IFN regulatory factor (IRF)-1 (SC-497), upstream stimulatory factor (USF)-1 (SC-229) and USF-2 (SC-862; all from Santa Cruz ... Upstream stimulatory factor binding to the E-box at −65 is required for insulin regulation of the fatty acid synthase promoter ... Chlamydial inhibition of MHC class II expression is correlated with degradation of upstream stimulatory factor (USF)-1, a ... Interferon γ-inducible Major Histocompatibility Complex Class II Expression by Degradation of Upstream Stimulatory Factor 1 ...
... also used successfully in a study of familial combined hyperlipidemia that identified the gene for upstream stimulatory factor ... Reiner AP, Carlson CS, Jenny NS, Durda JP, Siscovick DS, Nickerson DA, Tracy RP: USF1 gene variants, cardiovascular risk, and ... environmental factors are critical risk factors for complex diseases. The incidence and prevalence of many common diseases may ... Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet. 2004, 36: 371-376. ...
Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein. ... Within-visit blood pressure variability and cardiovascular risk factors in hypertensive patients with non-dialysis chronic ... Among these binding motifs, we showed that the E-box specifically binds upstream stimulatory factor (Usf) 1 and Usf2, which are ... However, HFD loading is not a direct stimulatory factor for AT1 receptor. In the present study, we investigated the effect of ...
... the upstream stimulatory factor 1 gene (USF1) was proposed as a candidate gene for familial combined hyperlipidemia (FCH). In ... Many hands make better trials: cutting cardiovascular risk in chronic kidney disease ... The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia. ... Recently, the upstream stimulatory factor 1 gene (USF1) was proposed as a candidate gene for familial combined hyperlipidemia ( ...
Professor of Cardiovascular Medicine - Queen Mary University London, Barts & The London School of Medicine and Dentistry ... The International Type 2 Diabetes 1q Consortium: Variation within the gene encoding the upstream stimulatory factor 1 does not ... The International Type 2 Diabetes 1q Consortium: Variation within the gene encoding the upstream stimulatory factor 1 does not ... University Research Lecturer & British Heart Foundation Research Fellow - Cardiovascular Medicine, RDM, University of Oxford ...
... upstream stimulatory factor. The part of TGF- in renal fibrosis Robust evidence suggests that essentially all progressive forms ... and cardiovascular disorders that stimulate and regulate a number of main pathways resulting in CKD and its own problems. ... 3C7 or enhancing factors that attenuate fibrosis, such as bone morphogenetic protein 7 (BMP-7) and hepatocyte growth element ( ... in which inhibiting factors that promote fibrosis, such as transforming growth element (TGF-), connective cells growth element ...
Variation within the gene encoding the Upstream Stimulatory Factor 1 (USF1) does not influence susceptibility to type 2 ... Genetic Variation in PEAR1 Is Associated With Platelet Aggregation and Cardiovascular Outcomes. Circ Cardiovasc Genet 6(2):184- ... Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 56:856-62 ... Evidence that Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old ...
... expression of APOA5 by activating the progress of de-phosphorylation of phosphorylation of upstream stimulatory factors (USFs ... They genotyped five tagging SNPs in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study ( ... By contrast, other factors have also been confirmed to down regulate expression of APOA5 gene. T0901317, a specific receptor ... Department of Cardiovascular Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China ...
... transcription is mediated by upstream stimulatory factors.." J. Biol. Chem.. 2006 Apr 21;281(16):10849-55. Pubmed PMID: ... Denton A. Cooley Cardiovascular Surgical Society. Past President American Vascular Association. American Heart Association. ... Factors influencing survival in 717 patients.." J. Thorac. Cardiovasc. Surg.. 1989 Nov;98(5):659-73. Pubmed PMID: 2811404 ... Svensson LG, Crawford ES, Coselli JS, Safi HJ, Hess KR "Impact of cardiovascular operation on survival in the Marfan patient.." ...
Ly6Chigh MC presented downregulated co-stimulatory receptors (CD2, GITR and TIM1) which direct immune cell proliferation, and ... upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. Ly6Chigh MC expressed ... Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional ... Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional ...
... promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).. J Biol Chem. ... neurodegenerative and cardiovascular diseases, and cancer. The redox-activated transcription factor Nrf2 has been shown to ... Among these factors, Upstream Transcription Factor 1 (USF1) was shown to play a critical role in controlling HDAC5 ... Upstream transcription factor 1 (USF1) regulates a variety of biological processes by transactivation of functional genes. In ...
Stimulatory and inhibitory effect of 14-3-3 zeta in vivo". The Journal of Biological Chemistry. 277 (26): 23116-22. doi:10.1074 ... Hassouna A, Matata BM, Galiñanes M (Nov 2004). "PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the ... Cardiovascular Research. 88 (1): 83-92. doi:10.1093/cvr/cvq154. PMC 2936125. PMID 20558438. Yang Z, Sun W, Hu K (Apr 2012). " ... "HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection". Journal of Molecular and Cellular ...
... relative to the Ad-LacZ endothelial control consistent with the known stimulatory function of these angiogenic factors (data ... Cardiovascular failure in mouse embryos deficient for VEGF Receptor-3. Science. 282:946-949. View this article via: PubMed ... Therefore, the upstream promoters of both human and mouse VEGFR-3 genes contain Notch-responsive CSL elements. ... Vascular-specific growth factors and blood vessel formation. Nature. 407:242-248. View this article via: PubMed Google Scholar ...
Table 3). Elongation factor 2 (Ef2) served as a housekeeping gene in mRNA analyses. In test samples, quantification of gene ... Heusch G, Libby P, Gersh B, Yellon D, Bohm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease ... It was previously shown that following MI, upstream progenitors are mobilized from the bone marrow niches and engrafted in the ... and other co-stimulatory molecules) on the surface (MHC++) make these cells highly professional antigen-presenting cells ...
Cooney AJ, Tsai SY, OMalley BW, Tsai MJ: Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to ... Hypertension is in turn a potent risk factor for cardiovascular diseases, such as stroke, atherosclerosis, and heart attacks [ ... Shi Q, Gross KW, Sigmund CD: NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. ... Tsai SY, Tsai MJ: Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev. 1997, 18: 229- ...
We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive ... La Sala, L. and A.E. Pontiroli, Prevention of Diabetes and Cardiovascular Disease in Obesity. Int J Mol Sci, 2020. 21(21). ... Here, we used a USF1 (upstream stimulatory factor 1) deficient mouse strain (USF1 KO) as a genetic model of constitutively ... Knol, M.J., et al., Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia, 2006 ...
... factors, HPV can be modulated by extrinsic factors, such as the nervous system [35, 36], endothelial factors (e.g. nitric oxide ... Lines ending with arrows indicate a stimulatory effect, whereas lines ending with a cross bar indicate inhibitory effect. For ... Measurement of reactive oxygen species in cardiovascular studies. Hypertension 2007; 49: 717-727. ... Although the specific role of nSMase in HPV and upstream mechanisms of nSMase activation, also with regard to potential ROS- ...
Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in ... Center of Research in Obesity and Cardiovascular Disease * Center on Drug and Alcohol Research ... Insulin Promoter Factor 1 Variation is Associated with Type 2 Diabetes in African Americans. BMC Med Genet., 2005 Oct; 17(6): ... Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans with Type 2 Diabetes. Diabetes. ...
Vascular endothelium contributes importantly to regulation of cardiovascular and metabolic homeostasis (1,2). Reciprocal ... Reaven GM: Multiple CHD risk factors in type 2 diabetes: beyond hyperglycaemia. Diabetes Obes Metab ... including direct stimulatory effects on adiponectin expression (60) and/or indirect effects to antagonize the inhibitory ... and thiazolidinedione therapies result in rebalanced signaling through PI 3-kinase and MAPK pathways that are the upstream ...
