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*  Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy | Journal of Translational Medicine | Full Text
Down-regulation of α-1-antitrypsin might contribute to extracellular matrix remodeling and left ventricular dilatation. We also ... left ventricular weight/tibia length +31 %) with sustained systolic heart function at 1 week after operation. Two-dimensional ... Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric ... identified PTRF as a potential signaling regulator of volume overload-induced cardiac hypertrophy. ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0898-5
*  Anti-Myosin Light Chain 2 antibody (ab48003) | Abcam
Rabbit polyclonal Myosin Light Chain 2 antibody validated for WB, ELISA, IHC, ICC/IF and tested in Rat. Referenced in 8 ... Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody. *Regulatory light chain of myosin antibody ... Lane 1 : Vascular myosin (rat aorta), loaded with 35 µg of lysate. Lane 2 : Cardiac myosin (mouse heart, loaded with 35 µg of ... Anti-Myosin Light Chain 2 antibody. See all Myosin Light Chain 2 primary antibodies. ...
  http://www.abcam.com/myosin-light-chain-2-antibody-ab48003.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Implantable cardioverter-defibrillators (ICDs) terminate ventricular tachycardia (VT) and ventricular fibrillation (VF) with ... Therefore, BIOTRONIK developed a ventricular lead called the LinoxSMART S DX, which allows for the detection of atrial signals ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ...
  https://www.jove.com/visualize/abstract/23331358/identification-alcohol-involvement-injury-related-hospitalisations
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... Identification and characterization of the properties and regulation of different connexin and pannexin isoforms as gap ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ...
  https://www.jove.com/visualize/abstract/19549873/paleocene-emergence-elephant-relatives-rapid-radiation-african
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ... aggregation or the addition of Activin A or BMP4 and robustly generates cultures of cells that are highly positive for cardiac ...
  https://www.jove.com/visualize/abstract/21899749/an-extended-phylogenetic-analysis-reveals-ancient-origin-non-green
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Notably, the C-terminal domain PHD of RBP2 is absent in the smaller RBP2 isoform4. It is conceivable that the small isoform of ... We observed that GF14 isoforms of the non-? group were more effective than ? group isoforms in the interaction with the H+- ... 14-3-3s exist as a number of isoforms that in Arabidopsis identifies two major groups named ? and non-?. Although isoform ...
  https://www.jove.com/visualize/abstract/24603559/specificity-non-isoforms-arabidopsis-14-3-3-proteins-towards-h-atpase
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... In addition, further observations revealed that specific stem cells, such as cardiac stem cells, mesenchymal stem cells and ... Here, we present the materials and methods to reliably deliver noncontractile cells into the left ventricular wall of ...
  https://www.jove.com/visualize/abstract/24098678/long-term-evaluation-impact-autologous-peripheral-blood-stem-cell
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... We present our established models for morphogenetic signaling, craniofacial, cardiac, vascular integrity, renal function, and ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ...
  https://www.jove.com/visualize/abstract/20838645/a-naturally-occurring-polymorphism-at-drosophila-melanogaster-lim3
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ... "RNA-seq Reveals Novel Transcriptome of Genes and Their Isoforms in Human Pulmonary Microvascular Endothelial Cells Treated with ...
  https://www.jove.com/visualize/abstract/19829692/il-3-oncogenic-abl-regulate-myeloblast-transcriptome-altering-mrna
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... Together, these site-specific differences support the view that, analogous to different muscle types (cardiac, smooth and ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ...
  https://www.jove.com/visualize/abstract/20027296/adult-rat-bones-maintain-distinct-regionalized-expression-markers
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Rare events in cardiac myocytes such as proliferation and apoptosis require an accurate identification of cardiac myocyte ... The production of corresponding protein isoforms is validated by immunoblotting assays. The method of detecting splice isoforms ... Using isoform-specific primer sets, the alternative splicing of interested mRNAs are analyzed by quantitative RT-PCR. ...
  https://www.jove.com/visualize/abstract/20041118/conserved-usage-of-alternative-5-untranslated-exons-of-the-gata4-gene
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Rare events in cardiac myocytes such as proliferation and apoptosis require an accurate identification of cardiac myocyte ... We show how to easily dissect hearts from neonates, dissociate the cardiac tissue and enrich cardiomyocytes from the cardiac ... Anti-apoptotic BCL-2 family proteins (e.g., BCL-2 related gene, long isoform, BCL-xL; myeloid cell leukemia 1, MCL-1) regulate ...
