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Gene Trapping Uncovers Sex-Specific Mechanisms for Upstream Stimulatory Factors 1 and 2 in Angiotensinogen Expression |...
Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... Gene Trapping Uncovers Sex-Specific Mechanisms for Upstream Stimulatory Factors 1 and 2 in Angiotensinogen Expression. Sungmi ... Gene Trapping Uncovers Sex-Specific Mechanisms for Upstream Stimulatory Factors 1 and 2 in Angiotensinogen Expression ... Gene Trapping Uncovers Sex-Specific Mechanisms for Upstream Stimulatory Factors 1 and 2 in Angiotensinogen Expression ...http://hyper.ahajournals.org/content/early/2012/04/29/HYPERTENSIONAHA.112.192971
Shuxia Wang, M.D., Ph.D. | Saha Cardiovascular Research Center
"Role of upstream stimulatory factor 2 in diabetic nephropathy." Frontiers in biology 10, 3 (2015): 221-229. [PubMed Link] , ... Shu Liu, Lihua Shi, and Shuxia Wang (2007). Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury ... "Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury." American journal of physiology. Renal ... "Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice." American journal of physiology ...http://cvrc.med.uky.edu/users/swang7
Association Analysis of Allelic Variants of USF1 in Coronary Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular...
Upstream stimulatory factor 1 regulates osteopontin expression in smooth muscle cells. Exp Cell Res. 1999; 250: 535-547. ... As a transcription factor regulating the expression of more than 40 cardiovascular related genes29 involved in lipid metabolism ... Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. Hum Genet. ... The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in ...http://atvb.ahajournals.org/content/28/5/983
Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism | Nutrition & Metabolism | Full Text
Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter ... Epigenetics and cardiovascular development. Annu Rev Physiol. 2012;74:41-68.View ArticleGoogle Scholar. ... Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter. J Biol Chem. 1995;270:28716 ... Casado M, Vallet VS, Kahn A, Vaulont S. Essential role in vivo of upstream stimulatory factors for a normal dietary response of ...https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0090-1
AP-1 Is Involved in UTP-Induced Osteopontin Expression in Arterial Smooth Muscle Cells | Circulation Research
Upstream stimulatory factor 1 regulates osteopontin expression in smooth muscle cells. Exp Cell Res. 1999; 250: 535-547. ... Giachelli CM, Liaw L, Murry CE, Schwartz SM, Almeida M. Osteopontin expression in cardiovascular diseases. Ann N Y Acad Sci. ... However, several transcription factors, such as NFAT, AP-1, CREB, SRF, STAT, and nuclear factor-κB, are activated by UTP in ... Indeed, the GC-rich region binds the Sp1 factor, an ubiquitous transcription factor believed to be important for the basal ...http://circres.ahajournals.org/content/93/7/674
JCI - Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene
... hepatocyte nuclear factor-4α; SHBG, sex hormone-binding globulin; USF, upstream stimulatory factor. ... Association of decreased sex hormone binding globulin and cardiovascular risk factors. Arteriosclerosis. 9:136-143. ... Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors. J. ... results were obtained using mice carrying a 4.3-kb human SHBG transgene mutated to disrupt an upstream stimulatory factor (USF ...https://www.jci.org/articles/view/32249
Via activation of upstream stimulatory factor 1 and Fos, hyperglycemia directly upregulates VSMC OPN expression (3). ... Ortlepp JR, Schmitz F, Bozoglu T, Hanrath P, and Hoffmann R. Cardiovascular risk factors in patients with aortic stenosis ... Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor ... Ishimura E, Okuno S, Kitatani K, Kim M, Shoji T, Nakatani T, Inaba M, and Nishizawa Y. Different risk factors for peripheral ...http://ajpendo.physiology.org/content/286/5/E686
USF2 purified MaxPab rabbit polyclonal antibody (D01P) - (H00007392-D01P) - Products - Abnova
c-fos interacting protein,upstream stimulatory factor 2. *Related Disease. *Alzheimer Disease ... and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich ...http://www.abnova.com/products/products_detail.asp?catalog_id=H00007392-D01P
USF2 monoclonal antibody (M01A), clone 5E9 - (H00007392-M01A) - Products - Abnova
c-fos interacting protein,upstream stimulatory factor 2. *Related Disease. *Alzheimer Disease ... and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich ...http://www.abnova.com/products/products_detail.asp?catalog_id=H00007392-M01A
Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid...