Other factors of possible importance for the mixture of T3 and T4 secreted by the thyroid are a relatively faster liberation of ... Maternal THs acted upstream of pax2a, pax7 and pax8 genes but downstream of shha and fgf8a signalling. The lack of inhibitory ... Stimulatory effects of thyroid hormone on brain angiogenesis in vivo and in vitro ... The Current Impact and Future of Technology within Cardiovascular Surgery September 23, 2023 ...
Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. J Dev Orig Health Dis ... How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. ... it supports the idea that androgens can act on brain regions upstream of the PVN to modulate the function of the HPA axis [107 ... Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats. Prog ...
Cytokine Growth Factor Rev 2012,23(1-2):25-35.PubMedCrossRef 51. Decarlo K, Emley A, Dadzie OE, Mahalingam M: Laser capture ... 5C). In the current study, we found the conserved motifs of the MtrAB two-component system upstream of a large list of genes ... Total cardiovascular diseaseh 5 1.05 0.93,1.18 1.02 0.86,1.21 0.86 0.79,0.94 1.02 0.93,1.13 1.01 0.88,1.16 Trend testb 0.37 ... by Lr1505 was triggered ROCK inhibitor by TLR2 signalling and included augmented expression of MHC-II and co-stimulatory ...
Based on the cytokine and chemokine screening results, there was minimal to no change in soluble factors participating in ... In addition, targeting the upstream modulators of OPN signaling is another possible strategy to inhibit OPN. Fam20C has ... When the immune-stimulatory aptamer is conjugated to an OPN-targeting aptamer, a costimulatory response could theoretically be ... New Therapeutic Targets in Cardiovascular Diseases (Mar 2022). *Immunometabolism (Jan 2022). * View all review series ... ...
... somatostatin transcription factor-1, upstream stimulatory factor-1, stress-activated protein kinase-2, phosphatidylinositol ... Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factors in over weight adolescents. J Pediatr 2003; ... Previously, the main factors influencing nutrient partitioning between the dam and fetus were shown to include the age of the ... Marbling (intramuscular fat) is one of the most important factors determining meat quality, especially texture and flavor. ...
Obesity is a risk factor for many diseases, including type 2 diabetes and cardiovascular disease, and is related to the rising ... In most cases, defective muscle aPKC/PKB activation reflects both impaired activation of IRS-1/PI3K, the upstream activator of ... and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). The ... Nuclear factor E2-related factor 2 (Nrf2) is a cap-n-collar basic leucine zipper (CNC-bZIP) transcription factor that is well ...
Cardiovascular risk factors in a Mexican middle-class urban population. The Lindavista Study. Baseline data. Arch Cardiol Mex. ... Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and ... Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. Bioorg ... Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc ...
Hypertension is a key risk factor for several cardiovascular diseases including coronary vascular disease and stroke (Lu et al ... Bohari, M., Pauliena, S., Hamid, M., Shaari, K., and Lajis, N. (2006). "Glucose uptake: stimulatory activity of Gynura ... procumbens is due to either direct or indirect effects on the upstream component(s) activities in the insulin signaling pathway ... Kaur, N., Awadh, A. I., Ali, R. B., Sadikun, A., Sattar, M. Z. B. A., and Asmawi, M. Z. B. (2012). Cardio-vascular activity of ...
Dokras A. Cardiovascular disease risk factors in polycystic ovary syndrome. Semin Reprod Med. 2008 Jan. 26(1):39-44. [QxMD ... 21] Individuals with PCOS were found more likely to be homozygous for a variant upstream of the PON1 gene and homozygous for an ... A proposed mechanism for anovulation and elevated androgen levels suggests that, under the increased stimulatory effect of ... Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol (Oxf). ...
ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways. Lee, Hye ... Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. Scott, John ... Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone ... Cardiovascular Research. 107(2), pp. 235 - 245. https://doi.org/10.1093/cvr/cvv166 ...
By thinking about the penis to increase the length, the penis is according to the stimulatory process of the penis, it will be ... Mr was a little dissatisfied, and said to Mr Why didnt you mention us, we are the main factor, okay? Cant motherland ... Contrates the free trial to avoid the cardiovascular rise to the sexual health stimulants. ... the output value and drive the upstream and downstream industries will be considerable, and It is also a good motherland ...