  https://www.jove.com/visualize/abstract/21088907/inhibitory-effect-hepatocyte-growth-factor-on-cardiomyocytes
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ... monitoring of a patient in cardiac arrest; (4) achieving normocapnia in intubated head trauma patients; (5) monitoring ...
  https://www.jove.com/visualize/abstract/23505427/exploratory-analysis-methods-for-automated-classification-laboratory
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... Computational simulations of ventricular activation maps and pseudo-ECGs in sinus rhythm and ventricular tachycardia indicated ... Ventricular geometry of a patient heart was extracted, via semiautomatic segmentation, from an in vivo computed tomography (CT ... In cardiac myocytes a complex network of membrane tubules - the transverse-axial tubule system (TATS) - controls deep ...
  https://www.jove.com/visualize/abstract/25265017/multivariate-longitudinal-shape-analysis-human-lateral-ventricles
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... These proteinaceous seeds serve as templates for the conversion and replication of their benign cellular isoform. Accumulating ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ...
  https://www.jove.com/visualize/abstract/26114750/genetic-non-genetic-inheritance-natural-antibodies-binding-keyhole
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ... We further extend our basic protocol to cultivate hPSCs on defined extracellular proteins such as the laminin isoform 521 (LN- ... offering us new opportunities to model very early stages of human cardiac development not otherwise accessible. In contrast to ...
  https://www.jove.com/visualize/abstract/23226362/contribution-stochastic-partitioning-at-human-embryonic-stem-cell
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... In cardiac myocytes a complex network of membrane tubules - the transverse-axial tubule system (TATS) - controls deep ... In ventricular myocytes (VMs), certain TATS components are highly abundant contributing to rectilinear tubule networks and ... The potential of exploiting human induced pluripotent stem cell (hiPSC) technology to generate cardiac muscle "in a dish" for ...
  https://www.jove.com/visualize/abstract/26153690/correction-epidemic-process-over-commute-network-metropolitan
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform ... We show how to easily dissect hearts from neonates, dissociate the cardiac tissue and enrich cardiomyocytes from the cardiac ... In cardiac myocytes a complex network of membrane tubules - the transverse-axial tubule system (TATS) - controls deep ... In ventricular myocytes (VMs), certain TATS components are highly abundant contributing to rectilinear tubule networks and ...
  https://www.jove.com/visualize/abstract/22506063/microtubular-stability-affects-pvhl-mediated-regulation-hif-1alpha
*  MYL3 - Wikipedia
Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This ... Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction. Cardiac, ventricular ... cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial ... two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform ( ...
  https://en.wikipedia.org/wiki/MYL3
*  MYL2 - Wikipedia
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin ... Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v ... "Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in ... This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and ...
  https://en.wikipedia.org/wiki/MYL2
*  MYH6 - Wikipedia
This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is ... cardiac ventricles predominantly express the MHC-β isoform and cardiac atria predominantly express the MHC-α isoform. The two ... MHC-α isoform is abundantly expressed in both cardiac atria and cardiac ventricles during embryonic development. Following ... 4kb downstream of the MYH7 gene encoding the other major cardiac muscle isoform of myosin heavy chain, MHC-β. MHC-α is a ...
  https://en.wikipedia.org/wiki/MYH6
*  MYL7 - Wikipedia
ALC-2 is an EF hand protein that binds to the neck region of alpha myosin heavy chain. ALC-2 and the ventricular isoform, VLC-2 ... "Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in ... A study in which the ventricular isoform of regulatory light chain was overexpressed to replace the ALC-2 in cardiac atria was ... Cummins P (July 1982). "Transitions in human atrial and ventricular myosin light-chain isoenzymes in response to cardiac- ...
  https://en.wikipedia.org/wiki/MYL7
*  MYL4 - Wikipedia
Morano I, Haase H (May 1997). "Different actin affinities of human cardiac essential myosin light chain isoforms". FEBS Letters ... Shift in atrial myosin heavy chains and in ventricular myosin light chains". European Heart Journal. 5 Suppl F: 85-93. doi: ... ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ... ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ...
  https://en.wikipedia.org/wiki/MYL4
*  Myotonin-protein kinase - Wikipedia
... and cardiac muscles. This kinase exists both as a membrane-associated and as a soluble form in human left ventricular samples. ... Data obtained by using antibodies that detect specific isoforms of DMPK indicate that the most abundant isoform of DMPK is an ... Myosin phosphatase is an enzyme that plays a role in muscle tensing (contraction) and relaxation. Dystrophia myotonica protein ... For example, myotonic dystrophy protein kinase has been shown to turn off (inhibit) part of a muscle protein called myosin ...
  https://en.wikipedia.org/wiki/Myotonin-protein_kinase