*  Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes - Full Text View...
Acid Sensing Ion Channel Blockers. Sodium Channel Blockers. Membrane Transport Modulators. Molecular Mechanisms of ... Cardiovascular Diseases. Urination Disorders. Urologic Diseases. Urological Manifestations. Signs and Symptoms. Amiloride. ... Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes. The safety and ... Proteinuria not only reflects glomerular damage, but also functions as a risk factor for cardiovascular disease, stroke, end ...
  https://clinicaltrials.gov/ct2/show/NCT01804777?recr=Open&cond=%22Proteinuria%22&rank=11
*  The Effect of Amiloride and Spironolactone in Healthy Persons - Full Text View - ClinicalTrials.gov
Acid Sensing Ion Channel Blockers. Sodium Channel Blockers. Membrane Transport Modulators. Molecular Mechanisms of ... The Effect of Amiloride and Spironolactone Measured on Cardiovascular and Kidney Related Variables in Healthy Subjects in a ... Cardiovascular Diseases. Spironolactone. Amiloride. Mineralocorticoid Receptor Antagonists. Hormone Antagonists. Hormones, ...
  https://clinicaltrials.gov/ct2/show/NCT00857909
*  Double Blind Crossover Comparison of Diuretics in the Young - Full Text View - ClinicalTrials.gov
Acid Sensing Ion Channel Blockers. Sodium Channel Blockers. Membrane Transport Modulators. Molecular Mechanisms of ... Cardiovascular Diseases. Diuretics. Spironolactone. Amiloride. Bendroflumethiazide. Natriuretic Agents. Physiological Effects ... since these are to expected to be in the so-called sodium channels (i.e. salt pumps)which the kidneys use to prevent salt being ... or receiving any antihypertensive drug other than a beta-blocker ...
  https://clinicaltrials.gov/ct2/show/NCT00429897
*  Hypertension Prevention in Pre-Hypertensive Individuals - Full Text View - ClinicalTrials.gov
Acid Sensing Ion Channel Blockers. Sodium Channel Blockers. Epithelial Sodium Channel Blockers. Diuretics, Potassium Sparing. ... Pre-hypertension Hypertension Cardiovascular Disease Drug: Chlorthalidone plus amiloride Drug: placebo Phase 3 ... fatal or major cardiovascular events: myocardial infarction, stroke, coronary interventions, heart failure, duplication of ... Does an association of low doses of chlorthalidone and amiloride reduce the incidence of cardiovascular events in patients with ...
  https://clinicaltrials.gov/ct2/show/NCT00970931?recr=Open&cond=%22Hypertension%22&rank=7
*  Ion channels | Pharmacology Education Project
... diuretics amiloride and triamterene are ENaC channel blockers.. Acid-sensing (proton-gated) ion channels (ASICs) are involved ... Calcium channel blockers (CCBs) -see also the topic 'Calcium channel blocking drugs' in the Cardiovascular system section of ... Ligand-gated ion channels Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for ... GABAA and glycine receptors as well as acid-sensing (proton-gated) ion channels (ASICs), epithelial sodium channels (ENaC), IP3 ...
  http://www.pharmacologyeducation.org/pharmacology/ion-channels
*  Abstracts From the 37th Annual Scientific Meeting of the HBPRCA | Hypertension
Background: Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and plays a major role in ... Given that altered cardiac autonomic tone is an adverse prognostic factor in cardiovascular disease and cardiovascular ... Since the ASIC1a-selective blocker PcTx1 is present at only 0.4% abundance in this venom, we wondered whether the observed ... NEUROPROTECTION IN A CONSCIOUS MODEL OF STROKE IN HYPERTENSIVE RATS VIA SELECTIVE INHIBITION OF ACID-SENSING ION CHANNEL 1A. ...
  http://hyper.ahajournals.org/content/67/5/e7
*  Bioinformatics Centre (DBT-BIF) | Our Publications
2015). Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid-Sensing Ion Channel-1a and ... 2014). In silico screening of some plant based natural products as angiotensin receptor blockers against cardiovascular ... 2015). In silico screening of some plant based natural products as Angiotensin Receptor Blockers against Cardiovascular ... Angiotensin Converting Enzyme inhibitory potential of Echinosystic acid relevance to Cardiovascular diseases: An in silico ...
  http://bioinfoaus.ac.in/publication.php
*  Toxins | Free Full-Text | Sea Anemones: Quiet Achievers in the Field of Peptide Toxins | HTML
This is surprising given the success of some anemone peptides that have been tested, such as the potassium channel blocker from ... APETx2, from Anthopleura elegantissima, inhibits the acid-sensing ion channel ASIC3, which is a proton-gated Na+ channel that ... channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. FEBS ... B showed initial promise as positive inotropes for use in cardiovascular disease [25,26], although they and their homologues ...
