Carnitine acyltransferases and their influence on CoA pools in health and disease - PubMed
Carnitine acyltransferases and their influence on CoA pools in health and disease Rona R Ramsay et al. Mol Aspects Med. 2004 ... Carnitine acyltransferases and their influence on CoA pools in health and disease Rona R Ramsay 1 , Victor A Zammit ... The carnitine acyltransferases and their role in modulating acyl-CoA pools. Ramsay RR, Arduini A. Ramsay RR, et al. Arch ... The location, properties of and deficiencies in the carnitine acyltransferases are described in relation to their influence on ...
Carnitine O-octanoyltransferase - Wikipedia
Other names in common use include medium-chain/long-chain carnitine acyltransferase, carnitine medium-chain acyltransferase, ... Farrell, S. O.; Fiol, C. J.; Reddy, J. K.; Bieber, L. L. (1984-11-10). "Properties of purified carnitine acyltransferases of ... In the absence of carnitine acetyltransferase (CRAT), acyltransferases such as CROT can catalyze the acetyl group transfer from ... The significant catalytic residue within all carnitine acyltransferases, including CROT, has been found to be a histidine ...
Transporter Classification Database - Wikipedia
Beta Oxidation and Ketones Flashcards
CPT1A gene: MedlinePlus Genetics
The CPT1A gene provides instructions for making an enzyme called carnitine palmitoyltransferase 1A, which is found in the liver ... Carnitine acyltransferases and their influence on CoA pools in health and disease. Mol Aspects Med. 2004 Oct-Dec;25(5-6):475-93 ... Carnitine palmitoyltransferase I deficiency. More than 20 mutations in the CPT1A gene have been found to cause carnitine ... Carnitine palmitoyltransferase 1A connects carnitine to long-chain fatty acids so they can cross the inner membrane of ...
Carnitine Inborn Errors of Metabolism - PubMed
Renal carnitine reabsorption along with dietary intake and endogenous production maintain carnitine homeostasi … ... In non-vegetarians, most of carnitine sources (~75%) are obtained from diet whereas endogenous synthesis accounts for around 25 ... Carnitine Acyltransferases / genetics Actions. * Search in PubMed * Search in MeSH * Add to Search ... organic cation/carnitine transporter novel type 2) transports carnitine into the cells. One of the major functions of carnitine ...
Cystic fibrosis - New World Encyclopedia
Alcoholic Ketoacidosis: Practice Essentials, Pathophysiology, Etiology
Biomarkers Search
9. Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of myc-induced lymphomagenesis.. Pacilli A; ... Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian ... Inhibition of carnitine palmitoyl transferase 1A-induced fatty acid oxidation suppresses cell progression in gastric cancer. ...
2h3w - Proteopedia, life in 3D
Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. They have ... Categories: Large Structures , Lk3 transgenic mice , Hsiao, Y S , Jogl, G , Tong, L , Carnitine acyltransferase , Transferase ... Carnitine acetyltransferase References *↑ Hsiao YS, Jogl G, Tong L. Crystal structures of murine carnitine acetyltransferase in ... CACP_MOUSE] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through ...
Frontiers | Contextualising Maximal Fat Oxidation During Exercise: Determinants and Normative Values
Fritz, I. B., and Yue, K. T. N. (1963). Long-chain carnitine acyl-transferase and the role of acylcarnitine derivatives in the ... Carnitine is a substrate in the CPT-I-catalyzed reaction resulting in mitochondrial fatty acid uptake (Fritz and Yue, 1963), ... This may be explained by exercise intensity-induced reductions in free carnitine availability (van Loon et al., 2001) and/or ... catalytic increase of fatty acid oxidation induced by carnitine. J. Lipid Res. 4, 279-88. ...
Fish Oil Fights Stress-Influenced Weight Gain
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells | Diabetes | American Diabetes...
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ... Production of malonyl-CoA near the mitochondrial membrane leads to inhibition of carnitine palmitoyl 1a (CPT1a) and thereby ... The glucose-dependent inhibition of glucagon secretion relies on pyruvate dehydrogenase and carnitine palmitoyl transferase 1a ... Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient ...
Phthalate Exposure Changes the Metabolic Profile of Cardiac Muscle Cells | Environmental Health Perspectives | Vol. 120, No. 9
Primer sequences for acetyl-CoA acyltransferase (ACAA2), long-chain acyl-CoA dehydrogenase (ACADL), acyl-CoA synthetase (ACSL1 ... Acyl-carnitine is translocated across the mitochondrial inner membrane (step 6) by acylcarnitine translocase (SLC25A20). Once ... 2001). Acyl-CoA is then converted to acyl-carnitine by CPT1 (step 3), which facilitates entry into the mitochondria. CPT1 ... The effect of di(ethylhexyl)phthalate on fatty acid oxidation and carnitine palmitoyltransferase in various rat tissues.Biochim ...
Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells | Reproductive Biology and Endocrinology |...
Moreover, the expression levels of diacylglycerol O-acyltransferase (DGAT)-1 and DGAT2, both of which encode enzymes catalyzing ... it significantly elevated the expression of carnitine palmitoyltransferase (CPT)-1A, a key enzyme involved in fatty acid ... carnitine palmitoyltransferase 1B (CPT1B), diacylglycerol O-acyltransferase 1 (DGAT1) and diacylglycerol O-acyltransferase 2 ( ... Qu Q, Zeng F, Liu X, Wang QJ, Deng F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets ...
DeCS
Carnitine Acyltransferases Entry term(s). Acylcarnitine Translocase Acyltransferases, Carnitine Carnitine Acylcarnitine ... Carnitine acyltransferases Entry term(s):. Acylcarnitine Translocase. Acyltransferases, Carnitine. Carnitine Acetylcarnitine ... Carnitine Acyltransferases - Preferred Concept UI. M0003496. Scope note. Acyltransferases in the inner mitochondrial membrane ... Carnitine Acylcarnitine Translocase. Carnitine Translocase. Carnitine-Acetylcarnitine Translocase. Carnitine-Acylcarnitine ...
MeSH Browser
Carnitine Acyltransferases [D08.811.913.050.350] * Carnitine O-Acetyltransferase [D08.811.913.050.350.170] * Carnitine O- ... do not confuse with CARNITINE ACETYLTRANSFERASE see CARNITINE O-ACETYLTRANSFERASE. Scope Note. Acyltransferases in the inner ... Carnitine Translocase Carnitine-Acetylcarnitine Translocase Carnitine-Acylcarnitine Translocase Registry Number. EC 2.3.1.-. ... Carnitine Acyltransferases Preferred Term Term UI T006708. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ...
MeSH Browser
Carnitine Acyltransferases [D08.811.913.050.350] * Carnitine O-Acetyltransferase [D08.811.913.050.350.170] * Carnitine O- ... do not confuse with CARNITINE ACETYLTRANSFERASE see CARNITINE O-ACETYLTRANSFERASE. Scope Note. Acyltransferases in the inner ... Carnitine Translocase Carnitine-Acetylcarnitine Translocase Carnitine-Acylcarnitine Translocase Registry Number. EC 2.3.1.-. ... Carnitine Acyltransferases Preferred Term Term UI T006708. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ...
Code System Concept
Publication Detail
Is hepatic lipid metabolism of beef cattle influenced by breed and dietary silage level? | BMC Veterinary Research | Full Text
Carnitine palmitoyltransferase 1A. DGAT1:. Diacylglycerol O-acyltransferase 1. DHA:. Docosahexaenoic acid. ELOVL2:. Fatty acid ... The carnitine palmitoyltransferase (CPT) system is an essential step in the β-oxidation of fatty acids, including LC-PUFA. ... as well as carnitine synthesis [28]. The fact that the mRNA level of CPT1A, which is controlled by PPARA, was unchanged across ... The diacylglycerol acyltransferase (DGAT) catalyses the final step in triacylglycerol biosynthesis by converting diacylgycerols ...
How is acetyl CoA produced?
The catalytic subunit contains the enzyme carnitine acyltransferase, which transfers acyl groups from acetyl-CoA to carnitine. ... These acylcarnitines bind to the active site of carnitine acyltransferase and prevent the transfer of acyl groups from acetyl- ... Carnitine acyltransferase is reversibly inhibited by palmitoylcarnitine and long-chain acylcarnitines. ... CoA is a coenzyme of acyltransferase reactions and is important in the formation of acyl-CoA compounds. It is also important ...
Ophiocordyceps australis 1348a (Ghana)
Bio2Vec
Pharos : Target Details - CPT2
Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. ... Acyltransferase. / Carnitine O-palmitoyltransferase 2, Mitochondrial Protein / Transferase. / Acetyltransferase. / Carnitine O- ... Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. ...
Fatty Acid Oxidation - NEET PG Biochemistry
Acyl CoA with carnitine gives acylcarnitine, and the enzyme is carnitine acyl transferase 1 (rate-limiting enzyme). Acyl ... Carnitine acyltransferase 2 releases the carnitine back and converts acylcarnitine to acyl CoA. ... carnitine crosses the inner mitochondrial membrane and enters the matrix. Once the acylcarnitine has entered the matrix if you ...
Palmityl-CoA (YMDB00301) - Yeast Metabolome Database
Carnitine O-acetyltransferase YAT2. General function:. Involved in acyltransferase activity. Specific function:. Involved in ... 2. Carnitine O-acetyltransferase, mitochondrial. General function:. Involved in acyltransferase activity. Specific function:. ... Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate ... Involved in acyltransferase activity. Specific function:. May be an acyltransferase with an altered substrate specificity that ...