Upstream stimulatory factor 1 transactivates the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase. Arch ... Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes. Postgrad Med. 2013;125(3): ... Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L. Does quercetin improve cardiovascular risk factors and inflammatory ... Chronic hyperglycemia remains the leading causal factor for the development of cardiovascular disease (CVD) and heart failure ( ...https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0200-8
Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced...
Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor ... Objective- Hyperglycemia is a recognized risk factor for cardiovascular disease in diabetes. Recently, we reported that high ... and upstream stimulatory factor in arterial smooth muscle cells. J. Biol. Chem. 2005; 280: 2708-2713. ... Nuclear factor of activated T-cells transcription factors in the vasculature: the good guys or the bad guys? Curr Opin Lipidol ...http://atvb.ahajournals.org/content/30/2/218
A Novel Transcriptional Mechanism of Cell Type-Specific Regulation of Vascular Gene Expression by Glucose | Arteriosclerosis,...
... growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2.J ... Cardiovascular Health Study. .Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with ... anti-upstream stimulatory factor (USF)1/2, and anti-peroxisome proliferator activated receptor (PPAR)-γ (Santa Cruz ... Platelet factor 4, beta-thromboglobulin and thrombospondin levels in type I diabetes mellitus patients.J Int Med Res.1994;22:90 ...http://atvb.ahajournals.org/content/31/3/634
USF1 Gene - GeneCards | USF1 Protein | USF1 Antibody
Upstream Transcription Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... upstream stimulatory transcription factor,ubiquitous (43 kDa),binding the AP-1/AP-4 site on the APP promoter *USF1 ... Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular ... intron-variant, upstream-variant-2KB. rs3737787. other. 161,039,733(-). GTGGA(C/T)GTGCA. upstream-variant-2KB, utr-variant-3- ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=USF1
Familial Combined Hyperlipidemia - Combined Hyperlipidemia, Familial Summary Report | CureHunter
Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY ... Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY ... 12/01/1997 - "Patients with familial combined hyperlipidemia (FCH) have an increased cardiovascular mortality despite only ... Fibrinogen (Factor I)FDA Link 05/01/1998 - "[Bezafibrate in the treatment of familial combined hyperlipidemia and its effect on ...http://www.curehunter.com/public/keywordSummaryD006950-Familial-Combined-Hyperlipidemia-Combined-Hyperlipidemia--Familial.do
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
... cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in ... C. Zeng, J. T. Lee, H. Chen, S. Chen, C. Y. Hsu, and J. Xu, "Amyloid-β peptide enhances tumor necrosis factor-α-induced iNOS ... B. Uttara, A. V. Singh, P. Zamboni, and R. T. Mahajan, "Oxidative stress and neurodegenerative diseases: a review of upstream ... The JNK-inhibitor L-JNK1 inhibited the stimulatory effects of C2-ceramide on caspase-9 and caspase-3 and prevented C2-ceramide- ...https://www.hindawi.com/journals/omcl/2015/346783/
Genetic Basis of Hypertension | Hypertension
... perhaps because of binding of the transcription factor USF (upstream stimulatory factor) to the −20C site, the −20A allele ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... Known transcription factor binding sites overlying SNPs are shown below the corresponding SNP. Putative transcription factor ... Factors that may predispose a person to essential hypertension include weight, age, sex, ethnicity, physical activity, diet, ...http://hyper.ahajournals.org/content/48/1/14.long
Medline ® Abstract for Reference 81 of 'Enterotoxicity of chemotherapeutic agents'
Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, ... result in genotypes with 0-5 functional upstream stimulatory factor (USF) E-box consensus elements. However, the relationship ...http://www.uptodate.com/contents/enterotoxicity-of-chemotherapeutic-agents/abstract/81
Protocols and Video Articles Authored by Max Gassmann
Among six basic helix-loop-helix transcription factors known to target CACGTG palindromes, we identified upstream stimulatory ... General Thoracic and Cardiovascular Surgery. *News in Physiological Sciences : an International Journal of Physiology Produced ... fibroblast growth factor 2 and vascular endothelial growth factor via hypoxia-inducible factor-1alpha (HIF-1alpha) ... Hypoxia-inducible factor-1 (HIF-1), the main transcription factor involved in the cellular response to reduced oxygenation, is ...https://www.jove.com/author/Max_Gassmann
Protocols and Video Articles Authored by Tao Yang (Translated to German)
... binding site and an upstream stimulatory factor (USF)-binding site was identified in the -100 bp fragment upstream of the ... and other cardiovascular (CV) risk factors in middle-aged and elderly Chinese population at high risk for the development of ... Increased BCAAs levels are independent risk factors of MS and CVD in addition to the traditional factors in middle-aged and ... without vascular disease and major arteriosclerotic risk factors were included. Clinical factors, oral glucose tolerance test ...https://www.jove.com/author/Tao_Yang?language=German
Fluid Shear Stress Increases the Production of Granulocyte-Macrophage Colony-Stimulating Factor by Endothelial Cells via mRNA...