  http://mdpi.com/2072-6651/10/1/36/htm
*  Activation of Heat-Shock Factor by Stretch-Activated Channels in Rat Hearts | Circulation
SAC and L-type calcium channel blocker) or diltiazem (specific L-type calcium channel blocker) for 60 minutes. To impose ... Yang X-C, Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science. 1989; ... Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res. 1998; 83: 117-132. ... For instance, Peterson and Lesch20 first reported that stretch could accelerate protein synthesis and amino acid transport. A ...
  http://circ.ahajournals.org/content/104/2/209
*  Dysgeusia - Wikipedia
There are few case reports claiming calcium channel blockers like Amlodipine also cause dysguesia by blocking calcium sensitive ... The distortion in the sense of taste is the only symptom, and diagnosis is usually complicated since the sense of taste is tied ... Alpha lipoic acid (ALA) is an antioxidant that is made naturally by human cells. It can also be administered in capsules or can ... Metronidazole and chlorhexidine have been found to interact with metal ions that associate with the cell membrane. Drugs that ...
  https://en.wikipedia.org/wiki/Dysgeusia
*  3. Psychochemicals | Possible Long-Term Health Effects of Short-Term Exposure To Chemical Agents, Volume 2: Cholinesterase...
K+ conductance speciflcally.l It also affects ion movements and has been show to be a potent blocker of both the Kin channel ( ... SMA does not affect the concentrations of histamine and glutamic acid, but it decreases the activity of glutamic acid ... sistent cardiovascular effects, is noteworthy. Although DMHP acetate elicits far greater cardiovascular consequences than other ... In one sense, this series of experiments provides some index of placebo responsi~reness-~inimal. Many subjects commented (as ...
  https://www.nap.edu/read/9136/chapter/5
*  Glycine Normalizes Hepatic Triglyceride-Rich VLDL Secretion by Triggering the CNS in High-Fat Fed RatsNovelty and Significance ...
NMDA receptor ion channel blocker, MK-801, negates the ability of glycine to lower hepatic VLDL-TG. B, Experimental protocol. ... Hypothalamic sensing of fatty acids. Nat Neurosci. 2005;8:579-584.. OpenUrlCrossRefPubMed ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... DVC glycine was coinfused with NMDA receptor ion channel blocker MK-801 (Figure 1A and 1B). The hypolipidemic effect of DVC ...
  http://circres.ahajournals.org/content/110/10/1345
*  Methamphetamine - Wikipedia
... to open the ion channel. Image legend Ion channel G proteins & linked receptors (Text color) Transcription factors United ... benzoic acid, hippuric acid, norephedrine, and phenylacetone, the metabolites of amphetamine. Among these metabolites, the ... Beta blockers with lipophilic properties and CNS penetration such as metoprolol and labetalol may be useful for treating CNS ... and cardiovascular toxicity. The mixed alpha- and beta-blocker labetalol is especially useful for treatment of concomitant ...
  https://en.wikipedia.org/wiki/Methamphetamine
*  Toxins | August 2014 - Browse Articles
... and there was no effect on BK channels. We demonstrated that HNTX-I was not a phrenic nerve conduction blocker or acutely toxic ... Fragment ion analysis for FB1, FB2, and FB3 showed that while the ions formed at m/z values of 200-800 were similar to those ... Open AccessReview Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect ... The chemical formula of Thu is C22H32O19N5P, and it is composed of adenosine, glucose, phosphoric acid, and gluconic diacid. In ...
  http://www.mdpi.com/2072-6651/6/8?listby=pagination
*  Glossary of diabetes - Wikipedia
Calcium channel blocker Calcium ions are used in many cells, including beta cells, as a signaling mechanism. Since it does not ... Its amino acid code (DNA triplet --> amino acid incorporation) is identical across all Terrestrial life except for a very few ... In that sense, they are catalysts. Epidemiology the study of the transmission of diseases. One of the first epidemiological ... Cardiovascular pertaining to the heart and vascular system (blood vessels). Carpal tunnel syndrome irritation and swelling of ...
  https://en.wikipedia.org/wiki/Glossary_of_diabetes
*  Psalmotoxin-1 | Abcam
... selective ASIC1a blocker. Join researchers using high quality Psalmotoxin-1 from Abcam and achieve your mission… ... Potent, selective acid sensing (proton gated) ion channel 1a (ASIC1a) blocker. Inhibits cation currents mediated by ASICs (IC50 ... Cardiovascular. Cell Biology. Epigenetics. Metabolism. Developmental Biology. By research area. Immunology. Microbiology. ... The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.. J Physiol 570:339-54 (2006). Read more ...
