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*  Long term results of septal myectomy in the treatment of obstructive hypertrophic cardiomyopathy
A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. ... Of the three patients who died of cardiac causes (one at the hospital and two in the first year after surgery) all patients had ... including death from cardiac causes occurred in the perioperative period until one year postoperatively. After this period, the ... despite being a nation-wide reference tertiary health service and perform a high volume of cardiac surgeries. Considering that ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382011000100016&lng=en&nrm=iso&tlng=en
*  Cytokinetics Announces Fundamental Research In Cardiac Myosin Activation In The Journal Science - Redorbit
The publication titled, "Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure," discusses the ... Omecamtiv mecarbil, a novel cardiac muscle myosin activator, has been the subject of a clinical trials program comprised of ... The authors concluded that cardiac myosin activation may provide a new therapeutic approach for patients with systolic heart ... Cytokinetics Announces Fundamental Research In Cardiac Myosin Activation In The Journal Science. by Sam Savage ...
  http://www.redorbit.com/news/science/2014544/cytokinetics_announces_fundamental_research_in_cardiac_myosin_activation_in_the/
*  Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and...
Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and ... Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and ... Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and ... Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy. Haploinsufficiency, Deranged Phosphorylation, and ...
  http://circ.ahajournals.org/content/early/2009/03/09/CIRCULATIONAHA.108.838672
*  Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in...
Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to ... Journal Article: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Title: Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic ... Tg-S15D-D166V mice were generated with the human cardiac RLC-S15D-D166V construct substituted for mouse cardiac RLC and were ...
  https://www.osti.gov/scitech/biblio/1212938-constitutive-phosphorylation-cardiac-myosin-regulatory-light-chain-prevents-development-hypertrophic-cardiomyopathy-mice
*  Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis | Heart
Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis ... Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis ...
  https://heart.bmj.com/content/early/2018/01/25/heartjnl-2017-312257.alerts
*  Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and...
Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and ... Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and ... Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and ... Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and ...
  http://circ.ahajournals.org/content/122/Suppl_21/A20476
*  Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein...
Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein ... Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein ...
  http://www.chem.wisc.edu/content/top-down-high-resolution-mass-spectrometry-cardiac-myosin-binding-protein-c-revealed
*  Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: mechanisms and therapeutic opportunities. - Semantic Scholar
Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filaments of the sarcomere. Understanding the structural ... The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.. * ... Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filaments of the sarcomere. Understanding the structural ... Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: mechanisms and therapeutic opportunities.. @article{ ...
  https://www.semanticscholar.org/paper/Cardiac-myosin-binding-protein-C-in-hypertrophic-Schlossarek-Mearini/ee2e62470c9d75981d5554077d0c72621dc56250
*  Cytokinetics to Present Clinical Data on CK-1827452, a Selective Cardiac Myosin Activator, at the 2008 Heart Failure Congress...
... a novel cardiac myosin activator being developed for the potential treatment of patients with either acutely decompensated or ... Cytokinetics' cardiovascular disease program is focused to cardiac myosin, a motor protein essential to cardiac muscle ... are performing joint research focused on identifying and characterizing activators of cardiac myosin as back-up and follow-on ... Cytokinetics to Present Clinical Data on CK-1827452, a Selective Cardiac Myosin Activator, at the 2008 Heart Failure Congress ...
  http://www.marketwired.com/press-release/cytokinetics-present-clinical-data-on-ck-1827452-selective-cardiac-myosin-activator-nasdaq-cytk-866364.htm
*  Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein...
Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein ... Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein ... Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein ... Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein ...
  http://circres.ahajournals.org/content/early/2007/07/19/CIRCRESAHA.107.153650
*  MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C | Journal of the American...
MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C. Qinghang Meng, Bidur ... Cardiac myosin binding protein‐C phosphorylation in a {beta}‐myosin heavy chain background. Circulation. 2009;119:1253-1262. ... MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C ... MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C ...
  http://jaha.ahajournals.org/content/6/9/e006590
*  Abstract P078: Dysregulated Calcium Handling in a Conditional Cardiac Myosin Binding Protein C Knockout Model of Hypertrophic...