The stimulatory effect of shear stress on GM-CSF production was compared with that of PMA (Sigma). The amount of GM-CSF ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... upstream region has been identified as an enhancer in PMA-treated T cells.44 In the present study, however, our run-on assay ... Effects of Shear Stress on the Binding Activity of AU-Binding Factors in HUVECs. To examine whether any AU-binding factors are ...http://circres.ahajournals.org/content/82/7/794
Frontiers | Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in...
These factors may vary from disease to disease and could include, in the case of SLE, type I IFNs (Baechler et al., 2003; ... In psoriasis, local production of type I IFNs, such as IFNα, by plasmacytoid dendritic cells (pDCs) is an important upstream ... This study hints that NETs provide a unique, stimulatory microenvironment that can break normal immune tolerance, and thereby ... Vordenbaumen, S., Sander, O., Bleck, E., Schneider, M., and Fischer-Betz, R. (2012). Cardiovascular disease and serum defensin ...https://www.frontiersin.org/articles/10.3389/fimmu.2012.00380/full
Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and...
14 upstream stimulatory factor (USF) contributes to SM α-actin gene expression, 15 and Sp1 activates SM-MHC gene expression.16 ... From the Pulmonary and Critical Care (M.D.L., S.-F.Y., X.L., B.I., M.A.P.) and Cardiovascular (K.M., C.-M.H., M.-E.L.) ... Sp1 and Sp3 Transcription Factors Bind to ACLP Promoter Elements. To characterize the transcription factors that bind to the − ... In particular, serum response factor (SRF), a transcription factor that binds to the CArG box, is involved in the regulation of ...http://circres.ahajournals.org/content/90/6/728.long
Protocols and Video Articles Authored by Elizabeth Jones (Translated to Korean)
The effects of the growth factors activin A, retinoic acid (RA) and basic fibroblast growth factor (bFGF) on the regulation of ... E-NTPDase2 therefore acts upstream of these EFTFs. To test whether ADP (the product of E-NTPDase2) might act to trigger eye ... Although blood flow is essential, it remains unclear to what extent flow is able to act on the developing cardiovascular system ... The vaccines contained transgenes for prostate specific antigen, a triad of co-stimulatory molecules and a tumor antigen whose ...https://www.jove.com/author/Elizabeth_Jones?language=Korean
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2) knockout mice. Proc ... cardiovascular disease, aging and other degenerative diseases (216, 217) NTBI is rapidly cleared from the plasma by the liver, ... One of the best known transcription factors that affects iron related gene expression is hypoxia inducible factor 1 (HIF 1). ... upstream stimulatory factor2) knockout mice develop a severe iron overload in various tissues, such as liver, pancreas and ...http://ufdc.ufl.edu/UFE0042392/00001
Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway | Journal of...
Cardiovascular diseases are the number one among the disease-caused mortality in the world. The use of stem cells as a ... For this purpose, we measured the transcription levels of upstream protein including β-catenin, wnt11, TCF, and JNK of Wnt/β- ... T-cell Factor (TCF), and c-Jun-N-terminal kinase (JNK), we used quantitative real time polymerase chain reaction (qPCR) to ... form the bone marrow cavities into beaker with MesenCult basal medium supplemented with Mesenchymal Stem Cell Stimulatory ...https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-017-0337-9