that would be ... or other proteomic or genetic engineered constructs including recombinant technique, binds. Examples of targeted carriers and ... In a first phase, targeted carriers (either carriers with an inherent targeting moiety or non-targeting carriers with a ...http://www.google.de/patents/US20070250139
Cells depleted of Plk or cdc5-1 protein arrest at multi | Open-i
Cells depleted of Plk or cdc5-1 protein arrest at multiple points of M phase. (A) Growth of cdc5Δ mutant conditionally rescued ... Protein Structure, Tertiary. *Protein-Serine-Threonine Kinases. *Recombinant Fusion Proteins/genetics/metabolism ... whereas the cdc5-1 protein disappeared after 3-4 h (Fig. 1 B). The fast removal of cdc5-1 protein, in comparison with Plk, may ... whereas the cdc5-1 protein disappeared after 3-4 h (Fig. 1 B). The fast removal of cdc5-1 protein, in comparison with Plk, may ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195991_JCB0004052.f1b&req=4
SMART: FN2 domain annotation
... as fusion proteins in Escherichia coli. These recombinant fragments were separated from the carrier maltose-binding protein by ... inserted immediately before the protein fragment of interest, was used. After treatment of the purified fusion proteins with ... Click on the protein counts, or double click on taxonomic names to display all proteins containing FN2 domain in the selected ... Of the recombinant proteins, we found that only the 4F1.5F1 exhibited significant fibrin binding activity, while 1F1, 1F1.2F1, ...http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=FN2&BLAST=DUMMY
Application # 2016/0194396. Bi-Specific Monovalent Fc Diabodies That Are Capable of Binding CD32B and CD79b and Uses...
... recombinant cells capable of expressing the antibody or fusion protein, receptor-mediated endocytosis (See, e.g., Wu et al. ( ... Bispecific Fusion Proteins," Cancer Res. 59:2909-2916; WO 2006/113665; WO 2008/157379; WO 2010/080538; WO 2012/018687; WO 2012/ ... The term "carrier" refers to a diluent, adjuvant (e.g., Freund's adjuvant (complete and incomplete), excipient, or vehicle with ... Of A Chimeric Anti-CD20 Single Chain Fv-Fv Fusion Protein Is Mediated Through Variable Domain Exchange," Protein Engineering 14 ...http://patents.com/us-20160194396.html
NAVER Academic | Controllable mineral coatings on PCL scaffolds as carriers for growth factor release
Peptide versions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP2) were bound with ... Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion ... Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures ... Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3- ...http://academic.naver.com/article.naver?doc_id=64842887
Protein tag - Wikipedia
Einhauer, A.; Jungbauer, A. (2001). "The FLAG™ peptide, a versatile fusion tag for the purification of recombinant proteins". ... a peptide which binds covalently to SnoopCatcher protein (KLGDIEFIKVNK) BCCP (Biotin Carboxyl Carrier Protein), a protein ... Protein tags are peptide sequences genetically grafted onto a recombinant protein. Often these tags are removable by chemical ... "One-Step Purification of Recombinant Proteins Using a Nanomolar-Affinity Streptavidin-Binding Peptide, the SBP-Tag". Protein ...https://en.wikipedia.org/wiki/Protein_tag