HCM is chiefly caused by mutations in myofibrillar proteins of the cardiac sarcomere, and cardiac myosin binding protein-C ( ... Abstract P078: Dysregulated Calcium Handling in a Conditional Cardiac Myosin Binding Protein C Knockout Model of Hypertrophic ... Abstract P078: Dysregulated Calcium Handling in a Conditional Cardiac Myosin Binding Protein C Knockout Model of Hypertrophic ... Abstract P078: Dysregulated Calcium Handling in a Conditional Cardiac Myosin Binding Protein C Knockout Model of Hypertrophic ...
  http://circres.ahajournals.org/content/109/Suppl_1/AP078
*  An Endogenously Produced Fragment of Cardiac Myosin Binding Protein C is Pathogenic and Can Lead to Heart Failure | Circulation...
An Endogenously Produced Fragment of Cardiac Myosin Binding Protein C is Pathogenic and Can Lead to Heart Failure. Md. Abdur ... Rationale: A stable 40 kD fragment is produced from cardiac myosin binding protein-C (cMyBP-C) when the heart is stressed, ... An Endogenously Produced Fragment of Cardiac Myosin Binding Protein C is Pathogenic and Can Lead to Heart Failure ... An Endogenously Produced Fragment of Cardiac Myosin Binding Protein C is Pathogenic and Can Lead to Heart Failure ...
  http://circres.ahajournals.org/content/early/2013/07/12/CIRCRESAHA.113.301225
*  Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart FailureClinical Perspective...
... cardiac myosin. This approach is made possible with the novel cardiac myosin-activating compound omecamtiv mecarbil (formerly ... Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart FailureClinical Perspective ... Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart FailureClinical Perspective ... Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart FailureClinical Perspective ...
  http://circheartfailure.ahajournals.org/content/3/4/522.full
*  Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain...
The C-terminal part of the structure of cC2 is very closely related to telokin, the myosin binding fragment of myosin light ... Our model of the cC2-S2Delta complex gives a first glimpse of details of the MyBP-C-myosin interaction. Using this model we ... Using NMR spectroscopy and isothermal titration calorimetry we demonstrate that cC2 alone binds to a fragment of myosin, ... binds to myosin with two binding sites, one close to the N terminus and the other at the C terminus. Here we present the ...
  https://www.semanticscholar.org/paper/Dissecting-the-N-terminal-myosin-binding-site-of-C.-Ababou-Gautel/6d88e1238ea103ce37ab390b6768e4de3fb9eb71
*  Spectrum of clinical phenotypes and gene variants in cardiac myosin-binding protein C mutation carriers with hypertrophic...
... caused by mutations in the myosin-binding protein C gene (MYBPC3) in 110 consecutive, unrelated patients and family members of ... Spectrum of clinical phenotypes and gene variants in cardiac myosin-binding protein C mutation carriers with hypertrophic ... article{Erdmann2001SpectrumOC, title={Spectrum of clinical phenotypes and gene variants in cardiac myosin-binding protein C ... OBJECTIVES We studied the clinical and genetic features of hypertrophic cardiomyopathy (HCM) caused by mutations in the myosin- ...
  https://www.semanticscholar.org/paper/Spectrum-of-clinical-phenotypes-and-gene-variants-C-Erdmann-Raible/101f0d388e78f7757297088499d9946ac7171acf
*  Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies :...
Mutations in the MYBPC3 gene encoding human cardiac myosin-binding protein-C (cMyBP-C) are associated with familial ... Mutations in the MYBPC3 gene encoding human cardiac myosin-binding protein-C (cMyBP-C) are associated with familial ...
  http://oxfordindex.oup.com/view/10.1093/hmg/ddi002
*  Cardiac myosin binding protein C phosphorylation affects cross...
Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.: ... Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.. ... Based on our recent finding that cardiac myosin binding protein C (cMyBP-C) phosphorylation affects muscle contractility in a ... We further conclude that cMyBP-C is an allosteric activator of myosin to increase cross-bridge force, and its phosphorylation ...
  https://www.mysciencework.com/publication/show/cardiac-myosin-binding-protein-c-phosphorylation-affects-cross-bridge-cycle-s-elementary-steps-site-specific-manner-daf8db45
*  Ovariectomy fails to modify the cardiac myosin isoenzyme profi...
Ovariectomy fails to modify the cardiac myosin isoenzyme profile of adult rats.: Estrogen has been shown to help maintain the ... Ovariectomy fails to modify the cardiac myosin isoenzyme profile of adult rats.. Authors * Morris, G S1 ... Distribution of myosin among its three isoenzymes was similar between groups (CONTR: V1, 80%, V2, 14%; V3, 6%; OVAR: V1, 77%, ... Estrogen has been shown to help maintain the elevated expression of the high ATPase myosin isoform, V1, present in the hearts ...
  https://www.mysciencework.com/publication/show/ovariectomy-fails-modify-cardiac-myosin-isoenzyme-profile-adult-rats-2eea2e7a
*  Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C. -...
Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C. ... Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C. ... Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C. ...
  https://www.rdm.ox.ac.uk/publications/104305
*  ABSENCE OF MAJOR DELETIONS OR REARRANGEMENTS OF CARDIAC MYOSIN HEAVY-CHAIN GENES IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY -...
ABSENCE OF MAJOR DELETIONS OR REARRANGEMENTS OF CARDIAC MYOSIN HEAVY-CHAIN GENES IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY ... ABSENCE OF MAJOR DELETIONS OR REARRANGEMENTS OF CARDIAC MYOSIN HEAVY-CHAIN GENES IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY ... ABSENCE OF MAJOR DELETIONS OR REARRANGEMENTS OF CARDIAC MYOSIN HEAVY-CHAIN GENES IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY ... Reilly Group - Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation ...
  https://www.rdm.ox.ac.uk/publications/719513
*  COMPARATIVE STUDIES OF LIGHT MEROMYOSIN PARACRYSTALS DERIVED FROM RED, WHITE, AND CARDIAC MUSCLE MYOSINS | JCB
COMPARATIVE STUDIES OF LIGHT MEROMYOSIN PARACRYSTALS DERIVED FROM RED, WHITE, AND CARDIAC MUSCLE MYOSINS. A. Nakamura, F. ... COMPARATIVE STUDIES OF LIGHT MEROMYOSIN PARACRYSTALS DERIVED FROM RED, WHITE, AND CARDIAC MUSCLE MYOSINS ... Tryptic and chymotryptic light meromyosin paracrystals from red and cardiac muscles of rabbit show a negative and positive ... The results are discussed in terms of the molecular structure and the functional properties of various myosins. ...
  http://jcb.rupress.org/content/49/3/883
*  Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase
... Osamu ... Cardiac-specific myosin light chain kinase (cMLCK) is the kinase predominantly responsible for the maintenance of the basal ... This phosphorylation repels the myosin heads from the thick myosin filament and moves them toward the thin actin filament. ... Keywords: Ca2+/calmodulin, Muscle contraction, Myosin light chain kinase, Regulatory myosin light chain ...
  https://www.jstage.jst.go.jp/article/circj/77/9/77_CJ-13-0627/_article
*  Unexpected myopathy associated with a mutation in MYBPC3 and misplacement of the cardiac myosin binding protein C
... Tajsharghi, ... There is one cardiac specific isoform and two skeletal muscle specific isoforms. Mutations in MYBPC3 encoding the cardiac ... BACKGROUND: Myosin binding protein C (MyBPC) is essential for the structure of the sarcomeres in striated muscle. ... The patient expressed the cardiac specific MyBPC isoform in skeletal muscle at transcript and protein levels. Numerous muscle ...
  http://his.diva-portal.org/smash/record.jsf?faces-redirect=true&language=en&searchType=SIMPLE&query=&af=%5B%5D&aq=%5B%5B%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&pid=diva2%3A906955&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
*  Myosin-binding protein C, cardiac-type (Q14896) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
  http://www.ebi.ac.uk/interpro/protein/Q14896