  http://www.abcam.com/psalmotoxin-1-ab120483.html
*  More Potent Anti-Clotting Drugs with Angiography May Benefit Patients with Acute Chest Pain - Healthcanal.com : Healthcanal.com
So hot it hurts - Leuven researchers uncover ion channel trio that mediates painful heat sensing ... Researchers followed the patients to track cardiovascular health outcomes-cardiovascular death, heart attack or stroke-at 30 ... New Study Explores Effects of Omega-3 Fatty Acids and Vitamin D in Type 1 Diabetes ... Prasugel is a stronger blocker of blood-clotting cells called platelets compared to clopidogrel. This benefit of prasugrel was ...
  https://www.healthcanal.com/disorders-conditions/pain/41955-more-potent-anti-clotting-drugs-with-angiography-may-benefit-patients-with-acute-chest-pain.html
*  Mechanisms Contributing to Myocardial Potassium Channel Diversity, Regulation and Remodeling
Caveolae, ion channels and cardiac arrhythmias. Prog Biophys Mol Biol. 2008;98(2-3):149-60. [PMC free article] [PubMed] ... 2. Gurney A, Manoury B. Two-pore potassium channels in the cardiovascular system. Eur Biophys J. 2009;38(3):305-18. [PubMed] ... has been shown to affect the open probabilities of Kv and Kir channels [47, 48]. Arachidonic acid, which is abundant in plasma ... influence of selective potassium channel blockers. J Pharmacol Exp Ther. 2000;292(1):381-6. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4715991/
*  DailyMed - AMLODIPINE BESYLATE- amlodipine besylate tablet
... calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth ... Special Senses: abnormal vision, conjunctivitis, diplopia, eye pain, tinnitus. Urinary System: micturition frequency, ... The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in ... uric acid, blood urea nitrogen, or creatinine. ... Amlodipine besylate tablets are calcium channel blockers and ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4911f343-6834-71b0-e054-00144ff8d46c
*  Aldosterone - Wikipedia
... ions into the urine (lumen of collecting duct). Aldosterone upregulates epithelial sodium channels (ENaCs) in the collecting ... which suggests that Ca2+ channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo. The ... An increase in sensed pressure results in an increased rate of firing by the baroreceptors and a negative feedback response, ... Liquorice, which contains glycyrrhetinic acid, can inhibit 11β-HSD and lead to a mineralocorticoid excess syndrome. Angiotensin ...
  https://en.wikipedia.org/wiki/Aldosterone
*  Micardis HCT - FDA prescribing information, side effects and uses
... nor does it bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. ... Special Senses: transient blurred vision, xanthopsia. Clinical Laboratory Findings. Creatinine, Blood Urea Nitrogen (BUN): ... It is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in ... Dual blockade of the renin-angiotensin-aldosterone system with angiotensin blockers, ACE inhibitors, or aliskiren is associated ...
  https://www.drugs.com/pro/micardis-hct.html
*  Sudden Cardiac Death | Circulation
Calcium channel blockers characteristically suppress this arrhythmia. Sudden cardiac death rarely occurs in this population. ... 71 Neither drug has specific and single ion channel actions. The reason ICDs are so successful is that a "dose of electricity" ... In one sense, sudden cardiac death can be considered an electrical accident because, although many individuals have anatomic ... Figure 1B⇓ shows idealized curves of survival from sudden cardiac death for a population free of major cardiovascular events ...
  http://circ.ahajournals.org/content/98/21/2334.long
*  Abstract 956: Acid-Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus...
It averaged 40.7±15.7 pA (n=5) at pH 5.0 and was blocked by the ASIC channel blocker amiloride (200 μm) to 2.5±1.6 pA. Na+ free ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... Abstract 956: Acid-Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus ... Abstract 956: Acid-Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus ...
  http://circ.ahajournals.org/content/116/Suppl_16/II_189.1
*  Unusual Pungency from Extra-Virgin Olive Oil Is Attributable to Restricted Spatial Expression of the Receptor of Oleocanthal |...
2007b) An ion channel essential for sensing chemical damage. J Neurosci 27:11412-11415. ... To test the hypothesis that OC acts on the TRPA1 ion channel in trigeminal neurons, we used the selective TRPA1 blocker HC- ... After 18 h incubation, neurons were loaded with 5 μm fura-2 AM using 80 μg/ml F-127 pluronic acid for 1 h. Intracellular ... S. Wakabayashi, National Cardiovascular Center Research Institute, Osaka, Japan), human TRPV4 (from Dr. W. Leidtke, Duke ...
  http://www.jneurosci.org/content/31/3/999.full
*  C Category Names List - Drug Information Portal - U.S. National Library of Medicine
... see Calcium Channel Blockers. Calcium Channel Agonists (8) • Agents that increase calcium influx into calcium channels of ... Cardiovascular Agents (775) • Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood ... Carbonic Anhydrase Inhibitors (12) • A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule ... Calcimimetic Agents (1) • Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in ...
  https://druginfo.nlm.nih.gov/drugportal/drug/categories/c